Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder / Mariana L. LAPORTA in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4301-4310 Titre : Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Mariana L. LAPORTA, Auteur ; Juraj SPRUNG, Auteur ; Caroline A. FEJEDELEM, Auteur ; Dustin T. HENNING, Auteur ; Amy L. WEAVER, Auteur ; Andrew C. HANSON, Auteur ; Darrell R. SCHROEDER, Auteur ; Scott M. MYERS, Auteur ; Robert G. VOIGT, Auteur ; Toby N. WEINGARTEN, Auteur ; Randall P. FLICK, Auteur ; David O. WARNER, Auteur Article en page(s) : p.4301-4310 Langues : Anglais (eng) Mots-clés : Asd  Anesthesia  Autism  Childhood  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : This study tested the hypothesis that exposure of children prior to their third birthday to procedures requiring general anesthesia is associated with an increased incidence of autism spectrum disorder (ASD) in later life. This study employed a nested, 1:2 matched-case control study design using ASD cases identified in a population-based birth cohort of children born in Olmsted County, MN from 1976 to 2000. Matching variables included sex, date of birth, and mother's age in conditional logistic regression including 499 ASD cases and 998 controls. After adjusting for birth weight and health status, there was no significant association between exposure and ASD (OR 1.27 [95% CI 0.92-1.76]), indicating that general anesthesia is not associated with an increased risk of ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05305-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder [texte imprimé] / Mariana L. LAPORTA, Auteur ; Juraj SPRUNG, Auteur ; Caroline A. FEJEDELEM, Auteur ; Dustin T. HENNING, Auteur ; Amy L. WEAVER, Auteur ; Andrew C. HANSON, Auteur ; Darrell R. SCHROEDER, Auteur ; Scott M. MYERS, Auteur ; Robert G. VOIGT, Auteur ; Toby N. WEINGARTEN, Auteur ; Randall P. FLICK, Auteur ; David O. WARNER, Auteur . - p.4301-4310. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4301-4310 Mots-clés : Asd  Anesthesia  Autism  Childhood  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : This study tested the hypothesis that exposure of children prior to their third birthday to procedures requiring general anesthesia is associated with an increased incidence of autism spectrum disorder (ASD) in later life. This study employed a nested, 1:2 matched-case control study design using ASD cases identified in a population-based birth cohort of children born in Olmsted County, MN from 1976 to 2000. Matching variables included sex, date of birth, and mother's age in conditional logistic regression including 499 ASD cases and 998 controls. After adjusting for birth weight and health status, there was no significant association between exposure and ASD (OR 1.27 [95% CI 0.92-1.76]), indicating that general anesthesia is not associated with an increased risk of ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05305-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort / Scott M. MYERS in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1455-1474 Titre : Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort Type de document : texte imprimé Auteurs : Scott M. MYERS, Auteur ; Robert G. VOIGT, Auteur ; Robert C. COLLIGAN, Auteur ; Amy L. WEAVER, Auteur ; Curtis B. STORLIE, Auteur ; Ruth E. STOECKEL, Auteur ; John D. PORT, Auteur ; Slavica K. KATUSIC, Auteur Article en page(s) : p.1455-1474 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Epidemiology  Incidence  Time trends Index. décimale : PER Périodiques Résumé : We retrospectively identified autism spectrum disorder (ASD) incident cases among 31,220 individuals in a population-based birth cohort based on signs and symptoms uniformly abstracted from medical and educational records. Inclusive and narrow research definitions of ASD (ASD-RI and ASD-RN, respectively) were explored, along with clinical diagnoses of ASD (ASD-C) obtained from the records. The incidence of ASD-RI, ASD-RN, and ASD-C increased significantly from 1985 to 1998, then ASD-RI and ASD-RN plateaued while the rate of ASD-C continued to increase during 1998-2004. The rising incidence of research-defined ASD may reflect improved recognition and documentation of ASD signs and symptoms. Although the frequency of threshold ASD symptoms stabilized, the rate of ASD-C continued to increase, narrowing the gap between clinical ascertainment and symptom documentation. En ligne : https://dx.doi.org/10.1007/s10803-018-3834-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort [texte imprimé] / Scott M. MYERS, Auteur ; Robert G. VOIGT, Auteur ; Robert C. COLLIGAN, Auteur ; Amy L. WEAVER, Auteur ; Curtis B. STORLIE, Auteur ; Ruth E. STOECKEL, Auteur ; John D. PORT, Auteur ; Slavica K. KATUSIC, Auteur . - p.1455-1474. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1455-1474 Mots-clés : Autism spectrum disorder  Epidemiology  Incidence  Time trends Index. décimale : PER Périodiques Résumé : We retrospectively identified autism spectrum disorder (ASD) incident cases among 31,220 individuals in a population-based birth cohort based on signs and symptoms uniformly abstracted from medical and educational records. Inclusive and narrow research definitions of ASD (ASD-RI and ASD-RN, respectively) were explored, along with clinical diagnoses of ASD (ASD-C) obtained from the records. The incidence of ASD-RI, ASD-RN, and ASD-C increased significantly from 1985 to 1998, then ASD-RI and ASD-RN plateaued while the rate of ASD-C continued to increase during 1998-2004. The rising incidence of research-defined ASD may reflect improved recognition and documentation of ASD signs and symptoms. Although the frequency of threshold ASD symptoms stabilized, the rate of ASD-C continued to increase, narrowing the gap between clinical ascertainment and symptom documentation. En ligne : https://dx.doi.org/10.1007/s10803-018-3834-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Dimensional assessment of schizotypal, psychotic, and other psychiatric traits in children and their parents: development and validation of the Childhood Oxford-Liverpool Inventory of Feelings and Experiences on a representative US sample / David W. EVANS in Journal of Child Psychology and Psychiatry, 59-5 (May 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-5 (May 2018) . - p.574-585 Titre : Dimensional assessment of schizotypal, psychotic, and other psychiatric traits in children and their parents: development and validation of the Childhood Oxford-Liverpool Inventory of Feelings and Experiences on a representative US sample Type de document : texte imprimé Auteurs : David W. EVANS, Auteur ; Laina G. LUSK, Auteur ; Mylissa M. SLANE, Auteur ; Andrew M. MICHAEL, Auteur ; Scott M. MYERS, Auteur ; Mirko ULJAREVIĆ, Auteur ; Oliver MASON, Auteur ; Gordon CLARIDGE, Auteur ; Thomas W. FRAZIER, Auteur Article en page(s) : p.574-585 Langues : Anglais (eng) Mots-clés : Dimensional psychiatric traits  parent-child psychiatric traits  schizotypy in children Index. décimale : PER Périodiques Résumé : BACKGROUND: Healthy functioning relies on a variety of perceptual, cognitive, emotional, and behavioral abilities that are distributed throughout the normal population. Variation in these traits define the wide range of neurodevelopmental (NDD) and neuropsychiatric (NPD) disorders. Here, we introduce a new measure for assessing these traits in typically developing children and children at risk for NDD and NPD from age 2 to 18 years. METHOD: The Childhood Oxford-Liverpool Inventory of Feelings and Experiences (CO-LIFE) was created as a dimensional, parent-report measure of schizotypal and psychotic traits in the general population. Parents of 2,786 children also self-reported on an adapted version of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE-US). RESULTS: The CO-LIFE resulted in continuous distributions for the total score and for each of three factor analytically-derived subscales. Item response theory (IRT) analyses indicated strong reliability across the score range for the O-LIFE-US and the CO-LIFE. Internal consistency and test-retest reliability were high across all scales. Parent-child intraclass correlations were consistent with high heritability. The scales discriminated participants who reported a lifetime psychiatric diagnosis from those who reported no diagnosis. The O-LIFE-US and CO-LIFE scores correlated positively with the Social Responsiveness Scale 2 (SRS-2) indicating good convergent validity. CONCLUSIONS: Like the original O-LIFE, the O-LIFE-US and the CO-LIFE are valid and reliable tools that reflect the spectrum of psychiatric and schizotypal traits in the general population. Such scales are necessary for conducting family studies that aim to examine a range of psychological and behavioral traits in both children and adults and are well-suited for the Research Domain Criteria (RDoC) initiative of the NIMH. En ligne : http://dx.doi.org/10.1111/jcpp.12827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Dimensional assessment of schizotypal, psychotic, and other psychiatric traits in children and their parents: development and validation of the Childhood Oxford-Liverpool Inventory of Feelings and Experiences on a representative US sample [texte imprimé] / David W. EVANS, Auteur ; Laina G. LUSK, Auteur ; Mylissa M. SLANE, Auteur ; Andrew M. MICHAEL, Auteur ; Scott M. MYERS, Auteur ; Mirko ULJAREVIĆ, Auteur ; Oliver MASON, Auteur ; Gordon CLARIDGE, Auteur ; Thomas W. FRAZIER, Auteur . - p.574-585. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-5 (May 2018) . - p.574-585 Mots-clés : Dimensional psychiatric traits  parent-child psychiatric traits  schizotypy in children Index. décimale : PER Périodiques Résumé : BACKGROUND: Healthy functioning relies on a variety of perceptual, cognitive, emotional, and behavioral abilities that are distributed throughout the normal population. Variation in these traits define the wide range of neurodevelopmental (NDD) and neuropsychiatric (NPD) disorders. Here, we introduce a new measure for assessing these traits in typically developing children and children at risk for NDD and NPD from age 2 to 18 years. METHOD: The Childhood Oxford-Liverpool Inventory of Feelings and Experiences (CO-LIFE) was created as a dimensional, parent-report measure of schizotypal and psychotic traits in the general population. Parents of 2,786 children also self-reported on an adapted version of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE-US). RESULTS: The CO-LIFE resulted in continuous distributions for the total score and for each of three factor analytically-derived subscales. Item response theory (IRT) analyses indicated strong reliability across the score range for the O-LIFE-US and the CO-LIFE. Internal consistency and test-retest reliability were high across all scales. Parent-child intraclass correlations were consistent with high heritability. The scales discriminated participants who reported a lifetime psychiatric diagnosis from those who reported no diagnosis. The O-LIFE-US and CO-LIFE scores correlated positively with the Social Responsiveness Scale 2 (SRS-2) indicating good convergent validity. CONCLUSIONS: Like the original O-LIFE, the O-LIFE-US and the CO-LIFE are valid and reliable tools that reflect the spectrum of psychiatric and schizotypal traits in the general population. Such scales are necessary for conducting family studies that aim to examine a range of psychological and behavioral traits in both children and adults and are well-suited for the Research Domain Criteria (RDoC) initiative of the NIMH. En ligne : http://dx.doi.org/10.1111/jcpp.12827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Letter to the editor / Brenda FINUCANE in Autism Research, 16-4 (April 2023)  

Public ISBD [article]  inAutism Research > 16-4 (April 2023) . - p.678-678 Titre : Letter to the editor Type de document : texte imprimé Auteurs : Brenda FINUCANE, Auteur ; Scott M. MYERS, Auteur ; Thomas D. CHALLMAN, Auteur ; Christa Lese MARTIN, Auteur ; David H. LEDBETTER, Auteur Article en page(s) : p.678-678 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.2921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Letter to the editor [texte imprimé] / Brenda FINUCANE, Auteur ; Scott M. MYERS, Auteur ; Thomas D. CHALLMAN, Auteur ; Christa Lese MARTIN, Auteur ; David H. LEDBETTER, Auteur . - p.678-678. Langues : Anglais (eng) in Autism Research > 16-4 (April 2023) . - p.678-678 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.2921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

MED13L-related disorder characterized by severe motor speech impairment / Marissa W. MITCHEL in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : MED13L-related disorder characterized by severe motor speech impairment Type de document : texte imprimé Auteurs : Marissa W. MITCHEL, Auteur ; Stefanie TURNER, Auteur ; Lauren K. WALSH, Auteur ; Rebecca I. TORENE, Auteur ; Scott M. MYERS, Auteur ; Cora M. TAYLOR, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Male  Female  Adolescent  Cross-Sectional Studies  Child, Preschool  Young Adult  Mediator Complex/genetics  Intellectual Disability/genetics/physiopathology  Speech Disorders/genetics/physiopathology  Dysarthria/physiopathology/genetics  Med13l  Apraxia of speech  Dysarthria  Motor impairment  Speech disorders  consent for study participation was obtained from all participants or their legal  representatives. Ethics approval for this study was obtained from the Geisinger  Institutional Review Board (#00008345) under protocol #2013–0446. This research  was conducted in accordance with the Declaration of Helsinki. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: MED13L-related disorder is associated with intellectual disability, motor delay, and speech deficits. Previous studies have focused on broad clinical descriptions of individuals, but limited information regarding specific speech diagnoses and results of direct testing has been published to date. We conducted deep phenotyping to characterize the speech, language, motor, cognitive, and adaptive phenotypes of individuals with MED13L-related disorder. METHODS: In this cross-sectional study, we administered standardized articulation, language, motor, and cognitive testing to 17 children and adolescents (mean age 9y 9m; SD 4y 5m; range 4y 2m to 19y 7m). In-person testing was supplemented with broad developmental, medical, and behavioral information collected virtually from a cohort of 67 individuals. RESULTS: All individuals who completed in-person articulation testing met diagnostic criteria for speech apraxia, dysarthria, or both. Language impairment was present in all of the in-person cohort and reported for almost all (97%) of the virtual cohort. Those who were able to complete motor testing demonstrated significant deficits in visual motor integration (mean 57.08, SD 9.26). Full scale IQs fell in the borderline to intellectual disability range, consistent with reported cognitive impairment in 97% of the virtual cohort. Notable medical features included hypotonia (83%), vision problems (72%), recurrent otitis media (58%), gastrointestinal problems (57%), and seizures (31%). CONCLUSIONS: MED13L-related disorder is characterized by a high rate of motor speech disorders that occur in the context of globally impaired motor, language, and cognitive skills. Children would benefit from early referrals to speech therapy to assess their speech, language, and support needs. En ligne : https://dx.doi.org/10.1186/s11689-025-09645-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] MED13L-related disorder characterized by severe motor speech impairment [texte imprimé] / Marissa W. MITCHEL, Auteur ; Stefanie TURNER, Auteur ; Lauren K. WALSH, Auteur ; Rebecca I. TORENE, Auteur ; Scott M. MYERS, Auteur ; Cora M. TAYLOR, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Child  Male  Female  Adolescent  Cross-Sectional Studies  Child, Preschool  Young Adult  Mediator Complex/genetics  Intellectual Disability/genetics/physiopathology  Speech Disorders/genetics/physiopathology  Dysarthria/physiopathology/genetics  Med13l  Apraxia of speech  Dysarthria  Motor impairment  Speech disorders  consent for study participation was obtained from all participants or their legal  representatives. Ethics approval for this study was obtained from the Geisinger  Institutional Review Board (#00008345) under protocol #2013–0446. This research  was conducted in accordance with the Declaration of Helsinki. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: MED13L-related disorder is associated with intellectual disability, motor delay, and speech deficits. Previous studies have focused on broad clinical descriptions of individuals, but limited information regarding specific speech diagnoses and results of direct testing has been published to date. We conducted deep phenotyping to characterize the speech, language, motor, cognitive, and adaptive phenotypes of individuals with MED13L-related disorder. METHODS: In this cross-sectional study, we administered standardized articulation, language, motor, and cognitive testing to 17 children and adolescents (mean age 9y 9m; SD 4y 5m; range 4y 2m to 19y 7m). In-person testing was supplemented with broad developmental, medical, and behavioral information collected virtually from a cohort of 67 individuals. RESULTS: All individuals who completed in-person articulation testing met diagnostic criteria for speech apraxia, dysarthria, or both. Language impairment was present in all of the in-person cohort and reported for almost all (97%) of the virtual cohort. Those who were able to complete motor testing demonstrated significant deficits in visual motor integration (mean 57.08, SD 9.26). Full scale IQs fell in the borderline to intellectual disability range, consistent with reported cognitive impairment in 97% of the virtual cohort. Notable medical features included hypotonia (83%), vision problems (72%), recurrent otitis media (58%), gastrointestinal problems (57%), and seizures (31%). CONCLUSIONS: MED13L-related disorder is characterized by a high rate of motor speech disorders that occur in the context of globally impaired motor, language, and cognitive skills. Children would benefit from early referrals to speech therapy to assess their speech, language, and support needs. En ligne : https://dx.doi.org/10.1186/s11689-025-09645-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Psychopharmacologic Approaches to Challenging Behaviors in Individuals with Autism / Scott M. MYERS

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Within-task variability on standardized language tests predicts autism spectrum disorder: a pilot study of the Response Dispersion Index / Abby E. HARE-HARRIS in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

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