Application of Latent Class Analysis to Identify Subgroups of Children with Autism Spectrum Disorders who Benefit from Social Skills Training / V. DEKKER in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2004-2018 Titre : Application of Latent Class Analysis to Identify Subgroups of Children with Autism Spectrum Disorders who Benefit from Social Skills Training Type de document : Texte imprimé et/ou numérique Auteurs : V. DEKKER, Auteur ; M. H. NAUTA, Auteur ; M. E. TIMMERMAN, Auteur ; E. J. MULDER, Auteur ; P. J. HOEKSTRA, Auteur ; Annelies A. DE BILDT, Auteur Article en page(s) : p.2004-2018 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Child  Communication  Female  Humans  Latent Class Analysis  Male  Parents  Social Skills  Autism spectrum disorder  Participant and intervention characteristics  Randomized controlled trial  Social skills training  for Health Research and Development  ZonMw, nr 157003005). The agency had no role in  data analyses, the decision to publish, or the preparation of the manuscript. She  also is first author on the Dutch ADOS manual for which Accare receives enumeration.  The other authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : With Latent Class Analysis applied on data of 98 children with autism spectrum disorder (ASD) (9-12 years; 17 girls) participating in social skills training (SST) in a randomized controlled trial (Dekker et al. 2019), four subgroups were detected, based on social-communicative skills before, and response patterns to training. Two subgroups improved after SST. Characterizing the subgroups based on participant and intervention characteristics showed that improvement was related to lower parent-reported perceived difficulty of social-communicative skills at start, higher verbal ability, younger age and milder symptoms of ASD and anxiety. The lowest performing non-improving subgroup participated more often in SST without parent/teacher involvement, compared to all other subgroups. Response to SST in ASD seems to vary depending on participant characteristics. En ligne : http://dx.doi.org/10.1007/s10803-020-04678-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Application of Latent Class Analysis to Identify Subgroups of Children with Autism Spectrum Disorders who Benefit from Social Skills Training [Texte imprimé et/ou numérique] / V. DEKKER, Auteur ; M. H. NAUTA, Auteur ; M. E. TIMMERMAN, Auteur ; E. J. MULDER, Auteur ; P. J. HOEKSTRA, Auteur ; Annelies A. DE BILDT, Auteur . - p.2004-2018. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2004-2018 Mots-clés : Autism Spectrum Disorder/therapy  Child  Communication  Female  Humans  Latent Class Analysis  Male  Parents  Social Skills  Autism spectrum disorder  Participant and intervention characteristics  Randomized controlled trial  Social skills training  for Health Research and Development  ZonMw, nr 157003005). The agency had no role in  data analyses, the decision to publish, or the preparation of the manuscript. She  also is first author on the Dutch ADOS manual for which Accare receives enumeration.  The other authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : With Latent Class Analysis applied on data of 98 children with autism spectrum disorder (ASD) (9-12 years; 17 girls) participating in social skills training (SST) in a randomized controlled trial (Dekker et al. 2019), four subgroups were detected, based on social-communicative skills before, and response patterns to training. Two subgroups improved after SST. Characterizing the subgroups based on participant and intervention characteristics showed that improvement was related to lower parent-reported perceived difficulty of social-communicative skills at start, higher verbal ability, younger age and milder symptoms of ASD and anxiety. The lowest performing non-improving subgroup participated more often in SST without parent/teacher involvement, compared to all other subgroups. Response to SST in ASD seems to vary depending on participant characteristics. En ligne : http://dx.doi.org/10.1007/s10803-020-04678-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Clinical precursors of tics: an EMTICS study / T. J. C. OPENNEER in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.305-314 Titre : Clinical precursors of tics: an EMTICS study Type de document : Texte imprimé et/ou numérique Auteurs : T. J. C. OPENNEER, Auteur ; C. HUYSER, Auteur ; D. MARTINO, Auteur ; A. SCHRAG, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur Article en page(s) : p.305-314 Langues : Anglais (eng) Mots-clés : Compulsions  clinical precursors  conduct problems  sex differences  tic onset Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with Tourette syndrome (TS) often have comorbid disorders, particularly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). While subtle premorbid symptoms have been described in various psychiatric disorders, the presence of clinical precursors that may exist before the onset of tics is unknown. This longitudinal study aimed to find clinical precursors of tics by assessing a range of clinical characteristics prior to tic onset in comparison with children without onset of tics. METHODS: A sample of 187 3- to 10-year-old first-degree unaffected relatives of children with TS were followed up to 7?years in the European Multicentre Tics in Children Study (EMTICS). We investigated whether clinical characteristics assessed at baseline predicted tic onset, comparing 126 children without tic onset to 61 children who developed tics. We used the least absolute shrinkage and selection operator (LASSO) method, a penalised logistic regression approach. We also explored sex differences and repeated our analyses in an age- and sex-matched subsample. RESULTS: Children with tic onset were more frequently male (??=?-0.36), had higher baseline severity of conduct problems (??=?0.23), autism spectrum disorder symptoms (ASD; ??=?0.08), compulsions (??=?0.02) and emotional problems (??=?0.03) compared to children without tic onset. Conduct and ASD problems were male-specific predictors, whereas severity of compulsions and oppositional (??=?0.39) and emotional problems were female-specific predictors. CONCLUSION: This study supports the presence of clinical precursors prior to tic onset and highlights the need of sex-specific monitoring of children at risk of developing tics. This may aid in the earlier detection of tics, particularly in females. We moreover found that tics most often persisted one year after tic onset, in contrast to the common belief that tics are mostly transient. En ligne : http://dx.doi.org/10.1111/jcpp.13472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Clinical precursors of tics: an EMTICS study [Texte imprimé et/ou numérique] / T. J. C. OPENNEER, Auteur ; C. HUYSER, Auteur ; D. MARTINO, Auteur ; A. SCHRAG, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur . - p.305-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.305-314 Mots-clés : Compulsions  clinical precursors  conduct problems  sex differences  tic onset Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with Tourette syndrome (TS) often have comorbid disorders, particularly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). While subtle premorbid symptoms have been described in various psychiatric disorders, the presence of clinical precursors that may exist before the onset of tics is unknown. This longitudinal study aimed to find clinical precursors of tics by assessing a range of clinical characteristics prior to tic onset in comparison with children without onset of tics. METHODS: A sample of 187 3- to 10-year-old first-degree unaffected relatives of children with TS were followed up to 7?years in the European Multicentre Tics in Children Study (EMTICS). We investigated whether clinical characteristics assessed at baseline predicted tic onset, comparing 126 children without tic onset to 61 children who developed tics. We used the least absolute shrinkage and selection operator (LASSO) method, a penalised logistic regression approach. We also explored sex differences and repeated our analyses in an age- and sex-matched subsample. RESULTS: Children with tic onset were more frequently male (??=?-0.36), had higher baseline severity of conduct problems (??=?0.23), autism spectrum disorder symptoms (ASD; ??=?0.08), compulsions (??=?0.02) and emotional problems (??=?0.03) compared to children without tic onset. Conduct and ASD problems were male-specific predictors, whereas severity of compulsions and oppositional (??