Altered tactile processing in children with autism spectrum disorder / Teresa TAVASSOLI in Autism Research, 9-6 (June 2016)  

Public ISBD [article]  inAutism Research > 9-6 (June 2016) . - p.616-620 Titre : Altered tactile processing in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Teresa TAVASSOLI, Auteur ; Katherine BELLESHEIM, Auteur ; Mark TOMMERDAHL, Auteur ; Jameson M. HOLDEN, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur Article en page(s) : p.616-620 Langues : Anglais (eng) Mots-clés : tactile processing  inhibition  autism spectrum disorder  GABA Index. décimale : PER Périodiques Résumé : Although tactile reactivity issues are commonly reported in children with autism spectrum disorder (ASD), the underlying mechanisms are poorly understood. Less feed-forward inhibition has been proposed as a potential mechanism for some symptoms of ASD. We tested static and dynamic tactile thresholds as a behavioral proxy of feed-forward inhibition in 42 children (21 children with ASD and 21 typically developing [TD] children). Subthreshold conditioning typically raises the dynamic detection threshold, thus comparison of the dynamic to the static threshold generates a metric that predicts gamma-aminobutyric acid (GABA) mediated feed-forward inhibition. Children with ASD had marginally higher static thresholds and a significantly lower ratio between thresholds as compared with TD children. The lower ratio, only seen in children with ASD, might be indicative of less inhibition. Static thresholds were correlated with autism spectrum quotient scores, indicating the higher the tactile threshold, the more ASD traits. The amount of feed-forward inhibition (ratio between dynamic/static) was negatively correlated with autism diagnostic observation schedule repetitive behavior scores, meaning the less inhibition the more ASD symptoms. In summary, children with ASD showed altered tactile processing compared with TD children; thus measuring static and dynamic thresholds could be a potential biomarker for ASD and might be useful for prediction of treatment response with therapeutics, including those that target the GABAergic system. Autism Res 2016, 9: 616–620. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Altered tactile processing in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Teresa TAVASSOLI, Auteur ; Katherine BELLESHEIM, Auteur ; Mark TOMMERDAHL, Auteur ; Jameson M. HOLDEN, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur . - p.616-620. Langues : Anglais (eng) in Autism Research > 9-6 (June 2016) . - p.616-620 Mots-clés : tactile processing  inhibition  autism spectrum disorder  GABA Index. décimale : PER Périodiques Résumé : Although tactile reactivity issues are commonly reported in children with autism spectrum disorder (ASD), the underlying mechanisms are poorly understood. Less feed-forward inhibition has been proposed as a potential mechanism for some symptoms of ASD. We tested static and dynamic tactile thresholds as a behavioral proxy of feed-forward inhibition in 42 children (21 children with ASD and 21 typically developing [TD] children). Subthreshold conditioning typically raises the dynamic detection threshold, thus comparison of the dynamic to the static threshold generates a metric that predicts gamma-aminobutyric acid (GABA) mediated feed-forward inhibition. Children with ASD had marginally higher static thresholds and a significantly lower ratio between thresholds as compared with TD children. The lower ratio, only seen in children with ASD, might be indicative of less inhibition. Static thresholds were correlated with autism spectrum quotient scores, indicating the higher the tactile threshold, the more ASD traits. The amount of feed-forward inhibition (ratio between dynamic/static) was negatively correlated with autism diagnostic observation schedule repetitive behavior scores, meaning the less inhibition the more ASD symptoms. In summary, children with ASD showed altered tactile processing compared with TD children; thus measuring static and dynamic thresholds could be a potential biomarker for ASD and might be useful for prediction of treatment response with therapeutics, including those that target the GABAergic system. Autism Res 2016, 9: 616–620. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Brief Report: Sensory Reactivity in Children with Phelan–McDermid Syndrome / A. M. MIESES in Journal of Autism and Developmental Disorders, 46-7 (July 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2508-2513 Titre : Brief Report: Sensory Reactivity in Children with Phelan–McDermid Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : A. M. MIESES, Auteur ; Teresa TAVASSOLI, Auteur ; E. LI, Auteur ; L. SOORYA, Auteur ; S. LURIE, Auteur ; A. Ting WANG, Auteur ; P. M. SIPER, Auteur ; A. KOLEVZON, Auteur Article en page(s) : p.2508-2513 Langues : Anglais (eng) Mots-clés : Phelan–McDermid syndrome  22q13 deletion syndrome  Autism  Autism spectrum disorder  Sensory reactivity  Sensory profile Index. décimale : PER Périodiques Résumé : Phelan–McDermid