Dépouillements

Commentary: The challenges and promises of competitively employing autistic adults in the United States / Jo Ann Yon HERNANDEZ ; Steve RUDER ; Surina BOTHRA ; Catherine GONZALES ; Kali KECSKEMETI ; Yukari TAKARAE in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2054-2060 Titre : Commentary: The challenges and promises of competitively employing autistic adults in the United States Type de document : Texte imprimé et/ou numérique Auteurs : Jo Ann Yon HERNANDEZ, Auteur ; Steve RUDER, Auteur ; Surina BOTHRA, Auteur ; Catherine GONZALES, Auteur ; Kali KECSKEMETI, Auteur ; Yukari TAKARAE, Auteur Article en page(s) : p.2054-2060 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Current United States statistics suggest that autistic individuals will experience high unemployment and underemployment rates throughout their lives. Furthermore, despite the passage of federal legislation to employ young autistic adults in competitive integrated settings, where they work alongside non-disabled workers and earn at least minimum wage, most individuals receiving state services still are placed in day programs or sheltered workshops. Since meaningful employment is the most important determinant of life satisfaction, this failure is a critical societal problem, exerting increasing pressure for systems change. But the news is not all bad. Private sector companies have increased their hiring of disabled workers, producing a growing base of expertise in the recruitment, on-boarding, training, and management of autistic employees. This has led to a growing recognition that autistic individuals can be ideal workers. Autism researchers have advanced the field by investigating these private industry programs as well as conducting efficacy trials of interventions and services that help autistic individuals in the workplace. However, gaps in knowledge persist stemming from the heterogeneity of autistic workers, limited knowledge about those not receiving state services, and a system of federal services that is fragmented, poorly coordinated, difficult to navigate, and over-taxed. Autism researchers can continue to improve outcomes of autistic workers through investigations of the fit between autistic workers, their preferences, and the characteristics of available jobs, and through effectiveness trails of promising employment interventions and services that promote systems change that help break down the barriers to better integration of existing state services and resources in the United States. En ligne : https://doi.org/10.1002/aur.3009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Commentary: The challenges and promises of competitively employing autistic adults in the United States [Texte imprimé et/ou numérique] / Jo Ann Yon HERNANDEZ, Auteur ; Steve RUDER, Auteur ; Surina BOTHRA, Auteur ; Catherine GONZALES, Auteur ; Kali KECSKEMETI, Auteur ; Yukari TAKARAE, Auteur . - p.2054-2060. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2054-2060 Index. décimale : PER Périodiques Résumé : Abstract Current United States statistics suggest that autistic individuals will experience high unemployment and underemployment rates throughout their lives. Furthermore, despite the passage of federal legislation to employ young autistic adults in competitive integrated settings, where they work alongside non-disabled workers and earn at least minimum wage, most individuals receiving state services still are placed in day programs or sheltered workshops. Since meaningful employment is the most important determinant of life satisfaction, this failure is a critical societal problem, exerting increasing pressure for systems change. But the news is not all bad. Private sector companies have increased their hiring of disabled workers, producing a growing base of expertise in the recruitment, on-boarding, training, and management of autistic employees. This has led to a growing recognition that autistic individuals can be ideal workers. Autism researchers have advanced the field by investigating these private industry programs as well as conducting efficacy trials of interventions and services that help autistic individuals in the workplace. However, gaps in knowledge persist stemming from the heterogeneity of autistic workers, limited knowledge about those not receiving state services, and a system of federal services that is fragmented, poorly coordinated, difficult to navigate, and over-taxed. Autism researchers can continue to improve outcomes of autistic workers through investigations of the fit between autistic workers, their preferences, and the characteristics of available jobs, and through effectiveness trails of promising employment interventions and services that promote systems change that help break down the barriers to better integration of existing state services and resources in the United States. En ligne : https://doi.org/10.1002/aur.3009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Why it is so challenging to perform economic evaluations of interventions in autism and what to do about it / Wendy J. UNGAR in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2061-2070 Titre : Why it is so challenging to perform economic evaluations of interventions in autism and what to do about it Type de document : Texte imprimé et/ou numérique Auteurs : Wendy J. UNGAR, Auteur Article en page(s) : p.2061-2070 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Economic evaluation is used to determine the optimal provision of services and programs under budget constraints and to inform public and private payer funding decisions. To maximize value-for-money in the design and delivery of programs and services for persons with autism spectrum disorder (ASD), it's essential to generate high-quality economic evidence to inform budget allocation. There is a paucity however, of economic evaluations of interventions for ASD. This is due in part to challenges in conducting economic evaluations in this population and the lack of guidance on suitable approaches. These challenges are related to the inherent heterogeneity of the autistic population; establishing short- and long-term effectiveness; measurement of costs and the availability of valid instruments for collecting economic data; the appropriateness of outcomes for use in economic evaluation; and achieving statistical power. This commentary addresses a lack of awareness and needed guidance on these issues by discussing the challenges and providing recommendations for how economic evaluations in ASD could be improved to generate high-quality evidence for program funding decision-making. En ligne : https://doi.org/10.1002/aur.3014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Why it is so challenging to perform economic evaluations of interventions in autism and what to do about it [Texte imprimé et/ou numérique] / Wendy J. UNGAR, Auteur . - p.2061-2070. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2061-2070 Index. décimale : PER Périodiques Résumé : Abstract Economic evaluation is used to determine the optimal provision of services and programs under budget constraints and to inform public and private payer funding decisions. To maximize value-for-money in the design and delivery of programs and services for persons with autism spectrum disorder (ASD), it's essential to generate high-quality economic evidence to inform budget allocation. There is a paucity however, of economic evaluations of interventions for ASD. This is due in part to challenges in conducting economic evaluations in this population and the lack of guidance on suitable approaches. These challenges are related to the inherent heterogeneity of the autistic population; establishing short- and long-term effectiveness; measurement of costs and the availability of valid instruments for collecting economic data; the appropriateness of outcomes for use in economic evaluation; and achieving statistical power. This commentary addresses a lack of awareness and needed guidance on these issues by discussing the challenges and providing recommendations for how economic evaluations in ASD could be improved to generate high-quality evidence for program funding decision-making. En ligne : https://doi.org/10.1002/aur.3014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

