ADHD-related symptoms and attention profiles in the unaffected siblings of probands with autism spectrum disorder: focus on the subtypes of autism and Asperger's disorder / Yi-Ling CHIEN in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 37p. Titre : ADHD-related symptoms and attention profiles in the unaffected siblings of probands with autism spectrum disorder: focus on the subtypes of autism and Asperger's disorder Type de document : texte imprimé Auteurs : Yi-Ling CHIEN, Auteur ; Miao-Churn CHOU, Auteur ; Yen-Nan CHIU, Auteur ; W. J. CHOU, Auteur ; Y. Y. WU, Auteur ; W. C. TSAI, Auteur ; S. S. GAU, Auteur Article en page(s) : 37p. Langues : Anglais (eng) Mots-clés : Attention  Autism spectrum disorder  Continuous performance test  Endophenotype  Sibling Index. décimale : PER Périodiques Résumé : BACKGROUND: The presence of attention-deficit/hyperactive disorder (ADHD) symptoms and impaired attention performance are commonly noted in individuals with autism spectrum disorder (ASD). However, little is known about attention performance in their unaffected siblings. This study aimed to investigate the ADHD-related traits and attention performance in unaffected siblings of probands with autism and Asperger syndrome (AS), as well as the clinical correlates of ADHD-related traits. METHODS: We assessed the intention, hyperactivity-impulsivity, and oppositional symptoms, and attention profiles of 199 probands with a diagnosis of ASD (122 autism, 77 AS), their unaffected siblings, and 196 typically developing controls (TD) by their parents' reports on the ADHD-related symptoms and the Connors' Continuous Performance Test (CCPT), respectively. RESULTS: Compared to TD, unaffected siblings of ASD probands were more hyperactive/impulsive and oppositional, particularly unaffected siblings of AS probands. In CCPT, unaffected siblings of AS have intermediate levels of performance between probands with AS and TD on focused attention and sustained attention but were not statistically different from AS probands or TD in these attention profiles. In contrast, unaffected siblings of autism probands have significantly better CCPT performance when compared to autism probands but not to TD. In addition, stereotyped behaviors predicted ADHD-related traits in both sibling groups, but distinctive patterns of other correlates for ADHD-related traits were found between the two sibling groups. CONCLUSIONS: This work suggested that unaffected siblings of AS, but not autism, have more hyperactive/impulsive traits and a trend of pervasive attention deficits assessed by CCPT which might serve as potential endophenotypes for genetic studies in AS. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01582256. En ligne : http://dx.doi.org/10.1186/s13229-017-0153-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] ADHD-related symptoms and attention profiles in the unaffected siblings of probands with autism spectrum disorder: focus on the subtypes of autism and Asperger's disorder [texte imprimé] / Yi-Ling CHIEN, Auteur ; Miao-Churn CHOU, Auteur ; Yen-Nan CHIU, Auteur ; W. J. CHOU, Auteur ; Y. Y. WU, Auteur ; W. C. TSAI, Auteur ; S. S. GAU, Auteur . - 37p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 37p. Mots-clés : Attention  Autism spectrum disorder  Continuous performance test  Endophenotype  Sibling Index. décimale : PER Périodiques Résumé : BACKGROUND: The presence of attention-deficit/hyperactive disorder (ADHD) symptoms and impaired attention performance are commonly noted in individuals with autism spectrum disorder (ASD). However, little is known about attention performance in their unaffected siblings. This study aimed to investigate the ADHD-related traits and attention performance in unaffected siblings of probands with autism and Asperger syndrome (AS), as well as the clinical correlates of ADHD-related traits. METHODS: We assessed the intention, hyperactivity-impulsivity, and oppositional symptoms, and attention profiles of 199 probands with a diagnosis of ASD (122 autism, 77 AS), their unaffected siblings, and 196 typically developing controls (TD) by their parents' reports on the ADHD-related symptoms and the Connors' Continuous Performance Test (CCPT), respectively. RESULTS: Compared to TD, unaffected siblings of ASD probands were more hyperactive/impulsive and oppositional, particularly unaffected siblings of AS probands. In CCPT, unaffected siblings of AS have intermediate levels of performance between probands with AS and TD on focused attention and sustained attention but were not statistically different from AS probands or TD in these attention profiles. In contrast, unaffected siblings of autism probands have significantly better CCPT performance when compared to autism probands but not to TD. In addition, stereotyped behaviors predicted ADHD-related traits in both sibling groups, but distinctive patterns of other correlates for ADHD-related traits were found between the two sibling groups. CONCLUSIONS: This work suggested that unaffected siblings of AS, but not autism, have more hyperactive/impulsive traits and a trend of pervasive attention deficits assessed by CCPT which might serve as potential endophenotypes for genetic studies in AS. