Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity / Margherita PROSPERI in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3574-3588 Titre : Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity Type de document : texte imprimé Auteurs : Margherita PROSPERI, Auteur ; Elisa SANTOCCHI, Auteur ; Giulia BALBONI, Auteur ; Antonio NARZISI, Auteur ; Margherita BOZZA, Auteur ; Francesca FULCERI, Auteur ; Fabio APICELLA, Auteur ; Roberta IGLIOZZI, Auteur ; Angela COSENZA, Auteur ; Raffaella TANCREDI, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur Article en page(s) : p.3574-3588 Langues : Anglais (eng) Mots-clés : Anxiety Problems  Child Behavior Checklist 1(1/2)-5  Externalizing Problems  Restrictive and repetitive behaviours  Sleep Problems  Young Children Index. décimale : PER Périodiques Résumé : This study investigated the prevalence and type of gastrointestinal (GI) and food selectivity (FS) symptoms in 163 preschoolers with ASD, and their possible links with core ASD features and emotional/behavioural problems. 40.5% of children with ASD had at least one severe GI symptom or FS. Preschoolers with and without GI symptoms and with and without FS were significantly different on several emotional/behavioural problems and restrictive/repetitive behaviours, whereas they did not differ significantly on performance IQ and autistic severity. The GI plus FS group presented with Sleep Problems, Self-injurious Behaviors and Anxiety Problems. Results indicated the need for early identification of GI disturbances and FS in order to design tailored intervention for these symptoms frequently associated to challenging behaviours in ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3271-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325 [article] Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity [texte imprimé] / Margherita PROSPERI, Auteur ; Elisa SANTOCCHI, Auteur ; Giulia BALBONI, Auteur ; Antonio NARZISI, Auteur ; Margherita BOZZA, Auteur ; Francesca FULCERI, Auteur ; Fabio APICELLA, Auteur ; Roberta IGLIOZZI, Auteur ; Angela COSENZA, Auteur ; Raffaella TANCREDI, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur . - p.3574-3588. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3574-3588 Mots-clés : Anxiety Problems  Child Behavior Checklist 1(1/2)-5  Externalizing Problems  Restrictive and repetitive behaviours  Sleep Problems  Young Children Index. décimale : PER Périodiques Résumé : This study investigated the prevalence and type of gastrointestinal (GI) and food selectivity (FS) symptoms in 163 preschoolers with ASD, and their possible links with core ASD features and emotional/behavioural problems. 40.5% of children with ASD had at least one severe GI symptom or FS. Preschoolers with and without GI symptoms and with and without FS were significantly different on several emotional/behavioural problems and restrictive/repetitive behaviours, whereas they did not differ significantly on performance IQ and autistic severity. The GI plus FS group presented with Sleep Problems, Self-injurious Behaviors and Anxiety Problems. Results indicated the need for early identification of GI disturbances and FS in order to design tailored intervention for these symptoms frequently associated to challenging behaviours in ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3271-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325

The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study / Alessandra RETICO in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 5p. Titre : The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study Type de document : texte imprimé Auteurs : Alessandra RETICO, Auteur ; Alessia GIULIANO, Auteur ; Raffaella TANCREDI, Auteur ; Angela COSENZA, Auteur ; Fabio APICELLA, Auteur ; Antonio NARZISI, Auteur ; Laura BIAGI, Auteur ; Michela TOSETTI, Auteur ; Filippo MURATORI, Auteur ; Sara CALDERONI, Auteur Article en page(s) : 5p. Langues : Anglais (eng) Mots-clés : Area Under Curve  Autism Spectrum Disorder/pathology  Cerebrospinal Fluid  Child  Child, Preschool  Female  Gray Matter/pathology  Humans  Infant  Intelligence  Magnetic Resonance Imaging  Male  Neuroimaging  Organ Size  Phenotype  Research Design  Severity of Illness Index  Sex Characteristics  Support Vector Machine  White Matter/pathology  Autism spectrum disorders  Gender differences  Structural MRI  Young children Index. décimale : PER Périodiques Résumé : BACKGROUND: Genetic, hormonal, and environmental factors contribute since infancy to sexual dimorphism in regional brain structures of subjects with typical development. However, the