Annual Research Review: On the developmental neuropsychology of substance use disorders / Patricia J. CONROD in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.371-394 Titre : Annual Research Review: On the developmental neuropsychology of substance use disorders Type de document : Texte imprimé et/ou numérique Auteurs : Patricia J. CONROD, Auteur ; Kyriaki NIKOLAOU, Auteur Article en page(s) : p.371-394 Langues : Anglais (eng) Mots-clés : Substance use  substance dependence  brain development  adolescence  reward processing  executive control  cognitive control  behavioural inhibition  fMRI  alcohol  marijuana  cigarette use Index. décimale : PER Périodiques Résumé : Background Adolescence represents a period of development during which critical biological, as well as social and cognitive, changes occur that are necessary for the transition into adulthood. A number of researchers have suggested that the pattern of normative brain changes that occurs during this period not only predisposes adolescents to engage in risk behaviours, such as experimentation with drugs, but that they additionally make the adolescent brain more vulnerable to the direct pharmacological impact of substances of abuse. The neural circuits that we examine in this review involve cortico-basal-ganglia/limbic networks implicated in the processing of rewards, emotion regulation, and the control of behaviour, emotion and cognition. Findings and Conclusions We identify certain neurocognitive and personality/comorbidity-based risk factors for the onset of substance misuse during adolescence, and summarise the evidence suggesting that these risk factors may be further impacted by the direct effect of drugs on the underlying neural circuits implicated in substance misuse vulnerability. En ligne : http://dx.doi.org/10.1111/jcpp.12516 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Annual Research Review: On the developmental neuropsychology of substance use disorders [Texte imprimé et/ou numérique] / Patricia J. CONROD, Auteur ; Kyriaki NIKOLAOU, Auteur . - p.371-394. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.371-394 Mots-clés : Substance use  substance dependence  brain development  adolescence  reward processing  executive control  cognitive control  behavioural inhibition  fMRI  alcohol  marijuana  cigarette use Index. décimale : PER Périodiques Résumé : Background Adolescence represents a period of development during which critical biological, as well as social and cognitive, changes occur that are necessary for the transition into adulthood. A number of researchers have suggested that the pattern of normative brain changes that occurs during this period not only predisposes adolescents to engage in risk behaviours, such as experimentation with drugs, but that they additionally make the adolescent brain more vulnerable to the direct pharmacological impact of substances of abuse. The neural circuits that we examine in this review involve cortico-basal-ganglia/limbic networks implicated in the processing of rewards, emotion regulation, and the control of behaviour, emotion and cognition. Findings and Conclusions We identify certain neurocognitive and personality/comorbidity-based risk factors for the onset of substance misuse during adolescence, and summarise the evidence suggesting that these risk factors may be further impacted by the direct effect of drugs on the underlying neural circuits implicated in substance misuse vulnerability. En ligne : http://dx.doi.org/10.1111/jcpp.12516 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Personality-specific pathways from bullying victimization to adolescent alcohol use: a multilevel longitudinal moderated mediation analysis / Flavie M. LAROQUE in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1454-1467 Titre : Personality-specific pathways from bullying victimization to adolescent alcohol use: a multilevel longitudinal moderated mediation analysis Type de document : Texte imprimé et/ou numérique Auteurs : Flavie M. LAROQUE, Auteur ; Elroy BOERS, Auteur ; Mohammad H. AFZALI, Auteur ; Patricia J. CONROD, Auteur Article en page(s) : p.1454-1467 Langues : Anglais (eng) Mots-clés : alcohol use  multilevel moderated mediation model  personality  psychopathology  victimization Index. décimale : PER Périodiques Résumé : Bullying victimization is common in adolescence and has been associated with a broad variety of psychopathology and alcohol use. The present study assessed time-varying associations between bullying victimization and alcohol use through internalizing and externalizing symptoms and whether this indirect association throughout time is moderated by personality. This 5-year longitudinal study (3,800 grade 7 adolescents) used Bayesian multilevel moderated mediation models: independent variable was bullying victimization; moderators were four personality dimensions (anxiety sensitivity, hopelessness, impulsivity, and sensation seeking); internalizing symptoms (anxiety, depressive symptoms) and externalizing symptoms (conduct, hyperactivity problems) were the mediators; and alcohol use, the