Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study / Alexandra HAVDAHL in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1070-1078 Titre : Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study Type de document : texte imprimé Auteurs : Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; Synnve SCHJØLBERG, Auteur ; Anne-Siri ØYEN, Auteur ; PÃ¥l SUREN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Per MAGNUS, Auteur ; Michaeline BRESNAHAN, Auteur ; Mady HORNIG, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Catherine LORD, Auteur ; Camilla STOLTENBERG, Auteur ; Audrey THURM, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.1070-1078 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Child  Cohort Studies  Humans  Intellectual Disability/epidemiology  Neurodevelopmental Disorders/epidemiology  Walking  Intellectual disability  MoBa  epidemiology  gross motor milestones  late walking  All profits from their research are donated to charity. The other authors report no  conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. OBJECTIVE: To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). METHODS: Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. RESULTS: The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, χ(2)  = 13.93, p = .0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio = 0.79, 95% CI: 0.78-0.85) in the NDD group compared to 8% (hazard ratio = 0.92, 95% CI: 0.86-0.98) in the ASD group. CONCLUSIONS: The finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs. En ligne : http://dx.doi.org/10.1111/jcpp.13369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study [texte imprimé] / Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; Synnve SCHJØLBERG, Auteur ; Anne-Siri ØYEN, Auteur ; PÃ¥l SUREN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Per MAGNUS, Auteur ; Michaeline BRESNAHAN, Auteur ; Mady HORNIG, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Catherine LORD, Auteur ; Camilla STOLTENBERG, Auteur ; Audrey THURM, Auteur ; Somer L. BISHOP, Auteur . - p.1070-1078. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1070-1078 Mots-clés : Autism Spectrum Disorder/epidemiology  Child  Cohort Studies  Humans  Intellectual Disability/epidemiology  Neurodevelopmental Disorders/epidemiology  Walking  Intellectual disability  MoBa  epidemiology  gross motor milestones  late walking  All profits from their research are donated to charity. The other authors report no  conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. OBJECTIVE: To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). METHODS: Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. RESULTS: The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, χ(2)  = 13.93, p = .0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio = 0.79, 95% CI: 0.78-0.85) in the NDD group compared to 8% (hazard ratio = 0.92, 95% CI: 0.86-0.98) in the ASD group. CONCLUSIONS: The finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs. En ligne : http://dx.doi.org/10.1111/jcpp.13369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study / Alexandra HAVDAHL in Journal of Child Psychology and Psychiatry, 65-5 (May 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.610-619 Titre : Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study Type de document : texte imprimé Auteurs : Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; PÃ¥l SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Per MAGNUS, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur ; Somer L. BISHOP, Auteur ; Audrey THURM, Auteur Article en page(s) : p.610-619 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Delays and loss of early-emerging social-communication skills are often discussed as unique to autism. However, most studies of regression have relied on retrospective recall and clinical samples. Here, we examine attainment and loss of social-communication skills in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa). Methods Mothers rated their child's attainment of 10 early-emerging social-communication skills at ages 18 and 36 months (N = 40,613, 50.9% male). Prospectively reported loss was defined as skill presence at 18 months but absence at 36 months. At 36 months, mothers also recalled whether the child had lost social-communication skills. The Norwegian Patient Registry was used to capture diagnoses of Autism Spectrum Disorder (autism) and other neurodevelopmental disabilities (NDDs). Results Delay in at least one skill was observed in 14% of the sample and loss in 5.4%. Recalled loss of social-communication skills was rare (0.86%) and showed low convergence with prospectively reported loss. Delay and especially loss were associated with elevated odds of an autism diagnosis (n = 383) versus no autism diagnosis (n = 40,230; 3 skills delayed: OR = 7.09[4.15,12.11]; 3 skills lost: OR = 30.66[17.30,54.33]). They were also associated with an increased likelihood of autism compared to some other NDDs. Delay (relative risk [RR] = 4.16[2.08, 8.33]) and loss (RR = 10.00[3.70, 25.00]) associated with increased likelihood of autism versus ADHD, and loss (RR = 4.35[1.28,14.29]), but not delay (RR = 2.00[0.78,5.26]), associated with increased likelihood of autism compared