The INSAR Community Collaborator Request: Using community-academic partnerships to enhance outcomes of participatory autism research / Patrick DWYER ; Dena GASSNER ; Melanie HEYWORTH ; Zachary J. WILLIAMS in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2071-2076 Titre : The INSAR Community Collaborator Request: Using community-academic partnerships to enhance outcomes of participatory autism research Type de document : Texte imprimé et/ou numérique Auteurs : Patrick DWYER, Auteur ; Dena GASSNER, Auteur ; Melanie HEYWORTH, Auteur ; Zachary J. WILLIAMS, Auteur Article en page(s) : p.2071-2076 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Participatory approaches, in which researchers work together with members of the autism community (e.g., autistic people, family members, caregivers, or other stakeholders) to design, conduct, and disseminate research, have become increasingly prominent within the field of autism research over the past decade. Despite growing academic and community interest in conducting participatory studies, stakeholder collaboration remains infrequent in autism research, at least partially due to systemic barriers. To help reduce barriers to engaging in participatory autism research, the International Society for Autism Research (INSAR) Autistic Researchers Committee has launched the INSAR Community Collaborator Request (ICCR; https://www.autism-insar.org/page/iccr), a platform on the INSAR website that allows autism researchers conducting participatory research to seek out stakeholder collaborators from the autism community (including both autistic people and their family members/caregivers, as relevant to a given research project). Interested stakeholders also have the opportunity to subscribe to ICCR posts, allowing them to be alerted of new opportunities for collaboration and potentially increasing their involvement in autism research. Overall, the ICCR provides a venue to connect autism researchers with potential community collaborators, reducing barriers to participatory autism research and increasing the frequency of successful community-academic partnerships within the field. We are hopeful that in the long term, such changes will lead to greater alignment between research outputs and the goals of the greater autism community, and consequently an increase in the overall quality and relevance of autism research. En ligne : https://doi.org/10.1002/aur.3027 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] The INSAR Community Collaborator Request: Using community-academic partnerships to enhance outcomes of participatory autism research [Texte imprimé et/ou numérique] / Patrick DWYER, Auteur ; Dena GASSNER, Auteur ; Melanie HEYWORTH, Auteur ; Zachary J. WILLIAMS, Auteur . - p.2071-2076. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2071-2076 Index. décimale : PER Périodiques Résumé : Abstract Participatory approaches, in which researchers work together with members of the autism community (e.g., autistic people, family members, caregivers, or other stakeholders) to design, conduct, and disseminate research, have become increasingly prominent within the field of autism research over the past decade. Despite growing academic and community interest in conducting participatory studies, stakeholder collaboration remains infrequent in autism research, at least partially due to systemic barriers. To help reduce barriers to engaging in participatory autism research, the International Society for Autism Research (INSAR) Autistic Researchers Committee has launched the INSAR Community Collaborator Request (ICCR; https://www.autism-insar.org/page/iccr), a platform on the INSAR website that allows autism researchers conducting participatory research to seek out stakeholder collaborators from the autism community (including both autistic people and their family members/caregivers, as relevant to a given research project). Interested stakeholders also have the opportunity to subscribe to ICCR posts, allowing them to be alerted of new opportunities for collaboration and potentially increasing their involvement in autism research. Overall, the ICCR provides a venue to connect autism researchers with potential community collaborators, reducing barriers to participatory autism research and increasing the frequency of successful community-academic partnerships within the field. We are hopeful that in the long term, such changes will lead to greater alignment between research outputs and the goals of the greater autism community, and consequently an increase in the overall quality and relevance of autism research. En ligne : https://doi.org/10.1002/aur.3027 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children / Gloria T. HAN ; Adam J. NAPLES ; Julie M. WOLF ; James C. MCPARTLAND in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2077-2089 Titre : Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Gloria T. HAN, Auteur ; Adam J. NAPLES, Auteur ; Julie M. WOLF, Auteur ; James C. MCPARTLAND, Auteur Article en page(s) : p.2077-2089 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Electroencephalographic peak alpha frequency (PAF) is a marker of neural maturation that increases with age throughout childhood. Distinct maturation of PAF is observed in children with autism spectrum disorder such that PAF does not increase with age and is instead positively associated with cognitive ability. The current study clarifies and extends previous findings by characterizing the effects of age and cognitive ability on PAF between diagnostic groups in a sample of children and adolescents with and without autism spectrum disorder. Resting EEG data and behavioral measures were collected from 45 autistic children and 34 neurotypical controls aged 8 to 18?years. Utilizing generalized additive models to account for nonlinear relations, we examined differences in the joint effect of age and nonverbal IQ by diagnosis as well as bivariate relations between age, nonverbal IQ, and PAF across diagnostic groups. Age was positively associated with PAF among neurotypical children but not among autistic children. In contrast, nonverbal IQ but not age was positively associated with PAF among autistic children. Models accounting for nonlinear relations revealed different developmental trajectories as a function of age and cognitive ability based on diagnostic status. Results align with prior evidence indicating that typical age-related increases in PAF are absent in autistic children and that PAF instead increases with cognitive ability in these children. Findings suggest the potential of PAF to index distinct trajectories of neural maturation in autistic children. En ligne : https://doi.org/10.1002/aur.3017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children [Texte imprimé et/ou numérique] / Gloria T. HAN, Auteur ; Adam J. NAPLES, Auteur ; Julie M. WOLF, Auteur ; James C. MCPARTLAND, Auteur . - p.2077-2089. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2077-2089 Index. décimale : PER Périodiques Résumé : Abstract Electroencephalographic peak alpha frequency (PAF) is a marker of neural maturation that increases with age throughout childhood. Distinct maturation of PAF is observed in children with autism spectrum disorder such that PAF does not increase with age and is instead positively associated with cognitive ability. The current study clarifies and extends previous findings by characterizing the effects of age and cognitive ability on PAF between diagnostic groups in a sample of children and adolescents with and without autism spectrum disorder. Resting EEG data and behavioral measures were collected from 45 autistic children and 34 neurotypical controls aged 8 to 18?years. Utilizing generalized additive models to account for nonlinear relations, we examined differences in the joint effect of age and nonverbal IQ by diagnosis as well as bivariate relations between age, nonverbal IQ, and PAF across diagnostic groups. Age was positively associated with PAF among neurotypical children but not among autistic children. In contrast, nonverbal IQ but not age was positively associated with PAF among autistic children. Models accounting for nonlinear relations revealed different developmental trajectories as a function of age and cognitive ability based on