Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study / Robert KEERS in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1921-1933 Titre : Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study Type de document : texte imprimé Auteurs : Robert KEERS, Auteur ; Michael PLUESS, Auteur Article en page(s) : p.1921-1933 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study [texte imprimé] / Robert KEERS, Auteur ; Michael PLUESS, Auteur . - p.1921-1933. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1921-1933 Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation / Sandra MACHLITT-NORTHEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1140-1152 Titre : Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation Type de document : texte imprimé Auteurs : Sandra MACHLITT-NORTHEN, Auteur ; Robert KEERS, Auteur ; Patricia B. MUNROE, Auteur ; David M. HOWARD, Auteur ; Vassily TRUBETSKOY, Auteur ; Michael PLUESS, Auteur Année de publication : 2022 Article en page(s) : p.1140-1152 Langues : Anglais (eng) Mots-clés : Cohort Studies  Depression  Depressive Disorder, Major/etiology/genetics  Gene-Environment Interaction  Genetic Predisposition to Disease  Genome-Wide Association Study  Humans  Multifactorial Inheritance  Risk Factors  Schizophrenia/epidemiology/genetics  Environment  genetics  major depressive disorder  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene-environment correlation (rGE). STUDY OBJECTIVE: This study aims to investigate: (a) whether the genetic risk for SCZ/MDD in children is correlated with established environmental and psychosocial risk factors in two British community samples, the 1958 National Child Development Study (NCDS) and the Millennium Cohort Study (MCS), (b) whether these associations vary between both psychopathologies, and (c) whether findings differ across the two cohorts which were born 42years apart. METHODS: Polygenic risk scores (PRS) from existing large genome-wide associations studies (GWAS) were applied to test the correlation between the child genetic risk for SCZ/MDD and known environmental risk factors. In addition, parental and child genetic data from MCS were used to distinguish between passive and evocative rGE. RESULTS: The child polygenic risk for SCZ and MDD was correlated with single parenthood in MCS. Moreover, the lack of father's involvement in child care was associated with the genetic risk for SCZ in NCDS. However, we also found associations between several indicators of low socioeconomic status and heightened genetic risk for MDD in children in both cohorts. Further, the genetic risk for MDD was associated with parental lack of interest in the child's education in NCDS as well as more maternal smoking and less maternal alcohol consumption during childhood in MCS. According to sensitivity analyses in MCS (controlling for parental genotype), more than half of our significant correlations reflected passive rGE. CONCLUSIONS: Findings suggest that several established environmental and psychosocial risk factors for SCZ and MDD are at least partially associated with children's genetic risk for these psychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation [texte imprimé] / Sandra MACHLITT-NORTHEN, Auteur ; Robert KEERS, Auteur ; Patricia B. MUNROE, Auteur ; David M. HOWARD, Auteur ; Vassily TRUBETSKOY, Auteur ; Michael PLUESS, Auteur . - 2022 . - p.1140-1152. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1140-1152 Mots-clés : Cohort Studies  Depression  Depressive Disorder, Major/etiology/genetics  Gene-Environment Interaction  Genetic Predisposition to Disease  Genome-Wide Association Study  Humans  Multifactorial Inheritance  Risk Factors  Schizophrenia/epidemiology/genetics  Environment  genetics  major depressive disorder  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene-environment correlation (rGE). STUDY OBJECTIVE: This study aims to investigate: (a) whether the genetic risk for SCZ/MDD in children is correlated with established environmental and psychosocial risk factors in two British community samples, the 1958 National Child Development Study (NCDS) and the Millennium Cohort Study (MCS), (b) whether these associations vary between both psychopathologies, and (c) whether findings differ across the two cohorts which were born 42years apart. METHODS: Polygenic risk scores (PRS) from existing large genome-wide associations studies (GWAS) were applied to test the correlation between the child genetic risk for SCZ/MDD and known environmental risk factors. In addition, parental and child genetic data from MCS were used to distinguish between passive and evocative rGE. RESULTS: The child polygenic risk for SCZ and MDD was correlated with single parenthood in MCS. Moreover, the lack of father's involvement in child care was associated with the genetic risk for SCZ in NCDS. However, we also found associations between several indicators of low socioeconomic status and heightened genetic risk for MDD in children in both cohorts. Further, the genetic risk for MDD was associated with parental lack of interest in the child's education in NCDS as well as more maternal smoking and less maternal alcohol consumption during childhood in MCS. According to sensitivity analyses in MCS (controlling for parental genotype), more than half of our significant correlations reflected passive rGE. CONCLUSIONS: Findings suggest that several established environmental and psychosocial risk factors for SCZ and MDD are at least partially associated with children's genetic risk for these psychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders / Anna MCKINNON in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.763-772 Titre : The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders Type de document : texte imprimé Auteurs : Anna MCKINNON, Auteur ; Robert KEERS, Auteur ; Jonathan R.I. COLEMAN, Auteur ; Kathryn