Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder / Marta MIGO in Journal of Autism and Developmental Disorders, 52-6 (June 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2379-2387 Titre : Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder Type de document : texte imprimé Auteurs : Marta MIGO, Auteur ; Sylvia B. GUILLORY, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Hannah E. GROSMAN, Auteur ; Katharine N. THAKKAR, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2379-2387 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Eeg  Lateralized readiness potential (LRP)  Motor preparation  Prediction Index. décimale : PER Périodiques Résumé : This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD+ADHD; n=12) and without (ASD?-?ADHD; n=9) comorbid ADHD and typical controls (n=29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD?-?ADHD children demonstrated LRP enhancement when their action produced an effect while ASD+ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05130-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder [texte imprimé] / Marta MIGO, Auteur ; Sylvia B. GUILLORY, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Hannah E. GROSMAN, Auteur ; Katharine N. THAKKAR, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2379-2387. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2379-2387 Mots-clés : Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Eeg  Lateralized readiness potential (LRP)  Motor preparation  Prediction Index. décimale : PER Périodiques Résumé : This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD+ADHD; n=12) and without (ASD?-?ADHD; n=9) comorbid ADHD and typical controls (n=29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD?-?ADHD children demonstrated LRP enhancement when their action produced an effect while ASD+ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05130-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Reduced engagement of visual attention in children with autism spectrum disorder / Christopher S. MCLAUGHLIN in Autism, 25-7 (October 2021)  

Public ISBD [article]  inAutism > 25-7 (October 2021) . - p.2064-2073 Titre : Reduced engagement of visual attention in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Ellen WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2064-2073 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Reduced engagement of visual attention in children with autism spectrum disorder [texte imprimé] / Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Ellen WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2064-2073. Langues : Anglais (eng) in Autism > 25-7 (October 2021) . - p.2064-2073 Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Reduced engagement of visual attention in children with autism spectrum disorder / Christopher S. MCLAUGHLIN in Autism, 26-7 (October 2022)  

Public ISBD [article]  inAutism > 26-7 (October 2022) . - p.2064-2073 Titre : Reduced engagement of visual attention in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2064-2073 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Reduced engagement of visual attention in children with autism spectrum disorder [texte imprimé] / Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2064-2073. Langues : Anglais (eng) in Autism > 26-7 (October 2022) . - p.2064-2073 Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study / Sylvia B. GUILLORY in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study Type de document : texte imprimé Auteurs : Sylvia B. GUILLORY, Auteur ; Victoria Z. BASKETT, Auteur ; Hannah E. GROSMAN, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Jordana WEISSMAN, Auteur ; Bari BRITVAN, Auteur ; M. Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Joseph D. BUXBAUM, Auteur ; Paige M. SIPER, Auteur ; A. Ting WANG, Auteur ; Alexander KOLEVZON, Auteur ; Jennifer H. FOSS-FEIG, Auteur Langues : Anglais (eng) Mots-clés : Attention  Autism Spectrum Disorder/genetics  Chromosome Deletion  Chromosome Disorders/complications/genetics  Chromosomes, Human, Pair 22  Eye-Tracking Technology  Humans  Autism spectrum disorder  Eye tracking  Phelan-McDermid syndrome  Recognition memory  Social processing  Visual attention  Therapeutics, and sema4. All other authors declare that they have no competing  interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The current study used eye tracking to investigate attention and recognition memory in Phelan-McDermid syndrome (PMS), a rare genetic disorder characterized by intellectual disability, motor delays, and a high likelihood of comorbid autism spectrum disorder (ASD). Social deficits represent a core feature of ASD, including decreased propensity to orient to or show preference for social stimuli. METHODS: We used a visual paired-comparison task with both social and non-social images, assessing looking behavior to a novel image versus a previously viewed familiar image to characterize social attention and recognition memory in PMS (n = 22), idiopathic ASD (iASD, n = 38), and typically developing (TD) controls (n = 26). The idiopathic ASD cohort was divided into subgroups with intellectual disabilities (ID; developmental quotient < 70) and without (developmental quotient > 70) and the PMS group into those with and without a co-morbid ASD diagnosis. RESULTS: On measures of attention, the PMS group with a comorbid ASD diagnosis spent less time viewing the social images compared to non-social images; the rate of looking back and forth between images was lowest in the iASD with ID group. Furthermore, while