Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample / E. COLVERT in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1077-1091 Titre : Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample Type de document : Texte imprimé et/ou numérique Auteurs : E. COLVERT, Auteur ; E. SIMONOFF, Auteur ; Simone J CAPP, Auteur ; A. RONALD, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1077-1091 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Child, Preschool  Diseases in Twins/diagnosis/epidemiology  Humans  Mental Health  Phenotype  Twins  Adolescents  Autism spectrum disorders  Longitudinal research Index. décimale : PER Périodiques Résumé : There is increasing concern regarding additional psychiatric problems that co-occur with Autism Spectrum Disorder (ASD), as reflected in recent changes to diagnostic schemes. However, there remains little research with population-based samples across childhood. We report on additional problems, as measured by the Strengths and Difficulties Questionnaire, in a population-based sample of 135 twins with ASD, 55 non-ASD co-twins, and 144 comparison twins low in ASD traits. Frequencies, associated demographic factors, and changes in mental health difficulties from age 4 to 13 years are presented. Our data confirm the high rates of additional difficulties reported in previous studies, and suggest that the profile, associated risk factors and longitudinal course of additional difficulties in ASD may differ from those in typically-developing populations. En ligne : http://dx.doi.org/10.1007/s10803-021-05006-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample [Texte imprimé et/ou numérique] / E. COLVERT, Auteur ; E. SIMONOFF, Auteur ; Simone J CAPP, Auteur ; A. RONALD, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur . - p.1077-1091. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1077-1091 Mots-clés : Adolescent  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Child, Preschool  Diseases in Twins/diagnosis/epidemiology  Humans  Mental Health  Phenotype  Twins  Adolescents  Autism spectrum disorders  Longitudinal research Index. décimale : PER Périodiques Résumé : There is increasing concern regarding additional psychiatric problems that co-occur with Autism Spectrum Disorder (ASD), as reflected in recent changes to diagnostic schemes. However, there remains little research with population-based samples across childhood. We report on additional problems, as measured by the Strengths and Difficulties Questionnaire, in a population-based sample of 135 twins with ASD, 55 non-ASD co-twins, and 144 comparison twins low in ASD traits. Frequencies, associated demographic factors, and changes in mental health difficulties from age 4 to 13 years are presented. Our data confirm the high rates of additional difficulties reported in previous studies, and suggest that the profile, associated risk factors and longitudinal course of additional difficulties in ASD may differ from those in typically-developing populations. En ligne : http://dx.doi.org/10.1007/s10803-021-05006-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies / S. GÓMEZ-VALLEJO in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1353-1362 Titre : Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies Type de document : Texte imprimé et/ou numérique Auteurs : S. GÓMEZ-VALLEJO, Auteur ; M. LEONI, Auteur ; A. RONALD, Auteur ; E. COLVERT, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur Article en page(s) : p.1353-1362 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/etiology/genetics  Autistic Disorder  Child  Diseases in Twins  Female  Humans  Infant, Newborn  Pregnancy  Siblings  Twins  Autism spectrum disorder  genetics  obstetric complications Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a strong genetic basis. Recent studies have suggested that its aetiology is also influenced by environmental factors. Some of the most examined environmental factors are obstetric complications. However, the results are inconsistent. METHODS: We aimed to explore the association between obstetric complications and autism in a population-based twin sample using the Obstetric Enquiry Scale (OES), a scale that measures the presence or absence of pre-, peri- and neonatal factors. Additionally, we report the meta-analytic results for obstetrical factors reported in previously published sibling studies. RESULTS: Our study included 115 cases pairs and 62 controls pairs and showed that children with autism and their unaffected co-twins present significantly more obstetric complications than controls (ASD vs. controls ? 1.26, CI 95% 1.11-1.40 p < .001; unaffected co-twin vs. controls ? 1.20, 95% CI 1.07-1.36 p < .003). However, we did not find statistically significant differences between children with ASD and their unaffected co-twins (? .96, 95% CI 0.85-1.09, p 0.55). Meta-analysis demonstrated that maternal hypertension (RR 1.35, CI 95% 1.23-1.48), uterine bleeding (RR 1.20 CI 95% 1.01-1.42) and exposure to antibiotic during pregnancy (1.11 CI 95% 1.00-1.22) increase risk of ASD. CONCLUSIONS: This study confirms that children with ASD and their unaffected twins show more obstetric complications than controls. However, these complications do not distinguish between ASD twins and their unaffected co-twins. In addition, the meta-analysis showed little influence of birth factors on ASD which suggests a shared familial liability for both obstetric complications and autism, rather than a causal association. En ligne : http://dx.doi.org/10.1111/jcpp.13526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies [Texte imprimé et/ou numérique] / S. GÓMEZ-VALLEJO, Auteur ; M. LEONI, Auteur ; A. RONALD, Auteur ; E. COLVERT, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur . - p.1353-1362. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1353-1362 Mots-clés : Autism Spectrum Disorder/etiology/genetics  Autistic Disorder  Child  Diseases in Twins  Female  Humans  Infant, Newborn  Pregnancy  Siblings  Twins  Autism spectrum disorder  genetics  obstetric complications Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a strong genetic basis. Recent studies have suggested that its aetiology is also influenced by environmental factors. Some of the most examined environmental factors are obstetric complications. However, the results are inconsistent. METHODS: We aimed to explore the association between obstetric complications and autism in a population-based twin sample using the Obstetric Enquiry Scale (OES), a scale that measures the presence or absence of pre-, peri- and neonatal factors. Additionally, we report the meta-analytic results for obstetrical factors reported in previously published sibling studies. RESULTS: Our study included 115 cases pairs and 62 controls pairs and showed that children with autism and their unaffected co-twins present significantly more obstetric complications than controls (ASD vs. controls ? 1.26, CI 95% 1.11-1.40 p < .001; unaffected co-twin vs. controls ? 1.20, 95% CI 1.07-1.36 p < .003). However, we did not find statistically significant differences between children with ASD and their unaffected co-twins (? .96, 95% CI 0.85-1.09, p 0.55). Meta-analysis demonstrated that maternal hypertension (RR 1.35, CI 95% 1.23-1.48), uterine bleeding (RR 1.20 CI 95% 1.01-1.42) and exposure to antibiotic during pregnancy (1.11 CI 95% 1.00-1.22) increase risk of ASD. CONCLUSIONS: This study confirms that children with ASD and their unaffected twins show more obstetric complications than controls. However, these complications do not distinguish between ASD twins and their unaffected co-twins. In addition, the meta-analysis showed little influence of birth factors on ASD which suggests a shared familial liability for both obstetric complications and autism, rather than a causal association. En ligne : http://dx.doi.org/10.1111/jcpp.13526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Good social skills despite poor theory of mind: exploring compensation in autism spectrum disorder / L. A. LIVINGSTON in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-1 (January 2019) . - p.102-110 Titre : Good social skills despite poor theory of mind: exploring compensation in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. A. LIVINGSTON, Auteur ; E. COLVERT, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.102-110 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  adaptation  camouflaging  compensation  compensatory mechanisms  executive function  remediation  theory of mind Index. décimale : PER Périodiques Résumé : BACKGROUND: It is proposed that some individuals with Autism Spectrum Disorder (ASD) can 'compensate' for their underlying difficulties (e.g. in theory of mind; ToM), thus demonstrating relatively few behavioural symptoms, despite continued core cognitive deficits. The mechanisms underpinning compensation are largely unexplored, as is its potential impact on mental health. This study aimed to estimate compensation patterns in ASD, by contrasting overt social behaviour with ToM task performance, in order to compare the characteristics of 'Low' and 'High' Compensators. METHODS: A total of 136 autistic adolescents, from the ongoing Social Relationships Study, completed a range of cognitive tasks, the Autistic Diagnostic Observation Schedule (ADOS) and a self-report anxiety questionnaire. Participants were assigned compensation group status; High Compensators demonstrated good ADOS scores despite poor ToM performance, while Low Compensators demonstrated similarly poor ToM, accompanied by poor ADOS scores. RESULTS: High Compensators demonstrated better IQ and executive function (EF), but greater self-reported anxiety, compared with Low Compensators. Such differences were not found when comparing individuals who had good versus poor ADOS scores, when ToM performance was good. Other core autistic characteristics (weak central coherence, nonsocial symptoms) did not differentiate the High and Low Compensators. CONCLUSIONS: IQ, EF and anxiety appear to be implicated in the processes by which certain autistic young people can compensate for their underlying ToM difficulties. This tendency to compensate does not appear to reflect the severity of 'hit' for ASD per se, suggesting that well-compensated individuals are not experiencing a milder form of ASD. The construct of compensation in ASD has implications for research and clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=374 [article] Good social skills despite poor theory of mind: exploring compensation in autism spectrum disorder [Texte imprimé et/ou numérique] / L. A. LIVINGSTON, Auteur ; E. COLVERT, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur . - p.102-110. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-1 (January 2019) . - p.102-110 Mots-clés : Autism spectrum disorder  adaptation  camouflaging  compensation  compensatory mechanisms  executive function  remediation  theory of mind Index. décimale : PER Périodiques Résumé : BACKGROUND: It is proposed that some individuals with Autism Spectrum Disorder (ASD) can 'compensate' for their underlying difficulties (e.g. in theory of mind; ToM), thus demonstrating relatively few behavioural symptoms, despite continued core cognitive deficits. The mechanisms underpinning compensation are largely unexplored, as is its potential impact on mental health. This study aimed to estimate compensation patterns in ASD, by contrasting overt social behaviour with ToM task performance, in order to compare the characteristics of 'Low' and 'High' Compensators. METHODS: A total of 136 autistic adolescents, from the ongoing Social Relationships Study, completed a range of cognitive tasks, the Autistic Diagnostic Observation Schedule (ADOS) and a self-report anxiety questionnaire. Participants were assigned compensation group status; High Compensators demonstrated good ADOS scores despite poor ToM performance, while Low Compensators demonstrated similarly poor ToM, accompanied by poor ADOS scores. RESULTS: High Compensators demonstrated better IQ and executive function (EF), but greater self-reported anxiety, compared with Low Compensators. Such differences were not found when comparing individuals who had good versus poor ADOS scores, when ToM performance was good. Other core autistic characteristics (weak central coherence, nonsocial symptoms) did not differentiate the High and Low Compensators. CONCLUSIONS: IQ, EF and anxiety appear to be implicated in the processes by which certain autistic young people can compensate for their underlying ToM difficulties. This tendency to compensate does not appear to reflect the severity of 'hit' for ASD per se, suggesting that well-compensated individuals are not experiencing a milder form of ASD. The construct of compensation in ASD has implications for research and clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=374

A Qualitative Exploration of the Female Experience of Autism Spectrum Disorder (ASD) / V. MILNER in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2389-2402 Titre : A Qualitative Exploration of the Female Experience of Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : V. MILNER, Auteur ; H. MCINTOSH, Auteur ; E. COLVERT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.2389-2402 Langues : Anglais (eng) Mots-clés : Autism  Experience  Female autism  Gender  Sex differences Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is thought to be a predominantly male diagnosis, however recent research suggests a smaller gender disparity in prevalence than previously assumed. Accounts of the female experience of autism are important to help reduce likely male-bias in current understanding and recognition of autism. Eighteen autistic females and four mothers of autistic females took part in discussions with a topic guide around diagnosis, impact and coping. A thematic analysis was conducted. Five themes were identified: fitting in the with the norm, potential obstacles for autistic women and girls, negative aspects of autism, the perspective of others, and positive aspects of having autism. We hope that greater understanding of the experiences of autistic females may lead to improved awareness, diagnosis and support for women and girls. En ligne : https://dx.doi.org/10.1007/s10803-019-03906-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] A Qualitative Exploration of the Female Experience of Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / V. MILNER, Auteur ; H. MCINTOSH, Auteur ; E. COLVERT, Auteur ; Francesca HAPPE, Auteur . - p.2389-2402. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2389-2402 Mots-clés : Autism  Experience  Female autism  Gender  Sex differences Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is thought to be a predominantly male diagnosis, however recent research suggests a smaller gender disparity in prevalence than previously assumed. Accounts of the female experience of autism are important to help reduce likely male-bias in current understanding and recognition of autism. Eighteen autistic females and four mothers of autistic females took part in discussions with a topic guide around diagnosis, impact and coping. A thematic analysis was conducted. Five themes were identified: fitting in the with the norm, potential obstacles for autistic women and girls, negative aspects of autism, the perspective of others, and positive aspects of having autism. We hope that greater understanding of the experiences of autistic females may lead to improved awareness, diagnosis and support for women and girls. En ligne : https://dx.doi.org/10.1007/s10803-019-03906-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

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