outcome. Results indicated significant between, within, and lagged effects on alcohol use through internalizing and externalizing symptoms. There were significant between and within effects on alcohol use through internalizing symptoms for adolescents with high anxiety sensitivity and hopelessness, and significant between, within, and lagged effects on alcohol use through externalizing symptoms for adolescents with high impulsivity and sensation seeking. These findings implicate two risk pathways that account for how bullying victimization enhances alcohol use risk and emphasize the importance of personality profiles that can shape the immediate and long-term consequences of victimization. En ligne : http://dx.doi.org/10.1017/S0954579421001358 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Personality-specific pathways from bullying victimization to adolescent alcohol use: a multilevel longitudinal moderated mediation analysis [Texte imprimé et/ou numérique] / Flavie M. LAROQUE, Auteur ; Elroy BOERS, Auteur ; Mohammad H. AFZALI, Auteur ; Patricia J. CONROD, Auteur . - p.1454-1467. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1454-1467 Mots-clés : alcohol use  multilevel moderated mediation model  personality  psychopathology  victimization Index. décimale : PER Périodiques Résumé : Bullying victimization is common in adolescence and has been associated with a broad variety of psychopathology and alcohol use. The present study assessed time-varying associations between bullying victimization and alcohol use through internalizing and externalizing symptoms and whether this indirect association throughout time is moderated by personality. This 5-year longitudinal study (3,800 grade 7 adolescents) used Bayesian multilevel moderated mediation models: independent variable was bullying victimization; moderators were four personality dimensions (anxiety sensitivity, hopelessness, impulsivity, and sensation seeking); internalizing symptoms (anxiety, depressive symptoms) and externalizing symptoms (conduct, hyperactivity problems) were the mediators; and alcohol use, the outcome. Results indicated significant between, within, and lagged effects on alcohol use through internalizing and externalizing symptoms. There were significant between and within effects on alcohol use through internalizing symptoms for adolescents with high anxiety sensitivity and hopelessness, and significant between, within, and lagged effects on alcohol use through externalizing symptoms for adolescents with high impulsivity and sensation seeking. These findings implicate two risk pathways that account for how bullying victimization enhances alcohol use risk and emphasize the importance of personality profiles that can shape the immediate and long-term consequences of victimization. En ligne : http://dx.doi.org/10.1017/S0954579421001358 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Personality-targeted interventions delay the growth of adolescent drinking and binge drinking / Patricia J. CONROD in Journal of Child Psychology and Psychiatry, 49-2 (February 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-2 (February 2008) . - p.181–190 Titre : Personality-targeted interventions delay the growth of adolescent drinking and binge drinking Type de document : Texte imprimé et/ou numérique Auteurs : Patricia J. CONROD, Auteur ; Natalie CASTELLANOS, Auteur ; Clare MACKIE, Auteur Année de publication : 2008 Article en page(s) : p.181–190 Langues : Anglais (eng) Mots-clés : Alcohol interventions personality follow-up-studies adolescence Index. décimale : PER Périodiques Résumé : Personality factors are implicated in the vulnerability to adolescent alcohol misuse. This study examined whether providing personality-targeted interventions in early adolescence can delay drinking and binge drinking in high-risk youth. Methods: A randomised control trial was carried out with 368 adolescents recruited from years 9 and 10 (median age 14) with personality risk factors for substance misuse. Participants received either a personality-targeted intervention or no intervention. Outcome data were collected on alcohol use through self-reports at 6 and 12-month post intervention and analyses were conducted on the full intent to treat sample. Results: Multi-group analysis of a latent growth curve model showed a group difference in the growth of alcohol use between baseline and 6-months follow-up, with the control group showing a greater increase in drinking than the intervention group for this period. Interventions were particularly effective in preventing the growth of binge drinking in those students with a sensation seeking (SS) personality. SS drinkers in the intervention group were 45% and 50% less likely to binge drink at 6 (OR = .45) and 12 months (OR = .50) respectively, than SS drinkers in the control group, p = .001, phi = .49, Number Needed to Treat = 2.0. Conclusions: Considering the robust, inverse relationship between age of onset of alcohol use and later alcohol dependence, this intervention strategy may prove effective in preventing the onset of adult alcohol use disorders, by helping high-risk youth delay the growth of their drinking to a later developmental stage. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01826.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320 [article] Personality-targeted interventions delay the growth of adolescent drinking and binge drinking [Texte imprimé et/ou numérique] / Patricia J. CONROD, Auteur ; Natalie CASTELLANOS, Auteur ; Clare MACKIE, Auteur . - 2008 . - p.181–190. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-2 (February 2008) . - p.181–190 Mots-clés : Alcohol interventions personality follow-up-studies adolescence Index. décimale : PER Périodiques Résumé : Personality factors are implicated in the vulnerability to adolescent alcohol misuse. This study examined whether providing personality-targeted interventions in early adolescence can delay drinking and binge drinking in high-risk youth. Methods: A randomised control trial was carried out with 368 adolescents recruited from years 9 and 10 (median age 14) with personality risk factors for substance misuse. Participants received either a personality-targeted intervention or no intervention. Outcome data were collected on alcohol use through self-reports at 6 and 12-month post intervention and analyses were conducted on the full intent to treat sample. Results: Multi-group analysis of a latent growth curve model showed a group difference in the growth of alcohol use between baseline and 6-months follow-up, with the control group showing a greater increase in drinking than the intervention group for this period. Interventions were particularly effective in preventing the growth of binge drinking in those students with a sensation seeking (SS) personality. SS drinkers in the intervention group were 45% and 50% less likely to binge drink at 6 (OR = .45) and 12 months (OR = .50) respectively, than SS drinkers in the control group, p = .001, phi = .49, Number Needed to Treat = 2.0. Conclusions: Considering the robust, inverse relationship between age of onset of alcohol use and later alcohol dependence, this intervention strategy may prove effective in preventing the onset of adult alcohol use disorders, by helping high-risk youth delay the growth of their drinking to a later developmental stage. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01826.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320

Structural brain correlates of adolescent resilience / Keith B. BURT in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1287-1296 Titre : Structural brain correlates of adolescent resilience Type de document : Texte imprimé et/ou numérique Auteurs : Keith B. BURT, Auteur ; Robert WHELAN, Auteur ; Patricia J. CONROD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; André GALINOWSKI, Auteur ; Juergen GALLINAT, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Karl MANN, Auteur ; Frauke NEES, Auteur ; Dimitrios PAPADOPOULOS, Auteur ; Tomas PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Luise POUSTKA, Auteur ; Marcella RIETSCHEL, Auteur ; Trevor W. ROBBINS, Auteur ; Michael N. SMOLKA, Auteur ; Andreas STRÖHLE, Auteur ; Gunter SCHUMANN, Auteur ; Hugh GARAVAN, Auteur ; Imagen Consortium THE, Auteur Article en page(s) : p.1287-1296 Langues : Anglais (eng) Mots-clés : Imaging  resilience  adolescence  competence  adversity  IMAGEN study Index. décimale : PER Périodiques Résumé : Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Structural brain correlates of adolescent resilience [Texte imprimé et/ou numérique] / Keith B. BURT, Auteur ; Robert WHELAN, Auteur ; Patricia J. CONROD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; André GALINOWSKI, Auteur ; Juergen GALLINAT, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Karl MANN, Auteur ; Frauke NEES, Auteur ; Dimitrios PAPADOPOULOS, Auteur ; Tomas PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Luise POUSTKA, Auteur ; Marcella RIETSCHEL, Auteur ; Trevor W. ROBBINS, Auteur ; Michael N. SMOLKA, Auteur ; Andreas STRÖHLE, Auteur ; Gunter SCHUMANN, Auteur ; Hugh GARAVAN, Auteur ; Imagen Consortium THE, Auteur . - p.1287-1296. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1287-1296 Mots-clés : Imaging  resilience  adolescence  competence  adversity  IMAGEN study Index. décimale : PER Périodiques Résumé : Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

