An observational study of emotion regulation in children with Tourette syndrome / J. HAGSTRØM in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.790-797 Titre : An observational study of emotion regulation in children with Tourette syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. HAGSTRØM, Auteur ; K. S. SPANG, Auteur ; S. VANGKILDE, Auteur ; K. MAIGAARD, Auteur ; L. SKOV, Auteur ; Anne Katrine PAGSBERG, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; K. J. PLESSEN, Auteur Article en page(s) : p.790-797 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology  Comorbidity  Emotional Regulation  Humans  Tic Disorders  Tourette Syndrome  Emotion regulation  attention-deficit/hyperactivity disorder  premonitory urges  tic severity Index. décimale : PER Périodiques Résumé : BACKGROUND: Explosive outbursts occur in 25%-70% of children with Tourette syndrome (TS) and may cause more distress than the tics themselves. Previous studies have indicated that a comorbid diagnosis of attention-deficit/hyperactivity disorder (ADHD) is associated with emotional dysregulation in TS; however, this relationship has almost exclusively been studied using parent-reported questionnaires. METHODS: We examined emotion regulation (ER) with an observational measure in 150 medication-naïve children aged 7-12 allocated to four groups: Forty-nine children with TS, 23 children with ADHD, 16 children with TS + ADHD, and 62 typically developing controls. We assessed participants' ER ability, as well as parent-child interactions in the context of a complex puzzle task, and coded the observed behavior with the Tangram Emotion Coding Manual (TEC-M). We examined group differences in ER, as well as associations between ER and severity of symptoms pertaining to TS and ADHD. RESULTS: Children with TS did not differ from controls in their ER ability. However, children with ADHD and TS + ADHD had more problems with ER than those with TS only and controls. Finally, parents of children with ADHD displayed more tension during the experimental task. ER ability was not associated with tic severity nor premonitory urges; however, better ER ability was associated with less severe symptoms of ADHD. CONCLUSIONS: This study is the first to evaluate ER with an observational, clinician-rated measure in a controlled social setting in children with TS. Our findings support earlier questionnaire-based studies by showing impaired ER in children with TS + ADHD, but not in children with TS without comorbidity. These findings inform our understanding of the phenomenology of emotional dysregulation in TS and the role of comorbid disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] An observational study of emotion regulation in children with Tourette syndrome [Texte imprimé et/ou numérique] / J. HAGSTRØM, Auteur ; K. S. SPANG, Auteur ; S. VANGKILDE, Auteur ; K. MAIGAARD, Auteur ; L. SKOV, Auteur ; Anne Katrine PAGSBERG, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; K. J. PLESSEN, Auteur . - p.790-797. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.790-797 Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology  Comorbidity  Emotional Regulation  Humans  Tic Disorders  Tourette Syndrome  Emotion regulation  attention-deficit/hyperactivity disorder  premonitory urges  tic severity Index. décimale : PER Périodiques Résumé : BACKGROUND: Explosive outbursts occur in 25%-70% of children with Tourette syndrome (TS) and may cause more distress than the tics themselves. Previous studies have indicated that a comorbid diagnosis of attention-deficit/hyperactivity disorder (ADHD) is associated with emotional dysregulation in TS; however, this relationship has almost exclusively been studied using parent-reported questionnaires. METHODS: We examined emotion regulation (ER) with an observational measure in 150 medication-naïve children aged 7-12 allocated to four groups: Forty-nine children with TS, 23 children with ADHD, 16 children with TS + ADHD, and 62 typically developing controls. We assessed participants' ER ability, as well as parent-child interactions in the context of a complex puzzle task, and coded the observed behavior with the Tangram Emotion Coding Manual (TEC-M). We examined group differences in ER, as well as associations between ER and severity of symptoms pertaining to TS and ADHD. RESULTS: Children with TS did not differ from controls in their ER ability. However, children with ADHD and TS + ADHD had more problems with ER than those with TS only and controls. Finally, parents of children with ADHD displayed more tension during the experimental task. ER ability was not associated with tic severity nor premonitory urges; however, better ER ability was associated with less severe symptoms of ADHD. CONCLUSIONS: This study is the first to evaluate ER with an observational, clinician-rated measure in a controlled social setting in children with TS. Our findings support earlier questionnaire-based studies by showing impaired ER in children with TS + ADHD, but not in children with TS without comorbidity. These findings inform our understanding of the phenomenology