neuroanatomical differences between male and female children with autism spectrum disorders (ASD) are an intriguing and still poorly investigated issue. This study aims to evaluate whether the brain of young children with ASD exhibits sex-related structural differences and if a correlation exists between clinical ASD features and neuroanatomical underpinnings. METHODS: A total of 152 structural MRI scans were analysed. Specifically, 76 young children with ASD (38 males and 38 females; 2-7 years of age; mean = 53 months, standard deviation = 17 months) were evaluated employing a support vector machine (SVM)-based analysis of the grey matter (GM). Group comparisons consisted of 76 age-, gender- and non-verbal-intelligence quotient-matched children with typical development or idiopathic developmental delay without autism. RESULTS: For both genders combined, SVM showed a significantly increased GM volume in young children with ASD with respect to control subjects, predominantly in the bilateral superior frontal gyrus (Brodmann area -BA- 10), bilateral precuneus (BA 31), bilateral superior temporal gyrus (BA 20/22), whereas less GM in patients with ASD was found in right inferior temporal gyrus (BA 37). For the within gender comparisons (i.e., females with ASD vs. controls and males with ASD vs. controls), two overlapping regions in bilateral precuneus (BA 31) and left superior frontal gyrus (BA 9/10) were detected. Sex-by-group analyses revealed in males with ASD compared to matched controls two male-specific regions of increased GM volume (left middle occipital gyrus-BA 19-and right superior temporal gyrus-BA 22). Comparisons in females with and without ASD demonstrated increased GM volumes predominantly in the bilateral frontal regions. Additional regions of significantly increased GM volume in the right anterior cingulate cortex (BA 32) and right cerebellum were typical only of females with ASD. CONCLUSIONS: Despite the specific behavioural correlates of sex-dimorphism in ASD, brain morphology as yet remains unclear and requires future dedicated investigations. This study provides evidence of structural brain gender differences in young children with ASD that possibly contribute to the different phenotypic disease manifestations in males and females. En ligne : http://dx.doi.org/10.1186/s13229-015-0067-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study [texte imprimé] / Alessandra RETICO, Auteur ; Alessia GIULIANO, Auteur ; Raffaella TANCREDI, Auteur ; Angela COSENZA, Auteur ; Fabio APICELLA, Auteur ; Antonio NARZISI, Auteur ; Laura BIAGI, Auteur ; Michela TOSETTI, Auteur ; Filippo MURATORI, Auteur ; Sara CALDERONI, Auteur . - 5p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 5p. Mots-clés : Area Under Curve  Autism Spectrum Disorder/pathology  Cerebrospinal Fluid  Child  Child, Preschool  Female  Gray Matter/pathology  Humans  Infant  Intelligence  Magnetic Resonance Imaging  Male  Neuroimaging  Organ Size  Phenotype  Research Design  Severity of Illness Index  Sex Characteristics  Support Vector Machine  White Matter/pathology  Autism spectrum disorders  Gender differences  Structural MRI  Young children Index. décimale : PER Périodiques Résumé : BACKGROUND: Genetic, hormonal, and environmental factors contribute since infancy to sexual dimorphism in regional brain structures of subjects with typical development. However, the neuroanatomical differences between male and female children with autism spectrum disorders (ASD) are an intriguing and still poorly investigated issue. This study aims to evaluate whether the brain of young children with ASD exhibits sex-related structural differences and if a correlation exists between clinical ASD features and neuroanatomical underpinnings. METHODS: A total of 152 structural MRI scans were analysed. Specifically, 76 young children with ASD (38 males and 38 females; 2-7 years of age; mean = 53 months, standard deviation = 17 months) were evaluated employing a support vector machine (SVM)-based analysis of the grey matter (GM). Group comparisons consisted of 76 age-, gender- and non-verbal-intelligence quotient-matched children with typical development or idiopathic developmental delay without autism. RESULTS: For both genders combined, SVM showed a significantly increased GM volume in young children with ASD with respect to control subjects, predominantly in the bilateral superior frontal gyrus (Brodmann area -BA- 10), bilateral precuneus (BA 31), bilateral superior temporal gyrus (BA 20/22), whereas less GM in patients with ASD was found in right inferior temporal gyrus (BA 37). For the within