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01582256. En ligne : http://dx.doi.org/10.1186/s13229-017-0153-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Altered Structure–Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study / Yu-Chun LO in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.561-570 Titre : Altered Structure–Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study Type de document : texte imprimé Auteurs : Yu-Chun LO, Auteur ; Tai-Li CHOU, Auteur ; Li-Ying FAN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Yih Isaac TSENG, Auteur Année de publication : 2013 Article en page(s) : p.561-570 Langues : Anglais (eng) Mots-clés : autism  dual stream model  diffusion spectrum imaging  functional MRI  tractography Index. décimale : PER Périodiques Résumé : Deficits in language and communication are among the core symptoms of autism, a common neurodevelopmental disorder with long-term impairment. Despite the striking nature of the autistic language impairment, knowledge about its corresponding alterations in the brain is still evolving. We hypothesized that the dual stream language network is altered in autism, and that this alteration could be revealed by changes in the relationships between microstructural integrity and functional activation. The study recruited 20 right-handed male youths with autism and 20 carefully matched individually, typically developing (TD) youths. Microstructural integrity of the left dorsal and left ventral pathways responsible for language processing and the functional activation of the connected brain regions were investigated by using diffusion spectrum imaging and functional magnetic resonance imaging of a semantic task, respectively. Youths with autism had significantly poorer language function, and lower functional activation in left dorsal and left ventral regions of the language network, compared with TD youths. The TD group showed a significant correlation of the functional activation of the left dorsal region with microstructural integrity of the left ventral pathway, whereas the autism group showed a significant correlation of the functional activation of the left ventral region with microstructural integrity of the left dorsal pathway, and moreover verbal comprehension index was correlated with microstructural integrity of the left ventral pathway. These altered structure–function relationships in autism suggest possible involvement of the dual pathways in supporting deficient semantic processing. En ligne : http://dx.doi.org/10.1002/aur.1315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Altered Structure–Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study [texte imprimé] / Yu-Chun LO, Auteur ; Tai-Li CHOU, Auteur ; Li-Ying FAN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Yih Isaac TSENG, Auteur . - 2013 . - p.561-570. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.561-570 Mots-clés : autism  dual stream model  diffusion spectrum imaging  functional MRI  tractography Index. décimale : PER Périodiques Résumé : Deficits in language and communication are among the core symptoms of autism, a common neurodevelopmental disorder with long-term impairment. Despite the striking nature of the autistic language impairment, knowledge about its corresponding alterations in the brain is still evolving. We hypothesized that the dual stream language network is altered in autism, and that this alteration could be revealed by changes in the relationships between microstructural integrity and functional activation. The study recruited 20 right-handed male youths with autism and 20 carefully matched individually, typically developing (TD) youths. Microstructural integrity of the left dorsal and left ventral pathways responsible for language processing and the functional activation of the connected brain regions were investigated by using diffusion spectrum imaging and functional magnetic resonance imaging of a semantic task, respectively. Youths with autism had significantly poorer language function, and lower functional activation in left dorsal and left ventral regions of the language network, compared with TD youths. The TD group showed a significant correlation of the functional activation of the left dorsal region with microstructural integrity of the left ventral pathway, whereas the autism group showed a significant correlation of the functional activation of the left ventral region with microstructural integrity of the left dorsal pathway, and moreover verbal comprehension index was correlated with microstructural integrity of the left ventral pathway. These altered structure–function relationships in autism suggest possible involvement of the dual pathways in supporting deficient semantic processing. En ligne : http://dx.doi.org/10.1002/aur.1315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS / Yi-Li TSENG ; Wen-Che TSAI ; Yen-Nan CHIU in Journal of Autism and Developmental Disorders, 55-5 (May 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1648-1659 Titre : Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS Type de document : texte imprimé Auteurs : Yi-Li TSENG, Auteur ; Wen-Che TSAI, Auteur ; Yen-Nan CHIU, Auteur Article en page(s) : p.1648-1659 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study applied the functional near-infrared spectroscopy (fNIRS) to investigate frontal activity in autism when performing verbal fluency test and emotion recall task. We recruited 32 autistic adults without intellectual disability and 30 typically-developing controls (TDC). Prefrontal hemodynamic changes were evaluated by fNIRS when the participants performed the verbal fluency test and emotion recall task. fNIRS signals in the prefrontal cortex were compared between autism and TDC. Compared to TDC, autistic adults showed comparable performance on the verbal fluency test but exhibited lower frontal activity on the vegetable category. In the verbal fluency test, left frontal activity in TDC significantly increased in the vegetable category (vs. fruit category). In the emotion recall task, left frontal activity increased significantly in TDC when recalling emotional (vs. neutral) events. This increase of left frontal activity on the more difficult works was not found in autism. Similarly, brain activities were related to test performance only in TDC but not in autism. In addition, more severe social deficits were associated with lower frontal activity when recalling emotional events, independent of autism diagnosis. Findings suggested reduced frontal activity in autism, as compared to TDC, when performing verbal fluency tests. The reduction of left frontal activation in verbal fluency test and emotion recall tasks might reflect on the social deficits of the individual. The fNIRS may potentially be applied in assessing frontal lobe function in autism and social deficits in general population. Trial registration number: NCT04010409. En ligne : https://doi.org/10.1007/s10803-024-06306-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS [texte imprimé] / Yi-Li TSENG, Auteur ; Wen-Che TSAI, Auteur ; Yen-Nan CHIU, Auteur . - p.1648-1659. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1648-1659 Index. décimale : PER Périodiques Résumé : This study applied the functional near-infrared spectroscopy (fNIRS) to investigate frontal activity in autism when performing verbal fluency test and emotion recall task. We recruited 32 autistic adults without intellectual disability and 30 typically-developing controls (TDC). Prefrontal hemodynamic changes were evaluated by fNIRS when the participants performed the verbal fluency test and emotion recall task. fNIRS signals in the prefrontal cortex were compared between autism and TDC. Compared to TDC, autistic adults showed comparable performance on the verbal fluency test but exhibited lower frontal activity on the vegetable category. In the verbal fluency test, left frontal activity in TDC significantly increased in the vegetable category (vs. fruit category). In the emotion recall task, left frontal activity increased significantly in TDC when recalling emotional (vs. neutral) events. This increase of left frontal activity on the more difficult works was not found in autism. Similarly, brain activities were related to test performance only in TDC but not in autism. In addition, more severe social deficits were associated with lower frontal activity when recalling emotional events, independent of autism diagnosis. Findings suggested reduced frontal activity in autism, as compared to TDC, when performing verbal fluency tests. The reduction of left frontal activation in verbal fluency test and emotion recall tasks might reflect on the social deficits of the individual. The fNIRS may potentially be applied in assessing frontal lobe function in autism and social deficits in general population. Trial registration number: NCT04010409. En ligne : https://doi.org/10.1007/s10803-024-06306-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Autistic Traits in Couple Dyads as a Predictor of Anxiety Spectrum Symptoms / Winnie Yu-Pow LAU in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2949-2963 Titre : Autistic Traits in Couple Dyads as a Predictor of Anxiety Spectrum Symptoms Type de document : texte imprimé Auteurs : Winnie Yu-Pow LAU, Auteur ; Susan Shur-Fen GAU, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur Article en page(s) : p.2949-2963 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Couple dyads  Parents  Anxiety symptoms  Taiwanese Index. décimale : PER Périodiques Résumé : The link between parental autistic tendency and anxiety symptoms was studied in 491 Taiwanese couples raising biological children with autism spectrum disorders (ASDs). Parental autistic tendency as measured by Autism Spectrum Quotient (AQ) was associated with anxiety symptoms across all domains. Large effect sizes were found in social phobia and post traumatic stress disorders for both parents, and in general anxiety disorder and agoraphobia for mothers. These associations were irrespective of child’s autistic tendency, spouse’s AQ scores and the couples’ compatibility in their autistic tendency. Perceived family support and parental education moderated the link but not child’s autistic severity. Research and clinical implications regarding psychiatric vulnerability of parents of children with ASD were drawn and discussed. En ligne : http://dx.doi.org/10.1007/s10803-014-2151-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Autistic Traits in Couple Dyads as a Predictor of Anxiety Spectrum Symptoms [texte imprimé] / Winnie Yu-Pow LAU, Auteur ; Susan Shur-Fen GAU, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur . - p.2949-2963. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2949-2963 Mots-clés : Autism spectrum disorders  Couple dyads  Parents  Anxiety symptoms  Taiwanese Index. décimale : PER Périodiques Résumé : The link between parental autistic tendency and anxiety symptoms was studied in 491 Taiwanese couples raising biological children with autism spectrum disorders (ASDs). Parental autistic tendency as measured by Autism Spectrum Quotient (AQ) was associated with anxiety symptoms across all domains. Large effect sizes were found in social phobia and post traumatic stress disorders for both parents, and in general anxiety disorder and agoraphobia for mothers. These associations were irrespective of child’s autistic tendency, spouse’s AQ scores and the couples’ compatibility in their autistic tendency. Perceived family support and parental education moderated the link but not child’s autistic severity. Research and clinical implications regarding psychiatric vulnerability of parents of children with ASD were drawn and discussed. En ligne : http://dx.doi.org/10.1007/s10803-014-2151-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Correction to: Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder / Yu-Ju LIN in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1736-1736 Titre : Correction to: Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Yu-Ju LIN, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur ; Wen-Che TSAI, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1736-1736 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-022-05609-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Correction to: Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder [texte imprimé] / Yu-Ju LIN, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur ; Wen-Che TSAI, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1736-1736. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1736-1736 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-022-05609-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Deep exon resequencing of DLGAP2 as a candidate gene of autism spectrum disorders / Wei-Hsien CHIEN in Molecular Autism, (August 2013)  