=?0.39) and emotional problems were female-specific predictors. CONCLUSION: This study supports the presence of clinical precursors prior to tic onset and highlights the need of sex-specific monitoring of children at risk of developing tics. This may aid in the earlier detection of tics, particularly in females. We moreover found that tics most often persisted one year after tic onset, in contrast to the common belief that tics are mostly transient. En ligne : http://dx.doi.org/10.1111/jcpp.13472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study / P. T. ROSENAU in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1444-1452 Titre : Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study Type de document : Texte imprimé et/ou numérique Auteurs : P. T. ROSENAU, Auteur ; T. J. C. OPENNEER, Auteur ; A. M. MATTHIJSSEN, Auteur ; G. H. H. VAN DE LOO-NEUS, Auteur ; Jan K. BUITELAAR, Auteur ; B. J. VAN DEN HOOFDAKKER, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur Article en page(s) : p.1444-1452 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/drug therapy  Central Nervous System Stimulants/adverse effects  Child  Double-Blind Method  Executive Function  Humans  Methylphenidate/adverse effects  Netherlands  Treatment Outcome  attention-deficit/hyperactivity disorder  executive functioning  long-term  methylphenidate  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Methylphenidate may improve executive functioning in children with attention-deficit/hyperactivity disorder (ADHD). However, it is unclear if there are still acute effects of methylphenidate on executive functioning after long-term use. METHODS: In a randomized double-blind, placebo-controlled discontinuation study, 94 children and adolescents (ages 8-18?years) who used methylphenidate beyond two years were either assigned to seven weeks of continued treatment with 36 or 54?mg of extended-release methylphenidate or to gradual withdrawal over three weeks to placebo for four weeks. Performance on neuropsychological tasks, measuring working memory, response inhibition, attentional flexibility and psychomotor speed was compared between both groups using mixed models for repeated measures. Additionally, we investigated within the discontinuation group if a deterioration on the investigator-rated Clinical Global Impressions Improvement scale after withdrawing to placebo was related to a worse performance on the neuropsychological tasks. This study was registered in the Netherlands Trial Register (www. Trialregister.nl) with identifier 5252. RESULTS: After withdrawal of methylphenidate, the discontinuation group made more errors on working memory (??=?-1.62, SD?=?0.56, t?=?-2.88, p?=?.01, Cohen's f2?=?.14), independent from reaction time compared to baseline, in contrast to the continuation group. We did not find differences in changes in response inhibition, attentional flexibility and psychomotor speed between the two groups. Also, there were no significant differences in task measures between the participants who deteriorated clinically and those who did not. CONCLUSIONS: Our study shows that methylphenidate has a beneficial effect on working memory after two years of use. Future studies should explore whether cognitive outcomes may aid clinical decision-making on the continued use of methylphenidate, given dissociation between cognitive and behavioural effects of stimulant medication. En ligne : http://dx.doi.org/10.1111/jcpp.13419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study [Texte imprimé et/ou numérique] / P. T. ROSENAU, Auteur ; T. J. C. OPENNEER, Auteur ; A. M. MATTHIJSSEN, Auteur ; G. H. H. VAN DE LOO-NEUS, Auteur ; Jan K. BUITELAAR, Auteur ; B. J. VAN DEN HOOFDAKKER, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur . - p.1444-1452. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1444-1452 Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/drug therapy  Central Nervous System Stimulants/adverse effects  Child  Double-Blind Method  Executive Function  Humans  Methylphenidate/adverse effects  Netherlands  Treatment Outcome  attention-deficit/hyperactivity disorder  executive functioning  long-term  methylphenidate  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Methylphenidate may improve executive functioning in children with attention-deficit/hyperactivity disorder (ADHD). However, it is unclear if there are still acute effects of methylphenidate on executive functioning after long-term use. METHODS: In a randomized double-blind, placebo-controlled discontinuation study, 94 children and adolescents (ages 8-18?years) who used methylphenidate beyond two years were either assigned to seven weeks of continued treatment with 36 or 54?mg of extended-release methylphenidate or to gradual withdrawal over three weeks to placebo for four weeks. Performance on neuropsychological tasks, measuring working memory, response inhibition, attentional flexibility and psychomotor speed was compared between both groups using mixed models for repeated measures. Additionally, we investigated within the discontinuation group if a deterioration on the investigator-rated Clinical Global Impressions Improvement scale after withdrawing to placebo was related to a worse performance on the neuropsychological tasks. This study was registered in the Netherlands Trial Register (www. Trialregister.nl) with identifier 5252. RESULTS: After withdrawal of methylphenidate, the discontinuation group made more errors on working memory (??