Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene / Bekh BRADLEY in Development and Psychopathology, 23-2 (May 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-2 (May 2011) . - p.439-452 Titre : Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene Type de document : Texte imprimé et/ou numérique Auteurs : Bekh BRADLEY, Auteur ; Drew WESTEN, Auteur ; Kristina B. MERCER, Auteur ; Elisabeth B. BINDER, Auteur ; Tanja JOVANOVIC, Auteur ; Daniel CRAIN, Auteur ; Aliza WINGO, Auteur ; Christine HEIM, Auteur Année de publication : 2011 Article en page(s) : p.439-452 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The ability to effectively regulate emotions and a secure attachment style are critical for maintaining mental health across the life span. The experience of childhood maltreatment interferes with normal development of emotional regulation and dramatically increases risk for a wide range of psychiatric disorders in adulthood. The central nervous system oxytocin systems are critically involved in mediating social attachment and buffering psychophysiological responses to stress. We therefore investigated the impact of childhood maltreatment and an oxytocin receptor (OXTR) single nucleotide polymorphism (rs53576) and their interaction on emotional dysregulation and attachment style in adulthood in a sample of low-income, African American men and women recruited from primary care clinics of an urban, public hospital. Consistent with prior research, we found that the severity of childhood maltreatment was associated with increased levels of emotional dysregulation in adulthood. Childhood maltreatment was also positively associated with ratings of disorganized/unresolved adult attachment style and negatively associated with ratings of secure adult attachment style. There was no direct association between rs53576 and emotional dysregulation or ratings of adult attachment style. However, there were significant interactions between rs53576 and childhood maltreatment in predicting level of adult emotional dysregulation and attachment style. Specifically, G/G genotype carriers were at risk for increased emotional dysregulation when exposed to three or more categories of childhood abuse. In addition, G/G genotype carriers exhibited enhanced disorganized adult attachment style when exposed to severe childhood abuse compared to A/A and A/G carriers. Our findings suggest that A allele carriers of OXTR rs53576 are resilient against the effects of severe childhood adversity, by protection against emotional dysregulation and disorganized attachment. En ligne : http://dx.doi.org/10.1017/S0954579411000162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene [Texte imprimé et/ou numérique] / Bekh BRADLEY, Auteur ; Drew WESTEN, Auteur ; Kristina B. MERCER, Auteur ; Elisabeth B. BINDER, Auteur ; Tanja JOVANOVIC, Auteur ; Daniel CRAIN, Auteur ; Aliza WINGO, Auteur ; Christine HEIM, Auteur . - 2011 . - p.439-452. Langues : Anglais (eng) in Development and Psychopathology > 23-2 (May 2011) . - p.439-452 Index. décimale : PER Périodiques Résumé : The ability to effectively regulate emotions and a secure attachment style are critical for maintaining mental health across the life span. The experience of childhood maltreatment interferes with normal development of emotional regulation and dramatically increases risk for a wide range of psychiatric disorders in adulthood. The central nervous system oxytocin systems are critically involved in mediating social attachment and buffering psychophysiological responses to stress. We therefore investigated the impact of childhood maltreatment and an oxytocin receptor (OXTR) single nucleotide polymorphism (rs53576) and their interaction on emotional dysregulation and attachment style in adulthood in a sample of low-income, African American men and women recruited from primary care clinics of an urban, public hospital. Consistent with prior research, we found that the severity of childhood maltreatment was associated with increased levels of emotional dysregulation in adulthood. Childhood maltreatment was also positively associated with ratings of disorganized/unresolved adult attachment style and negatively associated with ratings of secure adult attachment style. There was no direct association between rs53576 and emotional dysregulation or ratings of adult attachment style. However, there were significant interactions between rs53576 and childhood maltreatment in predicting level of adult emotional dysregulation and attachment style. Specifically, G/G genotype carriers were at risk for increased emotional dysregulation when exposed to three or more categories of childhood abuse. In addition, G/G genotype carriers exhibited enhanced disorganized adult attachment style when exposed to severe childhood abuse compared to A/A and A/G carriers. Our findings suggest that A allele carriers of OXTR rs53576 are resilient against the effects of severe childhood adversity, by protection against emotional dysregulation and disorganized attachment. En ligne : http://dx.doi.org/10.1017/S0954579411000162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Children