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Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder / Yu-Ju LIN in Journal of Autism and Developmental Disorders, 53-7 (July 2023)  

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Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders / Chia-Hsiang CHEN in Molecular Autism, (June 2014)  

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Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder / C. L. YIN in Molecular Autism, 7 (2016)  

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Impaired sustained attention, focused attention, and vigilance in youths with autistic disorder and Asperger's disorder / Yi-Ling CHIEN in Research in Autism Spectrum Disorders, 8-7 (July 2014)  

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A preliminary randomized controlled study of the PEERS® program for Taiwanese autistic adolescents: The effectiveness on reducing school bullying and enhancing social function / Yi-Ling CHIEN ; Yueh-Ming TAI ; Heng-Man CHEN ; Hsien-Hsueh SHIH ; Li-Wei CHEN ; Yu-Ying CHEN ; Wei-Tsuen SOONG ; Yen-Nan CHIU ; Wen-Che TSAI ; Elizabeth LAUGESON ; Mei-Hui TSENG ; Susan Shur-Fen GAU in Autism Research, 17-8 (August 2024)  

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Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder / Yi-Ling CHIEN in Autism, 23-3 (April 2019)  

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Psychometric properties of the Chinese version of the Social Communication Questionnaire / Susan Shur-Fen GAU in Research in Autism Spectrum Disorders, 5-2 (April-June 2011)  

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Psychometric properties of the Chinese version of the Social Responsiveness Scale / Susan Shur-Fen GAU in Research in Autism Spectrum Disorders, 7-2 (February 2013)  

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School dysfunction in youth with autistic spectrum disorder in Taiwan: The effect of subtype and ADHD / Huey-Ling CHIANG in Autism Research, 11-6 (June 2018)  

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