Functional MRI connectivity of children with autism and low verbal and cognitive performance / Terisa P. GABRIELSEN in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 67 p. Titre : Functional MRI connectivity of children with autism and low verbal and cognitive performance Type de document : texte imprimé Auteurs : Terisa P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; Kevin G. STEPHENSON, Auteur ; Jonathan BECK, Auteur ; Jace B. KING, Auteur ; Ryan KELLEMS, Auteur ; David N. TOP, Auteur ; Nicholas C.C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; Rebecca A. LUNDWALL, Auteur ; Blake D. HANSEN, Auteur ; Mikle SOUTH, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Functional MRI connectivity of children with autism and low verbal and cognitive performance [texte imprimé] / Terisa P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; Kevin G. STEPHENSON, Auteur ; Jonathan BECK, Auteur ; Jace B. KING, Auteur ; Ryan KELLEMS, Auteur ; David N. TOP, Auteur ; Nicholas C.C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; Rebecca A. LUNDWALL, Auteur ; Blake D. HANSEN, Auteur ; Mikle SOUTH, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 67 p. Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Looking good but feeling bad: "Camouflaging" behaviors and mental health in women with autistic traits / Jonathan S. BECK in Autism, 24-4 (May 2020)  

Public ISBD [article]  inAutism > 24-4 (May 2020) . - p.809-821 Titre : Looking good but feeling bad: "Camouflaging" behaviors and mental health in women with autistic traits Type de document : texte imprimé Auteurs : Jonathan S. BECK, Auteur ; Rebecca A. LUNDWALL, Auteur ; Terisa P. GABRIELSEN, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur Article en page(s) : p.809-821 Langues : Anglais (eng) Mots-clés : autism spectrum  camouflage  diagnosis  disorders  female  mental health  women Index. décimale : PER Périodiques Résumé : Women who try to hide or "camouflage" their autistic traits are likely to report that they feel distressed, think of suicide, and/or struggle to function in everyday life. We asked 58 women with autistic traits to complete questionnaires about camouflaging and mental health. Most of these women did not have a formal diagnosis of autism, yet a majority reported that they camouflaged autistic traits, and a large majority reported significant mental health challenges. Some researchers have suggested that women with autistic traits are more likely than autistic men to experience mental health challenges because women may try more to "fit in" socially by camouflaging their autistic traits. Analyses showed that camouflaging was associated with feeling distressed (depressed, anxious, and/or stressed). For women who reported above-average levels of camouflaging, camouflaging was also associated with having thoughts about suicide and struggling to function in everyday life. Trying to camouflage autistic traits was associated with mental health challenges, regardless of whether those traits were very mild or more severe. The findings of this study may influence how mental health professionals evaluate and treat women with autistic traits. En ligne : http://dx.doi.org/10.1177/1362361320912147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Looking good but feeling bad: "Camouflaging" behaviors and mental health in women with autistic traits [texte imprimé] / Jonathan S. BECK, Auteur ; Rebecca A. LUNDWALL, Auteur ; Terisa P. GABRIELSEN, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur . - p.809-821. Langues : Anglais (eng) in Autism > 24-4 (May 2020) . - p.809-821 Mots-clés : autism spectrum  camouflage  diagnosis  disorders  female  mental health  women Index. décimale : PER Périodiques Résumé : Women who try to hide or "camouflage" their autistic traits are likely to report that they feel distressed, think of suicide, and/or struggle to function in everyday life. We asked 58 women with autistic traits to complete questionnaires about camouflaging and mental health. Most of these women did not have a formal diagnosis of autism, yet a majority reported that they camouflaged autistic traits, and a large majority reported significant mental health challenges. Some researchers have suggested that women with autistic traits are more likely than autistic men to experience mental health challenges because women may try more to "fit in" socially by camouflaging their autistic traits. Analyses showed that camouflaging was associated with feeling distressed (depressed, anxious, and/or stressed). For women who reported above-average levels of camouflaging, camouflaging was also associated with having thoughts about suicide and struggling to function in everyday life. Trying to camouflage autistic traits was associated with mental health challenges, regardless of whether those traits were very mild or more severe. The findings of this study may influence how mental health professionals evaluate and treat women with autistic traits. En ligne : http://dx.doi.org/10.1177/1362361320912147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

