Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment / Pamela VENTOLA in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2813-2820 Titre : Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment Type de document : Texte imprimé et/ou numérique Auteurs : Pamela VENTOLA, Auteur ; Daniel YANG, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Courtney A. PAISLEY, Auteur ; Megan L. BRACONNIER, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.2813-2820 Langues : Anglais (eng) Mots-clés : Restricted and repetitive behaviors  Pivotal Response Treatment (PRT)  Behavior therapy  Repetitive Behavior Scale-Revised (RBS-R) Index. décimale : PER Périodiques Résumé : Children with ASD show high frequency of restricted and repetitive behaviors (RRBs); however, higher-order RRBs, such as restricted interests, have remained largely resistant to treatment. This study evaluated change in severity of RRBs following a 16-weeks open trial of Pivotal Response Treatment (PRT). Participants included 15 children with ASD ages 4–7 years. RRBs, as measured by the repetitive behavioral scales-revised (RBS-R) and aberrant behaviors checklist, decreased significantly after treatment. These reductions remained significant after controlling for change in social communication skills. PRT shows promise in reducing RRBs; although PRT explicitly addresses pivotal social communication skills, there is a secondary and less direct effect on RRBs. En ligne : http://dx.doi.org/10.1007/s10803-016-2813-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment [Texte imprimé et/ou numérique] / Pamela VENTOLA, Auteur ; Daniel YANG, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Courtney A. PAISLEY, Auteur ; Megan L. BRACONNIER, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.2813-2820. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2813-2820 Mots-clés : Restricted and repetitive behaviors  Pivotal Response Treatment (PRT)  Behavior therapy  Repetitive Behavior Scale-Revised (RBS-R) Index. décimale : PER Périodiques Résumé : Children with ASD show high frequency of restricted and repetitive behaviors (RRBs); however, higher-order RRBs, such as restricted interests, have remained largely resistant to treatment. This study evaluated change in severity of RRBs following a 16-weeks open trial of Pivotal Response Treatment (PRT). Participants included 15 children with ASD ages 4–7 years. RRBs, as measured by the repetitive behavioral scales-revised (RBS-R) and aberrant behaviors checklist, decreased significantly after treatment. These reductions remained significant after controlling for change in social communication skills. PRT shows promise in reducing RRBs; although PRT explicitly addresses pivotal social communication skills, there is a secondary and less direct effect on RRBs. En ligne : http://dx.doi.org/10.1007/s10803-016-2813-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification / D. Y. YANG in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 11p. Titre : Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification Type de document : Texte imprimé et/ou numérique Auteurs : D. Y. YANG, Auteur ; D. BEAM, Auteur ; Kevin A. PELPHREY, Auteur ; Sebiha M. ABDULLAHI, Auteur ; R. J. JOU, Auteur Article en page(s) : 11p. Langues : Anglais (eng) Mots-clés : Age Factors  Cerebral Cortex/pathology  Child  Child Development Disorders, Pervasive/pathology  Child, Preschool  Gray Matter/pathology  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Neuroimaging  Organ Size  White Matter/pathology  Autism spectrum disorder  Brain development  Brain structure  Neuroanatomy  Surface-based morphometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) have been characterized by altered cerebral cortical structures; however, the field has yet to identify consistent markers and prior studies have included mostly adolescents and adults. While there are multiple cortical morphological measures, including cortical thickness, surface area, cortical volume, and cortical gyrification, few single studies have examined all these measures. The current study analyzed all of the four measures and focused on pre-adolescent children with ASD. METHODS: We employed the FreeSurfer pipeline to examine surface-based morphometry in 60 high-functioning boys with ASD (mean age = 8.35 years, range = 4-12 years) and 41 gender-, age-, and IQ-matched typically developing (TD) peers (mean age = 8.83 years), while testing for age-by-diagnosis interaction and between-group differences. RESULTS: During childhood and in specific regions, ASD participants exhibited a lack of normative age-related cortical thinning and volumetric reduction and an abnormal age-related increase in gyrification. Regarding surface area, ASD and TD