Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety / John D. HERRINGTON in Journal of Autism and Developmental Disorders, 47-12 (December 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3682-3691 Titre : Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety Type de document : texte imprimé Auteurs : John D. HERRINGTON, Auteur ; Brenna B. MADDOX, Auteur ; Connor M. KERNS, Auteur ; Keiran M. RUMP, Auteur ; Julie A. WORLEY, Auteur ; Jennifer C. BUSH, Auteur ; Alana J. MCVEY, Auteur ; Robert T. SCHULTZ, Auteur ; Judith S. MILLER, Auteur Année de publication : 2017 Article en page(s) : p.3682-3691 Langues : Anglais (eng) Mots-clés : Amygdala  Anxiety disorders  Brain morphometry  Comorbidity Index. décimale : PER Périodiques Résumé : Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory. En ligne : http://dx.doi.org/10.1007/s10803-017-3206-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325 [article] Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety [texte imprimé] / John D. HERRINGTON, Auteur ; Brenna B. MADDOX, Auteur ; Connor M. KERNS, Auteur ; Keiran M. RUMP, Auteur ; Julie A. WORLEY, Auteur ; Jennifer C. BUSH, Auteur ; Alana J. MCVEY, Auteur ; Robert T. SCHULTZ, Auteur ; Judith S. MILLER, Auteur . - 2017 . - p.3682-3691. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3682-3691 Mots-clés : Amygdala  Anxiety disorders  Brain morphometry  Comorbidity Index. décimale : PER Périodiques Résumé : Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory. En ligne : http://dx.doi.org/10.1007/s10803-017-3206-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325

An Examination of Racial Bias in Scoring the Autism Diagnostic Observation Schedule (ADOS) Module 3: An Item Response Theory Analysis / Yuen Yvonne YU in Autism Research, 19-2 (February 2026)  