Not So Fast: Autistic traits and Anxious Apprehension in Real-World Visual Search Scenarios / Nicholas C.C. RUSSELL in Journal of Autism and Developmental Disorders, 49-5 (May 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1795-1806 Titre : Not So Fast: Autistic traits and Anxious Apprehension in Real-World Visual Search Scenarios Type de document : texte imprimé Auteurs : Nicholas C.C. RUSSELL, Auteur ; Steven G. LUKE, Auteur ; Rebecca A. LUNDWALL, Auteur ; Mikle SOUTH, Auteur Article en page(s) : p.1795-1806 Langues : Anglais (eng) Mots-clés : Anxiety  Autism  Contextual integration  Eye tracking  Visual search Index. décimale : PER Périodiques Résumé : Autistic individuals have shown superior performance in simple, albeit difficult, visual search tasks. We compared eye movements and behavioral markers across two visual search tasks based on real-world scenes in young adults. Context-aided search increased speed and accuracy for all groups. Autistic adults (n = 29) were on average consistently slower and less accurate than a non-anxious neurotypical comparison group (n = 48), but similar to neurotypical adults with elevated anxious apprehension (n = 26). Dimensional analyses suggest that autism traits, not anxious apprehension, are most associated with search efficiency of naturalistic stimuli suggesting that autistic individuals can effectively integrate contextual information to aid visual search, but that advantages in less visually complex tasks, reported in previous studies, may not transfer to situations involving real-world scenes. En ligne : http://dx.doi.org/10.1007/s10803-018-03874-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Not So Fast: Autistic traits and Anxious Apprehension in Real-World Visual Search Scenarios [texte imprimé] / Nicholas C.C. RUSSELL, Auteur ; Steven G. LUKE, Auteur ; Rebecca A. LUNDWALL, Auteur ; Mikle SOUTH, Auteur . - p.1795-1806. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1795-1806 Mots-clés : Anxiety  Autism  Contextual integration  Eye tracking  Visual search Index. décimale : PER Périodiques Résumé : Autistic individuals have shown superior performance in simple, albeit difficult, visual search tasks. We compared eye movements and behavioral markers across two visual search tasks based on real-world scenes in young adults. Context-aided search increased speed and accuracy for all groups. Autistic adults (n = 29) were on average consistently slower and less accurate than a non-anxious neurotypical comparison group (n = 48), but similar to neurotypical adults with elevated anxious apprehension (n = 26). Dimensional analyses suggest that autism traits, not anxious apprehension, are most associated with search efficiency of naturalistic stimuli suggesting that autistic individuals can effectively integrate contextual information to aid visual search, but that advantages in less visually complex tasks, reported in previous studies, may not transfer to situations involving real-world scenes. En ligne : http://dx.doi.org/10.1007/s10803-018-03874-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder / Rebecca A. LUNDWALL in Research in Autism Spectrum Disorders, 34 (February 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Titre : Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder Type de document : texte imprimé Auteurs : Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D.B. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder [texte imprimé] / Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D.B. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.44-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Silently screaming: A collective case study of non-suicidal self-injury in women with autistic traits / Rebecca A. LUNDWALL in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202725 Titre : Silently screaming: A collective case study of non-suicidal self-injury in women with autistic traits Type de document : texte imprimé Auteurs : Rebecca A. LUNDWALL, Auteur ; Elizabeth A. CUTRER-PÁRRAGA, Auteur ; Rachel LUNDWALL, Auteur ; Megan E. SQUIRES, Auteur ; Jonathan S. BECK, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.202725 Langues : Anglais (eng) Mots-clés : Autism  Self-harm  Non-suicidal self-injury  Deliberate self-harm  Female Index. décimale : PER Périodiques Résumé : Introduction Recognition of autism in females has been growing, with concerns that NSSI is more common in this group. Listening to autistic women who self-harm can expand understanding and improve support. Methods Adult autistic females and those with a clinical best estimate of autism completed a developmental screener, the Suicide Behavior Questionnaire-Revised (SBQ-R), and follow-up interviews prompting collective case study analysis of 23 transcriptions (n = 13 autism; n = 10 clinical best estimate of autism). Insider and external autism experts reviewed analyses. Results Eighteen of the 23 participants self-injured. We found younger ages of onset for self-injury (as early as 8 years old) than previously reported in other studies. Powerlessness, self-punishment for social mistakes, and difficulty displaying the “right” emotions were common themes related to reasons why autistic women self-injured. Experiences of NSSI aligned with literature linking it to the need for emotional regulation and focus when overwhelmed. Cutting was sometimes associated with suicidal thoughts/behaviors. Our inside experts were people with lived experience of autism, and they reviewed the study’s findings. Conclusion Participants reported that parents, therapists, and clergy who listened without judgment and validated social stressors were helpful. Dismissive reactions, assumptions regarding motivations, and hospitalization were described as not helpful. Overall, participants expressed a desire for greater self-control over quality of life. En ligne : https://doi.org/10.1016/j.reia.2025.202725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Silently screaming: A collective case study of non-suicidal self-injury in women with autistic traits [texte imprimé] / Rebecca A. LUNDWALL, Auteur ; Elizabeth A. CUTRER-PÁRRAGA, Auteur ; Rachel LUNDWALL, Auteur ; Megan E. SQUIRES, Auteur ; Jonathan S. BECK, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.202725. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202725 Mots-clés : Autism  Self-harm  Non-suicidal self-injury  Deliberate self-harm  Female Index. décimale : PER Périodiques Résumé : Introduction Recognition of autism in females has been growing, with concerns that NSSI is more common in this group. Listening to autistic women who self-harm can expand understanding and improve support. Methods Adult autistic females and those with a clinical best estimate of autism completed a developmental screener, the Suicide Behavior Questionnaire-Revised (SBQ-R), and follow-up interviews prompting collective case study analysis of 23 transcriptions (n = 13 autism; n = 10 clinical best estimate of autism). Insider and external autism experts reviewed analyses. Results Eighteen of the 23 participants self-injured. We found younger ages of onset for self-injury (as early as 8 years old) than previously reported in other studies. Powerlessness, self-punishment for social mistakes, and difficulty displaying the “right” emotions were common themes related to reasons why autistic women self-injured. Experiences of NSSI aligned with literature linking it to the need for emotional regulation and focus when overwhelmed. Cutting was sometimes associated with suicidal thoughts/behaviors. Our inside experts were people with lived experience of autism, and they reviewed the study’s findings. Conclusion Participants reported that parents, therapists, and clergy who listened without judgment and validated social stressors were helpful. Dismissive reactions, assumptions regarding motivations, and hospitalization were described as not helpful. Overall, participants expressed a desire for greater self-control over quality of life. En ligne : https://doi.org/10.1016/j.reia.2025.202725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Unrelenting Depression and Suicidality in Women with Autistic Traits / Mikle SOUTH in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

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