Brief Report: Differences in Multisensory Integration Covary with Sensory Responsiveness in Children with and without Autism Spectrum Disorder / J. I. FELDMAN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.397-403 Titre : Brief Report: Differences in Multisensory Integration Covary with Sensory Responsiveness in Children with and without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. I. FELDMAN, Auteur ; W. KUANG, Auteur ; J. G. CONRAD, Auteur ; A. TU, Auteur ; P. SANTAPURAM, Auteur ; D. M. SIMON, Auteur ; J. H. FOSS-FEIG, Auteur ; L. D. KWAKYE, Auteur ; R. A. STEVENSON, Auteur ; Mark T. WALLACE, Auteur ; Tiffany G. WOYNAROSKI, Auteur Article en page(s) : p.397-403 Langues : Anglais (eng) Mots-clés : Audiovisual  Autism  Multisensory integration  Sensory  Speech perception  Temporal binding Index. décimale : PER Périodiques Résumé : Research shows that children with autism spectrum disorder (ASD) differ in their behavioral patterns of responding to sensory stimuli (i.e., sensory responsiveness) and in various other aspects of sensory functioning relative to typical peers. This study explored relations between measures of sensory responsiveness and multisensory speech perception and integration in children with and without ASD. Participants were 8-17 year old children, 18 with ASD and 18 matched typically developing controls. Participants completed a psychophysical speech perception task, and parents reported on children's sensory responsiveness. Psychophysical measures (e.g., audiovisual accuracy, temporal binding window) were associated with patterns of sensory responsiveness (e.g., hyporesponsiveness, sensory seeking). Results indicate that differences in multisensory speech perception and integration covary with atypical patterns of sensory responsiveness. En ligne : http://dx.doi.org/10.1007/s10803-018-3667-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Differences in Multisensory Integration Covary with Sensory Responsiveness in Children with and without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. I. FELDMAN, Auteur ; W. KUANG, Auteur ; J. G. CONRAD, Auteur ; A. TU, Auteur ; P. SANTAPURAM, Auteur ; D. M. SIMON, Auteur ; J. H. FOSS-FEIG, Auteur ; L. D. KWAKYE, Auteur ; R. A. STEVENSON, Auteur ; Mark T. WALLACE, Auteur ; Tiffany G. WOYNAROSKI, Auteur . - p.397-403. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.397-403 Mots-clés : Audiovisual  Autism  Multisensory integration  Sensory  Speech perception  Temporal binding Index. décimale : PER Périodiques Résumé : Research shows that children with autism spectrum disorder (ASD) differ in their behavioral patterns of responding to sensory stimuli (i.e., sensory responsiveness) and in various other aspects of sensory functioning relative to typical peers. This study explored relations between measures of sensory responsiveness and multisensory speech perception and integration in children with and without ASD. Participants were 8-17 year old children, 18 with ASD and 18 matched typically developing controls. Participants completed a psychophysical speech perception task, and parents reported on children's sensory responsiveness. Psychophysical measures (e.g., audiovisual accuracy, temporal binding window) were associated with patterns of sensory responsiveness (e.g., hyporesponsiveness, sensory seeking). Results indicate that differences in multisensory speech perception and integration covary with atypical patterns of sensory responsiveness. En ligne : http://dx.doi.org/10.1007/s10803-018-3667-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder / Kaela E. SCOTT in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1322-1331 Titre : Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kaela E. SCOTT, Auteur ; S. E. SCHULZ, Auteur ; D. MOEHRLE, Auteur ; Brian L. ALLMAN, Auteur ; Janis ORAM CARDY, Auteur ; R. A. STEVENSON, Auteur ; S. SCHMID, Auteur Article en page(s) : p.1322-1331 Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder  Cognition  Evoked Potentials  Humans  Mice  Perception  Sensation  auditory processing  experimental design  framework  sensory phenotypes  species translation Index. décimale : PER Périodiques Résumé : The study of sensory phenotypes has great potential for increasing research translation between species, a necessity to decipher the