Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Immediate impact of child maltreatment on mental, developmental, and physical health trajectories / Sibylle Maria WINTER in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1027-1045 Titre : Immediate impact of child maltreatment on mental, developmental, and physical health trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Sibylle Maria WINTER, Auteur ; Katja DITTRICH, Auteur ; Peggy DORR, Auteur ; Judith OVERFELD, Auteur ; Imke MOEBUS, Auteur ; Elena MURRAY, Auteur ; Gergana KARABOYCHEVA, Auteur ; Christian ZIMMERMANN, Auteur ; Andrea KNOP, Auteur ; Manuel VOELKLE, Auteur ; Sonja ENTRINGER, Auteur ; Claudia BUSS, Auteur ; John-Dylan HAYNES, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1027-1045 Langues : Anglais (eng) Mots-clés : Child  Child Abuse/psychology  Emotions  Humans  Longitudinal Studies  Mental Disorders/psychology  Physical Abuse  Child development  follow-up studies  maltreatment  psychopathology  somatic problems Index. décimale : PER Périodiques Résumé : OBJECTIVE: The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow-up are needed. METHOD: We assessed health and developmental outcomes in 6-month intervals over 2years in 173 children, aged 3-5years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6months and 87 nonmaltreated children. Assessments included clinician-administered, self- and parent-report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories. RESULTS: Maltreated children exhibited greater numbers of psychiatric diagnoses (b=1.998, p<.001), externalizing (b=13.29, p<.001) and internalizing (b=11.70, p<.001) symptoms, impairments in cognitive (b=-11.586, p<.001), verbal (b=-10.687, p<.001), and motor development (b=-7.904, p=.006), and greater numbers of medical symptoms (b=1.021, p<.001) compared to nonmaltreated children across all time-points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time. CONCLUSION: The profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism-driven interventions that mitigate adverse trajectories in maltreated children. En ligne : http://dx.doi.org/10.1111/jcpp.13550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Immediate impact of child maltreatment on mental, developmental, and physical health trajectories [Texte imprimé et/ou numérique] / Sibylle Maria WINTER, Auteur ; Katja DITTRICH, Auteur ; Peggy DORR, Auteur ; Judith OVERFELD, Auteur ; Imke MOEBUS, Auteur ; Elena MURRAY, Auteur ; Gergana KARABOYCHEVA, Auteur ; Christian ZIMMERMANN, Auteur ; Andrea KNOP, Auteur ; Manuel VOELKLE, Auteur ; Sonja ENTRINGER, Auteur ; Claudia BUSS, Auteur ; John-Dylan HAYNES, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1027-1045. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1027-1045 Mots-clés : Child  Child Abuse/psychology  Emotions  Humans  Longitudinal Studies  Mental Disorders/psychology  Physical Abuse  Child development  follow-up studies  maltreatment  psychopathology  somatic problems Index. décimale : PER Périodiques Résumé : OBJECTIVE: The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow-up are needed. METHOD: We assessed health and developmental outcomes in 6-month intervals over 2years in 173 children, aged 3-5years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6months and 87 nonmaltreated children. Assessments included clinician-administered, self- and parent-report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories. RESULTS: Maltreated children exhibited greater numbers of psychiatric diagnoses (b=1.998, p<.001), externalizing (b=13.29, p<.001) and internalizing (b=11.70, p<.001) symptoms, impairments in cognitive (b=-11.586, p<.001), verbal (b=-10.687, p<.001), and motor development (b=-7.904, p=.006), and greater numbers of medical symptoms (b=1.021, p<.001) compared to nonmaltreated children across all time-points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time. CONCLUSION: The profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism-driven interventions that mitigate adverse trajectories in maltreated children. En ligne : http://dx.doi.org/10.1111/jcpp.13550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

---

1 (1 - 2 / 2)