with maltreatment exposure exhibit rumination-like spontaneous thought patterns: association with symptoms of depression, subcallosal cingulate cortex thickness, and cortisol levels / Roman LINZ ; Nikolaus STEINBEIS ; Martin BAUER ; Felix DAMMERING ; Claudia LAZARIDES ; Heiko KLAWITTER ; Lea BENTZ ; Sonja ENTRINGER ; Sibylle M. WINTER ; Claudia BUSS ; Christine HEIM in Journal of Child Psychology and Psychiatry, 65-1 (January 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-1 (January 2024) . - p.31-41 Titre : Children with maltreatment exposure exhibit rumination-like spontaneous thought patterns: association with symptoms of depression, subcallosal cingulate cortex thickness, and cortisol levels Type de document : Texte imprimé et/ou numérique Auteurs : Roman LINZ, Auteur ; Nikolaus STEINBEIS, Auteur ; Martin BAUER, Auteur ; Felix DAMMERING, Auteur ; Claudia LAZARIDES, Auteur ; Heiko KLAWITTER, Auteur ; Lea BENTZ, Auteur ; Sonja ENTRINGER, Auteur ; Sibylle M. WINTER, Auteur ; Claudia BUSS, Auteur ; Christine HEIM, Auteur Article en page(s) : p.31-41 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Childhood maltreatment is associated with pervasive risk for depression. However, the immediate cognitive and neural mechanisms that mediate this risk during development are unknown. We here studied the impact of maltreatment on self-generated thought (SGT) patterns and their association with depressive symptoms, subcallosal cingulate cortex (SCC) thickness, and cortisol levels in children. Methods We recruited 183 children aged 6?12?years, 96 of which were exposed to maltreatment. Children performed a mind wandering task to elicit SGTs. A subgroup of children underwent structural magnetic resonance imaging (N?=?155) for SCC thickness analyses and saliva collection for quantification of free cortisol concentrations (N?=?126) was collected. Using network analysis, we assessed thought networks and compared these networks between children with and without maltreatment exposure. Using multilevel analyses, we then tested the association between thought networks of children with maltreatment exposure with depressive symptoms, SCC thickness, and cortisol levels. Results Children exposed to maltreatment generated fewer positively valenced thoughts. Network analysis revealed rumination-like thought patterns in children with maltreatment exposure, which were associated with depressive symptoms, SCC thickness, and cortisol levels. Children with maltreatment exposure further exhibited decreased future-self thought coupling, which was associated with depressive symptoms, while other-related and past-oriented thoughts had the greatest importance within the network. Conclusions Using a novel network analytic approach, we provide evidence that children exposed to maltreatment exhibit ruminative clustering of thoughts, which is associated with depressive symptoms and neurobiological correlates of depression. Our results provide a specific target for clinical translation to design early interventions for middle childhood. Targeting thought patterns in children with maltreatment exposure may be an effective strategy to effectively mitigate depression risk early in life. En ligne : https://doi.org/10.1111/jcpp.13853 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Children with maltreatment exposure exhibit rumination-like spontaneous thought patterns: association with symptoms of depression, subcallosal cingulate cortex thickness, and cortisol levels [Texte imprimé et/ou numérique] / Roman LINZ, Auteur ; Nikolaus STEINBEIS, Auteur ; Martin BAUER, Auteur ; Felix DAMMERING, Auteur ; Claudia LAZARIDES, Auteur ; Heiko KLAWITTER, Auteur ; Lea BENTZ, Auteur ; Sonja ENTRINGER, Auteur ; Sibylle M. WINTER, Auteur ; Claudia BUSS, Auteur ; Christine HEIM, Auteur . - p.31-41. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-1 (January 2024) . - p.31-41 Index. décimale : PER Périodiques Résumé : Background Childhood maltreatment is associated with pervasive risk for depression. However, the immediate cognitive and neural mechanisms that mediate this risk during development are unknown. We here studied the impact of maltreatment on self-generated thought (SGT) patterns and their association with depressive symptoms, subcallosal cingulate cortex (SCC) thickness, and cortisol levels in children. Methods We recruited 183 children aged 6?12?years, 96 of which were exposed to maltreatment. Children performed a mind wandering task to elicit SGTs. A subgroup of children underwent structural magnetic resonance imaging (N?=?155) for SCC thickness analyses and saliva collection for quantification of free cortisol concentrations (N?