neural mechanisms that contribute to higher-order differences in neurological conditions such as autism spectrum disorder (ASD). Over the past decade, despite separate advances in our understanding of the structural and functional differences within the brain of autistic and non-autistic individuals and in rodent models for ASD, researchers have had difficulty translating the findings in murine species to humans, mostly due to incompatibility in experimental methodologies used to screen for ASD phenotypes. Focusing on sensory phenotypes offers an avenue to close the species gap because sensory pathways are highly conserved across species and are affected by the same risk-factors as the higher-order brain areas mostly responsible for the diagnostic criteria for ASD. By first reviewing how sensory processing has been studied to date, we direct our focus to electrophysiological and behavioral techniques that can be used to study sensory phenotypes consistently across species. Using auditory sensory phenotypes as a template, we seek to improve the accessibility of translational methods by providing a framework for collecting cohesive data in both rodents and humans. Specifically, evoked-potentials, acoustic startle paradigms, and psychophysical detection/discrimination paradigms can be created and implemented in a coordinated and systematic fashion across species. Through careful protocol design and collaboration, sensory processing phenotypes can be harnessed to bridge the gap that exists between preclinical animal studies and human testing, so that mutually held questions in autism research can be answered. LAY SUMMARY: It has always been difficult to relate results from animal research to humans. We try to close this gap by studying changes in sensory processing using careful protocol design and collaboration between clinicians and researchers. Sensory pathways are comparable between animals and humans, and are affected in the same way as the rest of the brain in ASD. Using changes in hearing as a template, we point the field in an innovative direction by providing a framework for collecting cohesive data in rodents and humans. En ligne : http://dx.doi.org/10.1002/aur.2533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder [Texte imprimé et/ou numérique] / Kaela E. SCOTT, Auteur ; S. E. SCHULZ, Auteur ; D. MOEHRLE, Auteur ; Brian L. ALLMAN, Auteur ; Janis ORAM CARDY, Auteur ; R. A. STEVENSON, Auteur ; S. SCHMID, Auteur . - p.1322-1331. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1322-1331 Mots-clés : Animals  Autism Spectrum Disorder  Cognition  Evoked Potentials  Humans  Mice  Perception  Sensation  auditory processing  experimental design  framework  sensory phenotypes  species translation Index. décimale : PER Périodiques Résumé : The study of sensory phenotypes has great potential for increasing research translation between species, a necessity to decipher the neural mechanisms that contribute to higher-order differences in neurological conditions such as autism spectrum disorder (ASD). Over the past decade, despite separate advances in our understanding of the structural and functional differences within the brain of autistic and non-autistic individuals and in rodent models for ASD, researchers have had difficulty translating the findings in murine species to humans, mostly due to incompatibility in experimental methodologies used to screen for ASD phenotypes. Focusing on sensory phenotypes offers an avenue to close the species gap because sensory pathways are highly conserved across species and are affected by the same risk-factors as the higher-order brain areas mostly responsible for the diagnostic criteria for ASD. By first reviewing how sensory processing has been studied to date, we direct our focus to electrophysiological and behavioral techniques that can be used to study sensory phenotypes consistently across species. Using auditory sensory phenotypes as a template, we seek to improve the accessibility of translational methods by providing a framework for collecting cohesive data in both rodents and humans. Specifically, evoked-potentials, acoustic startle paradigms, and psychophysical detection/discrimination paradigms can be created and implemented in a coordinated and systematic fashion across species. Through careful protocol design