gender comparisons (i.e., females with ASD vs. controls and males with ASD vs. controls), two overlapping regions in bilateral precuneus (BA 31) and left superior frontal gyrus (BA 9/10) were detected. Sex-by-group analyses revealed in males with ASD compared to matched controls two male-specific regions of increased GM volume (left middle occipital gyrus-BA 19-and right superior temporal gyrus-BA 22). Comparisons in females with and without ASD demonstrated increased GM volumes predominantly in the bilateral frontal regions. Additional regions of significantly increased GM volume in the right anterior cingulate cortex (BA 32) and right cerebellum were typical only of females with ASD. CONCLUSIONS: Despite the specific behavioural correlates of sex-dimorphism in ASD, brain morphology as yet remains unclear and requires future dedicated investigations. This study provides evidence of structural brain gender differences in young children with ASD that possibly contribute to the different phenotypic disease manifestations in males and females. En ligne : http://dx.doi.org/10.1186/s13229-015-0067-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Tracing back to the onset of abnormal head circumference growth in Italian children with autism spectrum disorder / Filippo MURATORI in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.442-449 Titre : Tracing back to the onset of abnormal head circumference growth in Italian children with autism spectrum disorder Type de document : texte imprimé Auteurs : Filippo MURATORI, Auteur ; Sara CALDERONI, Auteur ; Fabio APICELLA, Auteur ; Tiziana FILIPPI, Auteur ; Elisa SANTOCCHI, Auteur ; Simona CALUGI, Auteur ; Angela COSENZA, Auteur ; Raffaella TANCREDI, Auteur ; Antonio NARZISI, Auteur Année de publication : 2012 Article en page(s) : p.442-449 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Children  Head circumference  Biomarker Index. décimale : PER Périodiques Résumé : This retrospective study aims to describe head circumference (HC) developmental course during the first year of life in 50 Italian children with autism spectrum disorder (ASD) and in a control group of 100 typically developing children (TD). To this end, we use anthropometric measurements (HC, body height, body weight) obtained at birth (T0), 1–2 months (T1), 3–5 months (T2) and 6–12 months (T3) from paediatricians and reported in the infant's ‘baby book’. Data indicate that at T2 and T3 HC was significantly greater in ASD group compared to TD, while from T1 weight was significantly smaller in ASD subjects compared to healthy infants. After controlling for weight and height, ASD HC shows an excessive rate of growth from birth. The abnormal HC growth is present in the majority of infants with ASD and could represent a biomarker that together with other clinical signs might promote an early ASD identification. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.07.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Tracing back to the onset of abnormal head circumference growth in Italian children with autism spectrum disorder [texte imprimé] / Filippo MURATORI, Auteur ; Sara CALDERONI, Auteur ; Fabio APICELLA, Auteur ; Tiziana FILIPPI, Auteur ; Elisa SANTOCCHI, Auteur ; Simona CALUGI, Auteur ; Angela COSENZA, Auteur ; Raffaella TANCREDI, Auteur ; Antonio NARZISI, Auteur . - 2012 . - p.442-449. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.442-449 Mots-clés : Autism spectrum disorders  Children  Head circumference  Biomarker Index. décimale : PER Périodiques Résumé : This retrospective study aims to describe head circumference (HC) developmental course during the first year of life in 50 Italian children with autism spectrum disorder (ASD) and in a control group of 100 typically developing children (TD). To this end, we use anthropometric measurements (HC, body height, body weight) obtained at birth (T0), 1–2 months (T1), 3–5 months (T2) and 6–12 months (T3) from paediatricians and reported in the infant's ‘baby book’. Data indicate that at T2 and T3 HC was significantly greater in ASD group compared to TD, while from T1 weight was significantly smaller in ASD subjects compared to healthy infants. After controlling for weight and height, ASD HC shows an excessive rate of growth from birth. The abnormal HC growth is present in the majority of infants with ASD and could represent a biomarker that together with other clinical signs might promote an early ASD identification. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.07.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

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