exhibited statistically comparable age-related development during childhood. Across childhood, ASD relative to TD participants tended to have higher mean levels of gyrification in specific regions. Within ASD, those with higher Social Responsiveness Scale total raw scores tended to have greater age-related increase in gyrification in specific regions during childhood. CONCLUSIONS: ASD is characterized by cortical neuroanatomical abnormalities that are age-, measure-, statistical model-, and region-dependent. The current study is the first to examine the development of all four cortical measures in one of the largest pre-adolescent samples. Strikingly, Neurosynth-based quantitative reverse inference of the surviving clusters suggests that many of the regions identified above are related to social perception, language, self-referential, and action observation networks-those frequently found to be functionally altered in individuals with ASD. The comprehensive, multilevel analyses across a wide range of cortical measures help fill a knowledge gap and present a complex but rich picture of neuroanatomical developmental differences in children with ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0076-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification [Texte imprimé et/ou numérique] / D. Y. YANG, Auteur ; D. BEAM, Auteur ; Kevin A. PELPHREY, Auteur ; Sebiha M. ABDULLAHI, Auteur ; R. J. JOU, Auteur . - 11p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 11p. Mots-clés : Age Factors  Cerebral Cortex/pathology  Child  Child Development Disorders, Pervasive/pathology  Child, Preschool  Gray Matter/pathology  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Neuroimaging  Organ Size  White Matter/pathology  Autism spectrum disorder  Brain development  Brain structure  Neuroanatomy  Surface-based morphometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) have been characterized by altered cerebral cortical structures; however, the field has yet to identify consistent markers and prior studies have included mostly adolescents and adults. While there are multiple cortical morphological measures, including cortical thickness, surface area, cortical volume, and cortical gyrification, few single studies have examined all these measures. The current study analyzed all of the four measures and focused on pre-adolescent children with ASD. METHODS: We employed the FreeSurfer pipeline to examine surface-based morphometry in 60 high-functioning boys with ASD (mean age = 8.35 years, range = 4-12 years) and 41 gender-, age-, and IQ-matched typically developing (TD) peers (mean age = 8.83 years), while testing for age-by-diagnosis interaction and between-group differences. RESULTS: During childhood and in specific regions, ASD participants exhibited a lack of normative age-related cortical thinning and volumetric reduction and an abnormal age-related increase in gyrification. Regarding surface area, ASD and TD exhibited statistically comparable age-related development during childhood. Across childhood, ASD relative to TD participants tended to have higher mean levels of gyrification in specific regions. Within ASD, those with higher Social Responsiveness Scale total raw scores tended to have greater age-related increase in gyrification in specific regions during childhood. CONCLUSIONS: ASD is characterized by cortical neuroanatomical abnormalities that are age-, measure-, statistical model-, and region-dependent. The current study is the first to examine the development of all four cortical measures in one of the largest pre-adolescent samples. Strikingly, Neurosynth-based quantitative reverse inference of the surviving clusters suggests that many of the regions identified above are related to social perception, language, self-referential, and action observation networks-those frequently found to be functionally altered in individuals with ASD. The comprehensive, multilevel analyses across a wide range of cortical measures help fill a knowledge gap and present a complex but rich picture of neuroanatomical developmental differences in children with ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0076-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Neural mechanisms of behavioral change in young adults with high?functioning autism receiving virtual reality social cognition training: A pilot study / Y. J. Daniel YANG in Autism Research, 11-5 (May 2018)  

