Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism / Megan BANCHIK ; Tawny TSANG ; Nana J OKADA ; Rebecca ALTSHULER ; Nicole MCDONALD ; Susan Y BOOKHEIMER ; Shafali S JESTE ; Shulamite GREEN ; Mirella DAPRETTO in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 6 Titre : Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism Type de document : Texte imprimé et/ou numérique Auteurs : Megan BANCHIK, Auteur ; Tawny TSANG, Auteur ; Nana J OKADA, Auteur ; Rebecca ALTSHULER, Auteur ; Nicole MCDONALD, Auteur ; Susan Y BOOKHEIMER, Auteur ; Shafali S JESTE, Auteur ; Shulamite GREEN, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : 6 Langues : Anglais (eng) Mots-clés : Humans  Infant  Male  Magnetic Resonance Imaging  Female  Language  Autism Spectrum Disorder/physiopathology/diagnostic imaging  Brain/diagnostic imaging/physiopathology  Autistic Disorder/physiopathology  Brain Mapping  Speech  Autism  Language  Native language  fMRI  obtained from all participants' caregivers and/or legal guardians. All study  protocols were approved by the UCLA Institutional Review Board. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Language difficulties are common in autism spectrum disorder (ASD), a neurodevelopmental condition characterized by impairments in social communication as well as restricted and repetitive behaviors. Amongst infant siblings of children with an ASD diagnosis - who are at higher likelihood for developing ASD - a high proportion also show difficulties and delays in language acquisition. METHODS: In this study, we used functional magnetic resonance imaging (fMRI) to examine differences in language processing in 9-month-old infants at high (HL) and typical (TL) familial likelihood for ASD. Infants were presented with native (English) and novel (Japanese) speech while sleeping naturally in the scanner. Whole-brain and a priori region-of-interest analyses were conducted to evaluate neural differences in language processing based on likelihood group and language condition. RESULTS: HL infants showed attenuated responses to speech in general, particularly in left temporal language areas, as well as a lack of neural discrimination between the native and novel languages compared to the TL group. Importantly, we also demonstrate that HL infants show distinctly atypical patterns of lateralization for speech processing, particularly during native speech processing, suggesting a failure to left-lateralize. LIMITATIONS: The sample size, particularly for the TL group, is relatively modest because of the challenges inherent to collecting auditory stimulus-evoked data from sleeping participants, as well as retention and follow-up difficulties posed by the COVID-19 pandemic. The groups were not matched on some demographic variables, but the present findings held even after accounting for these differences. CONCLUSIONS: To our knowledge, this is the first fMRI study to directly measure autism-associated atypicalities in native language uptake during infancy. These findings provide a better understanding of the neurodevelopmental underpinnings of language delay in ASD, which is a prerequisite step for developing earlier and more effective interventions for autistic children and HL siblings who experience language impairments. En ligne : https://dx.doi.org/10.1186/s13229-025-00640-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism [Texte imprimé et/ou numérique] / Megan BANCHIK, Auteur ; Tawny TSANG, Auteur ; Nana J OKADA, Auteur ; Rebecca ALTSHULER, Auteur ; Nicole MCDONALD, Auteur ; Susan Y BOOKHEIMER, Auteur ; Shafali S JESTE, Auteur ; Shulamite GREEN, Auteur ; Mirella DAPRETTO, Auteur . - 6. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 6 Mots-clés : Humans  Infant  Male  Magnetic Resonance Imaging  Female  Language  Autism Spectrum Disorder/physiopathology/diagnostic imaging  Brain/diagnostic imaging/physiopathology  Autistic Disorder/physiopathology  Brain Mapping  Speech  Autism  Language  Native language  fMRI  obtained from all participants' caregivers and/or legal guardians. All study  protocols were approved by the UCLA Institutional Review Board. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Language difficulties are common in autism spectrum disorder (ASD), a neurodevelopmental condition characterized by impairments in social communication as well as restricted and repetitive behaviors. Amongst infant siblings of children with an ASD diagnosis - who are at higher likelihood for developing ASD - a high proportion also show difficulties and delays in language acquisition. METHODS: In this study, we used functional magnetic resonance imaging (fMRI) to examine differences in language processing in 9-month-old infants at high (HL) and typical (TL) familial likelihood for ASD. Infants were presented with native (English) and novel (Japanese) speech while sleeping naturally in the scanner. Whole-brain and a priori region-of-interest analyses were conducted to evaluate neural differences in language processing based on likelihood group and language condition. RESULTS: HL infants showed attenuated responses to speech in general, particularly in left temporal language areas, as well as a lack of neural discrimination between the native and novel languages compared to the TL group. Importantly, we also demonstrate that HL infants show distinctly atypical patterns of lateralization for speech processing, particularly during native speech processing, suggesting a failure to left-lateralize. LIMITATIONS: The sample size, particularly for the TL group, is relatively modest because of the challenges inherent to collecting auditory stimulus-evoked data from sleeping participants, as well as retention and follow-up difficulties posed by the COVID-19 pandemic. The groups were not matched on some demographic variables, but the present findings held even after accounting for these differences. CONCLUSIONS: To our knowledge, this is the first fMRI study to directly measure autism-associated atypicalities in native language uptake during infancy. These findings provide a better understanding of the neurodevelopmental underpinnings of language delay in ASD, which is a prerequisite step for developing earlier and more effective interventions for autistic children and HL siblings who experience language impairments. En ligne : https://dx.doi.org/10.1186/s13229-025-00640-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Improvements in Social and Adaptive Functioning Following Short-Duration PRT Program: A Clinical Replication / Pamela VENTOLA in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2862-2870 Titre : Improvements in Social and Adaptive Functioning Following Short-Duration PRT Program: A Clinical Replication Type de document : Texte imprimé et/ou numérique Auteurs : Pamela VENTOLA, Auteur ; Hannah E. FRIEDMAN, Auteur ; Laura C. ANDERSON, Auteur ; Julie M. WOLF, Auteur ; Devon OOSTING, Auteur ; Jennifer FOSS-FEIG, Auteur ; Nicole MCDONALD, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur Article en page(s) : p.2862-2870 Langues : Anglais (eng) Mots-clés : Pivotal Response Treatment  Intervention  Outcome  Adaptive skills  Social communication skills  Early intervention Index. décimale : PER Périodiques Résumé : Pivotal Response Treatment (PRT) is an empirically validated behavioral treatment for individuals with autism spectrum disorders (ASD). The purpose of the current study was to assess the efficacy of PRT for ten cognitively-able preschool-aged children with ASD in the context of a short-duration (4-month) treatment model. Most research on PRT used individual behavioral goals as outcome measures, but the current study utilized standardized assessments of broader-based social communication and adaptive skills. The children made substantial gains; however, magnitude and consistency of response across measures were variable. The results provide additional support for the efficacy of PRT as well as evidence for improvements in higher-order social communication and adaptive skill development within the context of a short-duration PRT model. En ligne : http://dx.doi.org/10.1007/s10803-014-2145-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Improvements in Social and Adaptive Functioning Following Short-Duration PRT Program: A Clinical Replication [Texte imprimé et/ou numérique] / Pamela VENTOLA, Auteur ; Hannah E. FRIEDMAN, Auteur ; Laura C. ANDERSON, Auteur ; Julie M. WOLF, Auteur ; Devon OOSTING, Auteur ; Jennifer FOSS-FEIG, Auteur ; Nicole MCDONALD, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur . - p.2862-2870. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2862-2870 Mots-clés : Pivotal Response Treatment  Intervention  Outcome  Adaptive skills  Social communication skills  Early intervention Index. décimale : PER Périodiques Résumé : Pivotal Response Treatment (PRT) is an empirically validated behavioral treatment for individuals with autism spectrum disorders (ASD). The purpose of the current study was to assess the efficacy of PRT for ten cognitively-able preschool-aged children with ASD in the context of a short-duration (4-month) treatment model. Most research on PRT used individual behavioral goals as outcome measures, but the current study utilized standardized assessments of broader-based social communication and adaptive skills. The children made substantial gains; however, magnitude and consistency of response across measures were variable. The results provide additional support for the efficacy of PRT as well as evidence for improvements in higher-order social communication and adaptive skill development within the context of a short-duration PRT model. En ligne : http://dx.doi.org/10.1007/s10803-014-2145-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