=?-1.62, SD?=?0.56, t?=?-2.88, p?=?.01, Cohen's f2?=?.14), independent from reaction time compared to baseline, in contrast to the continuation group. We did not find differences in changes in response inhibition, attentional flexibility and psychomotor speed between the two groups. Also, there were no significant differences in task measures between the participants who deteriorated clinically and those who did not. CONCLUSIONS: Our study shows that methylphenidate has a beneficial effect on working memory after two years of use. Future studies should explore whether cognitive outcomes may aid clinical decision-making on the continued use of methylphenidate, given dissociation between cognitive and behavioural effects of stimulant medication. En ligne : http://dx.doi.org/10.1111/jcpp.13419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder / J. TILLMANN in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2490-2505 Titre : Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. TILLMANN, Auteur ; K. ASHWOOD, Auteur ; M. ABSOUD, Auteur ; Sven BÖLTE, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Jan K. BUITELAAR, Auteur ; Sara CALDERONI, Auteur ; R. CALVO, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Roberto CANITANO, Auteur ; Annelies A. DE BILDT, Auteur ; Marie GOMOT, Auteur ; P. J. HOEKSTRA, Auteur ; A. KAALE, Auteur ; H. MCCONACHIE, Auteur ; D. G. MURPHY, Auteur ; A. NARZISI, Auteur ; I. OOSTERLING, Auteur ; M. PEJOVIC-MILOVANCEVIC, Auteur ; A. M. PERSICO, Auteur ; O. PUIG, Auteur ; H. ROEYERS, Auteur ; Nanda N. ROMMELSE, Auteur ; R. SACCO, Auteur ; V. SCANDURRA, Auteur ; A. C. STANFIELD, Auteur ; E. ZANDER, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2490-2505 Langues : Anglais (eng) Mots-clés : Age  Autism Spectrum Disorder  Phenotype  Sex  Symptom severity Index. décimale : PER Périodiques Résumé : Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology. En ligne : http://dx.doi.org/10.1007/s10803-018-3510-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. TILLMANN, Auteur ; K. ASHWOOD, Auteur ; M. ABSOUD, Auteur ; Sven BÖLTE, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Jan K. BUITELAAR, Auteur ; Sara CALDERONI, Auteur ; R. CALVO, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Roberto CANITANO, Auteur ; Annelies A. DE BILDT, Auteur ; Marie GOMOT, Auteur ; P. J. HOEKSTRA, Auteur ; A. KAALE, Auteur ; H. MCCONACHIE, Auteur ; D. G. MURPHY, Auteur ; A. NARZISI, Auteur ; I. OOSTERLING, Auteur ; M. PEJOVIC-MILOVANCEVIC, Auteur ; A. M. PERSICO, Auteur ; O. PUIG, Auteur ; H. ROEYERS, Auteur ; Nanda N. ROMMELSE, Auteur ; R. SACCO, Auteur ; V. SCANDURRA, Auteur ; A. C. STANFIELD, Auteur ; E. ZANDER, Auteur ; Tony CHARMAN, Auteur . - p.2490-2505. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2490-2505 Mots-clés : Age  Autism Spectrum Disorder  Phenotype  Sex  Symptom severity Index. décimale : PER Périodiques Résumé : Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology. En ligne : http://dx.doi.org/10.1007/s10803-018-3510-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Substance use and nicotine dependence in persistent, remittent, and late-onset ADHD: a 10-year longitudinal study from childhood to young adulthood / S. ILBEGI in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 42 p. Titre : Substance use and nicotine dependence in persistent, remittent, and late-onset ADHD: a 10-year longitudinal study from childhood to young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : S. ILBEGI, Auteur ; A. P. GROENMAN, Auteur ; A. SCHELLEKENS, Auteur ; Catharina A. HARTMAN, Auteur ; P. J. HOEKSTRA, Auteur ; B. FRANKE, Auteur ; S. V. FARAONE, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur Année de publication : 2018 Article en page(s) : 42 p. Langues : Anglais (eng) Mots-clés : ADHD course  Late-onset ADHD  Nicotine dependence  Substance use disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with substance use disorders (SUD; alcohol and/or drug dependence) and nicotine dependence. This study aims to advance our knowledge about the association between SUD, nicotine