Public ISBD [article]  inAutism Research > 11-5 (May 2018) . - p.713-725 Titre : Neural mechanisms of behavioral change in young adults with high?functioning autism receiving virtual reality social cognition training: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : Y. J. Daniel YANG, Auteur ; Tandra T. ALLEN, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Kevin A. PELPHREY, Auteur ; Fred R. VOLKMAR, Auteur ; Sandra B. CHAPMAN, Auteur Article en page(s) : p.713-725 Langues : Anglais (eng) Mots-clés : neuroplasticity  adults with autism  emotion recognition  theory of mind  clinical trials  computerized treatment  virtual reality Index. décimale : PER Périodiques Résumé : Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses this void by investigating neural and behavioral changes in a Phase I trial in young adults with high?functioning ASD who received an evidence?based behavioral intervention, Virtual Reality?Social Cognition Training over 5 weeks for a total of 10 hr. The participants were tested pre? and post?training with a validated biological/social versus scrambled/nonsocial motion neuroimaging task, previously shown to activate regions within the social brain networks. Three significant brain?behavior changes were identified. First, the right posterior superior temporal sulcus, a hub for socio?cognitive processing, showed increased brain activation to social versus nonsocial stimuli in individuals with greater gains on a theory?of?mind measure. Second, the left inferior frontal gyrus, a region for socio?emotional processing, tracked individual gains in emotion recognition with decreased activation to social versus nonsocial stimuli. Finally, the left superior parietal lobule, a region for visual attention, showed significantly decreased activation to nonsocial versus social stimuli across all participants, where heightened attention to nonsocial contingencies has been considered a disabling aspect of ASD. This study provides, albeit preliminary, some of the first evidence of the harnessable neuroplasticity in adults with ASD through an age?appropriate intervention in brain regions tightly linked to social abilities. This pilot trial motivates future efforts to develop and test social interventions to improve behaviors and supporting brain networks in adults with ASD. Autism Res 2018, 11: 713?725. ? 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay Summary This study addresses how the behavioral changes after treatment for ASD reflect underlying brain changes. Before and after receiving VR?SCT, young adults with high?functioning ASD passively viewed biological motion stimuli in a MRI scanner, tapping changes in the social brain network. The results reveal neuroplasticity in this age population, extending the window of opportunity for interventions to impact social competency in adults with ASD. En ligne : https://doi.org/10.1002/aur.1941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Neural mechanisms of behavioral change in young adults with high?functioning autism receiving virtual reality social cognition training: A pilot study [Texte imprimé et/ou numérique] / Y. J. Daniel YANG, Auteur ; Tandra T. ALLEN, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Kevin A. PELPHREY, Auteur ; Fred R. VOLKMAR, Auteur ; Sandra B. CHAPMAN, Auteur . - p.713-725. Langues : Anglais (eng) in Autism Research > 11-5 (May 2018) . - p.713-725 Mots-clés : neuroplasticity  adults with autism  emotion recognition  theory of mind  clinical trials  computerized treatment  virtual reality Index. décimale : PER Périodiques Résumé : Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses this void by investigating neural and behavioral changes in a Phase I trial in young adults with high?functioning ASD who received an evidence?based behavioral intervention, Virtual Reality?Social Cognition Training over 5 weeks for a total of 10 hr. The participants were tested pre? and post?training with a validated biological/social versus scrambled/nonsocial motion neuroimaging task, previously shown to activate regions within the social brain networks. Three significant brain?behavior changes were identified. First, the right posterior superior temporal sulcus, a hub for socio?cognitive processing, showed increased brain activation to social versus nonsocial stimuli in individuals with greater gains on a theory?of?mind measure. Second, the left inferior frontal gyrus, a region for socio?emotional processing, tracked individual gains in emotion recognition with decreased activation to social versus nonsocial stimuli. Finally, the left superior parietal lobule, a region for visual attention, showed significantly decreased activation to nonsocial versus social stimuli across all participants, where heightened attention to nonsocial contingencies has been considered a disabling aspect of ASD. This study provides, albeit preliminary, some of the first evidence of the harnessable neuroplasticity in adults with ASD through an age?appropriate intervention in brain regions tightly linked to social abilities. This pilot trial motivates future efforts to develop and test social interventions to improve behaviors and supporting brain networks in adults with ASD. Autism Res 2018, 11: 713?725. ? 