Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants / D. A. GHEORGHE in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.822-830 Titre : Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants Type de document : Texte imprimé et/ou numérique Auteurs : D. A. GHEORGHE, Auteur ; C. LI, Auteur ; J. GALLACHER, Auteur ; S. BAUERMEISTER, Auteur Article en page(s) : p.822-830 Langues : Anglais (eng) Mots-clés : Adverse Childhood Experiences  Aged  Aged, 80 and over  Biological Specimen Banks  Brain/diagnostic imaging  Humans  Middle Aged  Retrospective Studies  Spouse Abuse  United Kingdom/epidemiology  Brain imaging  adversity  early life experience  large data Index. décimale : PER Périodiques Résumé : BACKGROUND: Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. We addressed mechanistic pathways by investigating the associations between multiple brain phenotypes and retrospectively reported AEs in early life (child adversity) and adulthood (partner abuse) in a large population sample, using a cross-sectional approach. METHODS: The UK Biobank resource was used to access imaging-derived phenotypes (IDPs) from 6,751 participants (aged: M = 62.1, SD = 7.2, range = 45-80), together with selected reports of childhood AEs and adult partner abuse. Principal component analysis was used to reduce the dimensionality of the data prior to multivariate tests. RESULTS: The data showed that participants who reported experiences of childhood emotional abuse ('felt hated by family member as a child') had smaller cerebellar and ventral striatum volumes. This result was also depicted in a random subset of participants; however, we note small effect sizes ( ?p2 ( ) < .01), suggestive of modest biological changes. CONCLUSIONS: Using a large population cohort, this study demonstrates the value of big datasets in the study of adversity and using automatically preprocessed neuroimaging phenotypes. While retrospective and cross-sectional characteristics limit interpretation, this study demonstrates that self-perceived adversity reports, however nonspecific, may still expose neural consequences, identifiable with increased statistical power. En ligne : http://dx.doi.org/10.1111/jcpp.13298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants [Texte imprimé et/ou numérique] / D. A. GHEORGHE, Auteur ; C. LI, Auteur ; J. GALLACHER, Auteur ; S. BAUERMEISTER, Auteur . - p.822-830. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.822-830 Mots-clés : Adverse Childhood Experiences  Aged  Aged, 80 and over  Biological Specimen Banks  Brain/diagnostic imaging  Humans  Middle Aged  Retrospective Studies  Spouse Abuse  United Kingdom/epidemiology  Brain imaging  adversity  early life experience  large data Index. décimale : PER Périodiques Résumé : BACKGROUND: Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. We addressed mechanistic pathways by investigating the associations between multiple brain phenotypes and retrospectively reported AEs in early life (child adversity) and adulthood (partner abuse) in a large population sample, using a cross-sectional approach. METHODS: The UK Biobank resource was used to access imaging-derived phenotypes (IDPs) from 6,751 participants (aged: M = 62.1, SD = 7.2, range = 45-80), together with selected reports of childhood AEs and adult partner abuse. Principal component analysis was used to reduce the dimensionality of the data prior to multivariate tests. RESULTS: The data showed that participants who reported experiences of childhood emotional abuse ('felt hated by family member as a child') had smaller cerebellar and ventral striatum volumes. This result was also depicted in a random subset of participants; however, we note small effect sizes ( ?p2 ( ) < .01), suggestive of modest biological changes. CONCLUSIONS: Using a large population cohort, this study demonstrates the value of big datasets in the study of adversity and using automatically preprocessed neuroimaging phenotypes. While retrospective and cross-sectional characteristics limit interpretation, this study demonstrates that self-perceived adversity reports, however nonspecific, may still expose neural consequences, identifiable with increased statistical power. En ligne : http://dx.doi.org/10.1111/jcpp.13298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai / C. LI in Autism Research, 11-9 (September 2018)  

