Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment / Sanne JENSEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Titre : Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment Type de document : texte imprimé Auteurs : Sanne JENSEN, Auteur ; Davíð R.M.A. HØJGAARD, Auteur ; Katja A. HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott N. COMPTON, Auteur ; Per Hove THOMSEN, Auteur Article en page(s) : p.969-978 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment [texte imprimé] / Sanne JENSEN, Auteur ; Davíð R.M.A. HØJGAARD, Auteur ; Katja A. HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott N. COMPTON, Auteur ; Per Hove THOMSEN, Auteur . - p.969-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Factors Associated with a Delayed Autism Spectrum Disorder Diagnosis in Children Previously Assessed on Suspicion of Autism / Sara Højslev AVLUND in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3843-3856 Titre : Factors Associated with a Delayed Autism Spectrum Disorder Diagnosis in Children Previously Assessed on Suspicion of Autism Type de document : texte imprimé Auteurs : Sara Højslev AVLUND, Auteur ; Per H. THOMSEN, Auteur ; Diana SCHENDEL, Auteur ; M. JØRGENSEN, Auteur ; A.H. CARLSEN, Auteur ; L. CLAUSEN, Auteur Article en page(s) : p.3843-3856 Langues : Anglais (eng) Mots-clés : Affect  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Early Diagnosis  Humans  Parents  Ados  Age at diagnosis  Autism spectrum disorder  Delayed diagnosis Index. décimale : PER Périodiques Résumé : This study aimed to investigate factors associated with a delayed autism spectrum (ASD) diagnosis when compared to children with either no or early ASD diagnosis. Among 893 children assessed for ASD before age 8, 39% had no ASD at baseline, of which 21% received a later ASD diagnosis. Autism symptoms, diagnostic history of other developmental disorders, cognitive ability, and socioeconomic factors were associated with delayed ASD. Autism Diagnostic Observation Schedule (ADOS) scores in delayed ASD fell between early and no ASD. Other developmental disorders, time and clinical trends like ADOS use and low parental education distinguished delayed and early ASD, whereas higher frequency of IQ < 70 at baseline and a diagnosis of emotional disorders during follow-up distinguished delayed and no ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04849-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Factors Associated with a Delayed Autism Spectrum Disorder Diagnosis in Children Previously Assessed on Suspicion of Autism [texte imprimé] / Sara Højslev AVLUND, Auteur ; Per H. THOMSEN, Auteur ; Diana SCHENDEL, Auteur ; M. JØRGENSEN, Auteur ; A.H. CARLSEN, Auteur ; L. CLAUSEN, Auteur . - p.3843-3856. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3843-3856 Mots-clés : Affect  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Early Diagnosis  Humans  Parents  Ados  Age at diagnosis  Autism spectrum disorder  Delayed diagnosis Index. décimale : PER Périodiques Résumé : This study aimed to investigate factors associated with a delayed autism spectrum (ASD) diagnosis when compared to children with either no or early ASD diagnosis. Among 893 children assessed for ASD before age 8, 39% had no ASD at baseline, of which 21% received a later ASD diagnosis. Autism symptoms, diagnostic history of other developmental disorders, cognitive ability, and socioeconomic factors were associated with delayed ASD. Autism Diagnostic Observation Schedule (ADOS) scores in delayed ASD fell between early and no ASD. Other developmental disorders, time and clinical trends like ADOS use and low parental education distinguished delayed and early ASD, whereas higher frequency of IQ < 70 at baseline and a diagnosis of emotional disorders during follow-up distinguished delayed and no ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04849-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Group Based Cognitive Behavioural Therapy for Anxiety in Children with Autism Spectrum Disorder: A Randomised Controlled Trial in a General Child Psychiatric Hospital Setting / Merete J. SØRENSEN ; Mikael THASTUM ; Ronald M. RAPEE ; Charlotte U. RASK ; Kristian ARENDT ; Anders H. CARLSEN ; Per H. THOMSEN in Journal of Autism and Developmental Disorders, 53-2 (February 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.525-538 Titre : Group Based Cognitive Behavioural Therapy for Anxiety in Children with Autism Spectrum Disorder: A Randomised Controlled Trial in a General Child Psychiatric Hospital Setting Type de document : texte imprimé Auteurs : Merete J. SØRENSEN, Auteur ; Mikael THASTUM, Auteur ; Ronald M. RAPEE, Auteur ; Charlotte U. RASK, Auteur ; Kristian ARENDT, Auteur ; Anders H. CARLSEN, Auteur ; Per H. THOMSEN, Auteur Article en page(s) : p.525-538 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Cognitive Behavioural Therapy (CBT) programs adapted to children with Autism Spectrum Disorder (ASD) effectively reduce anxiety when run in university clinics. Forty-nine children aged 8-14 years participated in a waitlist controlled study in a general child psychiatric hospital setting. Post-treatment 30% of the children were free of their primary anxiety diagnoses and 5% were free of all anxiety diagnoses. No statistically significant difference between the two trial conditions were found on primary outcomes. However, statistically significant differences were found on secondary outcomes indicating clinically meaningful treatment responses. Together with high program satisfaction this study shows the CBT program to be feasible and potentially efficacious in treating anxiety in children with ASD in a general child psychiatric hospital setting. En ligne : https://doi.org/10.1007/s10803-020-04471-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 [article] Group Based Cognitive Behavioural Therapy for Anxiety in Children with Autism Spectrum Disorder: A Randomised Controlled Trial in a General Child Psychiatric Hospital Setting [texte imprimé] / Merete J. SØRENSEN, Auteur ; Mikael THASTUM, Auteur ; Ronald M. RAPEE, Auteur ; Charlotte U. RASK, Auteur ; Kristian ARENDT, Auteur ; Anders H. CARLSEN, Auteur ; Per H. THOMSEN, Auteur . - p.525-538. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.525-538 Index. décimale : PER Périodiques Résumé : Cognitive Behavioural Therapy (CBT) programs adapted to children with Autism Spectrum Disorder (ASD) effectively reduce anxiety when run in university clinics. Forty-nine children aged 8-14 years participated in a waitlist controlled study in a general child psychiatric hospital setting. Post-treatment 30% of the children were free of their primary anxiety diagnoses and 5% were free of all anxiety diagnoses. No statistically significant difference between the two trial conditions were found on primary outcomes. However, statistically significant differences were found on secondary outcomes indicating clinically meaningful treatment responses. Together with high program satisfaction this study shows the CBT program to be feasible and potentially efficacious in treating anxiety in children with ASD in a general child psychiatric hospital setting. En ligne : https://doi.org/10.1007/s10803-020-04471-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495

How much impairment is required for ADHD? No evidence of a discrete threshold / T.W. ARILDSKOV in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.229-237 Titre : How much impairment is required for ADHD? No evidence of a discrete threshold Type de document : texte imprimé Auteurs : T.W. ARILDSKOV, Auteur ; Edmund J.S. SONUGA-BARKE, Auteur ; Per H. THOMSEN, Auteur ; A. VIRRING, Auteur ; S.D. ØSTERGAARD, Auteur Article en page(s) : p.229-237 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  continuity  diagnosis  schoolchildren  symptomatology Index. décimale : PER Périodiques Résumé : BACKGROUND: A diagnosis of attention-deficit/hyperactivity disorder (ADHD) requires the presence of impairment alongside symptoms above a specific frequency and severity threshold. However, the question of whether that symptom threshold represents anything more than an arbitrary cutoff on a continuum of impairment requires further empirical study. Therefore, we present the first study investigating if the relationship between ADHD symptom severity and functional impairment is nonlinear in a way that suggests a discrete, nonarbitrary symptom level threshold associated with a marked step increase in impairment. METHODS: Parent reports on the ADHD-Rating Scale (ADHD-RS-IV), the Weiss Functional Impairment Rating Scale (WFIRS-P), and the Strengths and Difficulties Questionnaire were collected in a general population sample of 1st, 2nd, and 3rd graders (N = 1,914-2,044). RESULTS: Piecewise linear regression analyses and nonlinear regression modeling both demonstrated that the relationship between symptom severity (ADHD-RS-IV total score) and impairment (WFIRS-P mean score) was characterized by a gradual linear increase in impairment with higher symptom severity and no apparent step increase or changing rate of increase in impairment at a certain high ADHD-RS-IV total score level. Controlling for socioeconomic status, sex, and co-occurring conduct and emotional symptoms did not alter these results, though comorbid symptoms had a significant effect on impairment. CONCLUSIONS: There was no clear evidence for a discrete, nonarbitrary symptom severity threshold with regard to impairment. The results highlight the continued need to consider both symptoms and impairment in the diagnosis of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13440 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] How much impairment is required for ADHD? No evidence of a discrete threshold [texte imprimé] / T.W. ARILDSKOV, Auteur ; Edmund J.S. SONUGA-BARKE, Auteur ; Per H. THOMSEN, Auteur ; A. VIRRING, Auteur ; S.D. ØSTERGAARD, Auteur . - p.229-237. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.229-237 Mots-clés : Attention-deficit/hyperactivity disorder  continuity  diagnosis  schoolchildren  symptomatology Index. décimale : PER Périodiques Résumé : BACKGROUND: A diagnosis of attention-deficit/hyperactivity disorder (ADHD) requires the presence of impairment alongside symptoms above a specific frequency and severity threshold. However, the question of whether that symptom threshold represents anything more than an arbitrary cutoff on a continuum of impairment requires further empirical study. Therefore, we present the first study investigating if the relationship between ADHD symptom severity and functional impairment is nonlinear in a way that suggests a discrete, nonarbitrary symptom level threshold associated with a marked step increase in impairment. METHODS: Parent reports on the ADHD-Rating Scale (ADHD-RS-IV), the Weiss Functional Impairment Rating Scale (WFIRS-P), and the Strengths and Difficulties Questionnaire were collected in a general population sample of 1st, 2nd, and 3rd graders (N = 1,914-2,044). RESULTS: Piecewise linear regression analyses and nonlinear regression modeling both demonstrated that the relationship between symptom severity (ADHD-RS-IV total score) and impairment (WFIRS-P mean score) was characterized by a gradual linear increase in impairment with higher symptom severity and no apparent step increase or changing rate of increase in impairment at a