of emotional dysregulation in TS and the role of comorbid disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome / A. VANGKILDE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.42 Titre : Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome Type de document : Texte imprimé et/ou numérique Auteurs : A. VANGKILDE, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; H. SCHMOCK, Auteur ; C. OLESEN, Auteur ; S. ARNARSDOTTIR, Auteur ; W. F. BAARE, Auteur ; K. J. PLESSEN, Auteur ; M. DIDRIKSEN, Auteur ; H. R. SIEBNER, Auteur ; T. WERGE, Auteur ; L. OLSEN, Auteur Article en page(s) : p.42 Langues : Anglais (eng) Mots-clés : 22q11 deletion syndrome  Emotional recognition task  Negative symptoms  Positive symptoms  Schizophrenia  Social cognition  Social function  Social skills  Theory of mind Index. décimale : PER Périodiques Résumé : BACKGROUND: Identification of the early signs of schizophrenia would be a major achievement for the early intervention and prevention strategies in psychiatry. Social impairments are defining features of schizophrenia. Impairments of individual layers of social competencies are frequently described in individuals with 22q11.2 deletion syndrome (22q11.2DS), who have high risk of schizophrenia. It is unclear whether and to what extent social impairments associate with subclinical negative and positive symptoms in 22q11.2DS, and which layer of social impairments are more correlated with schizophrenia-related symptoms. The aims of this study were to conduct a comprehensive investigation of social impairments at three different levels (function, skill, and cognition) and their interrelationship and to determine to what degree the social impairments correlate to subclinical levels of negative and positive symptoms, respectively, in a young cohort of 22q11.2DS not diagnosed with schizophrenia. METHODS: The level of social impairment was addressed using questionnaires and objective measures of social functioning (The Adaptive Behavior Assessment System), skills (Social Responsiveness Scale), and cognition (The Awareness of Social Inference Test and CANTAB Emotional Recognition Task), and the presence of subclinical symptoms of schizophrenia were evaluated using the Structured Interview for Prodromal Syndromes in a cross-sectional case-control study of 29 cases and 29 controls, aged 12 to 25 years. Association between social impairment and negative and positive symptoms levels was examined in cases only. RESULTS: Subjects with 22q11.2DS were highly impaired in social function, social skills, and social cognition (p En ligne : http://dx.doi.org/10.1186/s11689-016-9175-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome [Texte imprimé et/ou numérique] / A. VANGKILDE, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; H. SCHMOCK, Auteur ; C. OLESEN, Auteur ; S. ARNARSDOTTIR, Auteur ; W. F. BAARE, Auteur ; K. J. PLESSEN, Auteur ; M. DIDRIKSEN, Auteur ; H. R. SIEBNER, Auteur ; T. WERGE, Auteur ; L. OLSEN, Auteur . - p.42. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.42 Mots-clés : 22q11 deletion syndrome  Emotional recognition task  Negative symptoms  Positive symptoms  Schizophrenia  Social cognition  Social function  Social skills  Theory of mind Index. décimale : PER Périodiques Résumé : BACKGROUND: Identification of the early signs of schizophrenia would be a major achievement for the early intervention and prevention strategies in psychiatry. Social impairments are defining features of schizophrenia. Impairments of individual layers of social competencies are frequently described in individuals with 22q11.2 deletion syndrome (22q11.2DS), who have high risk of schizophrenia. It is unclear whether and to what extent social impairments associate with subclinical negative and positive symptoms in 22q11.2DS, and which layer of social impairments are more correlated with schizophrenia-related symptoms. The aims of this study were to conduct a comprehensive investigation of social impairments at three different levels (function, skill, and cognition) and their interrelationship and to determine to what degree the social impairments correlate to subclinical levels of negative and positive symptoms, respectively, in a young cohort of 22q11.2DS not diagnosed with schizophrenia. METHODS: The level of social impairment was addressed using questionnaires and objective measures of social functioning (The Adaptive Behavior Assessment System), skills (Social Responsiveness Scale), and cognition (The Awareness of Social Inference Test and CANTAB Emotional Recognition Task), and the presence of subclinical symptoms of schizophrenia were evaluated using the Structured Interview for Prodromal Syndromes in a cross-sectional case-control study of 29 cases and 29 controls, aged 12 to 25 years. Association between social impairment and negative and positive symptoms levels was examined in cases only. RESULTS: Subjects with 22q11.2DS were highly impaired in social function, social skills, and social cognition (p En ligne : http://dx.doi.org/10.1186/s11689-016-9175-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