The Brief Observation of Symptoms of Autism (BOSA): Development of a New Adapted Assessment Measure for Remote Telehealth Administration Through COVID-19 and Beyond / Deanna DOW in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5383-5394 Titre : The Brief Observation of Symptoms of Autism (BOSA): Development of a New Adapted Assessment Measure for Remote Telehealth Administration Through COVID-19 and Beyond Type de document : Texte imprimé et/ou numérique Auteurs : Deanna DOW, Auteur ; Alison HOLBROOK, Auteur ; Christina TOOLAN, Auteur ; Nicole MCDONALD, Auteur ; Kyle STERRETT, Auteur ; Nicole ROSEN, Auteur ; So Hyun KIM, Auteur ; Catherine LORD, Auteur Année de publication : 2022 Article en page(s) : p.5383-5394 Langues : Anglais (eng) Mots-clés : Humans  Autistic Disorder/diagnosis/psychology  Autism Spectrum Disorder/diagnosis/psychology  Reproducibility of Results  covid-19  Telemedicine  Assessment  Autism spectrum disorder  Diagnosis  Screening  the ADOS-2, SCQ and ADI-R. The BOSA is copyrighted by WPS because of its overlap  with the ADOS and BOSCC. Deanna Dow, Alison Holbrook, So Hyun Kim, and Catherine  Lord are authors of the BOSA, but it is not currently for sale and does not  yield any royalties at this time. Index. décimale : PER Périodiques Résumé : Interest in telehealth assessment for autism has increased due to COVID-19 and subsequent expansion of remote psychological services, though options that are easy for clinicians to adopt and available through the lifespan are limited. The Brief Observation of Symptoms of Autism (BOSA) provides a social context with standardized materials and activities that can be coded by clinicians trained in the Autism Diagnostic Observation Schedule. The current project examined psychometric properties to determine optimal use for each BOSA version. Three hundred and seven participants with 453 BOSAs were included to determine best performing items for algorithms, validity, sensitivity, specificity, recommended cut-offs, and proposed ranges of concern. While preliminary, the BOSA provides a promising new option for telehealth-administered assessment for autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05395-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] The Brief Observation of Symptoms of Autism (BOSA): Development of a New Adapted Assessment Measure for Remote Telehealth Administration Through COVID-19 and Beyond [Texte imprimé et/ou numérique] / Deanna DOW, Auteur ; Alison HOLBROOK, Auteur ; Christina TOOLAN, Auteur ; Nicole MCDONALD, Auteur ; Kyle STERRETT, Auteur ; Nicole ROSEN, Auteur ; So Hyun KIM, Auteur ; Catherine LORD, Auteur . - 2022 . - p.5383-5394. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5383-5394 Mots-clés : Humans  Autistic Disorder/diagnosis/psychology  Autism Spectrum Disorder/diagnosis/psychology  Reproducibility of Results  covid-19  Telemedicine  Assessment  Autism spectrum disorder  Diagnosis  Screening  the ADOS-2, SCQ and ADI-R. The BOSA is copyrighted by WPS because of its overlap  with the ADOS and BOSCC. Deanna Dow, Alison Holbrook, So Hyun Kim, and Catherine  Lord are authors of the BOSA, but it is not currently for sale and does not  yield any royalties at this time. Index. décimale : PER Périodiques Résumé : Interest in telehealth assessment for autism has increased due to COVID-19 and subsequent expansion of remote psychological services, though options that are easy for clinicians to adopt and available through the lifespan are limited. The Brief Observation of Symptoms of Autism (BOSA) provides a social context with standardized materials and activities that can be coded by clinicians trained in the Autism Diagnostic Observation Schedule. The current project examined psychometric properties to determine optimal use for each BOSA version. Three hundred and seven participants with 453 BOSAs were included to determine best performing items for algorithms, validity, sensitivity, specificity, recommended cut-offs, and proposed ranges of concern. While preliminary, the BOSA provides a promising new option for telehealth-administered assessment for autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05395-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

---

1 (1 - 3 / 3)