to language disability. Conversely, delay conferred decreased likelihood of autism versus intellectual disability (RR = 0.11[0.06,0.21]), and loss was not reliably associated with likelihood of autism versus intellectual disability (RR = 1.89[0.44,8.33]). Conclusions This population-based study suggests that loss of early social communication skills is more common than studies using retrospective reports have indicated and is observed across several NDD diagnoses (not just autism). Nevertheless, most children with NDD diagnoses showed no reported delay or loss in these prospectively measured skills. En ligne : https://doi.org/10.1111/jcpp.13792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study [texte imprimé] / Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; PÃ¥l SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Per MAGNUS, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur ; Somer L. BISHOP, Auteur ; Audrey THURM, Auteur . - p.610-619. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.610-619 Index. décimale : PER Périodiques Résumé : Background Delays and loss of early-emerging social-communication skills are often discussed as unique to autism. However, most studies of regression have relied on retrospective recall and clinical samples. Here, we examine attainment and loss of social-communication skills in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa). Methods Mothers rated their child's attainment of 10 early-emerging social-communication skills at ages 18 and 36 months (N = 40,613, 50.9% male). Prospectively reported loss was defined as skill presence at 18 months but absence at 36 months. At 36 months, mothers also recalled whether the child had lost social-communication skills. The Norwegian Patient Registry was used to capture diagnoses of Autism Spectrum Disorder (autism) and other neurodevelopmental disabilities (NDDs). Results Delay in at least one skill was observed in 14% of the sample and loss in 5.4%. Recalled loss of social-communication skills was rare (0.86%) and showed low convergence with prospectively reported loss. Delay and especially loss were associated with elevated odds of an autism diagnosis (n = 383) versus no autism diagnosis (n = 40,230; 3 skills delayed: OR = 7.09[4.15,12.11]; 3 skills lost: OR = 30.66[17.30,54.33]). They were also associated with an increased likelihood of autism compared to some other NDDs. Delay (relative risk [RR] = 4.16[2.08, 8.33]) and loss (RR = 10.00[3.70, 25.00]) associated with increased likelihood of autism versus ADHD, and loss (RR = 4.35[1.28,14.29]), but not delay (RR = 2.00[0.78,5.26]), associated with increased likelihood of autism compared to language disability. Conversely, delay conferred decreased likelihood of autism versus intellectual disability (RR = 0.11[0.06,0.21]), and loss was not reliably associated with likelihood of autism versus intellectual disability (RR = 1.89[0.44,8.33]). Conclusions This population-based study suggests that loss of early social communication skills is more common than studies using retrospective reports have indicated and is observed across several NDD diagnoses (not just autism). Nevertheless, most children with NDD diagnoses showed no reported delay or loss in these prospectively measured skills. En ligne : https://doi.org/10.1111/jcpp.13792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Childhood antecedents of being a cigarette smoker in early adulthood. The Finnish 'From a Boy to a Man'Study / Solja NIEMELA in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.341-353 Titre : Childhood antecedents of being a cigarette smoker in early adulthood. The Finnish 'From a Boy to a Man'Study Type de document : texte imprimé Auteurs : Solja NIEMELA, Auteur ; Irma MOILANEN, Auteur ; Kirsti KUMPULAINEN, Auteur ; Jorma PIHA, Auteur ; Hans HELENIUS, Auteur ; Ezra SUSSER, Auteur ; Andre SOURANDER, Auteur ; Daniel J. PILOWSKY, Auteur ; Fredrik ALMQVIST, Auteur ; Tuula TAMMINEN, Auteur Année de publication : 2009 Article en page(s) : p.341-353 Langues : Anglais (eng) Mots-clés : Smoking childhood risk-factor follow-up-studies epidemiology prediction Index. décimale : PER Périodiques Résumé : Objective: To identify childhood psychiatric symptoms as antecedents of cigarette smoking at age 18. Methods: In 1989, a general population sample of 2946 8-year-old boys born in Finland in 1981 was assessed using the Rutter's parent and teacher questionnaires, and the Child Depression Inventory. This birth cohort was followed up in 1999, when the subjects reported for their obligatory military service at age 18. Information about cigarette smoking frequency was obtained from 78% (n = 2307) of the boys attending the study in 1989. Results: Childhood hyperactivity and self-reported depressive symptoms correlated with moderate daily (1–10 cigarettes), and heavy daily (>10 cigarettes) smoking at age 18. Conduct problems correlated with heavy daily smoking. A high level of childhood depressive symptoms, particularly in conjunction with a low educational level of the father, increased the risk of daily smoking. Emotional problems decreased the risk of smoking at age 18. In general, teacher reports had a better predictive power than parent reports for subsequent smoking. Conclusion: Future developmental studies with special focus on interaction between individual and environmental factors are warranted to reveal the mechanisms underlying the association between childhood psychopathology and adult smoking. In particular, the associations between childhood depression and future smoking need more clarification. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01968.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719 [article] Childhood antecedents of being a cigarette smoker in early adulthood. The Finnish 'From a Boy to a Man'Study [texte imprimé] / Solja NIEMELA, Auteur ; Irma MOILANEN, Auteur ; Kirsti KUMPULAINEN, Auteur ; Jorma PIHA, Auteur ; Hans HELENIUS, Auteur ; Ezra SUSSER, Auteur ; Andre SOURANDER, Auteur ; Daniel J. PILOWSKY, Auteur ; Fredrik ALMQVIST, Auteur ; Tuula TAMMINEN, Auteur . - 2009 . - p.341-353. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.341-353 Mots-clés : Smoking childhood risk-factor follow-up-studies epidemiology prediction Index. décimale : PER Périodiques Résumé : Objective: To identify childhood psychiatric symptoms as antecedents of cigarette smoking at age 18. Methods: In 1989, a general population sample of 2946 8-year-old boys born in Finland in 1981 was assessed using the Rutter's parent and teacher questionnaires, and the Child Depression Inventory. This birth cohort was followed up in 1999, when the subjects reported for their obligatory military service at age 18. Information about cigarette smoking frequency was obtained from 78% (n = 2307) of the boys attending the study in 1989. Results: Childhood hyperactivity and self-reported depressive symptoms correlated with moderate daily (1–10 cigarettes), and heavy daily (>10 cigarettes) smoking at age 18. Conduct problems correlated with heavy daily smoking. A high level of childhood depressive symptoms, particularly in conjunction with a low educational level of the father, increased the risk of daily smoking. Emotional problems decreased the risk of smoking at age 18. In general, teacher reports had a better predictive power than parent reports for subsequent smoking. Conclusion: Future developmental studies with special focus on interaction between individual and environmental factors are warranted to reveal the mechanisms underlying the association between childhood psychopathology and adult smoking. In particular, the associations between childhood depression and future smoking need more clarification. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01968.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719

Prevalence of treated autism spectrum disorders in Aruba / Ingrid D.C. VAN BALKOM in Journal of Neurodevelopmental Disorders, 1-3 (September 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.197-204 Titre : Prevalence of treated autism spectrum disorders in Aruba Type de document : texte imprimé Auteurs : Ingrid D.C. VAN BALKOM, Auteur ; Michaeline BRESNAHAN, Auteur ; M.F. VOGTLANDER, Auteur ; Daphne VAN HOEKEN, Auteur ; Ruud B. MINDERAA, Auteur ; Ezra SUSSER, Auteur ; Hans W. HOEK, Auteur Article en page(s) : p.197-204 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : To study autism outside of a narrow range of settings previously studied, and in a particularly distinctive setting in the Caribbean. The aim of the Aruba Autism Project was to determine the prevalence of autism spectrum disorders (ASDs) in birth years 1990-1999 in Aruba. A record review study was conducted; cases were ascertained from children treated at the Child & Adolescent Psychiatry Clinic of Aruba, the first and only child psychiatry service on the island. In these 10 birth years we found a prevalence for autistic disorder (AD) of 1.9 per 1,000 (95% CI 1.2-2.8) and for autism spectrum disorders of 5.3 per 1,000 (95% CI 4.1-6.7). Comparison analysis with a cumulative incidence report from the UK, showed a similar cumulative incidence to age five in Aruba. Prevalence of ASDs in birth years 1990-1999 and cumulative incidence to age five in Aruba are similar to recent reports from the United Kingdom and the United States. En ligne : http://dx.doi.org/10.1007/s11689-009-9011-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Prevalence of treated autism spectrum disorders in Aruba [texte imprimé] / Ingrid D.C. VAN BALKOM, Auteur ; Michaeline BRESNAHAN, Auteur ; M.F. VOGTLANDER, Auteur ; Daphne VAN HOEKEN, Auteur ; Ruud B. MINDERAA, Auteur ; Ezra SUSSER, Auteur ; Hans W. HOEK, Auteur . - p.197-204. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.197-204 Index. décimale : PER Périodiques Résumé : To study autism outside of a narrow range of settings previously studied, and in a particularly distinctive setting in the Caribbean. The aim of the Aruba Autism Project was to determine the prevalence of autism spectrum disorders (ASDs) in birth years 1990-1999 in Aruba. A record review study was conducted; cases were ascertained from children treated at the Child & Adolescent Psychiatry Clinic of Aruba, the first and only child psychiatry service on the island. In these 10 birth years we found a prevalence for autistic disorder (AD) of 1.9 per 1,000 (95% CI 1.2-2.8) and for autism spectrum disorders of 5.3 per 1,000 (95% CI 4.1-6.7). Comparison analysis with a cumulative incidence report from the UK, showed a similar cumulative incidence to age five in Aruba. Prevalence of ASDs in birth years 1990-1999 and cumulative incidence to age five in Aruba are similar to recent reports from the United Kingdom and the United States. En ligne : http://dx.doi.org/10.1007/s11689-009-9011-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

