Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders / Michael K. YEUNG in Research in Autism Spectrum Disorders, 8-11 (November 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1567-1577 Titre : Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders Type de document : texte imprimé Auteurs : Michael K. YEUNG, Auteur ; Yvonne M. Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Agnes S. CHAN, Auteur Article en page(s) : p.1567-1577 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Facial emotion  Social  Connectivity  Theta  Coherence Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that autism spectrum disorders (ASD) is associated with altered functional connectivity of the brain and with impairment in recognizing others’ emotions. To better understand the relationships among these neural and behavioral abnormalities, we examined cortical connectivity which was indicated by theta coherence during tasks of facial emotion recognition in 18 children with ASD and 18 typically developing (TD) children who were between 6 and 18 years of age. We found that the children with ASD had general impairment in recognizing facial emotions, after controlling for response bias. Additionally, we found that the TD children demonstrated significant modulation of right frontal theta coherence in response to emotional faces compared to neutral faces, whereas children with ASD did not exhibit any modulation of theta coherence. The extent of modulation of theta coherence to emotions was further found to be related to the severity of social impairments in ASD. Our findings of a general impairment in facial emotion recognition and the involvement of disordered cortical connectivity in social deficits in children with ASD have shed light for future exploration of interventions regarding emotional processing and social functioning in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders [texte imprimé] / Michael K. YEUNG, Auteur ; Yvonne M. Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Agnes S. CHAN, Auteur . - p.1567-1577. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1567-1577 Mots-clés : Autism spectrum disorders  Facial emotion  Social  Connectivity  Theta  Coherence Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that autism spectrum disorders (ASD) is associated with altered functional connectivity of the brain and with impairment in recognizing others’ emotions. To better understand the relationships among these neural and behavioral abnormalities, we examined cortical connectivity which was indicated by theta coherence during tasks of facial emotion recognition in 18 children with ASD and 18 typically developing (TD) children who were between 6 and 18 years of age. We found that the children with ASD had general impairment in recognizing facial emotions, after controlling for response bias. Additionally, we found that the TD children demonstrated significant modulation of right frontal theta coherence in response to emotional faces compared to neutral faces, whereas children with ASD did not exhibit any modulation of theta coherence. The extent of modulation of theta coherence to emotions was further found to be related to the severity of social impairments in ASD. Our findings of a general impairment in facial emotion recognition and the involvement of disordered cortical connectivity in social deficits in children with ASD have shed light for future exploration of interventions regarding emotional processing and social functioning in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence / Michael K. YEUNG in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 48 Titre : Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence Type de document : texte imprimé Auteurs : Michael K. YEUNG, Auteur ; Cassie T. Y. LI, Auteur ; Harris C. W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur ; Michael K. YEUNG, Auteur ; Cassie T. Y. LI, Auteur ; Harris C. W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur Article en page(s) : 48 Langues : Anglais (eng) Mots-clés : Humans  Executive Function/physiology  Autistic Disorder/psychology/physiopathology  Male  Adult  Bayes Theorem  Aq  Autism spectrum quotient  Autistic traits  Executive function  Meta-analysis  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals generally exhibit real-world executive function (EF) difficulties and perform poorly on EF tasks. However, while autistic traits are distributed continuously throughout the general population, the relationships between autistic traits and EF among nonclinical individuals remain unclear. Here, we conducted complementary meta-analyses to clarify the relationships between autistic traits and various aspects of EF in the general population. METHODS: A literature search was conducted using PubMed, PsycINFO, and Web of Science on July 11, 2025. After screening by two independent reviewers, 39 articles that reported 40 studies were included. These studies either compared EF between groups with high and low autistic traits, based on a cutoff, or investigated the relationships between continuous measures of autistic traits and EF. RESULTS: We found significant negative associations between autistic traits and EF among nonclinical individuals across EF processes. Notably, these relationships were observed only when EFs were measured using questionnaires rather than behavioral tasks. Specifically, random-effects and robust Bayesian meta-analyses revealed significant, strong correlations between higher autistic traits and poorer ratings on EF questionnaires, with primarily substantial evidence supporting the presence than absence of relationships. In contrast, the meta-analyses indicated nonsignificant, very weak correlations between higher autistic traits and poorer performances on EF tasks, with primarily substantial evidence supporting the absence than presence of relationships. LIMITATIONS: These findings were mainly based on self-reported measures of autistic traits in adults and