diagnostic status. Results align with prior evidence indicating that typical age-related increases in PAF are absent in autistic children and that PAF instead increases with cognitive ability in these children. Findings suggest the potential of PAF to index distinct trajectories of neural maturation in autistic children. En ligne : https://doi.org/10.1002/aur.3017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Rhythmic attentional sampling in autism / Tamar KOLODNY ; Kristin M. WOODARD ; Aydin TASEVAC ; Wesley R. GANZ ; Hannah M. REA ; Evangeline C. KURTZ-NELSON ; Sara Jane WEBB ; Scott O. MURRAY in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2090-2099 Titre : Rhythmic attentional sampling in autism Type de document : Texte imprimé et/ou numérique Auteurs : Tamar KOLODNY, Auteur ; Kristin M. WOODARD, Auteur ; Aydin TASEVAC, Auteur ; Wesley R. GANZ, Auteur ; Hannah M. REA, Auteur ; Evangeline C. KURTZ-NELSON, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur Article en page(s) : p.2090-2099 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism often display alterations in visual spatial attention toward visual stimuli, but the underlying cause of these differences remains unclear. Recent evidence has demonstrated that covert spatial attention, rather than remaining constant at a cued location, samples stimuli rhythmically at a frequency of 4-8?Hz (theta). Here we tested whether rhythmic sampling of attention is altered in autism. Participants were asked to monitor three locations to detect a brief target presented 300-1200?ms after a spatial cue. Visual attention was oriented to the cue and modified visual processing at the cued location, consistent with previous studies. We measured detection performance at different cue-target intervals when the target occurred at the cued location. Significant oscillations in detection performance were identified using both a traditional time-shuffled approach and a new autoregressive surrogate method developed by Brookshire in 2022. We found that attention enhances behavioral performance rhythmically at the same frequency in both autism and control group at the cued location. However, rhythmic temporal structure was not observed in a subgroup of autistic individuals with co-occurring attention-deficit/hyperactivity disorder (ADHD). Our results imply that intrinsic brain rhythms which organize neural activity into alternating attentional states is functional in autistic individuals, but may be altered in autistic participants who have a concurrent ADHD diagnosis. En ligne : https://doi.org/10.1002/aur.3021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Rhythmic attentional sampling in autism [Texte imprimé et/ou numérique] / Tamar KOLODNY, Auteur ; Kristin M. WOODARD, Auteur ; Aydin TASEVAC, Auteur ; Wesley R. GANZ, Auteur ; Hannah M. REA, Auteur ; Evangeline C. KURTZ-NELSON, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur . - p.2090-2099. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2090-2099 Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism often display alterations in visual spatial attention toward visual stimuli, but the underlying cause of these differences remains unclear. Recent evidence has demonstrated that covert spatial attention, rather than remaining constant at a cued location, samples stimuli rhythmically at a frequency of 4-8?Hz (theta). Here we tested whether rhythmic sampling of attention is altered in autism. Participants were asked to monitor three locations to detect a brief target presented 300-1200?ms after a spatial cue. Visual attention was oriented to the cue and modified visual processing at the cued location, consistent with previous studies. We measured detection performance at different cue-target intervals when the target occurred at the cued location. Significant oscillations in detection performance were identified using both a traditional time-shuffled approach and a new autoregressive surrogate method developed by Brookshire in 2022. We found that attention enhances behavioral performance rhythmically at the same frequency in both autism and control group at the cued location. However, rhythmic temporal structure was not observed in a subgroup of autistic individuals with co-occurring attention-deficit/hyperactivity disorder (ADHD). Our results imply that intrinsic brain rhythms which organize neural activity into alternating attentional states is functional in autistic individuals, but may be altered in autistic participants who have a concurrent ADHD diagnosis. En ligne : https://doi.org/10.1002/aur.3021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Are people with autism prosopagnosic? / Tirta SUSILO ; Grace IAROCCI ; Ipek ORUC in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2100-2109 Titre : Are people with autism prosopagnosic? Type de document : Texte imprimé et/ou numérique Auteurs : Tirta SUSILO, Auteur ; Grace IAROCCI, Auteur ; Ipek ORUC, Auteur Article en page(s) : p.2100-2109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Difficulties in various face processing tasks have been well documented in autism spectrum disorder (ASD). Several meta-analyses and numerous case-control studies have indicated that this population experiences a moderate degree of impairment, with a small percentage of studies failing to detect any impairment. One possible account of this mixed pattern of findings is heterogeneity in face processing abilities stemming from the presence of a subpopulation of prosopagnosic individuals with ASD alongside those with normal face processing skills. Samples randomly drawn from such a population, especially relatively smaller ones, would vary in the proportion of participants with prosopagnosia, resulting in a wide range of group-level deficits from mild (or none) to severe across studies. We test this prosopagnosic subpopulation hypothesis by examining three groups of participants: adults with ASD, adults with developmental prosopagnosia (DP), and a comparison group. Our results show that the prosopagnosic subpopulation hypothesis does not account for the face impairments in the broader autism spectrum. ASD observers show a continuous and graded, rather than categorical, heterogeneity that span a range of face processing skills including many with mild to moderate deficits, inconsistent with a prosopagnosic subtype account. We suggest that pathogenic origins of face deficits for at least some with ASD differ from those of DP. En ligne : https://doi.org/10.1002/aur.3030 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Are people with autism prosopagnosic? [Texte imprimé et/ou numérique] / Tirta SUSILO, Auteur ; Grace IAROCCI, Auteur ; Ipek ORUC, Auteur . - p.2100-2109. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2100-2109 Index. décimale : PER Périodiques Résumé : Abstract Difficulties in various face processing tasks have been well documented in autism spectrum disorder (ASD). Several meta-analyses and numerous case-control studies have indicated that this population experiences a moderate degree of impairment, with a small percentage of studies failing to detect any impairment. One possible account of this mixed pattern of findings is heterogeneity in face processing abilities stemming from the presence of a subpopulation of prosopagnosic individuals with ASD alongside those with normal face processing skills. Samples randomly drawn from such a population, especially relatively smaller ones, would vary in the proportion of participants with prosopagnosia, resulting in a wide range of group-level deficits from mild (or none) to severe across studies. We test this prosopagnosic subpopulation hypothesis by examining three groups of participants: adults with ASD, adults with developmental prosopagnosia (DP), and a comparison group. Our results show that the prosopagnosic subpopulation hypothesis does not account for the face impairments in the broader autism spectrum. ASD observers show a continuous and graded, rather than categorical, heterogeneity that span a range of face processing skills including many with mild to moderate deficits, inconsistent with a prosopagnosic subtype account. We suggest that pathogenic origins of face deficits for at least some with ASD differ from those of DP. En ligne : https://doi.org/10.1002/aur.3030 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Neural sensitivity to facial identity and facial expression discrimination in adults with autism / Michelle HENDRIKS ; Silke VOS ; Hans OP DE BEECK ; Bart BOETS in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2110-2124 Titre : Neural sensitivity to facial identity and facial expression discrimination in adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : Michelle HENDRIKS, Auteur ; Silke VOS, Auteur ; Hans OP DE BEECK, Auteur ; Bart BOETS, Auteur Article en page(s) : p.2110-2124 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The fluent processing of faces can be challenging for autistic individuals. Here, we assessed the neural sensitivity to rapid changes in subtle facial cues in 23 autistic men and 23 age and IQ matched non-autistic (NA) controls using frequency-tagging electroencephalography (EEG). In oddball paradigms examining the automatic and implicit discrimination of facial identity and facial expression, base rate images were presented at 6?Hz, periodically interleaved every fifth image with an oddball image (i.e. 1.2?Hz oddball frequency). These distinctive frequency tags for base rate and oddball stimuli allowed direct and objective quantification of the neural discrimination responses. We found no large differences in the neural sensitivity of participants in both groups, not for facial identity discrimination, nor for facial expression discrimination. Both groups also showed a clear face-inversion effect, with reduced brain responses for inverted versus upright faces. Furthermore, sad faces generally elicited significantly lower neural amplitudes than angry, fearful and happy faces. The only minor group difference is the larger involvement of high-level right-hemisphere visual areas in NA men for facial expression processing. These findings are discussed from a developmental perspective, as they strikingly contrast with robust face processing deficits observed in autistic children using identical EEG paradigms. En ligne : https://doi.org/10.1002/aur.3036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Neural sensitivity to facial identity and facial expression discrimination in adults with autism [Texte imprimé et/ou numérique] / Michelle HENDRIKS, Auteur ; Silke VOS, Auteur ; Hans OP DE BEECK, Auteur ; Bart BOETS, Auteur . - p.2110-2124. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2110-2124 Index. décimale : PER Périodiques Résumé : Abstract The fluent processing of faces can be challenging for autistic individuals. Here, we assessed the neural sensitivity to rapid changes in subtle facial cues in 23 autistic men and 23 age and IQ matched non-autistic (NA) controls using frequency-tagging electroencephalography (EEG). In oddball paradigms examining the automatic and implicit discrimination of facial identity and facial expression, base rate images were presented at 6?Hz, periodically interleaved every fifth image with an oddball image (i.e. 1.2?Hz oddball frequency). These distinctive frequency tags for base rate and oddball stimuli allowed direct and objective quantification of the neural discrimination responses. We found no large differences in the neural sensitivity of participants in both groups, not for facial identity discrimination, nor for facial expression discrimination. Both groups also showed a clear face-inversion effect, with reduced brain responses for inverted versus upright faces. Furthermore, sad faces generally elicited significantly lower neural amplitudes than angry, fearful and happy faces. The only minor group difference is the larger involvement of high-level right-hemisphere visual areas in NA men for facial expression processing. These findings are discussed from a developmental perspective, as they strikingly contrast with robust face processing deficits observed in autistic children using identical EEG paradigms. En ligne : https://doi.org/10.1002/aur.3036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Altered markers of mitochondrial function in adults with autism spectrum disorder / Mia MENKE ; Dominique ENDRES ; Kimon RUNGE ; Sara TUCCI ; Anke SCHUMANN ; Katharina DOMSCHKE ; Ludger TEBARTZ VAN ELST ; Simon MAIER in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2125-2138 Titre : Altered markers of mitochondrial function in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mia MENKE, Auteur ; Dominique ENDRES, Auteur ; Kimon RUNGE, Auteur ; Sara TUCCI, Auteur ; Anke SCHUMANN, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Simon MAIER, Auteur Article en page(s) : p.2125-2138 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Previous research suggests potential mitochondrial dysfunction and changes in fatty acid metabolism in a subgroup of individuals with autism spectrum disorder (ASD), indicated by higher lactate, pyruvate levels, and mitochondrial disorder prevalence. This study aimed to further investigate potential mitochondrial dysfunction in ASD by assessing blood metabolite levels linked to mitochondrial metabolism. Blood levels of creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, pyruvate, free and total carnitine, as well as acylcarnitines were obtained in 73 adults with ASD (47 males, 26 females) and compared with those of 71 neurotypical controls (NTC) (44 males, 27 females). Correlations between blood parameters and psychometric ASD symptom scores were also explored. Lower CK (pcorr=0.045) levels were found exclusively in males with ASD compared to NTC, with no such variation in females. ALT and AST levels did not differ significantly between both groups. After correction for antipsychotic and antidepressant medication, CK remained significant. ASD participants had lower serum lactate levels (pcorr=0.036) compared to NTC, but pyruvate and carnitine concentrations showed no significant difference. ASD subjects had significantly increased levels of certain acylcarnitines, with a decrease in tetradecadienoyl-carnitine (C14:2), and certain acylcarnitines correlated significantly with autistic symptom scores. We found reduced serum lactate levels in ASD, in contrast to previous studies suggesting elevated lactate or pyruvate. This difference may reflect the focus of our study on high-functioning adults with ASD, who are likely to have fewer secondary genetic conditions associated with mitochondrial dysfunction. Our findings of significantly altered acylcarnitine levels in ASD support the hypothesis of altered fatty acid metabolism in a subset of ASD patients. En ligne : https://doi.org/10.1002/aur.3029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Altered markers of mitochondrial function in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Mia MENKE, Auteur ; Dominique ENDRES, Auteur ; Kimon RUNGE, Auteur ; Sara TUCCI, Auteur ; Anke SCHUMANN, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Simon MAIER, Auteur . - p.2125-2138. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2125-2138 Index. décimale : PER Périodiques Résumé : Abstract Previous research suggests potential mitochondrial dysfunction and changes in fatty acid metabolism in a subgroup of individuals with autism spectrum disorder (ASD), indicated by higher lactate, pyruvate levels, and mitochondrial disorder prevalence. This study aimed to further investigate potential mitochondrial dysfunction in ASD by assessing blood metabolite levels linked to mitochondrial metabolism. Blood levels of creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, pyruvate, free and total carnitine, as well as acylcarnitines were obtained in 73 adults with ASD (47 males, 26 females) and compared with those of 71 neurotypical controls (NTC) (44 males, 27 females). Correlations between blood parameters and psychometric ASD symptom scores were also explored. Lower CK (pcorr=0.045) levels were found exclusively in males with ASD compared to NTC, with no such variation in females. ALT and AST levels did not differ significantly between both groups. After correction for antipsychotic and antidepressant medication, CK remained significant. ASD participants had lower serum lactate levels (pcorr=0.036) compared to NTC, but pyruvate and carnitine concentrations showed no significant difference. ASD subjects had significantly increased levels of