and collaboration, sensory processing phenotypes can be harnessed to bridge the gap that exists between preclinical animal studies and human testing, so that mutually held questions in autism research can be answered. LAY SUMMARY: It has always been difficult to relate results from animal research to humans. We try to close this gap by studying changes in sensory processing using careful protocol design and collaboration between clinicians and researchers. Sensory pathways are comparable between animals and humans, and are affected in the same way as the rest of the brain in ASD. Using changes in hearing as a template, we point the field in an innovative direction by providing a framework for collecting cohesive data in rodents and humans. En ligne : http://dx.doi.org/10.1002/aur.2533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Convergent Validity of Behavioural and Subjective Sensitivity in Relation to Autistic Traits / S. E. SCHULZ in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.758-770 Titre : Convergent Validity of Behavioural and Subjective Sensitivity in Relation to Autistic Traits Type de document : Texte imprimé et/ou numérique Auteurs : S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.758-770 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Humans  Sensation  Surveys and Questionnaires  Visual Perception  Autism spectrum disorder  Autistic traits  Sensory processing  Sensory reactivity  Sensory sensitivity Index. décimale : PER Périodiques Résumé : Sensory issues are highly prevalent in autism and previous findings support a relationship between questionnaires of sensitivity and autistic symptoms and traits, whereas studies that examine this relationship through behavioural assessments of sensitivity are less consistent. The current study explores these differences and suggests that behavioural thresholds for sensitivity and subjective sensitivity are distinct constructs. One hundred and eighteen adults completed a visual and auditory detection task and questionnaires on sensory processing and autistic traits. Visual thresholds and subjective visual sensitivity were not correlated, but both were related to autistic traits. Auditory thresholds and subjective auditory sensitivity were also unrelated. Overall, sensitivity is highly associated with autistic traits, however, behavioural and questionnaire assessments lack convergent validity and therefore, likely assess distinct constructs. En ligne : http://dx.doi.org/10.1007/s10803-021-04974-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Convergent Validity of Behavioural and Subjective Sensitivity in Relation to Autistic Traits [Texte imprimé et/ou numérique] / S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur . - p.758-770. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.758-770 Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Humans  Sensation  Surveys and Questionnaires  Visual Perception  Autism spectrum disorder  Autistic traits  Sensory processing  Sensory reactivity  Sensory sensitivity Index. décimale : PER Périodiques Résumé : Sensory issues are highly prevalent in autism and previous findings support a relationship between questionnaires of sensitivity and autistic symptoms and traits, whereas studies that examine this relationship through behavioural assessments of sensitivity are less consistent. The current study explores these differences and suggests that behavioural thresholds for sensitivity and subjective sensitivity are distinct constructs. One hundred and eighteen adults completed a visual and auditory detection task and questionnaires on sensory processing and autistic traits. Visual thresholds and subjective visual sensitivity were not correlated, but both were related to autistic traits. Auditory thresholds and subjective auditory sensitivity were also unrelated. Overall, sensitivity is highly associated with autistic traits, however, behavioural and questionnaire assessments lack convergent validity and therefore, likely assess distinct constructs. En ligne : http://dx.doi.org/10.1007/s10803-021-04974-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Differentiating between sensory sensitivity and sensory reactivity in relation to restricted interests and repetitive behaviours / S. E. SCHULZ in Autism, 24-1 (January 2020)  