syndrome (PMS), a monogenic form of autism spectrum disorder (ASD), results from deletion or mutation of the SHANK3 gene. Atypical sensory reactivity is now included in the diagnostic criteria for ASD. Examining the sensory phenotype in monogenic forms of ASD, such as PMS, may help identify underlying mechanisms of sensory reactivity. Using the Short Sensory Profile, the current study compared sensory reactivity in 24 children with PMS to 61 children with idiopathic ASD (iASD). Results suggest that children with PMS show more low energy/weak symptoms and less sensory sensitivity as compared to children with iASD. This study is the first to demonstrate differences in sensory reactivity between children with PMS and iASD, helping to refine the PMS phenotype. En ligne : http://dx.doi.org/10.1007/s10803-016-2754-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Brief Report: Sensory Reactivity in Children with Phelan–McDermid Syndrome [Texte imprimé et/ou numérique] / A. M. MIESES, Auteur ; Teresa TAVASSOLI, Auteur ; E. LI, Auteur ; L. SOORYA, Auteur ; S. LURIE, Auteur ; A. Ting WANG, Auteur ; P. M. SIPER, Auteur ; A. KOLEVZON, Auteur . - p.2508-2513. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2508-2513 Mots-clés : Phelan–McDermid syndrome  22q13 deletion syndrome  Autism  Autism spectrum disorder  Sensory reactivity  Sensory profile Index. décimale : PER Périodiques Résumé : Phelan–McDermid syndrome (PMS), a monogenic form of autism spectrum disorder (ASD), results from deletion or mutation of the SHANK3 gene. Atypical sensory reactivity is now included in the diagnostic criteria for ASD. Examining the sensory phenotype in monogenic forms of ASD, such as PMS, may help identify underlying mechanisms of sensory reactivity. Using the Short Sensory Profile, the current study compared sensory reactivity in 24 children with PMS to 61 children with idiopathic ASD (iASD). Results suggest that children with PMS show more low energy/weak symptoms and less sensory sensitivity as compared to children with iASD. This study is the first to demonstrate differences in sensory reactivity between children with PMS and iASD, helping to refine the PMS phenotype. En ligne : http://dx.doi.org/10.1007/s10803-016-2754-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD / Paige M. SIPER in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1133-1140 Titre : A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; A. Ting WANG, Auteur ; Joseph D. BUXBAUM, Auteur ; Teresa TAVASSOLI, Auteur Article en page(s) : p.1133-1140 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  sensory reactivity  sensory processing  assessment Index. décimale : PER Périodiques Résumé : Background: Sensory reactivity is a new criterion for autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, there is no consensus on how to reliably measure sensory reactivity, particularly in minimally verbal individuals. The current study is an initial validation of the Sensory Assessment for Neurodevelopmental Disorders (SAND), a novel clinician-administered observation and corresponding caregiver interview that captures sensory symptoms based on DSM-5 criteria for ASD. Methods: Eighty children between the ages of 2 and 12 participated in this study; 44 children with ASD and 36 typically developing (TD) children. Sensory reactivity symptoms were measured using the SAND and the already validated Short Sensory Profile (SSP). Initial psychometric properties of the SAND were examined including reliability, validity, sensitivity and specificity. Results: Children with ASD showed significantly more sensory reactivity symptoms compared to TD children across sensory domains (visual, tactile, and auditory) and within sensory subtypes (hyperreactivity, hyporeactivity and seeking). The SAND showed strong internal consistency, inter-rater reliability and test-retest reliability, high sensitivity (95.5%) and specificity (91.7%), and strong convergent validity with the SSP. Significance: The SAND provides a novel method to characterize sensory reactivity symptoms based on DSM-5 criteria for ASD. This is the first known sensory assessment that combines a clinician-administered observation and caregiver interview to optimally capture sensory phenotypes characteristic of individuals with neurodevelopmental disorders. The SAND offers a beneficial new tool for both research and clinical purposes and has the potential to meaningfully enhance gold-standard assessment of ASD. En ligne : http://dx.doi.org/10.1002/aur.1750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD [Texte imprimé et/ou numérique] / Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; A. Ting WANG, Auteur ; Joseph D. BUXBAUM, Auteur ; Teresa TAVASSOLI, Auteur . - p.1133-1140. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1133-1140 Mots-clés : autism spectrum disorder  sensory reactivity  sensory processing  assessment Index. décimale : PER Périodiques Résumé : Background: Sensory reactivity is a new criterion for autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, there is no consensus on how to reliably measure sensory reactivity, particularly in minimally verbal individuals. The current study is an initial validation of the Sensory Assessment for Neurodevelopmental Disorders (SAND), a novel clinician-administered observation and corresponding caregiver interview that captures sensory symptoms based on DSM-5 criteria for ASD. Methods: Eighty children between the ages of 2 and 12 participated in this study; 44 children with ASD and 36 typically developing (TD) children. Sensory reactivity symptoms were measured using the SAND and the already validated Short Sensory Profile (SSP). Initial psychometric properties of the SAND were examined including reliability, validity, sensitivity and specificity. Results: Children with ASD showed significantly more sensory reactivity symptoms compared to TD children across sensory domains (visual, tactile, and auditory) and within sensory subtypes (hyperreactivity, hyporeactivity and seeking). The SAND showed strong internal consistency, inter-rater reliability and test-retest reliability, high sensitivity (95.5%) and specificity (91.7%), and strong convergent validity with the SSP. Significance: The SAND provides a novel method to characterize sensory reactivity symptoms based on DSM-5 criteria for ASD. This is the first known sensory assessment that combines a clinician-administered observation and caregiver interview to optimally capture sensory phenotypes characteristic of individuals with neurodevelopmental disorders. The SAND offers a beneficial new tool for both research and clinical purposes and has the potential to meaningfully enhance gold-standard assessment of ASD. En ligne : http://dx.doi.org/10.1002/aur.1750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Comparing eating and mealtime experiences in families of children with autism, attention deficit hyperactivity disorder and dual diagnosis / Zoe Matthews ; Donna Pigden-Bennett ; Teresa TAVASSOLI ; Sarah Snuggs in Autism, 29-2 (February 2025)  

Public ISBD [article]  inAutism > 29-2 (February 2025) . - p.518-535 Titre : Comparing eating and mealtime experiences in families of children with autism, attention deficit hyperactivity disorder and dual diagnosis : Autism Type de document : Texte imprimé et/ou numérique Auteurs : Zoe Matthews, Auteur ; Donna Pigden-Bennett, Auteur ; Teresa TAVASSOLI, Auteur ; Sarah Snuggs, Auteur Article en page(s) : p.518-535 Langues : Anglais (eng) Mots-clés : ADHD  autism spectrum disorders  family functioning and support  school-age children Index. décimale : PER Périodiques Résumé : Shared family meals are associated with family functioning and thought to protect against disordered eating in families with neurotypical children. Limited research, however, has examined the mealtime structure or experience in families with children with autism (Autism spectrum condition) and/or attention deficit hyperactivity disorder, despite eating behaviour differences in these populations. This study sought to compare children?s eating behaviours and caregivers' mealtime experiences between families with neurotypical children and those with Autism spectrum condition, attention deficit hyperactivity disorder and dual diagnosis (Autism spectrum condition?+?attention deficit hyperactivity disorder). Think-Aloud methods established validity for the Children?s Eating Behaviour Questionnaire, Meals in our Household and Perceived Stress Scale measures (N = 9), prior to administering these to caregivers of children aged 3-15 (N = 351). Neurodevelopmental condition groups (Autism spectrum condition, n = 80; Attention deficit hyperactivity disorder, n = 88; Autism spectrum condition?+?attention deficit hyperactivity disorder, n = 65) reported higher food fussiness, emotional undereating, problematic child mealtime behaviours, dietary concerns, caregiver and spousal stress, and less conventionally structured mealtimes than neurotypical families (n = 118). Attention deficit hyperactivity disorder and Autism spectrum condition?+?attention deficit hyperactivity disorder groups reported higher food responsiveness, problematic behaviour and caregiver stress than the Autism spectrum condition group. Conversely, Autism spectrum condition and Autism spectrum condition?+?attention deficit hyperactivity disorder groups reported lower food enjoyment and mealtime structure than the attention deficit hyperactivity disorder group. Distinct eating and mealtime patterns in neurodevelopmental condition families may adversely impact family functioning, emphasising the need for bio-psychosocial approaches and transdiagnostic mealtime support. Lay abstract Children with neurodevelopmental conditions like autism and attention deficit hyperactivity disorder may experience eating difficulties and related health issues later in life. Sharing family meals can help prevent these issues developing, but most studies have looked at families with neurotypical children. Our goal was to learn more about how families of children with autism, attention deficit hyperactivity disorder and both conditions (autism?