Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample / Ellen VAN DER PLAS in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3115-3125 Titre : Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample Type de document : texte imprimé Auteurs : Ellen VAN DER PLAS, Auteur ; Annie DUPUIS, Auteur ; Paul D. ARNOLD, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur Article en page(s) : p.3115-3125 Langues : Anglais (eng) Mots-clés : Autism  Attention/deficits hyperactivity disorder  Obsessive compulsive disorder  Familial  Traits  Community sample Index. décimale : PER Périodiques Résumé : We examined co-occurrence of autism spectrum disorder (ASD) with (traits of) attention-deficit/hyperactivity (ADHD), obsessive-compulsive (OCD) and inhibition deficits in a community sample (n = 16,676) and tested whether having a sibling with ASD manifested in increased features of ADHD, OCD or inhibition deficits. Individuals with ASD had increased ADHD and OCD traits compared with individuals without ASD. Individuals with a sibling with ASD exhibited more ADHD traits than did individuals whose sibling did not have ASD. The “sibling effect” on manifestation of ADHD traits was observed in individuals with and without ASD. Having a sibling with ASD did not affect OCD traits. Inhibition was impaired in individuals with ASD who had a sibling with ASD only. En ligne : http://dx.doi.org/10.1007/s10803-016-2853-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample [texte imprimé] / Ellen VAN DER PLAS, Auteur ; Annie DUPUIS, Auteur ; Paul D. ARNOLD, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur . - p.3115-3125. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3115-3125 Mots-clés : Autism  Attention/deficits hyperactivity disorder  Obsessive compulsive disorder  Familial  Traits  Community sample Index. décimale : PER Périodiques Résumé : We examined co-occurrence of autism spectrum disorder (ASD) with (traits of) attention-deficit/hyperactivity (ADHD), obsessive-compulsive (OCD) and inhibition deficits in a community sample (n = 16,676) and tested whether having a sibling with ASD manifested in increased features of ADHD, OCD or inhibition deficits. Individuals with ASD had increased ADHD and OCD traits compared with individuals without ASD. Individuals with a sibling with ASD exhibited more ADHD traits than did individuals whose sibling did not have ASD. The “sibling effect” on manifestation of ADHD traits was observed in individuals with and without ASD. Having a sibling with ASD did not affect OCD traits. Inhibition was impaired in individuals with ASD who had a sibling with ASD only. En ligne : http://dx.doi.org/10.1007/s10803-016-2853-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders / Elizabeth W. PANG in Autism Research, 16-3 (March 2023)  

Public ISBD [article]  inAutism Research > 16-3 (March 2023) . - p.535-542 Titre : Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders Type de document : texte imprimé Auteurs : Elizabeth W. PANG, Auteur ; Chris HAMMILL, Auteur ; Margot J. TAYLOR, Auteur ; Jamie NEAR, Auteur ; Russell SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Paul D. ARNOLD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur Article en page(s) : p.535-542 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (GABA) and glutamate in the brain. Recent evidence has shown the involvement of the cerebellum in cognition and affect regulation, and cerebellar atypical function or damage is reported frequently in NDDs. Magnetic resonance spectroscopy studies have reported decreases in GABA in cortical brain areas in the NDDs, however, GABA levels in the cerebellum have not been examined. To determine possible group effects, we used a MEGA-PRESS acquisition to investigate GABA+ levels in a cerebellar voxel in 343 individuals (aged 2.5-22 years) with ASD, ADHD, OCD and controls. Using a mixed effects model, we found no significant differences between groups in GABA+ concentration. Our findings suggest that cerebellar GABA+ levels do not differentiate NDD groups. En ligne : https://doi.org/10.1002/aur.2888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders [texte imprimé] / Elizabeth W. PANG, Auteur ; Chris HAMMILL, Auteur ; Margot J. TAYLOR, Auteur ; Jamie NEAR, Auteur ; Russell SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Paul D. ARNOLD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur . - p.535-542. Langues : Anglais (eng) in Autism Research > 16-3 (March 2023) . - p.535-542 Index. décimale : PER Périodiques Résumé : Abstract Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (GABA) and glutamate in the brain. Recent evidence has shown the involvement of the cerebellum in cognition and affect regulation, and cerebellar atypical function or damage is reported frequently in NDDs. Magnetic resonance spectroscopy studies have reported decreases in GABA in cortical brain areas in the NDDs, however, GABA levels in the cerebellum have not been examined. To determine possible group effects, we used a MEGA-PRESS acquisition to investigate GABA+ levels in a cerebellar voxel in 343 individuals (aged 2.5-22 years) with ASD, ADHD, OCD and controls. Using a mixed effects model, we found no significant differences between groups in GABA+ concentration. Our findings suggest that cerebellar GABA+ levels do not differentiate NDD groups. En ligne : https://doi.org/10.1002/aur.2888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Co-Occurrence of Autism and Deafness: Diagnostic Considerations / Louise ROPER in Autism, 7-3 (September 2003)  