certain acylcarnitines, with a decrease in tetradecadienoyl-carnitine (C14:2), and certain acylcarnitines correlated significantly with autistic symptom scores. We found reduced serum lactate levels in ASD, in contrast to previous studies suggesting elevated lactate or pyruvate. This difference may reflect the focus of our study on high-functioning adults with ASD, who are likely to have fewer secondary genetic conditions associated with mitochondrial dysfunction. Our findings of significantly altered acylcarnitine levels in ASD support the hypothesis of altered fatty acid metabolism in a subset of ASD patients. En ligne : https://doi.org/10.1002/aur.3029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9-year chart review study / Lorenzo BASSANI ; Marco GARZITTO ; Marco LAMBERTI ; Alessandro SIMONATI ; Francesca DARRA ; Sagnik BHATTACHARYYA ; Carla COMACCHIO ; Matteo BALESTRIERI ; Donatella ARCANGELI ; Marco COLIZZI in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2139-2149 Titre : Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9-year chart review study Type de document : Texte imprimé et/ou numérique Auteurs : Lorenzo BASSANI, Auteur ; Marco GARZITTO, Auteur ; Marco LAMBERTI, Auteur ; Alessandro SIMONATI, Auteur ; Francesca DARRA, Auteur ; Sagnik BHATTACHARYYA, Auteur ; Carla COMACCHIO, Auteur ; Matteo BALESTRIERI, Auteur ; Donatella ARCANGELI, Auteur ; Marco COLIZZI, Auteur Article en page(s) : p.2139-2149 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Psychosocial stressors have been suggested to precipitate psychotic episodes in patients with pre-existing psychosis and otherwise healthy subjects. However, such a risk has never been formally investigated in individuals with autism spectrum disorder (ASD). Sixty-nine autistic adolescents hospitalized for psychotic/manic symptoms (PSY) and other mental health issues (NPSY) over a 9-year period were compared with reference to their previous exposure to psychosocial stressors. ASD diagnoses satisfied the International Classification of Diseases (ICD)-10 criteria. Psychotic/manic symptom assessment followed the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Psychosocial stressor exposure was collected separately at each admission. Preliminarily, univariate between-group comparisons were conducted. Then, a binomial model was adopted to investigate associations with previous exposure to psychosocial stressors. Results were reported with a change in AIC (?AIC). PSY patients presented with higher previous exposure to adverse life events (30.43% vs. 6.52%, OR=6.079 [1.209, 40.926], p=0.013) and school/work difficulties (30.43% vs. 8.70%, OR=4.478 [0.984, 23.846], p=0.034) than NPSY ones. Admissions for psychotic/manic symptoms occurred more likely in the context of family disturbances (OR=2.275 [1.045, 5.045], p=0.030) and adverse life events (OR=3.489 [1.194, 11.161], p=0.014). The fitted binomial model was found to be significant compared to the random effects model (?AIC=?1.962; ?210=21.96, p=0.015), with the risk of presenting psychotic/manic symptoms being increased by family disturbances (z=+4.118) and school/work difficulties (z=+2.455). The results suggest a potential psychosis-inducing effect of psychosocial stressors in ASD, which has clinical and policy implications. En ligne : https://doi.org/10.1002/aur.3042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9-year chart review study [Texte imprimé et/ou numérique] / Lorenzo BASSANI, Auteur ; Marco GARZITTO, Auteur ; Marco LAMBERTI, Auteur ; Alessandro SIMONATI, Auteur ; Francesca DARRA, Auteur ; Sagnik BHATTACHARYYA, Auteur ; Carla COMACCHIO, Auteur ; Matteo BALESTRIERI, Auteur ; Donatella ARCANGELI, Auteur ; Marco COLIZZI, Auteur . - p.2139-2149. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2139-2149 Index. décimale : PER Périodiques Résumé : Abstract Psychosocial stressors have been suggested to precipitate psychotic episodes in patients with pre-existing psychosis and otherwise healthy subjects. However, such a risk has never been formally investigated in individuals with autism spectrum disorder (ASD). Sixty-nine autistic adolescents hospitalized for psychotic/manic symptoms (PSY) and other mental health issues (NPSY) over a 9-year period were compared with reference to their previous exposure to psychosocial stressors. ASD diagnoses satisfied the International Classification of Diseases (ICD)-10 criteria. Psychotic/manic symptom assessment followed the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Psychosocial stressor exposure was collected separately at each admission. Preliminarily, univariate between-group comparisons were conducted. Then, a binomial model was adopted to investigate associations with previous exposure to psychosocial stressors. Results were reported with a change in AIC (?AIC). PSY patients presented with higher previous exposure to adverse life events (30.43% vs. 6.52%, OR=6.079 [1.209, 40.926], p=0.013) and school/work difficulties (30.43% vs. 8.70%, OR=4.478 [0.984, 23.846], p=0.034) than NPSY ones. Admissions for psychotic/manic symptoms occurred more likely in the context of family disturbances (OR=2.275 [1.045, 5.045], p=0.030) and adverse life events (OR=3.489 [1.194, 11.161], p=0.014). The fitted binomial model was found to be significant compared to the random effects model (?AIC=?1.962; ?210=21.96, p=0.015), with the risk of presenting psychotic/manic symptoms being increased by family disturbances (z=+4.118) and school/work difficulties (z=+2.455). The results suggest a potential psychosis-inducing effect of psychosocial stressors in ASD, which has clinical and policy implications. En ligne : https://doi.org/10.1002/aur.3042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study / Erin C. BARNEY ; Adam J. NAPLES ; Kelsey J. DOMMER ; Shou An CHANG ; Beibin LI ; Takumi MCALLISTER ; Adham ATYABI ; Quan WANG ; Raphael BERNIER ; Geraldine DAWSON ; James DZIURA ; Susan FAJA ; Shafali Spurling JESTE ; Michael MURIAS ; Scott P. JOHNSON ; Maura SABATOS-DEVITO ; Gerhard HELLEMAN ; Damla SENTURK ; Catherine A. SUGAR ; Sara Jane WEBB ; James C. MCPARTLAND ; Katarzyna CHAWARSKA ; The Autism Biomarkers Consortium for Clinical TRIALS in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2150-2159 Titre : The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study Type de document : Texte imprimé et/ou numérique Auteurs : Erin C. BARNEY, Auteur ; Adam J. NAPLES, Auteur ; Kelsey J. DOMMER, Auteur ; Shou An CHANG, Auteur ; Beibin LI, Auteur ; Takumi MCALLISTER, Auteur ; Adham ATYABI, Auteur ; Quan WANG, Auteur ; Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur ; James DZIURA, Auteur ; Susan FAJA, Auteur ; Shafali Spurling JESTE, Auteur ; Michael MURIAS, Auteur ; Scott P. JOHNSON, Auteur ; Maura SABATOS-DEVITO, Auteur ; Gerhard HELLEMAN, Auteur ; Damla SENTURK, Auteur ; Catherine A. SUGAR, Auteur ; Sara Jane WEBB, Auteur ; James C. MCPARTLAND, Auteur ; Katarzyna CHAWARSKA, Auteur ; The Autism Biomarkers Consortium for Clinical TRIALS, Auteur Article en page(s) : p.2150-2159 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The Selective Social Attention (SSA) task is a brief eye-tracking task involving experimental conditions varying along socio-communicative axes. Traditionally the SSA has been used to probe socially-specific attentional patterns in infants and toddlers who develop autism spectrum disorder (ASD). This current work extends these findings to preschool and school-age children. Children 4- to 12-years-old with ASD (N=23) and a typically-developing comparison group (TD; N=25) completed the SSA task as well as standardized clinical assessments. Linear mixed models examined group and condition effects on two outcome variables: percent of time spent looking at the scene relative to scene presentation time (%Valid), and percent of time looking at the face relative to time spent looking at the scene (%Face). Age and IQ were included as covariates. Outcome variables' relationships to clinical data were assessed via correlation analysis. The ASD group, compared to the TD group, looked less at the scene and focused less on the actress' face during the most socially-engaging experimental conditions. Additionally, within the ASD group, %Face negatively correlated with SRS total T-scores with a