Public ISBD [article]  inAutism > 24-1 (January 2020) . - p.121-134 Titre : Differentiating between sensory sensitivity and sensory reactivity in relation to restricted interests and repetitive behaviours Type de document : Texte imprimé et/ou numérique Auteurs : S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.121-134 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorders  behavioural measurement  reactivity  repetitive behaviours and interests  sensitivity  sensory impairments Index. décimale : PER Périodiques Résumé : Recent studies have suggested that individuals who exhibit heightened sensitivity also exhibit higher rates and severity of restricted interests and repetitive behaviours. This line of research has been conducted almost exclusively through caregiver reports of sensitivity. Here, a more rigorous psychophysics paradigm was applied to assess sensory sensitivity and relate hypersensitivity to restricted interests and repetitive behaviours. In addition, commonly used questionnaire measures of sensory sensitivity were collected to determine if self-reported measures accurately reflect behavioural measures of sensory sensitivity. In all, 90 typically developing participants completed a visual detection task, a questionnaire measure of sensory processing and a measure of restricted interests and repetitive behaviours. Visual sensitivity, measured both behaviourally and with questionnaires, is positively related to restricted interests and repetitive behaviours. Surprisingly, visual sensitivity as measured behaviourally and through self-report are unrelated. Furthermore, a regression analysis suggests that while restricted interests and repetitive behaviours can be predicted based on both behavioural and self-reported sensitivity, these two predictors account for different portions of the variance in restricted interests and repetitive behaviours. Thus, while these results provide evidence supporting the contribution of sensory sensitivity to restricted interests and repetitive behaviours, these results also indicate that behavioural and questionnaire measures of sensory sensitivity are measuring two distinct constructs. We hypothesize that behavioural measures are measuring sensory sensitivity, while questionnaires measures are in fact measuring sensory reactivity. En ligne : http://dx.doi.org/10.1177/1362361319850402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Differentiating between sensory sensitivity and sensory reactivity in relation to restricted interests and repetitive behaviours [Texte imprimé et/ou numérique] / S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur . - p.121-134. Langues : Anglais (eng) in Autism > 24-1 (January 2020) . - p.121-134 Mots-clés : adults  autism spectrum disorders  behavioural measurement  reactivity  repetitive behaviours and interests  sensitivity  sensory impairments Index. décimale : PER Périodiques Résumé : Recent studies have suggested that individuals who exhibit heightened sensitivity also exhibit higher rates and severity of restricted interests and repetitive behaviours. This line of research has been conducted almost exclusively through caregiver reports of sensitivity. Here, a more rigorous psychophysics paradigm was applied to assess sensory sensitivity and relate hypersensitivity to restricted interests and repetitive behaviours. In addition, commonly used questionnaire measures of sensory sensitivity were collected to determine if self-reported measures accurately reflect behavioural measures of sensory sensitivity. In all, 90 typically developing participants completed a visual detection task, a questionnaire measure of sensory processing and a measure of restricted interests and repetitive behaviours. Visual sensitivity, measured both behaviourally and with questionnaires, is positively related to restricted interests and repetitive behaviours. Surprisingly, visual sensitivity as measured behaviourally and through self-report are unrelated. Furthermore, a regression analysis suggests that while restricted interests and repetitive behaviours can be predicted based on both behavioural and self-reported sensitivity, these two predictors account for different portions of the variance in restricted interests and repetitive behaviours. Thus, while these results provide evidence supporting the contribution of sensory sensitivity to restricted interests and repetitive behaviours, these results also indicate that behavioural and questionnaire measures of sensory sensitivity are measuring two distinct constructs. We hypothesize that behavioural measures are measuring sensory sensitivity, while questionnaires measures are in fact measuring sensory reactivity. En ligne : http://dx.doi.org/10.1177/1362361319850402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