Public ISBD [article]  inAutism > 7-3 (September 2003) . - p.245-253 Titre : Co-Occurrence of Autism and Deafness: Diagnostic Considerations Type de document : texte imprimé Auteurs : Louise ROPER, Auteur ; Paul D. ARNOLD, Auteur ; Brendan MONTEIRO, Auteur Article en page(s) : p.245-253 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are particularly difficult to diagnose in the presence of early profound deafness because of communication related issues. Two parts of the Autism Screening Instrument were administered to 13 deaf individuals with autism and two comparison groups: hearing autistic and deaf learning disabled. A parental questionnaire was also used. No differences in autistic symptomatology were found between the deaf autistic and the hearing autistic group. However, the deaf autistic group was diagnosed later than the hearing autistic group. It is concluded that autism can be diagnosed in the deaf; that it resembles autism in the hearing; and that it is not a consequence of deafness per se. Learning disabled deaf individuals who are not autistic do not resemble people with autism in behavioural terms. The findings have implications for remediation, education, and the emergence and management of challenging behaviours. En ligne : http://dx.doi.org/10.1177/1362361303007003002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Co-Occurrence of Autism and Deafness: Diagnostic Considerations [texte imprimé] / Louise ROPER, Auteur ; Paul D. ARNOLD, Auteur ; Brendan MONTEIRO, Auteur . - p.245-253. Langues : Anglais (eng) in Autism > 7-3 (September 2003) . - p.245-253 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are particularly difficult to diagnose in the presence of early profound deafness because of communication related issues. Two parts of the Autism Screening Instrument were administered to 13 deaf individuals with autism and two comparison groups: hearing autistic and deaf learning disabled. A parental questionnaire was also used. No differences in autistic symptomatology were found between the deaf autistic and the hearing autistic group. However, the deaf autistic group was diagnosed later than the hearing autistic group. It is concluded that autism can be diagnosed in the deaf; that it resembles autism in the hearing; and that it is not a consequence of deafness per se. Learning disabled deaf individuals who are not autistic do not resemble people with autism in behavioural terms. The findings have implications for remediation, education, and the emergence and management of challenging behaviours. En ligne : http://dx.doi.org/10.1177/1362361303007003002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores / Alexandra LAUTARESCU ; Tony CHARMAN ; Jennifer CROSBIE ; Russell J SCHACHAR ; Alana IABONI ; Stelios GEORGIADES ; Robert NICOLSON ; Elizabeth KELLEY ; Muhammad AYUB ; Jessica JONES ; Paul D. ARNOLD ; Jason P LERCH ; Evdokia ANAGNOSTOU ; Azadeh KUSHKI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 51 Titre : Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores Type de document : texte imprimé Auteurs : Alexandra LAUTARESCU, Auteur ; Tony CHARMAN, Auteur ; Jennifer CROSBIE, Auteur ; Russell J SCHACHAR, Auteur ; Alana IABONI, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica JONES, Auteur ; Paul D. ARNOLD, Auteur ; Jason P LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : 51 Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Child  Adolescent  *Adaptation, Psychological  Autistic Disorder/diagnosis/psychology Index. décimale : PER Périodiques Résumé : BACKGROUND: Very large sample sizes are often needed to capture heterogeneity in autism, necessitating data sharing across multiple studies with diverse assessment instruments. In these cases, data harmonization can be a critical tool for deriving a single dataset for analysis. This can be done through computational approaches that enable the conversion of scores across various instruments. To this end, our study examined the use of analytical approaches for mapping scores on two measures of adaptive functioning, namely predicting the scores on the vineland adaptive behavior scales II (VABS) from the scores on the adaptive behavior assessment system II (ABAS). METHODS: Data from the province of Ontario neurodevelopmental disorders network were used. The dataset included scores VABS and the ABAS for 720 participants (autism n = 547, 433 male, age: 11.31+3.63 years; neurotypical n = 173, 95 male, age: 12.53+4.05 years). Six regression approaches (ordinary least squares (OLS) linear regression, ridge regression, ElasticNet, LASSO, AdaBoost, random forest) were used to predict VABS total scores from the ABAS scores, demographic variables (age, sex), and phenotypic measures (diagnosis; core and co-occurring features; IQ; internalizing and externalizing symptoms). RESULTS: The VABS scores were significantly higher than the ABAS scores in the autism group, but not the neurotypical group (median difference: 8, 95% CI = (7,9)). The difference was negatively associated with age (beta = -1.2+0.12, t = -10.6, p < 0.0001). All estimators demonstrated similar performance, with no statistically significant