Auditory processing in autism spectrum disorder: Mismatch negativity deficits / Chantal VLASKAMP in Autism Research, 10-11 (November 2017)  

Public ISBD [article]  inAutism Research > 10-11 (November 2017) . - p.1857-1865 Titre : Auditory processing in autism spectrum disorder: Mismatch negativity deficits Type de document : Texte imprimé et/ou numérique Auteurs : Chantal VLASKAMP, Auteur ; Bob ORANJE, Auteur ; Gitte Falcher MADSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Sarah DURSTON, Auteur ; Cathriona CANTIO, Auteur ; Birte GLENTHØJ, Auteur ; Niels BILENBERG, Auteur Article en page(s) : p.1857-1865 Langues : Anglais (eng) Mots-clés : auditory processing  ASD  MMN  P3a  schizophrenia Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC). Thirty-five children (aged 8–12 years) with ASD and 38 age and gender matched TDC were assessed with a MMN paradigm with three types of deviants, i.e., frequency, duration and a combination of these two. MMN elicited by duration and frequency-duration deviants was significantly reduced in the ASD group. P3a-amplitude elicited by duration deviants was significantly increased in the ASD group. Reduced MMN in children with ASD suggests that children with ASD may be less responsive to environmentally deviant stimuli at an early (sensory) level. P3a-amplitude was increased in ASD, implying a hyper-responsivity at the attentional level. In addition, as similar MMN deficits are found in schizophrenia, these MMN results may explain some of the frequently reported increased risk of children with ASD to develop schizophrenia later in life. Autism Res 2017, 10: 1857–1865. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Automatic detection of deviant sounds in the environment, such as upcoming traffic, is often affected in children with autism spectrum disorders (ASD). Mismatch negativity (MMN) is a way to quantify automatic deviancy detection, using electroencephalography. In this study, auditory MMN was assessed in 35 children with ASD and 38 matched control children, revealing significantly reduced MMN in the ASD group. This may indicate that children with ASD are less able to automatically detect environmentally deviant stimuli. En ligne : http://dx.doi.org/10.1002/aur.1821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] Auditory processing in autism spectrum disorder: Mismatch negativity deficits [Texte imprimé et/ou numérique] / Chantal VLASKAMP, Auteur ; Bob ORANJE, Auteur ; Gitte Falcher MADSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Sarah DURSTON, Auteur ; Cathriona CANTIO, Auteur ; Birte GLENTHØJ, Auteur ; Niels BILENBERG, Auteur . - p.1857-1865. Langues : Anglais (eng) in Autism Research > 10-11 (November 2017) . - p.1857-1865 Mots-clés : auditory processing  ASD  MMN  P3a  schizophrenia Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC). Thirty-five children (aged 8–12 years) with ASD and 38 age and gender matched TDC were assessed with a MMN paradigm with three types of deviants, i.e., frequency, duration and a combination of these two. MMN elicited by duration and frequency-duration deviants was significantly reduced in the ASD group. P3a-amplitude elicited by duration deviants was significantly increased in the ASD group. Reduced MMN in children with ASD suggests that children with ASD may be less responsive to environmentally deviant stimuli at an early (sensory) level. P3a-amplitude was increased in ASD, implying a hyper-responsivity at the attentional level. In addition, as similar MMN deficits are found in schizophrenia, these MMN results may explain some of the frequently reported increased risk of children with ASD to develop schizophrenia later in life. Autism Res 2017, 10: 1857–1865. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Automatic detection of deviant sounds in the environment, such as upcoming traffic, is often affected in children with autism spectrum disorders (ASD). Mismatch negativity (MMN) is a way to quantify automatic deviancy detection, using electroencephalography. In this study, auditory MMN was assessed in 35 children with ASD and 38 matched control children, revealing significantly reduced MMN in the ASD group. This may indicate that children with ASD are less able to automatically detect environmentally deviant stimuli. En ligne : http://dx.doi.org/10.1002/aur.1821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

Do cognitive deficits persist into adolescence in autism? / Cathriona CANTIO in Autism Research, 11-9 (September 2018)  