Exploring sensory phenotypes in autism spectrum disorder / N. E. SCHEERER in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 67 p. Titre : Exploring sensory phenotypes in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : N. E. SCHEERER, Auteur ; K. CURCIN, Auteur ; B. STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; E. KELLEY, Auteur ; S. GEORGIADES, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : ADHD traits  Adaptive behaviour  Autism spectrum disorder  Cluster analysis  OCD traits  Restrictive and repetitive behaviours  Sensory phenotypes  Sensory processing  Social communication  have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical reactions to the sensory environment are often reported in autistic individuals, with a high degree of variability across the sensory modalities. These sensory differences have been shown to promote challenging behaviours and distress in autistic individuals and are predictive of other functions including motor, social, and cognitive abilities. Preliminary research suggests that specific sensory differences may cluster together within individuals creating discrete sensory phenotypes. However, the manner in which these sensory differences cluster, and whether the resulting phenotypes are associated with specific cognitive and social challenges is unclear. METHODS: Short sensory profile data from 599 autistic children and adults between the ages of 1 and 21 years were subjected to a K-means cluster analysis. Analysis of variances compared age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder across the resultant clusters. RESULTS: A five-cluster model was found to minimize error variance and produce five sensory phenotypes: (1) sensory adaptive, (2) generalized sensory differences, (3) taste and smell sensitivity, (4) under-responsive and sensation seeking, and (5) movement difficulties with low energy. Age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder were found to differ significantly across the five phenotypes. LIMITATIONS: The results were based on parent-report measures of sensory processing, adaptive behaviour, traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder, which may limit the generalizability of the findings. Further, not all measures are standardized, or psychometrically validated with an autism population. Autistic individuals with an intellectual disability were underrepresented in this sample. Further, as these data were obtained from established records from a large provincial database, not all measures were completed for all individuals. CONCLUSIONS: These findings suggest that sensory difficulties in autistic individuals can be clustered into sensory phenotypes, and that these phenotypes are associated with behavioural differences. Given the large degree of heterogeneity in sensory difficulties seen in the autistic population, these sensory phenotypes represent an effective way to parse that heterogeneity and create phenotypes that may aid in the development of effective treatments and interventions for sensory difficulties. En ligne : http://dx.doi.org/10.1186/s13229-021-00471-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Exploring sensory phenotypes in autism spectrum disorder [Texte imprimé et/ou numérique] / N. E. SCHEERER, Auteur ; K. CURCIN, Auteur ; B. STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; E. KELLEY, Auteur ; S. GEORGIADES, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 67 p. Mots-clés : ADHD traits  Adaptive behaviour  Autism spectrum disorder  Cluster analysis  OCD traits  Restrictive and repetitive behaviours  Sensory phenotypes  Sensory processing  Social communication  have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical reactions to the sensory environment are often reported in autistic individuals, with a high degree of variability across the sensory modalities. These sensory differences have been shown to promote challenging behaviours and distress in autistic individuals and are predictive of other functions including motor, social, and cognitive abilities. Preliminary research suggests that specific sensory differences may cluster together within individuals creating discrete sensory phenotypes. However, the manner in which these sensory differences cluster, and whether the resulting phenotypes are associated with specific cognitive and social challenges is unclear. METHODS: Short sensory profile data from 599 autistic children and adults between the ages of 1 and 21 years were subjected to a K-means cluster analysis. Analysis of variances compared age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder across the resultant clusters. RESULTS: A five-cluster model was found to minimize error variance and produce five sensory phenotypes: (1) sensory adaptive, (2) generalized sensory differences, (3) taste and smell sensitivity, (4) under-responsive and sensation seeking, and (5) movement difficulties with low energy. Age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder were found to differ significantly across the five phenotypes. LIMITATIONS: The results were based on parent-report measures of sensory processing, adaptive behaviour, traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder, which may limit the generalizability of the findings. Further, not all measures are standardized, or psychometrically validated with an autism population. Autistic individuals with an intellectual disability were underrepresented in this sample. Further, as these data were obtained from established records from a large provincial database, not all measures were completed for all individuals. CONCLUSIONS: These findings suggest that sensory difficulties in autistic individuals can be clustered into sensory phenotypes, and that these phenotypes are associated with behavioural differences. Given the large degree of heterogeneity in sensory difficulties seen in the autistic population, these sensory phenotypes represent an effective way to parse that heterogeneity and create phenotypes that may aid in the development of effective treatments and interventions for sensory difficulties. En ligne : http://dx.doi.org/10.1186/s13229-021-00471-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder / N. J. BRIERLEY in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Permalink

Seeing the Forest and the Trees: Default Local Processing in Individuals with High Autistic Traits Does Not Come at the Expense of Global Attention / R. A. STEVENSON in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Permalink

Sensory hypersensitivity predicts repetitive behaviours in autistic and typically-developing children / S. E. SCHULZ in Autism, 23-4 (May 2019)  

Permalink

The cascading influence of multisensory processing on speech perception in autism / R. A. STEVENSON in Autism, 22-5 (July 2018)  

Permalink

---

1 (1 - 9 / 9)