The long-term effectiveness of a selective, personality-targeted prevention program in reducing alcohol use and related harms: a cluster randomized controlled trial / Nicola C. NEWTON in Journal of Child Psychology and Psychiatry, 57-9 (September 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1056-1065 Titre : The long-term effectiveness of a selective, personality-targeted prevention program in reducing alcohol use and related harms: a cluster randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Nicola C. NEWTON, Auteur ; Patricia J. CONROD, Auteur ; Tim SLADE, Auteur ; Natacha CARRAGHER, Auteur ; Katrina E. CHAMPION, Auteur ; Emma L. BARRETT, Auteur ; Erin V. KELLY, Auteur ; Natasha K. NAIR, Auteur ; Lexine STAPINSKI, Auteur ; Maree TEESSON, Auteur Article en page(s) : p.1056-1065 Langues : Anglais (eng) Mots-clés : Prevention  personality  alcohol abuse  adolescence  school Index. décimale : PER Périodiques Résumé : Background This study investigated the long-term effectiveness of Preventure, a selective personality-targeted prevention program, in reducing the uptake of alcohol, harmful use of alcohol, and alcohol-related harms over a 3-year period. Methods A cluster randomized controlled trial was conducted to assess the effectiveness of Preventure. Schools were block randomized to one of two groups: the Preventure group (n = 7 schools) and the Control group (n = 7 schools). Only students screening as high-risk on one of four personality profiles (anxiety sensitivity, negative thinking, impulsivity, and sensation seeking) were included in the analysis. All students were assessed at five time points over a 3-year period: baseline; immediately after the intervention; and 12, 24, and 36 months after baseline. Students were assessed on frequency of drinking, binge drinking, and alcohol-related harms. Two-part latent growth models were used to analyze intervention effects, which included all students with data available at each time point. This trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000026820; www.anzctr.org.au). Results A total of 438 high-risk adolescents (mean age, 13.4 years; SD = 0.47) from 14 Australian schools were recruited to the study and completed baseline assessments. Relative to high-risk Control students, high-risk Preventure students displayed significantly reduced growth in their likelihood to consume alcohol [b = ?0.225 (0.061); p < .001], to binge drink [b = ?0.305 (.096); p = 0.001], and to experience alcohol-related harms [b = ?0.255 (0.096); p = .008] over 36 months. Conclusions Findings from this study support the use of selective personality-targeted preventive interventions in reducing the uptake of alcohol, alcohol misuse, and related harms over the long term. This trial is the first to demonstrate the effects of a selective alcohol prevention program over a 3-year period and the first to demonstrate the effects of a selective preventive intervention in Australia. En ligne : http://dx.doi.org/10.1111/jcpp.12558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] The long-term effectiveness of a selective, personality-targeted prevention program in reducing alcohol use and related harms: a cluster randomized controlled trial [Texte imprimé et/ou numérique] / Nicola C. NEWTON, Auteur ; Patricia J. CONROD, Auteur ; Tim SLADE, Auteur ; Natacha CARRAGHER, Auteur ; Katrina E. CHAMPION, Auteur ; Emma L. BARRETT, Auteur ; Erin V. KELLY, Auteur ; Natasha K. NAIR, Auteur ; Lexine STAPINSKI, Auteur ; Maree TEESSON, Auteur . - p.1056-1065. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1056-1065 Mots-clés : Prevention  personality  alcohol abuse  adolescence  school Index. décimale : PER Périodiques Résumé : Background This study investigated the long-term effectiveness of Preventure, a selective personality-targeted prevention program, in reducing the uptake of alcohol, harmful use of alcohol, and alcohol-related harms over a 3-year period. Methods A cluster randomized controlled trial was conducted to assess the effectiveness of Preventure. Schools were block randomized to one of two groups: the Preventure group (n = 7 schools) and the Control group (n = 7 schools). Only students screening as high-risk on one of four personality profiles (anxiety sensitivity, negative thinking, impulsivity, and sensation seeking) were included in the analysis. All students were assessed at five time points over a 3-year period: baseline; immediately after the intervention; and 12, 24, and 36 months after baseline. Students were assessed on frequency of drinking, binge drinking, and alcohol-related harms. Two-part latent growth models were used to analyze intervention effects, which included all students with data available at each time point. This trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000026820; www.anzctr.org.au). Results A total of 438 high-risk adolescents (mean age, 13.4 years; SD = 0.47) from 14 Australian schools were recruited to the study and completed baseline assessments. Relative to high-risk Control students, high-risk Preventure students displayed significantly reduced growth in their likelihood to consume alcohol [b = ?0.225 (0.061); p < .001], to binge drink [b = ?0.305 (.096); p = 0.001], and to experience alcohol-related harms [b = ?0.255 (0.096); p = .008] over 36 months. Conclusions Findings from this study support the use of selective personality-targeted preventive interventions in reducing the uptake of alcohol, alcohol misuse, and related harms over the long term. This trial is the first to demonstrate the effects of a selective alcohol prevention program over a 3-year period and the first to demonstrate the effects of a selective preventive intervention in Australia. En ligne : http://dx.doi.org/10.1111/jcpp.12558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

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