derived from single studies without follow up or replication. CONCLUSIONS: Autistic traits are associated with lower perceived real-world EF behavior rather than poorer EF task performance in the general population. These findings underscore the importance of paying closer attention to addressing the concerns of individuals with high autistic traits and their parents regarding their own and their children's EF behavior. Based on the available evidence, we construct a picture of the relationships between autistic traits and EF across the trait's continuum. REGISTRATION: This study was preregistered at https://osf.io/zncv3 . En ligne : https://dx.doi.org/10.1186/s13229-025-00680-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence [texte imprimé] / Michael K. YEUNG, Auteur ; Cassie T. Y. LI, Auteur ; Harris C. W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur ; Michael K. YEUNG, Auteur ; Cassie T. Y. LI, Auteur ; Harris C. W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur . - 48. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 48 Mots-clés : Humans  Executive Function/physiology  Autistic Disorder/psychology/physiopathology  Male  Adult  Bayes Theorem  Aq  Autism spectrum quotient  Autistic traits  Executive function  Meta-analysis  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals generally exhibit real-world executive function (EF) difficulties and perform poorly on EF tasks. However, while autistic traits are distributed continuously throughout the general population, the relationships between autistic traits and EF among nonclinical individuals remain unclear. Here, we conducted complementary meta-analyses to clarify the relationships between autistic traits and various aspects of EF in the general population. METHODS: A literature search was conducted using PubMed, PsycINFO, and Web of Science on July 11, 2025. After screening by two independent reviewers, 39 articles that reported 40 studies were included. These studies either compared EF between groups with high and low autistic traits, based on a cutoff, or investigated the relationships between continuous measures of autistic traits and EF. RESULTS: We found significant negative associations between autistic traits and EF among nonclinical individuals across EF processes. Notably, these relationships were observed only when EFs were measured using questionnaires rather than behavioral tasks. Specifically, random-effects and robust Bayesian meta-analyses revealed significant, strong correlations between higher autistic traits and poorer ratings on EF questionnaires, with primarily substantial evidence supporting the presence than absence of relationships. In contrast, the meta-analyses indicated nonsignificant, very weak correlations between higher autistic traits and poorer performances on EF tasks, with primarily substantial evidence supporting the absence than presence of relationships. LIMITATIONS: These findings were mainly based on self-reported measures of autistic traits in adults and derived from single studies without follow up or replication. CONCLUSIONS: Autistic traits are associated with lower perceived real-world EF behavior rather than poorer EF task performance in the general population. These findings underscore the importance of paying closer attention to addressing the concerns of individuals with high autistic traits and their parents regarding their own and their children's EF behavior. Based on the available evidence, we construct a picture of the relationships between autistic traits and EF across the trait's continuum. REGISTRATION: This study was preregistered at https://osf.io/zncv3 . En ligne : https://dx.doi.org/10.1186/s13229-025-00680-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Frontal lobe dysfunction underlies the differential word retrieval impairment in adolescents with high-functioning autism / Michael K. YEUNG in Autism Research, 12-4 (April 2019)  

Public ISBD [article]  inAutism Research > 12-4 (April 2019) . - p.600-613 Titre : Frontal lobe dysfunction underlies the differential word retrieval impairment in adolescents with high-functioning autism Type de document : texte imprimé Auteurs : Michael K. YEUNG, Auteur ; T. L. LEE, Auteur ; A. S. CHAN, Auteur Article en page(s) : p.600-613 Langues : Anglais (eng) Mots-clés : adolescent  autism spectrum disorder  category fluency  frontal lobe  near-infrared spectroscopy (NIRS)/optical imaging  word retrieval Index. décimale : PER Périodiques Résumé : There is substantial evidence of word retrieval impairment as indicated by poor performance on the category fluency test in autism spectrum disorder (ASD). However, little is known about the neural mechanisms underlying this impairment. Functional neuroimaging studies have shown that the lateral frontal cortex plays a key role in flexible word retrieval. Thus, we examined whether individuals with ASD exhibited altered frontal processing during the category fluency test using functional near-infrared spectroscopy (fNIRS). Twenty-two adolescents with high-functioning ASD (20 males) and 22 typically developing (TD) adolescents (16 males) aged 11-18 years were recruited. All underwent a category fluency paradigm, which required production of animal or means of transportation words for 1 min each although their frontal hemodynamic changes were recorded with fNIRS. We found that adolescents with ASD produced fewer animal but not transportation words (group-by-category interaction: P = 0.003), suggesting differential word retrieval impairment. In addition, unlike TD adolescents who exhibited activation primarily in lateral frontal regions during word production, adolescents with ASD had comparable activation across lateral and medial frontal regions. More importantly, this lack of lateral-medial distinction of activation, which was associated with poor word retrieval, differed significantly between groups only in the animal category (group-by-category interaction: P = 0.018). Thus, our findings implicate frontal lobe dysfunction in the impairment of differential word retrieval in adolescents with ASD. The relatively greater involvement of the medial frontopolar cortex might reflect the use of nonspecialized brain regions to compensate for the category-dependent difficulties with word retrieval in ASD. Autism Res 2019, 12: 600-613. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using an optical imaging tool, we found that adolescents with autism had difficulties with producing semantically related words and exhibited frontal lobe dysfunction. Nonetheless, poor word production and altered brain processing was only seen when these adolescents were asked to produce words from a category of living things but not nonliving things (i.e., animals but not means of transportation). Category-dependent word retrieval problems and frontal lobe dysfunction might be two features of this disorder. En ligne : https://dx.doi.org/10.1002/aur.2082 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Frontal lobe dysfunction underlies the differential word retrieval impairment in adolescents with high-functioning autism [texte imprimé] / Michael K. YEUNG, Auteur ; T. L. LEE, Auteur ; A. S. CHAN, Auteur . - p.600-613. Langues : Anglais (eng) in Autism Research > 12-4 (April 2019) . - p.600-613 Mots-clés : adolescent  autism spectrum disorder  category fluency  frontal lobe  near-infrared spectroscopy (NIRS)/optical imaging  word retrieval Index. décimale : PER Périodiques Résumé : There is substantial evidence of word retrieval impairment as indicated by poor performance on the category fluency test in autism spectrum disorder (ASD). However, little is known about the neural mechanisms underlying this impairment. Functional neuroimaging studies have shown that the lateral frontal cortex plays a key role in flexible word retrieval. Thus, we examined whether individuals with ASD exhibited altered frontal processing during the category fluency test using functional near-infrared spectroscopy (fNIRS). Twenty-two adolescents with high-functioning ASD (20 males) and 22 typically developing (TD) adolescents (16 males) aged 11-18 years were recruited. All underwent a category fluency paradigm, which required production of animal or means of transportation words for 1 min each although their frontal hemodynamic changes were recorded with fNIRS. We found that adolescents with ASD produced fewer animal but not transportation words (group-by-category interaction: P = 0.003), suggesting differential word retrieval impairment. In addition, unlike TD adolescents who exhibited activation primarily in lateral frontal regions during word production, adolescents with ASD had comparable activation across lateral and medial frontal regions. More importantly, this lack of lateral-medial distinction of activation, which was associated with poor word retrieval, differed significantly between groups only in the animal category (group-by-category interaction: P = 0.018). Thus, our findings implicate frontal lobe dysfunction in the impairment of differential word retrieval in adolescents with ASD. The relatively greater involvement of the medial frontopolar cortex might reflect the use of nonspecialized brain regions to compensate for the category-dependent difficulties with word retrieval in ASD. Autism Res 2019, 12: 600-613. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using an optical imaging tool, we found that adolescents with autism had difficulties with producing semantically related words and exhibited frontal lobe dysfunction. Nonetheless, poor word production and altered brain processing was only seen when these adolescents were asked to produce words from a category of living things but not nonliving things (i.e., animals but not means of transportation). Category-dependent word retrieval problems and frontal lobe dysfunction might be two features of this disorder. En ligne : https://dx.doi.org/10.1002/aur.2082 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Impaired Recognition of Negative Facial Expressions is Partly Related to Facial Perception Deficits in Adolescents with High-Functioning Autism Spectrum Disorder / Michael K. YEUNG in Journal of Autism and Developmental Disorders, 50-5 (May 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1596-1606 Titre : Impaired Recognition of Negative Facial Expressions is Partly Related to Facial Perception Deficits in Adolescents with High-Functioning Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Michael K. YEUNG, Auteur ; Tsz L. LEE, Auteur ; Agnes S. CHAN, Auteur Article en page(s) : p.1596-1606 Langues : Anglais (eng) Mots-clés : Adolescent  Autism spectrum disorder  Facial emotion recognition  Facial perception  Unbiased hit rate Index. décimale : PER Périodiques Résumé : Accumulating studies have reported facial emotion recognition or facial perception impairments in autism spectrum disorder (ASD). To clarify the specificity of the emotion recognition impairment, this study examined the relationships between facial emotion recognition and facial perception abilities in ASD. Twenty-two adolescents with high-functioning ASD (20 males) and 22 typically developing (TD) adolescents (16 males) aged 11-18 years undertook a facial emotion labeling task and a facial perception test. We found that adolescents with ASD had deficits in recognizing negative facial expressions, which correlated with both facial perception deficits and severity of social impairment. In addition, the emotion recognition deficits remained after adjusting for facial perception performance. Thus, our findings suggest an emotion-specific impairment in facial emotion recognition in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-03915-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Impaired Recognition of Negative Facial Expressions is Partly Related to Facial Perception Deficits in Adolescents with High-Functioning Autism Spectrum Disorder [texte imprimé] / Michael K. YEUNG, Auteur ; Tsz L. LEE, Auteur ; Agnes S. CHAN, Auteur . - p.1596-1606. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1596-1606 Mots-clés : Adolescent  Autism spectrum disorder  Facial emotion recognition  Facial perception  Unbiased hit rate Index. décimale : PER Périodiques Résumé : Accumulating studies have reported facial emotion recognition or facial perception impairments in autism spectrum disorder (ASD). To clarify the specificity of the emotion recognition impairment, this study examined the relationships between facial emotion recognition and facial perception abilities in ASD. Twenty-two adolescents with high-functioning ASD (20 males) and 22 typically developing (TD) adolescents (16 males) aged 11-18 years undertook a facial emotion labeling task and a facial perception test. We found that adolescents with ASD had deficits in recognizing negative facial expressions, which correlated with both facial perception deficits and severity of social impairment. In addition, the emotion recognition deficits remained after adjusting for facial perception performance. Thus, our findings suggest an emotion-specific impairment in facial emotion recognition in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-03915-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses / Michael K. YEUNG in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2045-2063 Titre : Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses Type de document : texte imprimé Auteurs : Michael K. YEUNG, Auteur ; Jieru BAI, Auteur ; Kwai-Lai MAK, Auteur Article en page(s) : p.2045-2063 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  development  executive function  longitudinal study  meta-analysis  systematic review Index. décimale : PER Périodiques Résumé : Abstract Individuals with an autism spectrum disorder (ASD) diagnosis show impairment in executive function (EF). However, findings are mixed regarding differences in the age effect on EF between autistic individuals and persons with typical development (TD). Questions remain regarding whether the age-related trajectories of EF in ASD are the same as or different from those in TD. To bridge this knowledge gap, we conducted a systematic review and meta-analyses of longitudinal studies that compared age-related changes in EF between ASD and TD groups (preregistration: osf.io/j5764). A literature search was conducted using PubMed, PsycINFO, and Web of Science on January 29, 2024. After screening by two independent reviewers, 14 longitudinal studies were included. Random-effects meta-analyses of studies involving a maximum total of 518 autistic and 3558 TD children and adolescents (mean baseline ages: 5.7 12.0 years) showed that ASD had significantly poorer EF than TD at both baseline and follow-up. However, there was no significant group difference in the age-related change in EF across domains, including working memory, inhibition, shifting, and planning. Robust Bayesian meta-analyses also provided substantial evidence in favor of the null hypothesis that ASD and TD groups showed similar changes over time for most EF processes. Limitations of the literature included the limited number of longitudinal studies and a narrow range of developmental stages and EF constructs analyzed across studies. Altogether, these findings suggest that autistic children and adolescents generally can improve in EF over time similarly to their neurotypical peers. This has important implications for parents and educators, encouraging appropriate EF training and intervention for autistic children and adolescents at an early stage. En ligne : https://doi.org/10.1002/aur.3196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses [texte imprimé] / Michael K. YEUNG, Auteur ; Jieru BAI, Auteur ; Kwai-Lai MAK, Auteur . - p.2045-2063. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2045-2063 Mots-clés : autism spectrum disorder  development  executive function  longitudinal study  meta-analysis  systematic review Index. décimale : PER Périodiques Résumé : Abstract Individuals with an autism spectrum disorder (ASD) diagnosis show impairment in executive function (EF). However, findings are mixed regarding differences in the age effect on EF between autistic individuals and persons with typical development (TD). Questions remain regarding whether the age-related trajectories of EF in ASD are the same as or different from those in TD. To bridge this knowledge gap, we conducted a systematic review and meta-analyses of longitudinal studies that compared age-related changes in EF between ASD and TD groups (preregistration: osf.io/j5764). A literature search was conducted using PubMed, PsycINFO, and Web of Science on January 29, 2024. After screening by two independent reviewers, 14 longitudinal studies were included. Random-effects meta-analyses of studies involving a maximum total of 518 autistic and 3558 TD children and adolescents (mean baseline ages: 5.7 12.0 years) showed that ASD had significantly poorer EF than TD at both baseline and follow-up. However, there was no significant group difference in the age-related change in EF across domains, including working memory, inhibition, shifting, and planning. Robust Bayesian meta-analyses also provided substantial evidence in favor of the null hypothesis that ASD and TD groups showed similar changes over time for most EF processes. Limitations of the literature included the limited number of longitudinal studies and a narrow range of developmental stages and EF constructs analyzed across studies. Altogether, these findings suggest that autistic children and adolescents generally can improve in EF over time similarly to their neurotypical peers. This has important implications for parents and educators, encouraging appropriate EF training and intervention for autistic children and adolescents at an early stage. En ligne : https://doi.org/10.1002/aur.3196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

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