particularly strong negative correlation with the Autistic Mannerism subscale T-score. These results highlight the extensibility of the SSA to older children with ASD, including replication of between-group differences previously seen in infants and toddlers, as well as its ability to capture meaningful clinical variation within the autism spectrum across a wide developmental span inclusive of preschool and school-aged children. The properties suggest that the SSA may have broad potential as a biomarker for ASD. En ligne : https://doi.org/10.1002/aur.3026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study [Texte imprimé et/ou numérique] / Erin C. BARNEY, Auteur ; Adam J. NAPLES, Auteur ; Kelsey J. DOMMER, Auteur ; Shou An CHANG, Auteur ; Beibin LI, Auteur ; Takumi MCALLISTER, Auteur ; Adham ATYABI, Auteur ; Quan WANG, Auteur ; Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur ; James DZIURA, Auteur ; Susan FAJA, Auteur ; Shafali Spurling JESTE, Auteur ; Michael MURIAS, Auteur ; Scott P. JOHNSON, Auteur ; Maura SABATOS-DEVITO, Auteur ; Gerhard HELLEMAN, Auteur ; Damla SENTURK, Auteur ; Catherine A. SUGAR, Auteur ; Sara Jane WEBB, Auteur ; James C. MCPARTLAND, Auteur ; Katarzyna CHAWARSKA, Auteur ; The Autism Biomarkers Consortium for Clinical TRIALS, Auteur . - p.2150-2159. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2150-2159 Index. décimale : PER Périodiques Résumé : Abstract The Selective Social Attention (SSA) task is a brief eye-tracking task involving experimental conditions varying along socio-communicative axes. Traditionally the SSA has been used to probe socially-specific attentional patterns in infants and toddlers who develop autism spectrum disorder (ASD). This current work extends these findings to preschool and school-age children. Children 4- to 12-years-old with ASD (N=23) and a typically-developing comparison group (TD; N=25) completed the SSA task as well as standardized clinical assessments. Linear mixed models examined group and condition effects on two outcome variables: percent of time spent looking at the scene relative to scene presentation time (%Valid), and percent of time looking at the face relative to time spent looking at the scene (%Face). Age and IQ were included as covariates. Outcome variables' relationships to clinical data were assessed via correlation analysis. The ASD group, compared to the TD group, looked less at the scene and focused less on the actress' face during the most socially-engaging experimental conditions. Additionally, within the ASD group, %Face negatively correlated with SRS total T-scores with a particularly strong negative correlation with the Autistic Mannerism subscale T-score. These results highlight the extensibility of the SSA to older children with ASD, including replication of between-group differences previously seen in infants and toddlers, as well as its ability to capture meaningful clinical variation within the autism spectrum across a wide developmental span inclusive of preschool and school-aged children. The properties suggest that the SSA may have broad potential as a biomarker for ASD. En ligne : https://doi.org/10.1002/aur.3026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Exploring the association between social skills struggles and social communication difficulties and depression in youth with autism spectrum disorder / Kaitlyn FORBES ; Laura DE LA ROCHE ; Brianne DERBY ; Elaine PSARADELLIS ; Evdokia ANAGNOSTOU ; Rob NICOLSON ; Stelios GEORGIADES ; Elizabeth KELLEY in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2160-2171 Titre : Exploring the association between social skills struggles and social communication difficulties and depression in youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kaitlyn FORBES, Auteur ; Laura DE LA ROCHE, Auteur ; Brianne DERBY, Auteur ; Elaine PSARADELLIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Rob NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Elizabeth KELLEY, Auteur Article en page(s) : p.2160-2171 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder is characterized by social communication difficulties and social skills abilities that are significantly differ from neurotypical populations as well as restricted and repetitive behaviors and interests. Furthermore, many autistic youth experience co-occurring conditions, with one of the most common being depression. This depression is suggested to be, in part, the result of the relative social isolation experienced by autistic youth. Therefore, it is important to examine social functioning differences in autistic youth and their association with depression. There has been limited research investigating the association between social communication difficulties and depression, or the association between social skills struggles and depression, and no research investigating both of these in the same population. We found that social communicative symptoms of autism (as measured by the Autism Diagnostic Observation Schedule) were not associated with depression scores (as measured by the Revised Checklist for Anxiety and Depression) after controlling for age, sex, and IQ. In contrast, we did find a significant association between social skills struggles (as measured by the Adaptive Behavior Assessment System-2) and depression in the same sample. Higher social skills struggles were associated with higher depression scores after controlling for age, sex, and IQ. Reasons for the potential discrepancy between these findings are discussed, and clinical implications of these findings are explored. En ligne : https://doi.org/10.1002/aur.3015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Exploring the association between social skills struggles and social communication difficulties and depression in youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Kaitlyn FORBES, Auteur ; Laura DE LA ROCHE, Auteur ; Brianne DERBY, Auteur ; Elaine PSARADELLIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Rob NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Elizabeth KELLEY, Auteur . - p.2160-2171. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2160-2171 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder is characterized by social communication difficulties and social skills abilities that are significantly differ from neurotypical populations as well as restricted and repetitive behaviors and interests. Furthermore, many autistic youth experience co-occurring conditions, with one of the most common being depression. This depression is suggested to be, in part, the result of the relative social isolation experienced by autistic youth. Therefore, it is important to examine social functioning differences in autistic youth and their association with depression. There has been limited research investigating the association between social communication difficulties and depression, or the association between social skills struggles and depression, and no research investigating both of these in the same population. We found that social communicative symptoms of autism (as measured by the Autism Diagnostic Observation Schedule) were not associated with depression scores (as measured by the Revised Checklist for Anxiety and Depression) after controlling for age, sex, and IQ. In contrast, we did find a significant association between social skills struggles (as measured by the Adaptive Behavior Assessment System-2) and depression in the same sample. Higher social skills struggles were associated with higher depression scores after controlling for age, sex, and IQ. Reasons for the potential discrepancy between these findings are discussed, and clinical implications of these findings are explored. En ligne : https://doi.org/10.1002/aur.3015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Investigating the quality of life for children with autism spectrum disorder scale using Rasch methodology / Jin LIU ; Ruiqin GAO ; Erik DRASGOW in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2172-2183 Titre : Investigating the quality of life for children with autism spectrum disorder scale using Rasch methodology Type de document : Texte imprimé et/ou numérique Auteurs : Jin LIU, Auteur ; Ruiqin GAO, Auteur ; Erik DRASGOW, Auteur Article en page(s) : p.2172-2183 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Our purpose in this study was to provide additional psychometric evidence of the Quality of Life for Children with Autism Spectrum Disorder (QOLASD-C) scale. We used Rasch modeling to investigate the QOLASD-C functioning, the characteristics of the items comprising the scale, and the item functioning across subgroups of children with ASD based on gender and race/ethnicity. Results showed that QOLASD-C was unidimensional, met the local independence assumption, and measured quality of life (QOL). The items showed excellent fit to the model and good discriminating ability between low and high QOL. Most items showed a moderate difficulty level. No differential item functioning was observed based on children's gender and race/ethnicity. Implications for research and practice are discussed. En ligne : https://doi.org/10.1002/aur.3016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Investigating the quality of life for children with autism spectrum disorder scale using Rasch methodology [Texte imprimé et/ou numérique] / Jin LIU, Auteur ; Ruiqin GAO, Auteur ; Erik DRASGOW, Auteur . - p.2172-2183. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2172-2183 Index. décimale : PER Périodiques Résumé : Abstract Our purpose in this study was to provide additional psychometric evidence of the Quality of Life for Children with Autism Spectrum Disorder (QOLASD-C) scale. We used Rasch modeling to investigate the QOLASD-C functioning, the characteristics of the items comprising the scale, and the item functioning across subgroups of children with ASD based on gender and race/ethnicity. Results showed that QOLASD-C was unidimensional, met the local independence assumption, and measured quality of life (QOL). The items showed excellent fit to the model and good discriminating ability between low and high QOL. Most items showed a moderate difficulty level. No differential item functioning was observed based on children's gender and race/ethnicity. Implications for research and practice are discussed. En ligne : https://doi.org/10.1002/aur.3016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism / Greg PASCO ; Jannath Begum ALI ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2184-2197 Titre : Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism Type de document : Texte imprimé et/ou numérique Auteurs : Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2184-2197 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36?months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36?months and autism trait scores at 36?months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36?months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism [Texte imprimé et/ou numérique] / Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur . - p.2184-2197. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2184-2197 Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36?months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36?months and autism trait scores at 36?months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36?months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

"We are exhausted, worn out, and broken": Understanding the impact of service satisfaction on caregiver well-being / Janet MCLAUGHLIN ; Margaret SCHNEIDER in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2198-2207 Titre : "We are exhausted, worn out, and broken": Understanding the impact of service satisfaction on caregiver well-being Type de document : Texte imprimé et/ou numérique Auteurs : Janet MCLAUGHLIN, Auteur ; Margaret SCHNEIDER, Auteur Article en page(s) : p.2198-2207 Langues : Anglais (eng) Mots-clés : autism  policy  qualitative  quantitative  service satisfaction  well-being Index. décimale : PER Périodiques Résumé : Abstract Few studies exist that have examined the impact of service-related factors and system-level disruptions (i.e., the pandemic) on families of autistic children in Canada using large sample sizes. To address this gap, the goal of this research was to examine the impact of satisfaction with autism services on caregiver stress, controlling for important demographic variables, such as family income, marital status, and child level of support needs. The impact of navigating and accessing services on parent well-being was also explored. A total of 1810 primary caregivers of autistic children or youth living in Ontario, Canada completed a survey with both closed- and open-ended questions in the summer of 2021. A hierarchical multiple regression was conducted to examine the impact of satisfaction with autism services on caregiver stress. Open-ended responses on the survey from a subset of the sample (n?=?637) were coded using thematic analysis to understand the impact of navigating and accessing services on parent well-being. Satisfaction with services significantly predicted caregiver stress after controlling for marital support, family income, and child level of support needs. Qualitative analysis revealed impacts of navigating and accessing services in three areas: (1) Physical, (2) Emotional/Psychological, and (3) Financial Well-being. Understanding parent perceptions of satisfaction with services can shed light on strategies for improving services that support parent well-being. En ligne : https://doi.org/10.1002/aur.3024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] "We are exhausted, worn out, and broken": Understanding the impact of service satisfaction on caregiver well-being [Texte imprimé et/ou numérique] / Janet MCLAUGHLIN, Auteur ; Margaret SCHNEIDER, Auteur . - p.2198-2207. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2198-2207 Mots-clés : autism  policy  qualitative  quantitative  service satisfaction  well-being Index. décimale : PER Périodiques Résumé : Abstract Few studies exist that have examined the impact of service-related factors and system-level disruptions (i.e., the pandemic) on families of autistic children in Canada using large sample sizes. To address this gap, the goal of this research was to examine the impact of satisfaction with autism services on caregiver stress, controlling for important demographic variables, such as family income, marital status, and child level of support needs. The impact of navigating and accessing services on parent well-being was also explored. A total of 1810 primary caregivers of autistic children or youth living in Ontario, Canada completed a survey with both closed- and open-ended questions in the summer of 2021. A hierarchical multiple regression was conducted to examine the impact of satisfaction with autism services on caregiver stress. Open-ended responses on the survey from a subset of the sample (n?=?637) were coded using thematic analysis to understand the impact of navigating and accessing services on parent well-being. Satisfaction with services significantly predicted caregiver stress after controlling for marital support, family income, and child level of support needs. Qualitative analysis revealed impacts of navigating and accessing services in three areas: (1) Physical, (2) Emotional/Psychological, and (3) Financial Well-being. Understanding parent perceptions of satisfaction with services can shed light on strategies for improving services that support parent well-being. En ligne : https://doi.org/10.1002/aur.3024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Measuring flexibility in autistic adults: Exploring the factor structure of the flexibility scale self report / Goldie A. MCQUAID ; Benjamin E. YERYS ; John F. STRANG ; Laura G. ANTHONY ; Lauren KENWORTHY ; Nancy R. LEE ; Gregory L. WALLACE in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2208-2219 Titre : Measuring flexibility in autistic adults: Exploring the factor structure of the flexibility scale self report Type de document : Texte imprimé et/ou numérique Auteurs : Goldie A. MCQUAID, Auteur ; Benjamin E. YERYS, Auteur ; John F. STRANG, Auteur ; Laura G. ANTHONY, Auteur ; Lauren KENWORTHY, Auteur ; Nancy R. LEE, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.2208-2219 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Cognitive flexibility differences are common for autistic individuals and have an impact on a range of clinical outcomes. However, there is currently a lack of