certain high ADHD-RS-IV total score level. Controlling for socioeconomic status, sex, and co-occurring conduct and emotional symptoms did not alter these results, though comorbid symptoms had a significant effect on impairment. CONCLUSIONS: There was no clear evidence for a discrete, nonarbitrary symptom severity threshold with regard to impairment. The results highlight the continued need to consider both symptoms and impairment in the diagnosis of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13440 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Promotive factors associated with reduced anxiety and depression across three years in a prospective clinical cohort of adolescents: Examining compensatory and protective models of resilience / Jan L. WALLANDER ; Stian LYDERSEN ; Per Hove THOMSEN ; Thomas JOZEFIAK in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1903-1918 Titre : Promotive factors associated with reduced anxiety and depression across three years in a prospective clinical cohort of adolescents: Examining compensatory and protective models of resilience Type de document : texte imprimé Auteurs : Jan L. WALLANDER, Auteur ; Stian LYDERSEN, Auteur ; Per Hove THOMSEN, Auteur ; Thomas JOZEFIAK, Auteur Article en page(s) : p.1903-1918 Langues : Anglais (eng) Mots-clés : Adolescence  anxiety  depression  longitudinal  psychological resilience Index. décimale : PER Périodiques Résumé : The rates of anxiety and depression increase across adolescence, many experience recurrence after treatment, yet longitudinal studies examining promotive factors are scarce. We prospectively examined the role of the promotive factors structured style, personal and social competencies, family functioning, and social resources in homotypic and heterotypic continuity and discontinuity of anxiety and depression across three years in a clinical sample. Participants were adolescents with anxiety or depressive disorders aged 13-18 years at T1 (N = 717, 44% initial participation rate) and aged 16-21 years at T2 (N = 549, 80% follow-up participation rate). At T1, diagnoses were collected from medical records and participants responded to questionnaires. At T2, semi-structured diagnostic interviews were conducted. Higher levels of all promotive factors were associated with reduced probability of anxiety or depression three years later. The promotive factors were not associated with homotypic continuity of anxiety, whereas personal competence beliefs, social competence, and, less strongly, family functioning were associated with reduced homotypic continuity of depression and heterotypic continuity from depression to anxiety. Analyses with interaction terms did not indicate moderation by the promotive factors. Our findings suggest that bolstering promotive factors may be vital for increasing treatment success and preventing recurrence of anxiety and depression in the transition toward adulthood. En ligne : https://dx.doi.org/10.1017/S0954579424001469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Promotive factors associated with reduced anxiety and depression across three years in a prospective clinical cohort of adolescents: Examining compensatory and protective models of resilience [texte imprimé] / Jan L. WALLANDER, Auteur ; Stian LYDERSEN, Auteur ; Per Hove THOMSEN, Auteur ; Thomas JOZEFIAK, Auteur . - p.1903-1918. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1903-1918 Mots-clés : Adolescence  anxiety  depression  longitudinal  psychological resilience Index. décimale : PER Périodiques Résumé : The rates of anxiety and depression increase across adolescence, many experience recurrence after treatment, yet longitudinal studies examining promotive factors are scarce. We prospectively examined the role of the promotive factors structured style, personal and social competencies, family functioning, and social resources in homotypic and heterotypic continuity and discontinuity of anxiety and depression across three years in a clinical sample. Participants were adolescents with anxiety or depressive disorders aged 13-18 years at T1 (N = 717, 44% initial participation rate) and aged 16-21 years at T2 (N = 549, 80% follow-up participation rate). At T1, diagnoses were collected from medical records and participants responded to questionnaires. At T2, semi-structured diagnostic interviews were conducted. Higher levels of all promotive factors were associated with reduced probability of anxiety or depression three years later. The promotive factors were not associated with homotypic continuity of anxiety, whereas personal competence beliefs, social competence, and, less strongly, family functioning were associated with reduced homotypic continuity of depression and heterotypic continuity from depression to anxiety. Analyses with interaction terms did not indicate moderation by the promotive factors. Our findings suggest that bolstering promotive factors may be vital for increasing treatment success and preventing recurrence of anxiety and depression in the transition toward adulthood. En ligne : https://dx.doi.org/10.1017/S0954579424001469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Time Trends in Diagnostics and Clinical Features of Young Children Referred on Suspicion of Autism: A Population-Based Clinical Cohort Study, 2000-2010 / Sara Højslev AVLUND in Journal of Autism and Developmental Disorders, 51-2 (February 2021)  

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Validating neuropsychological subtypes of ADHD: how do children with and without an executive function deficit differ? / Rikke LAMBEK in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)  

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