=?126) was collected. Using network analysis, we assessed thought networks and compared these networks between children with and without maltreatment exposure. Using multilevel analyses, we then tested the association between thought networks of children with maltreatment exposure with depressive symptoms, SCC thickness, and cortisol levels. Results Children exposed to maltreatment generated fewer positively valenced thoughts. Network analysis revealed rumination-like thought patterns in children with maltreatment exposure, which were associated with depressive symptoms, SCC thickness, and cortisol levels. Children with maltreatment exposure further exhibited decreased future-self thought coupling, which was associated with depressive symptoms, while other-related and past-oriented thoughts had the greatest importance within the network. Conclusions Using a novel network analytic approach, we provide evidence that children exposed to maltreatment exhibit ruminative clustering of thoughts, which is associated with depressive symptoms and neurobiological correlates of depression. Our results provide a specific target for clinical translation to design early interventions for middle childhood. Targeting thought patterns in children with maltreatment exposure may be an effective strategy to effectively mitigate depression risk early in life. En ligne : https://doi.org/10.1111/jcpp.13853 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Immediate impact of child maltreatment on mental, developmental, and physical health trajectories / Sibylle Maria WINTER in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1027-1045 Titre : Immediate impact of child maltreatment on mental, developmental, and physical health trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Sibylle Maria WINTER, Auteur ; Katja DITTRICH, Auteur ; Peggy DORR, Auteur ; Judith OVERFELD, Auteur ; Imke MOEBUS, Auteur ; Elena MURRAY, Auteur ; Gergana KARABOYCHEVA, Auteur ; Christian ZIMMERMANN, Auteur ; Andrea KNOP, Auteur ; Manuel VOELKLE, Auteur ; Sonja ENTRINGER, Auteur ; Claudia BUSS, Auteur ; John-Dylan HAYNES, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1027-1045 Langues : Anglais (eng) Mots-clés : Child  Child Abuse/psychology  Emotions  Humans  Longitudinal Studies  Mental Disorders/psychology  Physical Abuse  Child development  follow-up studies  maltreatment  psychopathology  somatic problems Index. décimale : PER Périodiques Résumé : OBJECTIVE: The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow-up are needed. METHOD: We assessed health and developmental outcomes in 6-month intervals over 2years in 173 children, aged 3-5years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6months and 87 nonmaltreated children. Assessments included clinician-administered, self- and parent-report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories. RESULTS: Maltreated children exhibited greater numbers of psychiatric diagnoses (b=1.998, p<.001), externalizing (b=13.29, p<.001) and internalizing (b=11.70, p<.001) symptoms, impairments in cognitive (b=-11.586, p<.001), verbal (b=-10.687, p<.001), and motor development (b=-7.904, p=.006), and greater numbers of medical symptoms (b=1.021, p<.001) compared to nonmaltreated children across all time-points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time. CONCLUSION: The profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism-driven interventions that mitigate adverse trajectories in maltreated children. En ligne : http://dx.doi.org/10.1111/jcpp.13550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Immediate impact of child maltreatment on mental, developmental, and physical health trajectories [Texte imprimé et/ou numérique] / Sibylle Maria WINTER, Auteur ; Katja DITTRICH, Auteur ; Peggy DORR, Auteur ; Judith OVERFELD, Auteur ; Imke MOEBUS, Auteur ; Elena MURRAY, Auteur ; Gergana KARABOYCHEVA, Auteur ; Christian ZIMMERMANN, Auteur ; Andrea KNOP, Auteur ; Manuel VOELKLE, Auteur ; Sonja ENTRINGER, Auteur ; Claudia BUSS, Auteur ; John-Dylan HAYNES, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1027-1045. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1027-1045 Mots-clés : Child  Child Abuse/psychology  Emotions  Humans  Longitudinal Studies  Mental Disorders/psychology  Physical Abuse  Child development  follow-up studies  maltreatment  psychopathology  somatic problems Index. décimale : PER Périodiques Résumé : OBJECTIVE: The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow-up are needed. METHOD: We assessed health and developmental outcomes in 6-month intervals over 2years in 173 children, aged 3-5years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6months and 87 nonmaltreated children. Assessments included clinician-administered, self- and parent-report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories. RESULTS: Maltreated children exhibited greater numbers of psychiatric diagnoses (b=1.998, p<.001), externalizing (b=13.29, p<.001) and internalizing (b=11.70, p<.001) symptoms, impairments in cognitive (b=-11.586, p<.001), verbal (b=-10.687, p<.001), and motor development (b=-7.904, p=.006), and greater numbers of medical symptoms (b=1.021, p<.001) compared to nonmaltreated children across all time-points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time. CONCLUSION: The profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism-driven interventions that mitigate adverse trajectories in maltreated children. En ligne : http://dx.doi.org/10.1111/jcpp.13550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

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