all groups demonstrated intact recognition memory when novel non-social stimuli were initially presented (pre-switch), participants with PMS showed no preference during the post-switch memory presentation. In iASD, the group without ID, but not the group with ID, showed a novelty preference for social stimuli. Across indices, individuals with PMS and ASD performed more similarly to PMS without ASD and less similarly to the iASD group. CONCLUSION: These findings demonstrate further evidence of differences in attention and memory for social stimuli in ASD and provide contrasts between iASD and PMS. En ligne : https://dx.doi.org/10.1186/s11689-021-09400-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study [texte imprimé] / Sylvia B. GUILLORY, Auteur ; Victoria Z. BASKETT, Auteur ; Hannah E. GROSMAN, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Jordana WEISSMAN, Auteur ; Bari BRITVAN, Auteur ; M. Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Joseph D. BUXBAUM, Auteur ; Paige M. SIPER, Auteur ; A. Ting WANG, Auteur ; Alexander KOLEVZON, Auteur ; Jennifer H. FOSS-FEIG, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Attention  Autism Spectrum Disorder/genetics  Chromosome Deletion  Chromosome Disorders/complications/genetics  Chromosomes, Human, Pair 22  Eye-Tracking Technology  Humans  Autism spectrum disorder  Eye tracking  Phelan-McDermid syndrome  Recognition memory  Social processing  Visual attention  Therapeutics, and sema4. All other authors declare that they have no competing  interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The current study used eye tracking to investigate attention and recognition memory in Phelan-McDermid syndrome (PMS), a rare genetic disorder characterized by intellectual disability, motor delays, and a high likelihood of comorbid autism spectrum disorder (ASD). Social deficits represent a core feature of ASD, including decreased propensity to orient to or show preference for social stimuli. METHODS: We used a visual paired-comparison task with both social and non-social images, assessing looking behavior to a novel image versus a previously viewed familiar image to characterize social attention and recognition memory in PMS (n = 22), idiopathic ASD (iASD, n = 38), and typically developing (TD) controls (n = 26). The idiopathic ASD cohort was divided into subgroups with intellectual disabilities (ID; developmental quotient < 70) and without (developmental quotient > 70) and the PMS group into those with and without a co-morbid ASD diagnosis. RESULTS: On measures of attention, the PMS group with a comorbid ASD diagnosis spent less time viewing the social images compared to non-social images; the rate of looking back and forth between images was lowest in the iASD with ID group. Furthermore, while all groups demonstrated intact recognition memory when novel non-social stimuli were initially presented (pre-switch), participants with PMS showed no preference during the post-switch memory presentation. In iASD, the group without ID, but not the group with ID, showed a novelty preference for social stimuli. Across indices, individuals with PMS and ASD performed more similarly to PMS without ASD and less similarly to the iASD group. CONCLUSION: These findings demonstrate further evidence of differences in attention and memory for social stimuli in ASD and provide contrasts between iASD and PMS. En ligne : https://dx.doi.org/10.1186/s11689-021-09400-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume / Sarah BANKER ; Jadyn TRAYVICK ; Sarah BARKLEY ; Arabella W PETERS ; Abigaël THINAKARAN ; Christopher S. MCLAUGHLIN ; Xiaosi GU ; Daniela SCHILLER ; Jennifer H. FOSS-FEIG in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 9 Titre : Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume Type de document : texte imprimé Auteurs : Sarah BANKER, Auteur ; Jadyn TRAYVICK, Auteur ; Sarah BARKLEY, Auteur ; Arabella W PETERS, Auteur ; Abigaël THINAKARAN, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Xiaosi GU, Auteur ; Daniela SCHILLER, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : 9 Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Gyrus Cinguli/diagnostic imaging  Depression/diagnostic imaging  Adult  Young Adult  Autism Spectrum Disorder/diagnostic imaging/psychology  Perception  Magnetic Resonance Imaging  Autistic Disorder/psychology/diagnostic imaging  Adolescent  Organ Size  Social Interaction  Amygdala/diagnostic imaging/pathology/physiopathology  Affiliation  Amygdala  Anterior cingulate cortex  Autism spectrum disorder  Depression  Self-awareness  Social impairments  Medicine at Mount Sinai?s Institutional Review Board approved the study protocol  (#16-01089 for onsite neuroimaging & #22-00171 for online replication sample  presented in Supplementary Materials). All participants gave written informed  consent and received compensation for their participation. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet the reasons for this disparity remain unclear. While social deficits central to ASD may contribute to depression, it is uncertain whether social interaction behavior themselves or individuals' introspection about their social behaviors are more impactful. Although the anterior cingulate cortex (ACC) is frequently implicated in ASD, depression, and social functioning, it is unknown if it explains differences between ASD adults with and without co-occurring depression. METHODS: The present study contrasted observed vs. subjective perception of autism symptoms and social interaction assessed with both standardized measures and a lab task, in 65 sex-balanced (52.24% male) autistic young adults. We also quantified ACC and amygdala volume with 7-Tesla structural neuroimaging to examine correlations with self-reported depression and social functioning. RESULTS: We found that ASD individuals with self-reported depression exhibited differences in subjective evaluations including heightened self-awareness of ASD symptoms, lower subjective satisfaction with social relations, and less perceived affiliation during the social interaction task, yet no differences in corresponding observed measures, compared to those without depression. Larger ACC volume was related to depression, greater self-awareness of ASD symptoms, and worse subjective satisfaction with social relations. In contrast, amygdala volume, despite its association with clinician-rated ASD symptoms, was not related to depression. LIMITATIONS: Due to the cross-sectional nature of our study, we cannot determine the directionality of the observed relationships. Additionally, we included only individuals with an IQ over 60 to ensure participants could complete the social task. We also utilized self-reported depression indices instead of clinically diagnosed depression, which may limit the comprehensiveness of the findings. CONCLUSIONS: Our approach highlights the unique role of subjective perception of autism symptoms and social interactions, beyond the observable manifestation of social impairment in ASD, in contributing to self-reported depression, with the ACC playing a crucial role. These findings imply possible heterogeneity of ASD concerning co-occurring depression. Using neuroimaging, we were able to demarcate depressive phenotypes co-occurring alongside autistic phenotypes. En ligne : https://dx.doi.org/10.1186/s13229-025-00638-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume [texte imprimé] / Sarah BANKER, Auteur ; Jadyn TRAYVICK, Auteur ; Sarah BARKLEY, Auteur ; Arabella W PETERS, Auteur ; Abigaël THINAKARAN, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Xiaosi GU, Auteur ; Daniela SCHILLER, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - 9. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 9 Mots-clés : Humans  Male  Female  Gyrus Cinguli/diagnostic imaging  Depression/diagnostic imaging  Adult  Young Adult  Autism Spectrum Disorder/diagnostic imaging/psychology  Perception  Magnetic Resonance Imaging  Autistic Disorder/psychology/diagnostic imaging  Adolescent  Organ Size  Social Interaction  Amygdala/diagnostic imaging/pathology/physiopathology  Affiliation  Amygdala  Anterior cingulate cortex  Autism spectrum disorder  Depression  Self-awareness  Social impairments  Medicine at Mount Sinai?s Institutional Review Board approved the study protocol  (#16-01089 for onsite neuroimaging & #22-00171 for online replication sample  presented in Supplementary Materials). All participants gave written informed  consent and received compensation for their participation. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet the reasons for this disparity remain unclear. While social deficits central to ASD may contribute to depression, it is uncertain whether social interaction behavior themselves or individuals' introspection about their social behaviors are more impactful. Although the anterior cingulate cortex (ACC) is frequently implicated in ASD, depression, and social functioning, it is unknown if it explains differences between ASD adults with and without co-occurring depression. METHODS: The present study contrasted observed vs. subjective perception of autism symptoms and social interaction assessed with both standardized measures and a lab task, in 65 sex-balanced (52.24% male) autistic young adults. We also quantified ACC and amygdala volume with 7-Tesla structural neuroimaging to examine correlations with self-reported depression and social functioning. RESULTS: We found that ASD individuals with self-reported depression exhibited differences in subjective evaluations including heightened self-awareness of ASD symptoms, lower subjective satisfaction with social relations, and less perceived affiliation during the social interaction task, yet no differences in corresponding observed measures, compared to those without depression. Larger ACC volume was related to depression, greater self-awareness of ASD symptoms, and worse subjective satisfaction with social relations. In contrast, amygdala volume, despite its association with clinician-rated ASD symptoms, was not related to depression. LIMITATIONS: Due to the cross-sectional nature of our study, we cannot determine the directionality of the observed relationships. Additionally, we included only individuals with an IQ over 60 to ensure participants could complete the social task. We also utilized self-reported depression indices instead of clinically diagnosed depression, which may limit the comprehensiveness of the findings. CONCLUSIONS: Our approach highlights the unique role of subjective perception of autism symptoms and social interactions, beyond the observable manifestation of social impairment in ASD, in contributing to self-reported depression, with the ACC playing a crucial role. These findings imply possible heterogeneity of ASD concerning co-occurring depression. Using neuroimaging, we were able to demarcate depressive phenotypes co-occurring alongside autistic phenotypes. En ligne : https://dx.doi.org/10.1186/s13229-025-00638-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

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