Public ISBD [article]  inAutism Research > 19-2 (February 2026) . - e70155 Titre : An Examination of Racial Bias in Scoring the Autism Diagnostic Observation Schedule (ADOS) Module 3: An Item Response Theory Analysis Type de document : texte imprimé Auteurs : Yuen Yvonne YU, Auteur ; Austin WYMAN, Auteur ; Calliana J. FAULK, Auteur ; Lizzy J. FULOP, Auteur ; Rebecca L. GREENBERG, Auteur ; Rachel M. BENECKE, Auteur ; Lauren K. STEINBECK, Auteur ; Jessica FOY, Auteur ; Caitlyn KIM, Auteur ; George O. EMORY, Auteur ; Eric A. STORCH, Auteur ; Casey J. ZAMPELLA, Auteur ; Benjamin E. YERYS, Auteur ; Robert T. SCHULTZ, Auteur ; Julia PARISH-MORRIS, Auteur ; John D. HERRINGTON, Auteur ; Caitlin C. CLEMENTS, Auteur Article en page(s) : e70155 Langues : Anglais (eng) Mots-clés : ADOS  autism  differential item functioning  item response theory  racial bias Index. décimale : PER Périodiques Résumé : ABSTRACT Given the rising prevalence of autism among racial minority children in the United States, but persistent service use disparities, this study examines potential bias in specific items from the autism diagnostic observation schedule (ADOS), a highly regarded autism evaluation. We leveraged unidimensional item response theory graded response models and a sample of 735 children to analyze the differential item functioning (DIF) of items within ADOS Module 3. Three items showed significant signs of racial bias: A1 (overall language level), A5 (offers information), and D5 (compulsions and rituals). On these items, Black/African American and Asian children were usually more likely to be rated as showing autistic behaviors than White children with similar autism levels. The impact of racial bias on the item score was small, and the impact on the overall test score was even smaller: on a scale of 0?48 points, the effect of racial bias was estimated at 0.23 total points for Black/African American children and 0.16 points for Asian children. Furthermore, none of the items showing significant bias contribute to the autism classification algorithm. This analysis suggests a small but detectable amount of bias in several specific ADOS items, but not in items central to informing an autism diagnosis. Thus, bias appears statistically, but not clinically, significant. This contributes to examinations of racial bias in the ADOS as the first analysis of Asian children and the first in-depth look at all items in the most commonly used version among school-aged children. En ligne : https://doi.org/10.1002/aur.70155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] An Examination of Racial Bias in Scoring the Autism Diagnostic Observation Schedule (ADOS) Module 3: An Item Response Theory Analysis [texte imprimé] / Yuen Yvonne YU, Auteur ; Austin WYMAN, Auteur ; Calliana J. FAULK, Auteur ; Lizzy J. FULOP, Auteur ; Rebecca L. GREENBERG, Auteur ; Rachel M. BENECKE, Auteur ; Lauren K. STEINBECK, Auteur ; Jessica FOY, Auteur ; Caitlyn KIM, Auteur ; George O. EMORY, Auteur ; Eric A. STORCH, Auteur ; Casey J. ZAMPELLA, Auteur ; Benjamin E. YERYS, Auteur ; Robert T. SCHULTZ, Auteur ; Julia PARISH-MORRIS, Auteur ; John D. HERRINGTON, Auteur ; Caitlin C. CLEMENTS, Auteur . - e70155. Langues : Anglais (eng) in Autism Research > 19-2 (February 2026) . - e70155 Mots-clés : ADOS  autism  differential item functioning  item response theory  racial bias Index. décimale : PER Périodiques Résumé : ABSTRACT Given the rising prevalence of autism among racial minority children in the United States, but persistent service use disparities, this study examines potential bias in specific items from the autism diagnostic observation schedule (ADOS), a highly regarded autism evaluation. We leveraged unidimensional item response theory graded response models and a sample of 735 children to analyze the differential item functioning (DIF) of items within ADOS Module 3. Three items showed significant signs of racial bias: A1 (overall language level), A5 (offers information), and D5 (compulsions and rituals). On these items, Black/African American and Asian children were usually more likely to be rated as showing autistic behaviors than White children with similar autism levels. The impact of racial bias on the item score was small, and the impact on the overall test score was even smaller: on a scale of 0?48 points, the effect of racial bias was estimated at 0.23 total points for Black/African American children and 0.16 points for Asian children. Furthermore, none of the items showing significant bias contribute to the autism classification algorithm. This analysis suggests a small but detectable amount of bias in several specific ADOS items, but not in items central to informing an autism diagnosis. Thus, bias appears statistically, but not clinically, significant. This contributes to examinations of racial bias in the ADOS as the first analysis of Asian children and the first in-depth look at all items in the most commonly used version among school-aged children. En ligne : https://doi.org/10.1002/aur.70155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder / Benjamin E. YERYS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 32 p. Titre : Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder Type de document : texte imprimé Auteurs : Benjamin E. YERYS, Auteur ; John D. HERRINGTON, Auteur ; Gregory K. BARTLEY, Auteur ; Hua-Shan LIU, Auteur ; John A. DETRE, Auteur ; Robert T. SCHULTZ, Auteur Année de publication : 2018 Article en page(s) : 32 p. Langues : Anglais (eng) Mots-clés : Autism  Blood flow  Faces  Mri  Social cognition  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on neurobiological markers of autism spectrum disorder (ASD) has been elusive. However, radionuclide studies of cerebral blood flow (CBF) have shown decreased blood flow (hypoperfusion) in the temporal lobes of individuals with ASD across ages and intelligence. This observation fits with current neuroscientific models that implicate temporal regions in social perception and social cognition. Arterial spin labeled perfusion MRI allows noninvasive quantification of regional CBF as part of a multimodal MRI protocol. This method is almost entirely absent from ASD research to date. Our a priori hypothesis was that children with ASD would present with hypoperfusion in the temporal lobes-most notably the fusiform gyrus (given its prominent role in ASD social perception deficits). We also sought to examine the reproducibility of CBF measures, and their relationship to individual differences in facial recognition and ASD symptoms. METHODS: A total of 58 males (33 with ASD) between the ages of 12 and 17 years participated in the study. All children completed two arterial spin labeling and structural (T1) scans using a 3 T Siemens Verio scanner approximately 8 weeks apart, as well as behavioral testing at time 1 that included diagnostic measures and the Benton Facial Recognition Test. CBF was the key dependent variable, as was facial recognition performance, and ASD symptoms. The two scans were used for reliability analyses. RESULTS: The ASD group showed hypoperfusion in the bilateral fusiform gyrus and in right inferior temporal gyrus. Intra-class correlations showed moderate to good reliability across time within both groups, and no diagnostic group x time interactions. CBF in the left fusiform gyrus was significantly positively correlated with facial recognition. No significant correlations were observed with core ASD symptoms. CONCLUSIONS: Arterial spin labeling revealed hypoperfusion in children with ASD in regions critical to social perception and cognition. The left fusiform gyrus plays an important role in facial recognition, and greater CBF in this region was correlated with more normative facial recognition performance in children with ASD. This study takes an important first step in establishing CBF of the temporal lobes as a reliable marker of ASD. En ligne : http://dx.doi.org/10.1186/s11689-018-9250-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder [texte imprimé] / Benjamin E. YERYS, Auteur ; John D. HERRINGTON, Auteur ; Gregory K. BARTLEY, Auteur ; Hua-Shan LIU, Auteur ; John A. DETRE, Auteur ; Robert T. SCHULTZ, Auteur . - 2018 . - 32 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 32 p. Mots-clés : Autism  Blood flow  Faces  Mri  Social cognition  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on neurobiological markers of autism spectrum disorder (ASD) has been elusive. However, radionuclide studies of cerebral blood flow (CBF) have shown decreased blood flow (hypoperfusion) in the temporal lobes of individuals with ASD across ages and intelligence. This observation fits with current neuroscientific models that implicate temporal regions in social perception and social cognition. Arterial spin labeled perfusion MRI allows noninvasive quantification of regional CBF as part of a multimodal MRI protocol. This method is almost entirely absent from ASD research to date. Our a priori hypothesis was that children with ASD would present with hypoperfusion in the temporal lobes-most notably the fusiform gyrus (given its prominent role in ASD social perception deficits). We also sought to examine the reproducibility of CBF measures, and their relationship to individual differences in facial recognition and ASD symptoms. METHODS: A total of 58 males (33 with ASD) between the ages of 12 and 17 years participated in the study. All children completed two arterial spin labeling and structural (T1) scans using a 3 T Siemens Verio scanner approximately 8 weeks apart, as well as behavioral testing at time 1 that included diagnostic measures and the Benton Facial Recognition Test. CBF was the key dependent variable, as was facial recognition performance, and ASD symptoms. The two scans were used for reliability analyses. RESULTS: The ASD group showed hypoperfusion in the bilateral fusiform gyrus and in right inferior temporal gyrus. Intra-class correlations showed moderate to good reliability across time within both groups, and no diagnostic group x time interactions. CBF in the left fusiform gyrus was significantly positively correlated with facial recognition. No significant correlations were observed with core ASD symptoms. CONCLUSIONS: Arterial spin labeling revealed hypoperfusion in children with ASD in regions critical to social perception and cognition. The left fusiform gyrus plays an important role in facial recognition, and greater CBF in this region was correlated with more normative facial recognition performance in children with ASD. This study takes an important first step in establishing CBF of the temporal lobes as a reliable marker of ASD. En ligne : http://dx.doi.org/10.1186/s11689-018-9250-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex / J. Christopher EDGAR in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-14 Titre : Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex Type de document : texte imprimé Auteurs : J. Christopher EDGAR, Auteur ; Charles L. IV FISK, Auteur ; Jeffrey I. BERMAN, Auteur ; Darina CHUDNOVSKAYA, Auteur ; Song LIU, Auteur ; Juhi PANDEY, Auteur ; John D. HERRINGTON, Auteur ; Russell G. PORT, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P.L. ROBERTS, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. En ligne : http://dx.doi.org/10.1186/s13229-015-0065-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex [texte imprimé] / J. Christopher EDGAR, Auteur ; Charles L. IV FISK, Auteur ; Jeffrey I. BERMAN, Auteur ; Darina CHUDNOVSKAYA, Auteur ; Song LIU, Auteur ; Juhi PANDEY, Auteur ; John D. HERRINGTON, Auteur ; Russell G. PORT, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P.L. ROBERTS, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. En ligne : http://dx.doi.org/10.1186/s13229-015-0065-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Autism and Anxiety: Etiologic Factors and Transdiagnostic Processes / Carla A. MAZEFSKY  