+?attention deficit hyperactivity disorder) experience mealtimes. We developed an online survey asking caregivers about their child?s eating, mealtime experience and if they experienced stress. We tested it with nine caregivers and made improvements based on their feedback before recruiting 351 caregivers to complete the main survey. We found that families of children with neurodevelopmental conditions experienced greater food fussiness, emotional undereating, 'problematic' child mealtime behaviours, dietary concerns, higher stress for caregivers and spouses and less frequent conventionally structured mealtimes compared to those without these conditions. Families of children with attention deficit hyperactivity disorder and autism?+?attention deficit hyperactivity disorder reported greater appetite, 'problematic' mealtime behaviours and increased stress for caregivers and spouses compared to families of children with autism. Meanwhile, families of children with autism and autism?+?attention deficit hyperactivity disorder reported less enjoyment of food and less structured mealtimes compared to those with attention deficit hyperactivity disorder. Our findings highlight that families of children with neurodevelopmental conditions, particularly those with autism?+?attention deficit hyperactivity disorder, have different mealtime experiences and eating behaviours compared to those with neurotypical children. These families may benefit from support at mealtimes. Learning why people o or do not participate in shared family meals will be crucial to developing improved mealtime support in the future. En ligne : https://dx.doi.org/10.1177/13623613241277605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Comparing eating and mealtime experiences in families of children with autism, attention deficit hyperactivity disorder and dual diagnosis : Autism [Texte imprimé et/ou numérique] / Zoe Matthews, Auteur ; Donna Pigden-Bennett, Auteur ; Teresa TAVASSOLI, Auteur ; Sarah Snuggs, Auteur . - p.518-535. Langues : Anglais (eng) in Autism > 29-2 (February 2025) . - p.518-535 Mots-clés : ADHD  autism spectrum disorders  family functioning and support  school-age children Index. décimale : PER Périodiques Résumé : Shared family meals are associated with family functioning and thought to protect against disordered eating in families with neurotypical children. Limited research, however, has examined the mealtime structure or experience in families with children with autism (Autism spectrum condition) and/or attention deficit hyperactivity disorder, despite eating behaviour differences in these populations. This study sought to compare children?s eating behaviours and caregivers' mealtime experiences between families with neurotypical children and those with Autism spectrum condition, attention deficit hyperactivity disorder and dual diagnosis (Autism spectrum condition?+?attention deficit hyperactivity disorder). Think-Aloud methods established validity for the Children?s Eating Behaviour Questionnaire, Meals in our Household and Perceived Stress Scale measures (N = 9), prior to administering these to caregivers of children aged 3-15 (N = 351). Neurodevelopmental condition groups (Autism spectrum condition, n = 80; Attention deficit hyperactivity disorder, n = 88; Autism spectrum condition?+?attention deficit hyperactivity disorder, n = 65) reported higher food fussiness, emotional undereating, problematic child mealtime behaviours, dietary concerns, caregiver and spousal stress, and less conventionally structured mealtimes than neurotypical families (n = 118). Attention deficit hyperactivity disorder and Autism spectrum condition?+?attention deficit hyperactivity disorder groups reported higher food responsiveness, problematic behaviour and caregiver stress than the Autism spectrum condition group. Conversely, Autism spectrum condition and Autism spectrum condition?+?attention deficit hyperactivity disorder groups reported lower food enjoyment and mealtime structure than the attention deficit hyperactivity disorder group. Distinct eating and mealtime patterns in neurodevelopmental condition families may adversely impact family functioning, emphasising the need for bio-psychosocial approaches and transdiagnostic mealtime support. Lay abstract Children with neurodevelopmental conditions like autism and attention deficit hyperactivity disorder may experience eating difficulties and related health issues later in life. Sharing family meals can help prevent these issues developing, but most studies have looked at families with neurotypical children. Our goal was to learn more about how families of children with autism, attention deficit hyperactivity disorder and both conditions (autism?