differences in mean absolute error (MAE) values across estimators (MAE range: 4.96-6.91). The highest contributing features to the prediction model were ABAS composite score, diagnosis, and age. LIMITATIONS: This study has several strengths, including the large sample. We did not examine the conversion of domain scores across the two measures of adaptive functioning and suggest this as a future area of investigation. CONCLUSION: Overall, our results supported the feasibility of harmonization. Our results suggest that a linear regression model trained on the ABAS composite score, the ABAS raw domain scores, and age, sex, and diagnosis would provide an acceptable trade-off between accuracy, parsimony, and data collection and processing complexity. En ligne : https://dx.doi.org/10.1186/s13229-024-00630-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores [texte imprimé] / Alexandra LAUTARESCU, Auteur ; Tony CHARMAN, Auteur ; Jennifer CROSBIE, Auteur ; Russell J SCHACHAR, Auteur ; Alana IABONI, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica JONES, Auteur ; Paul D. ARNOLD, Auteur ; Jason P LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur . - 51. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 51 Mots-clés : Humans  Male  Female  Child  Adolescent  *Adaptation, Psychological  Autistic Disorder/diagnosis/psychology Index. décimale : PER Périodiques Résumé : BACKGROUND: Very large sample sizes are often needed to capture heterogeneity in autism, necessitating data sharing across multiple studies with diverse assessment instruments. In these cases, data harmonization can be a critical tool for deriving a single dataset for analysis. This can be done through computational approaches that enable the conversion of scores across various instruments. To this end, our study examined the use of analytical approaches for mapping scores on two measures of adaptive functioning, namely predicting the scores on the vineland adaptive behavior scales II (VABS) from the scores on the adaptive behavior assessment system II (ABAS). METHODS: Data from the province of Ontario neurodevelopmental disorders network were used. The dataset included scores VABS and the ABAS for 720 participants (autism n = 547, 433 male, age: 11.31+3.63 years; neurotypical n = 173, 95 male, age: 12.53+4.05 years). Six regression approaches (ordinary least squares (OLS) linear regression, ridge regression, ElasticNet, LASSO, AdaBoost, random forest) were used to predict VABS total scores from the ABAS scores, demographic variables (age, sex), and phenotypic measures (diagnosis; core and co-occurring features; IQ; internalizing and externalizing symptoms). RESULTS: The VABS scores were significantly higher than the ABAS scores in the autism group, but not the neurotypical group (median difference: 8, 95% CI = (7,9)). The difference was negatively associated with age (beta = -1.2+0.12, t = -10.6, p < 0.0001). All estimators demonstrated similar performance, with no statistically significant differences in mean absolute error (MAE) values across estimators (MAE range: 4.96-6.91). The highest contributing features to the prediction model were ABAS composite score, diagnosis, and age. LIMITATIONS: This study has several strengths, including the large sample. We did not examine the conversion of domain scores across the two measures of adaptive functioning and suggest this as a future area of investigation. CONCLUSION: Overall, our results supported the feasibility of harmonization. Our results suggest that a linear regression model trained on the ABAS composite score, the ABAS raw domain scores, and age, sex, and diagnosis would provide an acceptable trade-off between accuracy, parsimony, and data collection and processing complexity. En ligne : https://dx.doi.org/10.1186/s13229-024-00630-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Magnetoencephalographic (MEG) brain activity during a mental flexibility task suggests some shared neurobiology in children with neurodevelopmental disorders / A. MOGADAM in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 19 p. Titre : Magnetoencephalographic (MEG) brain activity during a mental flexibility task suggests some shared neurobiology in children with neurodevelopmental disorders Type de document : texte imprimé Auteurs : A. MOGADAM, Auteur ; A. E. KELLER, Auteur ; Paul D. ARNOLD, Auteur ; Russell SCHACHAR, Auteur ; J. P. LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Elizabeth W. PANG, Auteur Article en page(s) : 19 p. Langues : Anglais (eng) Mots-clés : Adhd  Asd  Corticostriatal projections  Executive function  Meg  Neurodevelopmental disorders  Ocd  Rbs-r  Set shifting  Tocs Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with neurodevelopmental disorders (NDDs) exhibit a shared phenotype that involves executive dysfunctions including impairments in mental flexibility (MF). It is of interest to understand if this phenotype stems from some shared neurobiology. METHODS: To investigate this possibility, we used magnetoencephalography (MEG) neuroimaging to compare brain activity in children (n = 88; 8-15 years) with autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), as