Public ISBD in Handbook of Autism and Anxiety / Thompson E. III DAVIS Titre : Autism and Anxiety: Etiologic Factors and Transdiagnostic Processes Type de document : texte imprimé Auteurs : Carla A. MAZEFSKY, Auteur ; John D. HERRINGTON, Auteur Année de publication : 2014 Importance : p.91-103 Langues : Anglais (eng) Index. décimale : PAR-B PAR-B - Anxiété En ligne : http://dx.doi.org/10.1007/978-3-319-06796-4_7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 in Handbook of Autism and Anxiety / Thompson E. III DAVIS Autism and Anxiety: Etiologic Factors and Transdiagnostic Processes [texte imprimé] / Carla A. MAZEFSKY, Auteur ; John D. HERRINGTON, Auteur . - 2014 . - p.91-103. Langues : Anglais (eng) Index. décimale : PAR-B PAR-B - Anxiété En ligne : http://dx.doi.org/10.1007/978-3-319-06796-4_7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301

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Brief measures of anxiety in non-treatment-seeking youth with autism spectrum disorder / Connor M. KERNS in Autism, 19-8 (November 2015)  

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Brief Report: Emotion Regulation and Respiratory Sinus Arrhythmia in Autism Spectrum Disorder / Lisa GUY in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

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Commentary: Cognitive and emotional empathy in transdiagnostic research – reflections on Klapwijk et al. (2016) / John D. HERRINGTON in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

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Computer Vision Analysis of Reduced Interpersonal Affect Coordination in Youth With Autism Spectrum Disorder / Casey J. ZAMPELLA in Autism Research, 13-12 (December 2020)  

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Effects of cognitive-behavioral therapy on core aspects of anxiety in anxious youth with autism / Matti CERVIN in Research in Autism Spectrum Disorders, 107 (September 2023)  

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Evaluating commercially available wireless cardiovascular monitors for measuring and transmitting real-time physiological responses in children with autism / Heather J. NUSKE in Autism Research, 15-1 (January 2022)  

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Evidence against the "normalization" prediction of the early brain overgrowth hypothesis of autism / Lisa D. YANKOWITZ in Molecular Autism, 11 (2020)  

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Globally weaker and topologically different: resting-state connectivity in youth with autism / Benjamin E. YERYS in Molecular Autism, 8 (2017)  

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Linguistic camouflage in girls with autism spectrum disorder / Julia PARISH-MORRIS in Molecular Autism, 8 (2017)  

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Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters / Coralie CHEVALLIER in Autism Research, 8-5 (October 2015)  

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