well validated measurement tools to assess flexibility in adulthood. The Flexibility Scale was originally designed as a parent-report measure of real-world flexibility challenges in youth. The original Flexibility Scale provides a total score and five subscales: Routines and Rituals, Transitions and Change, Special Interests, Social Flexibility, and Generativity. In this study, we evaluate the factorial validity of the Flexibility Scale as a self-report (Flexibility Scale Self Report) measure of cognitive flexibility, adapted from the original Flexibility Scale, for use by autistic adults. This study includes both a primary sample (n=813; mean age=40.3; 59% female) and an independently recruited replication sample (n=120; mean age=32.8; 74% female) of individuals who completed the Flexibility Scale Self Report. The analysis consisted of an initial confirmatory factor analysis (CFA) of the original Flexibility Scale structure, followed by exploratory factor analysis (EFA) and factor optimization within a structural equation modeling framework to identify the optimal structure for the questionnaire in adults. The identified structure was then replicated through CFA in the replication sample. Our results indicate an alternative optimal scale structure from the original Flexibility Scale, which includes fewer items, and only three (Routines/Rituals, Transitions and Change, Special Interests) of the five subscales contributing to the flexibility total score. Comparisons revealed no structural differences within the scale based on sex assigned at birth. Here the Generativity and Social Flexibility scales are treated as independent but related scales. The implications for measurement of cognitive flexibility in clinical and research settings, as well as theoretical underpinnings are discussed. En ligne : https://doi.org/10.1002/aur.3025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Measuring flexibility in autistic adults: Exploring the factor structure of the flexibility scale self report [Texte imprimé et/ou numérique] / Goldie A. MCQUAID, Auteur ; Benjamin E. YERYS, Auteur ; John F. STRANG, Auteur ; Laura G. ANTHONY, Auteur ; Lauren KENWORTHY, Auteur ; Nancy R. LEE, Auteur ; Gregory L. WALLACE, Auteur . - p.2208-2219. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2208-2219 Index. décimale : PER Périodiques Résumé : Abstract Cognitive flexibility differences are common for autistic individuals and have an impact on a range of clinical outcomes. However, there is currently a lack of well validated measurement tools to assess flexibility in adulthood. The Flexibility Scale was originally designed as a parent-report measure of real-world flexibility challenges in youth. The original Flexibility Scale provides a total score and five subscales: Routines and Rituals, Transitions and Change, Special Interests, Social Flexibility, and Generativity. In this study, we evaluate the factorial validity of the Flexibility Scale as a self-report (Flexibility Scale Self Report) measure of cognitive flexibility, adapted from the original Flexibility Scale, for use by autistic adults. This study includes both a primary sample (n=813; mean age=40.3; 59% female) and an independently recruited replication sample (n=120; mean age=32.8; 74% female) of individuals who completed the Flexibility Scale Self Report. The analysis consisted of an initial confirmatory factor analysis (CFA) of the original Flexibility Scale structure, followed by exploratory factor analysis (EFA) and factor optimization within a structural equation modeling framework to identify the optimal structure for the questionnaire in adults. The identified structure was then replicated through CFA in the replication sample. Our results indicate an alternative optimal scale structure from the original Flexibility Scale, which includes fewer items, and only three (Routines/Rituals, Transitions and Change, Special Interests) of the five subscales contributing to the flexibility total score. Comparisons revealed no structural differences within the scale based on sex assigned at birth. Here the Generativity and Social Flexibility scales are treated as independent but related scales. The implications for measurement of cognitive flexibility in clinical and research settings, as well as theoretical underpinnings are discussed. En ligne : https://doi.org/10.1002/aur.3025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Stress and well-being in autistic adults: Exploring the moderating role of coping / Amanda L. RICHDALE ; Lauren P. LAWSON in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2220-2233 Titre : Stress and well-being in autistic adults: Exploring the moderating role of coping Type de document : Texte imprimé et/ou numérique Auteurs : Amanda L. RICHDALE, Auteur ; Lauren P. LAWSON, Auteur Article en page(s) : p.2220-2233 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The wider stress literature points to negative associations between stress and well-being. Similarly, the use of engagement coping strategies and disengagement coping strategies in the face of stress are related to improved and reduced well-being respectively. However, in the autistic population stress and coping research is limited to date, and the extent to which coping may moderate the relationship between stress and well-being is not known. Using data from an Australian online study, we explored the potential moderating (i.e. buffering or exacerbating) role of coping in the relationship between stress and well-being in a sample of autistic adults (N=86). Our findings indicated that increased stress was associated with lower well-being. Further, moderation analyses showed that while both engagement coping (e.g. problem solving, positive appraisal) and disengagement coping (e.g., self-distraction, being in denial) strategies had significant positive and negative direct effects on well-being respectively; engagement coping also moderated the relationship between stress and well-being, buffering the impact of stress on well-being. Our results illustrate the different underlying mechanisms by which coping strategies may be associated with stress and well-being. They also highlight the potential protective role of engagement coping strategies, which can be incorporated into the promotion and maintenance of well-being in autistic adults. En ligne : https://doi.org/10.1002/aur.3028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Stress and well-being in autistic adults: Exploring the moderating role of coping [Texte imprimé et/ou numérique] / Amanda L. RICHDALE, Auteur ; Lauren P. LAWSON, Auteur . - p.2220-2233. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2220-2233 Index. décimale : PER Périodiques Résumé : Abstract The wider stress literature points to negative associations between stress and well-being. Similarly, the use of engagement coping strategies and disengagement coping strategies in the face of stress are related to improved and reduced well-being respectively. However, in the autistic population stress and coping research is limited to date, and the extent to which coping may moderate the relationship between stress and well-being is not known. Using data from an Australian online study, we explored the potential moderating (i.e. buffering or exacerbating) role of coping in the relationship between stress and well-being in a sample of autistic adults (N=86). Our findings indicated that increased stress was associated with lower well-being. Further, moderation analyses showed that while both engagement coping (e.g. problem solving, positive appraisal) and disengagement coping (e.g., self-distraction, being in denial) strategies had significant positive and negative direct effects on well-being respectively; engagement coping also moderated the relationship between stress and well-being, buffering the impact of stress on well-being. Our results illustrate the different underlying mechanisms by which coping strategies may be associated with stress and well-being. They also highlight the potential protective role of engagement coping strategies, which can be incorporated into the promotion and maintenance of well-being in autistic adults. En ligne : https://doi.org/10.1002/aur.3028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517