Public ISBD [article]  inAutism Research > 11-9 (September 2018) . - p.1229-1238 Titre : Do cognitive deficits persist into adolescence in autism? Type de document : Texte imprimé et/ou numérique Auteurs : Cathriona CANTIO, Auteur ; S. WHITE, Auteur ; G. F. MADSEN, Auteur ; Niels BILENBERG, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur Article en page(s) : p.1229-1238 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  adolescent development  cognition  executive function  theory of mind Index. décimale : PER Périodiques Résumé : SEVERAL THEORIES HAVE ATTEMPTED TO CHARACTERISE AUTISM SPECTRUM DISORDERS (ASDS) AT THE COGNITIVE LEVEL, MOST NOTABLY: THEORY OF MIND (TOM), EXECUTIVE FUNCTION (EF), AND A LOCAL PROCESSING BIAS (LB). THE AIM OF THIS STUDY WAS TO INVESTIGATE HOW THESE COGNITIVE FUNCTIONS DEVELOP OVER TIME: The three cognitive domains (ToM, EF, and LB) were examined in a group of high-functioning children (age: 8-12, mean 10.85; IQ: 78-139, mean 105.48) with ASD and a matched group of children with neurotypical development (NTD) (IQ: 75-145, mean: 109.47), and several tasks were used within each domain to ensure the validity of the cognitive measures. Approximately 3 years later (mean age: 14.34), all children and their families were invited to participate in the follow-up (ASD, N = 21; NTD, N = 30). While the understanding of other's minds does improve from childhood to adolescence, ToM impairment persists in adolescents with ASD relative to their peers. Likewise, a development in EF was observed in the ASD group, while no significant improvement was seen in the NTD group, leading the ASD group to catch up in this domain. We did not detect any group differences at any time point regarding local bias processing (LB). Individual patterns of development were seen, but remarkably, ToM deficits were present in every child with ASD in whom we could detect any cognitive impairment at baseline, and a similar pattern was found at follow-up. These findings indicate that ToM is a persistent cognitive deficit in ASD. Autism Res 2018, 11: 1229-1238. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This was the first study to investigate the development of three well-known cognitive functions into adolescence: While the understanding of other's minds improves from childhood to adolescence, adolescents with ASD are still impaired relative to their peers. The EFs, however, seem to improve to a neurotypical level in ASD as children enter adolescence, while local processing bias seems to differentiate the groups only in early childhood. En ligne : http://dx.doi.org/10.1002/aur.1976 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Do cognitive deficits persist into adolescence in autism? [Texte imprimé et/ou numérique] / Cathriona CANTIO, Auteur ; S. WHITE, Auteur ; G. F. MADSEN, Auteur ; Niels BILENBERG, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur . - p.1229-1238. Langues : Anglais (eng) in Autism Research > 11-9 (September 2018) . - p.1229-1238 Mots-clés : Autism spectrum disorders  adolescent development  cognition  executive function  theory of mind Index. décimale : PER Périodiques Résumé : SEVERAL THEORIES HAVE ATTEMPTED TO CHARACTERISE AUTISM SPECTRUM DISORDERS (ASDS) AT THE COGNITIVE LEVEL, MOST NOTABLY: THEORY OF MIND (TOM), EXECUTIVE FUNCTION (EF), AND A LOCAL PROCESSING BIAS (LB). THE AIM OF THIS STUDY WAS TO INVESTIGATE HOW THESE COGNITIVE FUNCTIONS DEVELOP OVER TIME: The three cognitive domains (ToM, EF, and LB) were examined in a group of high-functioning children (age: 8-12, mean 10.85; IQ: 78-139, mean 105.48) with ASD and a matched group of children with neurotypical development (NTD) (IQ: 75-145, mean: 109.47), and several tasks were used within each domain to ensure the validity of the cognitive measures. Approximately 3 years later (mean age: 14.34), all children and their families were invited to participate in the follow-up (ASD, N = 21; NTD, N = 30). While the understanding of other's minds does improve from childhood to adolescence, ToM impairment persists in adolescents with ASD relative to their peers. Likewise, a development in EF was observed in the ASD group, while no significant improvement was seen in the NTD group, leading the ASD group to catch up in this domain. We did not detect any group differences at any time point regarding local bias processing (LB). Individual patterns of development were seen, but remarkably, ToM deficits were present in every child with ASD in whom we could detect any cognitive impairment at baseline, and a similar pattern was found at follow-up. These findings indicate that ToM is a persistent cognitive deficit in ASD. Autism Res 2018, 11: 1229-1238. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This was the first study to investigate the development of three well-known cognitive functions into adolescence: While the understanding of other's minds improves from childhood to adolescence, adolescents with ASD are still impaired relative to their peers. The EFs, however, seem to improve to a neurotypical level in ASD as children enter adolescence, while local processing bias seems to differentiate the groups only in early childhood. En ligne : http://dx.doi.org/10.1002/aur.1976 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Exploring ‘The autisms’ at a cognitive level / Cathriona CANTIO in Autism Research, 9-12 (December 2016)  