dependence, and the course of ADHD (persistent versus remittent ADHD and late-onset ADHD). METHODS: ADHD, SUD, and nicotine dependence were longitudinally assessed (mean age at study entry 11.3 years, mean age at follow-up 21.1 years) using structured psychiatric interviews and multi-informant questionnaires in a subsample of the Dutch part of the International Multicenter ADHD Genetics study. Individuals with persistent ADHD (n = 62), remittent ADHD (n = 12), late-onset ADHD (n = 18; age of onset after 12 years), unaffected siblings (n = 50), and healthy controls (n = 47) were assessed. Hazard ratios (HR) with 95% confidence intervals (CIs) were estimated by Cox regression and adjusted for clustered family data, gender, follow-up length, and current age. RESULTS: Individuals with persistent ADHD were at significantly higher risk of development of SUD relative to healthy controls (HR = 4.56, CI 1.17-17.81). In contrast, levels of SUD in those with remittent ADHD were not different from healthy controls (HR = 1.00, CI .07-13.02). ADHD persisters had also higher prevalence rates of nicotine dependence (24.2%) than ADHD remitters (16.7%) and healthy controls (4.3%). A similar pattern was found in initially unaffected siblings who met ADHD criteria at follow-up ("late-onset" ADHD); they had also a higher prevalence of SUD (33%) compared to stable unaffected siblings (20%) and were at significantly increased risk of development of nicotine dependence compared to healthy controls (HR = 13.04, CI 2.08-81.83). CONCLUSIONS: SUD and nicotine dependence are associated with a negative ADHD outcome. Results further emphasize the need for clinicians to comprehensively assess substance use when diagnosing ADHD in adolescents and adults. En ligne : http://dx.doi.org/10.1186/s11689-018-9260-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Substance use and nicotine dependence in persistent, remittent, and late-onset ADHD: a 10-year longitudinal study from childhood to young adulthood [Texte imprimé et/ou numérique] / S. ILBEGI, Auteur ; A. P. GROENMAN, Auteur ; A. SCHELLEKENS, Auteur ; Catharina A. HARTMAN, Auteur ; P. J. HOEKSTRA, Auteur ; B. FRANKE, Auteur ; S. V. FARAONE, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur . - 2018 . - 42 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 42 p. Mots-clés : ADHD course  Late-onset ADHD  Nicotine dependence  Substance use disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with substance use disorders (SUD; alcohol and/or drug dependence) and nicotine dependence. This study aims to advance our knowledge about the association between SUD, nicotine dependence, and the course of ADHD (persistent versus remittent ADHD and late-onset ADHD). METHODS: ADHD, SUD, and nicotine dependence were longitudinally assessed (mean age at study entry 11.3 years, mean age at follow-up 21.1 years) using structured psychiatric interviews and multi-informant questionnaires in a subsample of the Dutch part of the International Multicenter ADHD Genetics study. Individuals with persistent ADHD (n = 62), remittent ADHD (n = 12), late-onset ADHD (n = 18; age of onset after 12 years), unaffected siblings (n = 50), and healthy controls (n = 47) were assessed. Hazard ratios (HR) with 95% confidence intervals (CIs) were estimated by Cox regression and adjusted for clustered family data, gender, follow-up length, and current age. RESULTS: Individuals with persistent ADHD were at significantly higher risk of development of SUD relative to healthy controls (HR = 4.56, CI 1.17-17.81). In contrast, levels of SUD in those with remittent ADHD were not different from healthy controls (HR = 1.00, CI .07-13.02). ADHD persisters had also higher prevalence rates of nicotine dependence (24.2%) than ADHD remitters (16.7%) and healthy controls (4.3%). A similar pattern was found in initially unaffected siblings who met ADHD criteria at follow-up ("late-onset" ADHD); they had also a higher prevalence of SUD (33%) compared to stable unaffected siblings (20%) and were at significantly increased risk of development of nicotine dependence compared to healthy controls (HR = 13.04, CI 2.08-81.83). CONCLUSIONS: SUD and nicotine dependence are associated with a negative ADHD outcome. Results further emphasize the need for clinicians to comprehensively assess substance use when diagnosing ADHD in adolescents and adults. En ligne : http://dx.doi.org/10.1186/s11689-018-9260-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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