Children with maltreatment exposure exhibit rumination-like spontaneous thought patterns: association with symptoms of depression, subcallosal cingulate cortex thickness, and cortisol levels / Roman LINZ ; Nikolaus STEINBEIS ; Martin BAUER ; Felix DAMMERING ; Claudia LAZARIDES ; Heiko KLAWITTER ; Lea BENTZ ; Sonja ENTRINGER ; Sibylle M. WINTER ; Claudia BUSS ; Christine HEIM in Journal of Child Psychology and Psychiatry, 65-1 (January 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-1 (January 2024) . - p.31-41 Titre : Children with maltreatment exposure exhibit rumination-like spontaneous thought patterns: association with symptoms of depression, subcallosal cingulate cortex thickness, and cortisol levels Type de document : Texte imprimé et/ou numérique Auteurs : Roman LINZ, Auteur ; Nikolaus STEINBEIS, Auteur ; Martin BAUER, Auteur ; Felix DAMMERING, Auteur ; Claudia LAZARIDES, Auteur ; Heiko KLAWITTER, Auteur ; Lea BENTZ, Auteur ; Sonja ENTRINGER, Auteur ; Sibylle M. WINTER, Auteur ; Claudia BUSS, Auteur ; Christine HEIM, Auteur Article en page(s) : p.31-41 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Childhood maltreatment is associated with pervasive risk for depression. However, the immediate cognitive and neural mechanisms that mediate this risk during development are unknown. We here studied the impact of maltreatment on self-generated thought (SGT) patterns and their association with depressive symptoms, subcallosal cingulate cortex (SCC) thickness, and cortisol levels in children. Methods We recruited 183 children aged 6?12?years, 96 of which were exposed to maltreatment. Children performed a mind wandering task to elicit SGTs. A subgroup of children underwent structural magnetic resonance imaging (N?=?155) for SCC thickness analyses and saliva collection for quantification of free cortisol concentrations (N?=?126) was collected. Using network analysis, we assessed thought networks and compared these networks between children with and without maltreatment exposure. Using multilevel analyses, we then tested the association between thought networks of children with maltreatment exposure with depressive symptoms, SCC thickness, and cortisol levels. Results Children exposed to maltreatment generated fewer positively valenced thoughts. Network analysis revealed rumination-like thought patterns in children with maltreatment exposure, which were associated with depressive symptoms, SCC thickness, and cortisol levels. Children with maltreatment exposure further exhibited decreased future-self thought coupling, which was associated with depressive symptoms, while other-related and past-oriented thoughts had the greatest importance within the network. Conclusions Using a novel network analytic approach, we provide evidence that children exposed to maltreatment exhibit ruminative clustering of thoughts, which is associated with depressive symptoms and neurobiological correlates of depression. Our results provide a specific target for clinical translation to design early interventions for middle childhood. Targeting thought patterns in children with maltreatment exposure may be an effective strategy to effectively mitigate depression risk early in life. En ligne : https://doi.org/10.1111/jcpp.13853 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Children with maltreatment exposure exhibit rumination-like spontaneous thought patterns: association with symptoms of depression, subcallosal cingulate cortex thickness, and cortisol levels [Texte imprimé et/ou numérique] / Roman LINZ, Auteur ; Nikolaus STEINBEIS, Auteur ; Martin BAUER, Auteur ; Felix DAMMERING, Auteur ; Claudia LAZARIDES, Auteur ; Heiko KLAWITTER, Auteur ; Lea BENTZ, Auteur ; Sonja ENTRINGER, Auteur ; Sibylle M. WINTER, Auteur ; Claudia BUSS, Auteur ; Christine HEIM, Auteur . - p.31-41. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-1 (January 2024) . - p.31-41 Index. décimale : PER Périodiques Résumé : Background Childhood maltreatment is associated with pervasive risk for depression. However, the immediate cognitive and neural mechanisms that mediate this risk during development are unknown. We here studied the impact of maltreatment on self-generated thought (SGT) patterns and their association with depressive symptoms, subcallosal cingulate cortex (SCC) thickness, and cortisol levels in children. Methods We recruited 183 children aged 6?12?years, 96 of which were exposed to maltreatment. Children performed a mind wandering task to elicit SGTs. A subgroup of children underwent structural magnetic resonance imaging (N?=?155) for SCC thickness analyses and saliva collection for quantification of free cortisol concentrations (N?=?126) was collected. Using network analysis, we assessed thought networks and compared these networks between children with and without maltreatment exposure. Using multilevel analyses, we then tested the association between thought networks of children with maltreatment exposure with depressive symptoms, SCC thickness, and cortisol levels. Results Children exposed to maltreatment generated fewer positively valenced thoughts. Network analysis revealed rumination-like thought patterns in children with maltreatment exposure, which were associated with depressive symptoms, SCC thickness, and cortisol levels. Children with maltreatment exposure further exhibited decreased future-self thought coupling, which was associated with depressive symptoms, while other-related and past-oriented thoughts had the greatest importance within the network. Conclusions Using a novel network analytic approach, we provide evidence that children exposed to maltreatment exhibit ruminative clustering of thoughts, which is associated with depressive symptoms and neurobiological correlates of depression. Our results provide a specific target for clinical translation to design early interventions for middle childhood. Targeting thought patterns in children with maltreatment exposure may be an effective strategy to effectively mitigate depression risk early in life. En ligne : https://doi.org/10.1111/jcpp.13853 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts / Hanna C. GUSTAFSSON in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1837-1848 Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1837-1848 Langues : Anglais (eng) Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts [Texte imprimé et/ou numérique] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1837-1848. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1837-1848 Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM / Hanna C. GUSTAFSSON in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1882-1882 Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1882-1882 Langues : Anglais (eng) Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001425 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM [Texte imprimé et/ou numérique] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1882-1882. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1882-1882 Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001425 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Immediate impact of child maltreatment on mental, developmental, and physical health trajectories / Sibylle Maria WINTER in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1027-1045 Titre : Immediate impact of child maltreatment on mental, developmental, and physical health trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Sibylle Maria WINTER, Auteur ; Katja DITTRICH, Auteur ; Peggy DORR, Auteur ; Judith OVERFELD, Auteur ; Imke MOEBUS, Auteur ; Elena MURRAY, Auteur ; Gergana KARABOYCHEVA, Auteur ; Christian ZIMMERMANN, Auteur ; Andrea KNOP, Auteur ; Manuel VOELKLE, Auteur ; Sonja ENTRINGER, Auteur ; Claudia BUSS, Auteur ; John-Dylan HAYNES, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1027-1045 Langues : Anglais (eng) Mots-clés : Child  Child Abuse/psychology  Emotions  Humans  Longitudinal Studies  Mental Disorders/psychology  Physical Abuse  Child development  follow-up studies  maltreatment  psychopathology  somatic problems Index. décimale : PER Périodiques Résumé : OBJECTIVE: The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow-up are needed. METHOD: We assessed health and developmental outcomes in 6-month intervals over 2years in 173 children, aged 3-5years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6months and 87 nonmaltreated children. Assessments included clinician-administered, self- and parent-report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories. RESULTS: Maltreated children exhibited greater numbers of psychiatric diagnoses (b=1.998, p<.001), externalizing (b=13.29, p<.001) and internalizing (b=11.70, p<.001) symptoms, impairments in cognitive (b=-11.586, p<.001), verbal (b=-10.687, p<.001), and motor development (b=-7.904, p=.006), and greater numbers of medical symptoms (b=1.021, p<.001) compared to nonmaltreated children across all time-points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time. CONCLUSION: The profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism-driven interventions that mitigate adverse trajectories in maltreated children. En ligne : http://dx.doi.org/10.1111/jcpp.13550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Immediate impact of child maltreatment on mental, developmental, and physical health trajectories [Texte imprimé et/ou numérique] / Sibylle Maria WINTER, Auteur ; Katja DITTRICH, Auteur ; Peggy DORR, Auteur ; Judith OVERFELD, Auteur ; Imke MOEBUS, Auteur ; Elena MURRAY, Auteur ; Gergana KARABOYCHEVA, Auteur ; Christian ZIMMERMANN, Auteur ; Andrea KNOP, Auteur ; Manuel VOELKLE, Auteur ; Sonja ENTRINGER, Auteur ; Claudia BUSS, Auteur ; John-Dylan HAYNES, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1027-1045. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1027-1045 Mots-clés : Child  Child Abuse/psychology  Emotions  Humans  Longitudinal Studies  Mental Disorders/psychology  Physical Abuse  Child development  follow-up studies  maltreatment  psychopathology  somatic problems Index. décimale : PER Périodiques Résumé : OBJECTIVE: The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow-up are needed. METHOD: We assessed health and developmental outcomes in 6-month intervals over 2years in 173 children, aged 3-5years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6months and 87 nonmaltreated children. Assessments included clinician-administered, self- and parent-report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories. RESULTS: Maltreated children exhibited greater numbers of psychiatric diagnoses (b=1.998, p<.001), externalizing (b=13.29, p<.001) and internalizing (b=11.70, p<.001) symptoms, impairments in cognitive (b=-11.586, p<.001), verbal (b=-10.687, p<.001), and motor development (b=-7.904, p=.006), and greater numbers of medical symptoms (b=1.021, p<.001) compared to nonmaltreated children across all time-points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time. CONCLUSION: The profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism-driven interventions that mitigate adverse trajectories in maltreated children. En ligne : http://dx.doi.org/10.1111/jcpp.13550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

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