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay Summary This study addresses how the behavioral changes after treatment for ASD reflect underlying brain changes. Before and after receiving VR?SCT, young adults with high?functioning ASD passively viewed biological motion stimuli in a MRI scanner, tapping changes in the social brain network. The results reveal neuroplasticity in this age population, extending the window of opportunity for interventions to impact social competency in adults with ASD. En ligne : https://doi.org/10.1002/aur.1941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Reduced anxiety following pivotal response treatment in young children with autism spectrum disorder / Jiedi LEI in Research in Autism Spectrum Disorders, 43-44 (November 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 43-44 (November 2017) . - p.1-7 Titre : Reduced anxiety following pivotal response treatment in young children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jiedi LEI, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Megan L. BRACONNIER, Auteur ; Pamela VENTOLA, Auteur Article en page(s) : p.1-7 Langues : Anglais (eng) Mots-clés : Pivotal response treatment (PRT)  Autism spectrum disorder (ASD)  Anxiety Index. décimale : PER Périodiques Résumé : Up to 40% of children with Autism Spectrum Disorder (ASD) exhibit co-occurring anxiety symptoms. Despite recent success in mitigating anxiety symptoms in school-aged children with ASD (mean age >9 years) using adapted versions of Cognitive Behavioural Therapy, little is known about potential treatment outcomes for younger children. To address the gap in the literature, this open-label study evaluated change in anxiety following a 16-week open-label trial of Pivotal Response Treatment (PRT) in children with ASD aged 4–8 years. PRT is a behavioural treatment based on the principles of Applied Behaviour Analysis and has a primary aim of increasing social communication skills in children with ASD through natural reinforcements. To minimise conflation of anxiety and other co-occurring symptoms such as disruptive behaviour and attention-deficit hyperactivity disorder, we measured anxiety using the autism anxiety subscale of the Child and Adolescent Symptom Inventory (CASI) devised by Sukhodolsky et al. (2008). We observed significant anxiety reduction over 16-weeks of PRT. Furthermore, anxiety reduction was independent of changes in autism symptom severity. This study shows promising results for PRT as an intervention for reducing anxiety in young children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2017.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Reduced anxiety following pivotal response treatment in young children with autism spectrum disorder [Texte imprimé et/ou numérique] / Jiedi LEI, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Megan L. BRACONNIER, Auteur ; Pamela VENTOLA, Auteur . - p.1-7. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 43-44 (November 2017) . - p.1-7 Mots-clés : Pivotal response treatment (PRT)  Autism spectrum disorder (ASD)  Anxiety Index. décimale : PER Périodiques Résumé : Up to 40% of children with Autism Spectrum Disorder (ASD) exhibit co-occurring anxiety symptoms. Despite recent success in mitigating anxiety symptoms in school-aged children with ASD (mean age >9 years) using adapted versions of Cognitive Behavioural Therapy, little is known about potential treatment outcomes for younger children. To address the gap in the literature, this open-label study evaluated change in anxiety following a 16-week open-label trial of Pivotal Response Treatment (PRT) in children with ASD aged 4–8 years. PRT is a behavioural treatment based on the principles of Applied Behaviour Analysis and has a primary aim of increasing social communication skills in children with ASD through natural reinforcements. To minimise conflation of anxiety and other co-occurring symptoms such as disruptive behaviour and attention-deficit hyperactivity disorder, we measured anxiety using the autism anxiety subscale of the Child and Adolescent Symptom Inventory (CASI) devised by Sukhodolsky et al. (2008). We observed significant anxiety reduction over 16-weeks of PRT. Furthermore, anxiety reduction was independent of changes in autism symptom severity. This study shows promising results for PRT as an intervention for reducing anxiety in young children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2017.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

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