J. LESTER, Auteur ; S. Wendy ROBERTS, Auteur ; Kristian ARENDT, Auteur ; Susan M. BOGELS, Auteur ; Peter J. COOPER, Auteur ; Cathy CRESWELL, Auteur ; Catharina A. HARTMAN, Auteur ; Krister W. FJERMESTAD, Auteur ; Tina IN-ALBON, Auteur ; Kristen LAVALLEE, Auteur ; Heidi J. LYNEHAM, Auteur ; Paula SMITH, Auteur ; Richard MEISER-STEDMAN, Auteur ; Maaike H. NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Yasmin REY, Auteur ; Silvia SCHNEIDER, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Gro Janne WERGELAND, Auteur ; Thalia C. ELEY, Auteur ; Jennifer L. HUDSON, Auteur Année de publication : 2018 Article en page(s) : p.763-772 Langues : Anglais (eng) Mots-clés : Anxiety  cognitive therapy  treatment trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Several delivery formats of cognitive behaviour therapy (CBT) for child anxiety have been proposed, however, there is little consensus on the optimal delivery format. The primary goal of this study was to investigate the impact of the child's primary anxiety diagnosis on changes in clinical severity (of the primary problem) during individual CBT, group CBT and guided parent-led CBT. The secondary goal was to investigate the impact of the child's primary anxiety diagnosis on rates of remission for the three treatment formats. METHODS: A sample of 1,253 children (5-12 years; Mage = 9.3, SD = 1.7) was pooled from CBT trials carried out at 10 sites. Children had a primary diagnosis of generalised anxiety disorder (GAD), social anxiety disorder (SoAD), specific phobia (SP) or separation anxiety disorder (SAD). Children and parents completed a semistructured clinical interview to assess the presence and severity of DSM-IV psychiatric disorders at preintervention, postintervention and follow-up. Linear mixture modelling was used to evaluate the primary research question and logistic modelling was used to investigate the secondary research question. RESULTS: In children with primary GAD, SAD or SoAD, there were no significant differences between delivery formats. However, children with primary SP showed significantly larger reductions in clinical severity following individual CBT compared to group CBT and guided parent-led CBT. The results were mirrored in the analysis of remission responses with the exception that individual CBT was no longer superior to group CBT for children with a primary SP. The difference between individual and group was not significant when follow-up data were examined separately. CONCLUSIONS: Data show there may be greater clinical benefit by allocating children with a primary SP to individual CBT, although future research on cost-effectiveness is needed to determine whether the additional clinical benefits justify the additional resources required. En ligne : http://dx.doi.org/10.1111/jcpp.12872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders [texte imprimé] / Anna MCKINNON, Auteur ; Robert KEERS, Auteur ; Jonathan R.I. COLEMAN, Auteur ; Kathryn J. LESTER, Auteur ; S. Wendy ROBERTS, Auteur ; Kristian ARENDT, Auteur ; Susan M. BOGELS, Auteur ; Peter J. COOPER, Auteur ; Cathy CRESWELL, Auteur ; Catharina A. HARTMAN, Auteur ; Krister W. FJERMESTAD, Auteur ; Tina IN-ALBON, Auteur ; Kristen LAVALLEE, Auteur ; Heidi J. LYNEHAM, Auteur ; Paula SMITH, Auteur ; Richard MEISER-STEDMAN, Auteur ; Maaike H. NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Yasmin REY, Auteur ; Silvia SCHNEIDER, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Gro Janne WERGELAND, Auteur ; Thalia C. ELEY, Auteur ; Jennifer L. HUDSON, Auteur . - 2018 . - p.763-772. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.763-772 Mots-clés : Anxiety  cognitive therapy  treatment trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Several delivery formats of cognitive behaviour therapy (CBT) for child anxiety have been proposed, however, there is little consensus on the optimal delivery format. The primary goal of this study was to investigate the impact of the child's primary anxiety diagnosis on changes in clinical severity (of the primary problem) during individual CBT, group CBT and guided parent-led CBT. The secondary goal was to investigate the impact of the child's primary anxiety diagnosis on rates of remission for the three treatment formats. METHODS: A sample of 1,253 children (5-12 years; Mage = 9.3, SD = 1.7) was pooled from CBT trials carried out at 10 sites. Children had a primary diagnosis of generalised anxiety disorder (GAD), social anxiety disorder (SoAD), specific phobia (SP) or separation anxiety disorder (SAD). Children and parents completed a semistructured clinical interview to assess the presence and severity of DSM-IV psychiatric disorders at preintervention, postintervention and follow-up. Linear mixture modelling was used to evaluate the primary research question and logistic modelling was used to investigate the secondary research question. RESULTS: In children with primary GAD, SAD or SoAD, there were no significant differences between delivery formats. However, children with primary SP showed significantly larger reductions in clinical severity following individual CBT compared to group CBT and guided parent-led CBT. The results were mirrored in the analysis of remission responses with the exception that individual CBT was no longer superior to group CBT for children with a primary SP. The difference between individual and group was not significant when follow-up data were examined separately. CONCLUSIONS: Data show there may be greater clinical benefit by allocating children with a primary SP to individual CBT, although future research on cost-effectiveness is needed to determine whether the additional clinical benefits justify the additional resources required. En ligne : http://dx.doi.org/10.1111/jcpp.12872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

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