they completed a set-shifting/mental flexibility task. RESULTS: Neuroimaging results revealed a similar parietal activation profile across the NDD, groups suggesting a link to their shared phenotype. Differences in frontal activity differentiated the three clinical groups. Brain-behaviour analyses showed a link with repetitive behaviours suggesting shared dysfunction in the associative loop of the corticostriatal system. CONCLUSION: Our study supports the notion that NDDs may exist along a complex phenotypic/biological continuum. All NDD groups showed a sustained parietal activity profile suggesting that they share a strong reliance on the posterior parietal cortices to complete the mental flexibility task; future studies could elucidate whether this is due to delayed brain development or compensatory functioning. The differences in frontal activity may play a role in differentiating the NDDs. The OCD group showed sustained prefrontal activity that may be reflective of hyperfrontality. The ASD group showed reduced frontal activation suggestive of frontal dysfunction and the ADHD group showed an extensive hypoactivity that included frontal and parietal regions. Brain-behaviour analyses showed a significant correlation with repetitive behaviours which may reflect dysfunction in the associative loop of the corticostriatal system, linked to inflexible behaviours. En ligne : https://dx.doi.org/10.1186/s11689-019-9280-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Magnetoencephalographic (MEG) brain activity during a mental flexibility task suggests some shared neurobiology in children with neurodevelopmental disorders [texte imprimé] / A. MOGADAM, Auteur ; A. E. KELLER, Auteur ; Paul D. ARNOLD, Auteur ; Russell SCHACHAR, Auteur ; J. P. LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Elizabeth W. PANG, Auteur . - 19 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 19 p. Mots-clés : Adhd  Asd  Corticostriatal projections  Executive function  Meg  Neurodevelopmental disorders  Ocd  Rbs-r  Set shifting  Tocs Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with neurodevelopmental disorders (NDDs) exhibit a shared phenotype that involves executive dysfunctions including impairments in mental flexibility (MF). It is of interest to understand if this phenotype stems from some shared neurobiology. METHODS: To investigate this possibility, we used magnetoencephalography (MEG) neuroimaging to compare brain activity in children (n = 88; 8-15 years) with autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), as they completed a set-shifting/mental flexibility task. RESULTS: Neuroimaging results revealed a similar parietal activation profile across the NDD, groups suggesting a link to their shared phenotype. Differences in frontal activity differentiated the three clinical groups. Brain-behaviour analyses showed a link with repetitive behaviours suggesting shared dysfunction in the associative loop of the corticostriatal system. CONCLUSION: Our study supports the notion that NDDs may exist along a complex phenotypic/biological continuum. All NDD groups showed a sustained parietal activity profile suggesting that they share a strong reliance on the posterior parietal cortices to complete the mental flexibility task; future studies could elucidate whether this is due to delayed brain development or compensatory functioning. The differences in frontal activity may play a role in differentiating the NDDs. The OCD group showed sustained prefrontal activity that may be reflective of hyperfrontality. The ASD group showed reduced frontal activation suggestive of frontal dysfunction and the ADHD group showed an extensive hypoactivity that included frontal and parietal regions. Brain-behaviour analyses showed a significant correlation with repetitive behaviours which may reflect dysfunction in the associative loop of the corticostriatal system, linked to inflexible behaviours. En ligne : https://dx.doi.org/10.1186/s11689-019-9280-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples / Russell SCHACHAR in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

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Self-Esteem, Aspirations and Expectations of Adolescents with Physical Disability / Paul D. ARNOLD in Developmental Medicine & Child Neurology, 34-2 (February 1992)

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Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study / V. M. SINOPOLI in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)  

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Subgrouping autism and ADHD based on structural MRI population modelling centiles / Clara PECCI-TERROBA in Molecular Autism, 16 (2025)  

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SWAN scale for ADHD trait-based genetic research: a validity and polygenic risk study / C. L. BURTON in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

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Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation / M. J. GAZZELLONE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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