Public ISBD [article]  inAutism Research > 9-12 (December 2016) . - p.1328-1339 Titre : Exploring ‘The autisms’ at a cognitive level Type de document : Texte imprimé et/ou numérique Auteurs : Cathriona CANTIO, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Gitte FALCHER MADSEN, Auteur ; Niels BILENBERG, Auteur ; Sarah J. WHITE, Auteur Article en page(s) : p.1328-1339 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  cognition  theory of mind  executive function  local bias  fractionation  symptomatology  Behavior Index. décimale : PER Périodiques Résumé : The autism spectrum is characterized by genetic and behavioral heterogeneity. However, it is still unknown whether there is a universal pattern of cognitive impairment in autism spectrum disorder (ASD) and whether multiple cognitive impairments are needed to explain the full range of behavioral symptoms. This study aimed to determine whether three widely acknowledged cognitive abnormalities (Theory of Mind (ToM) impairment, Executive Function (EF) impairment, and the presence of a Local Processing Bias (LB)) are universal and fractionable in autism, and whether the relationship between cognition and behavior is dependent on the method of behavioral assessment. Thirty-one high-functioning children with ASD and thirty-seven children with neurotypical development (NTD), comparable in age, gender and Intelligence Quotient (IQ), completed several tasks tapping into ToM, EF, and LB, and autistic symptomatology was assessed through parental and teacher questionnaires, parental interview and direct observation. We found that ToM and EF deficits differentiated the groups and some ToM and EF tasks were related to each other. ToM and EF were together able to correctly classify more than three-quarters of the children into cases and controls, despite relating to none of the specific behavioral measures. Only a small subgroup of individuals displayed a LB, which was unrelated to ToM and EF, and did not aid diagnostic classification, most likely contributing to non-diagnostic symptoms in a subgroup. Despite the characteristic heterogeneity of the autism spectrum, it remains a possibility therefore that a single cognitive cause may underlie the range of diagnostic symptoms in all individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.1630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Exploring ‘The autisms’ at a cognitive level [Texte imprimé et/ou numérique] / Cathriona CANTIO, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Gitte FALCHER MADSEN, Auteur ; Niels BILENBERG, Auteur ; Sarah J. WHITE, Auteur . - p.1328-1339. Langues : Anglais (eng) in Autism Research > 9-12 (December 2016) . - p.1328-1339 Mots-clés : autism spectrum disorders  cognition  theory of mind  executive function  local bias  fractionation  symptomatology  Behavior Index. décimale : PER Périodiques Résumé : The autism spectrum is characterized by genetic and behavioral heterogeneity. However, it is still unknown whether there is a universal pattern of cognitive impairment in autism spectrum disorder (ASD) and whether multiple cognitive impairments are needed to explain the full range of behavioral symptoms. This study aimed to determine whether three widely acknowledged cognitive abnormalities (Theory of Mind (ToM) impairment, Executive Function (EF) impairment, and the presence of a Local Processing Bias (LB)) are universal and fractionable in autism, and whether the relationship between cognition and behavior is dependent on the method of behavioral assessment. Thirty-one high-functioning children with ASD and thirty-seven children with neurotypical development (NTD), comparable in age, gender and Intelligence Quotient (IQ), completed several tasks tapping into ToM, EF, and LB, and autistic symptomatology was assessed through parental and teacher questionnaires, parental interview and direct observation. We found that ToM and EF deficits differentiated the groups and some ToM and EF tasks were related to each other. ToM and EF were together able to correctly classify more than three-quarters of the children into cases and controls, despite relating to none of the specific behavioral measures. Only a small subgroup of individuals displayed a LB, which was unrelated to ToM and EF, and did not aid diagnostic classification, most likely contributing to non-diagnostic symptoms in a subgroup. Despite the characteristic heterogeneity of the autism spectrum, it remains a possibility therefore that a single cognitive cause may underlie the range of diagnostic symptoms in all individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.1630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Language deficits in specific language impairment, attention deficit/hyperactivity disorder, and autism spectrum disorder: An analysis of polygenic risk / Ron NUDEL in Autism Research, 13-3 (March 2020)  

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Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 / Maja GREGERSEN in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

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Normal P50 Gating in Children with Autism, Yet Attenuated P50 Amplitude in the Asperger Subcategory / Gitte Falcher MADSEN in Autism Research, 8-4 (August 2015)  

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Post-error adjustment among children aged 7 years with a familial high risk of schizophrenia or bipolar disorder: A population-based cohort study / Birgitte Klee BURTON in Development and Psychopathology, 34-5 (December 2022)  

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Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta-analysis / Birgitte K. BURTON in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

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Toward a cumulative science of vocal markers of autism: A cross-linguistic meta-analysis-based investigation of acoustic markers in American and Danish autistic children / Riccardo FUSAROLI in Autism Research, 15-4 (April 2022)  

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Vocal markers of autism: Assessing the generalizability of machine learning models / Astrid RYBNER in Autism Research, 15-6 (June 2022)  

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