Public ISBD [article]  inAutism Research > 11-9 (September 2018) . - p.1206-1217 Titre : Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai Type de document : Texte imprimé et/ou numérique Auteurs : C. LI, Auteur ; G. ZHU, Auteur ; J. FENG, Auteur ; Q. XU, Auteur ; Z. ZHOU, Auteur ; B. ZHOU, Auteur ; C. HU, Auteur ; C. LIU, Auteur ; H. LI, Auteur ; Y. WANG, Auteur ; W. YAN, Auteur ; X. GE, Auteur ; X. XU, Auteur Article en page(s) : p.1206-1217 Langues : Anglais (eng) Mots-clés : Chat-23  China  autism spectrum disorder  community-based  early screening Index. décimale : PER Périodiques Résumé : Most children with autism spectrum disorder (ASD) are not diagnosed until the age of 4, thus missing the opportunity for early intervention. The objective of this study was to investigate the feasibility of an early screening program for ASD applied during well-child visits in a community-based sample. The study lasted for 4 years and was divided into two stages. Stage I involved the implementation of the basic screening model in 2014. Toddlers received level 1 screening via section A of the Chinese-validated version of the Checklist for Autism in Toddlers (CHAT-23) during 18- and 24-month well-child visits in Xuhui District, Shanghai, China. Screen-positive children were referred to receive section B of the CHAT-23 for level 2 screening, and those still screen-positive were referred to undergo diagnosis and evaluation. Stage II involved the implementation of the improved screening model from 2015 to 2017 with the following modifications: (a) an added observational component in level 1 screening; (b) telephone follow-ups with the screen-positive families; and (c) dissemination of information on ASD to families. The results showed that 42 of 22,247 screened children were diagnosed with ASD. The ASD diagnosis rates were 0.1% in Stage I and 0.21% in Stage II. The screen-positive rate and the show rate of referral for level 1 screening increased by 76.92% and 58.43%, respectively, in Stage II compared to Stage I. Our results suggest that with appropriate logistic support, this two-level screening model is feasible and effective for the early screening of ASD during well-child visits. Autism Res 2018, 11: 1206-1217. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Difficulty in the timely identification of autism spectrum disorder (ASD) results in missed opportunities for many ASD children to receive early intervention. In this study, we established an early screening model for ASD among children aged 18-24 months in the community by relying on the three-level child healthcare system in China. The results showed that this model can effectively identify and diagnose ASD in children at an early age and thus enable early intervention. En ligne : http://dx.doi.org/10.1002/aur.1984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai [Texte imprimé et/ou numérique] / C. LI, Auteur ; G. ZHU, Auteur ; J. FENG, Auteur ; Q. XU, Auteur ; Z. ZHOU, Auteur ; B. ZHOU, Auteur ; C. HU, Auteur ; C. LIU, Auteur ; H. LI, Auteur ; Y. WANG, Auteur ; W. YAN, Auteur ; X. GE, Auteur ; X. XU, Auteur . - p.1206-1217. Langues : Anglais (eng) in Autism Research > 11-9 (September 2018) . - p.1206-1217 Mots-clés : Chat-23  China  autism spectrum disorder  community-based  early screening Index. décimale : PER Périodiques Résumé : Most children with autism spectrum disorder (ASD) are not diagnosed until the age of 4, thus missing the opportunity for early intervention. The objective of this study was to investigate the feasibility of an early screening program for ASD applied during well-child visits in a community-based sample. The study lasted for 4 years and was divided into two stages. Stage I involved the implementation of the basic screening model in 2014. Toddlers received level 1 screening via section A of the Chinese-validated version of the Checklist for Autism in Toddlers (CHAT-23) during 18- and 24-month well-child visits in Xuhui District, Shanghai, China. Screen-positive children were referred to receive section B of the CHAT-23 for level 2 screening, and those still screen-positive were referred to undergo diagnosis and evaluation. Stage II involved the implementation of the improved screening model from 2015 to 2017 with the following modifications: (a) an added observational component in level 1 screening; (b) telephone follow-ups with the screen-positive families; and (c) dissemination of information on ASD to families. The results showed that 42 of 22,247 screened children were diagnosed with ASD. The ASD diagnosis rates were 0.1% in Stage I and 0.21% in Stage II. The screen-positive rate and the show rate of referral for level 1 screening increased by 76.92% and 58.43%, respectively, in Stage II compared to Stage I. Our results suggest that with appropriate logistic support, this two-level screening model is feasible and effective for the early screening of ASD during well-child visits. Autism Res 2018, 11: 1206-1217. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Difficulty in the timely identification of autism spectrum disorder (ASD) results in missed opportunities for many ASD children to receive early intervention. In this study, we established an early screening model for ASD among children aged 18-24 months in the community by relying on the three-level child healthcare system in China. The results showed that this model can effectively identify and diagnose ASD in children at an early age and thus enable early intervention. En ligne : http://dx.doi.org/10.1002/aur.1984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis / W. YAN in Autism, 25-7 (October 2021)  

Public ISBD [article]  inAutism > 25-7 (October 2021) . - p.1872-1884 Titre : Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis Type de document : Texte imprimé et/ou numérique Auteurs : W. YAN, Auteur ; R. J. SIEGERT, Auteur ; H. ZHOU, Auteur ; X. ZOU, Auteur ; L. WU, Auteur ; X. LUO, Auteur ; T. LI, Auteur ; Y. HUANG, Auteur ; H. GUAN, Auteur ; X. CHEN, Auteur ; M. MAO, Auteur ; K. XIA, Auteur ; L. ZHANG, Auteur ; E. LI, Auteur ; C. LI, Auteur ; X. ZHANG, Auteur ; Y. ZHOU, Auteur ; A. SHIH, Auteur ; E. FOMBONNE, Auteur ; Y. ZHENG, Auteur ; J. HAN, Auteur ; Z. SUN, Auteur ; Y. H. JIANG, Auteur ; Y. WANG, Auteur Article en page(s) : p.1872-1884 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  China  Humans  Parents  Psychometrics  Reproducibility of Results  Autism Spectrum Rating Scale  Rasch analysis  autism spectrum disorders  parent version  psychometrics  school-age children Index. décimale : PER Périodiques Résumé : The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services. En ligne : http://dx.doi.org/10.1177/13623613211004054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis [Texte imprimé et/ou numérique] / W. YAN, Auteur ; R. J. SIEGERT, Auteur ; H. ZHOU, Auteur ; X. ZOU, Auteur ; L. WU, Auteur ; X. LUO, Auteur ; T. LI, Auteur ; Y. HUANG, Auteur ; H. GUAN, Auteur ; X. CHEN, Auteur ; M. MAO, Auteur ; K. XIA, Auteur ; L. ZHANG, Auteur ; E. LI, Auteur ; C. LI, Auteur ; X. ZHANG, Auteur ; Y. ZHOU, Auteur ; A. SHIH, Auteur ; E. FOMBONNE, Auteur ; Y. ZHENG, Auteur ; J. HAN, Auteur ; Z. SUN, Auteur ; Y. H. JIANG, Auteur ; Y. WANG, Auteur . - p.1872-1884. Langues : Anglais (eng) in Autism > 25-7 (October 2021) . - p.1872-1884 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  China  Humans  Parents  Psychometrics  Reproducibility of Results  Autism Spectrum Rating Scale  Rasch analysis  autism spectrum disorders  parent version  psychometrics  school-age children Index. décimale : PER Périodiques Résumé : The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services. En ligne : http://dx.doi.org/10.1177/13623613211004054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

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