The influence of parental concern on the utility of autism diagnostic instruments / Alexandra HAVDAHL in Autism Research, 10-10 (October 2017)  

Public ISBD [article]  inAutism Research > 10-10 (October 2017) . - p.1672-1686 Titre : The influence of parental concern on the utility of autism diagnostic instruments Type de document : texte imprimé Auteurs : Alexandra HAVDAHL, Auteur ; Somer L. BISHOP, Auteur ; PÃ¥l SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Catherine LORD, Auteur ; Andrew PICKLES, Auteur ; Stephen VON TETZCHNER, Auteur ; Synnve SCHJØLBERG, Auteur ; Nina GUNNES, Auteur ; Mady HORNIG, Auteur ; W. Ian LIPKIN, Auteur ; Ezra SUSSER, Auteur ; Michaeline BRESNAHAN, Auteur ; Per MAGNUS, Auteur ; Nina STENBERG, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur Article en page(s) : p.1672-1686 Langues : Anglais (eng) Mots-clés : Autism Diagnostic Interview-Revised  Autism Diagnostic Observation Schedule  early diagnosis  screening Index. décimale : PER Périodiques Résumé : The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35–47 months) from the Norwegian Mother and Child Cohort. We also examined whether parental concern about ASD influenced instrument performance, comparing toddlers identified based on parental ASD concern (n = 48) and parent-reported signs of developmental problems (screening) without a specific concern about ASD (n = 400). The ADOS cutoffs showed consistently well-balanced sensitivity and specificity. The ADI-R cutoffs demonstrated good specificity, but reduced sensitivity, missing 43% of toddlers whose parents were not specifically concerned about ASD. The ADI-R and ADOS dimensional scores agreed well with clinical diagnoses (area under the curve ≥ 0.85), contributing additively to their prediction. On the ADI-R, different cutoffs were needed according to presence or absence of parental ASD concern, in order to achieve comparable balance of sensitivity and specificity. These results highlight the importance of taking parental concern about ASD into account when interpreting scores from parental report-based instruments such as the ADI-R. While the ADOS cutoffs performed consistently well, the additive contributions of ADI-R and ADOS scores to the prediction of ASD diagnosis underscore the value of combining instruments based on parent accounts and clinician observation in evaluation of ASD. Autism Res 2017, 10: 1672–1686. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] The influence of parental concern on the utility of autism diagnostic instruments [texte imprimé] / Alexandra HAVDAHL, Auteur ; Somer L. BISHOP, Auteur ; PÃ¥l SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Catherine LORD, Auteur ; Andrew PICKLES, Auteur ; Stephen VON TETZCHNER, Auteur ; Synnve SCHJØLBERG, Auteur ; Nina GUNNES, Auteur ; Mady HORNIG, Auteur ; W. Ian LIPKIN, Auteur ; Ezra SUSSER, Auteur ; Michaeline BRESNAHAN, Auteur ; Per MAGNUS, Auteur ; Nina STENBERG, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur . - p.1672-1686. Langues : Anglais (eng) in Autism Research > 10-10 (October 2017) . - p.1672-1686 Mots-clés : Autism Diagnostic Interview-Revised  Autism Diagnostic Observation Schedule  early diagnosis  screening Index. décimale : PER Périodiques Résumé : The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35–47 months) from the Norwegian Mother and Child Cohort. We also examined whether parental concern about ASD influenced instrument performance, comparing toddlers identified based on parental ASD concern (n = 48) and parent-reported signs of developmental problems (screening) without a specific concern about ASD (n = 400). The ADOS cutoffs showed consistently well-balanced sensitivity and specificity. The ADI-R cutoffs demonstrated good specificity, but reduced sensitivity, missing 43% of toddlers whose parents were not specifically concerned about ASD. The ADI-R and ADOS dimensional scores agreed well with clinical diagnoses (area under the curve ≥ 0.85), contributing additively to their prediction. On the ADI-R, different cutoffs were needed according to presence or absence of parental ASD concern, in order to achieve comparable balance of sensitivity and specificity. These results highlight the importance of taking parental concern about ASD into account when interpreting scores from parental report-based instruments such as the ADI-R. While the ADOS cutoffs performed consistently well, the additive contributions of ADI-R and ADOS scores to the prediction of ASD diagnosis underscore the value of combining instruments based on parent accounts and clinician observation in evaluation of ASD. Autism Res 2017, 10: 1672–1686. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and Trends / Diana SCHENDEL in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

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