+?attention deficit hyperactivity disorder) experience mealtimes. We developed an online survey asking caregivers about their child?s eating, mealtime experience and if they experienced stress. We tested it with nine caregivers and made improvements based on their feedback before recruiting 351 caregivers to complete the main survey. We found that families of children with neurodevelopmental conditions experienced greater food fussiness, emotional undereating, 'problematic' child mealtime behaviours, dietary concerns, higher stress for caregivers and spouses and less frequent conventionally structured mealtimes compared to those without these conditions. Families of children with attention deficit hyperactivity disorder and autism?+?attention deficit hyperactivity disorder reported greater appetite, 'problematic' mealtime behaviours and increased stress for caregivers and spouses compared to families of children with autism. Meanwhile, families of children with autism and autism?+?attention deficit hyperactivity disorder reported less enjoyment of food and less structured mealtimes compared to those with attention deficit hyperactivity disorder. Our findings highlight that families of children with neurodevelopmental conditions, particularly those with autism?+?attention deficit hyperactivity disorder, have different mealtime experiences and eating behaviours compared to those with neurotypical children. These families may benefit from support at mealtimes. Learning why people o or do not participate in shared family meals will be crucial to developing improved mealtime support in the future. En ligne : https://dx.doi.org/10.1177/13623613241277605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Dyspraxia and autistic traits in adults with and without autism spectrum conditions / Sarah A. CASSIDY in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 48p. Titre : Dyspraxia and autistic traits in adults with and without autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Sarah A. CASSIDY, Auteur ; P. HANNANT, Auteur ; Teresa TAVASSOLI, Auteur ; Carrie ALLISON, Auteur ; P. SMITH, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 48p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aged  Apraxias/complications/physiopathology/psychology  Autism Spectrum Disorder/complications/physiopathology/psychology  Autistic Disorder/complications/physiopathology/psychology  Case-Control Studies  Empathy  Female  Humans  Male  Middle Aged  Phenotype  Psychological Tests  Psychomotor Performance  Social Skills  Surveys and Questionnaires  Autism spectrum conditions  Autistic traits  Co-morbidity  Dyspraxia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (ASC) are frequently associated with motor coordination difficulties. However, no studies have explored the prevalence of dyspraxia in a large sample of individuals with and without ASC or associations between dyspraxia and autistic traits in these individuals. METHODS: Two thousand eight hundred seventy-one adults (with ASC) and 10,706 controls (without ASC) self-reported whether they have been diagnosed with dyspraxia. A subsample of participants then completed the Autism Spectrum Quotient (AQ; 1237 ASC and 6765 controls) and the Empathy Quotient (EQ; 1147 ASC and 6129 controls) online through the Autism Research Centre website. The prevalence of dyspraxia was compared between those with and without ASC. AQ and EQ scores were compared across the four groups: (1) adults with ASC with dyspraxia, (2) adults with ASC without dyspraxia, (3) controls with dyspraxia, and (4) controls without dyspraxia. RESULTS: Adults with ASC were significantly more likely to report a diagnosis of dyspraxia (6.9%) than those without ASC (0.8%). In the ASC group, those with co-morbid diagnosis of dyspraxia did not have significantly different AQ or EQ scores than those without co-morbid dyspraxia. However, in the control group (without ASC), those with dyspraxia had significantly higher AQ and lower EQ scores than those without dyspraxia. CONCLUSIONS: Dyspraxia is significantly more prevalent in adults with ASC compared to controls, confirming reports that motor coordination difficulties are significantly more common in this group. Interestingly, in the general population, dyspraxia was associated with significantly higher autistic traits and lower empathy. These results suggest that motor coordination skills are important for effective social skills and empathy. En ligne : http://dx.doi.org/10.1186/s13229-016-0112-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Dyspraxia and autistic traits in adults with and without autism spectrum conditions [Texte imprimé et/ou numérique] / Sarah A. CASSIDY, Auteur ; P. HANNANT, Auteur ; Teresa TAVASSOLI, Auteur ; Carrie ALLISON, Auteur ; P. SMITH, Auteur ; Simon BARON-COHEN, Auteur . - 48p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 48p. Mots-clés : Adolescent  Adult  Aged  Apraxias/complications/physiopathology/psychology  Autism Spectrum Disorder/complications/physiopathology/psychology  Autistic Disorder/complications/physiopathology/psychology  Case-Control Studies  Empathy  Female  Humans  Male  Middle Aged  Phenotype  Psychological Tests  Psychomotor Performance  Social Skills  Surveys and Questionnaires  Autism spectrum conditions  Autistic traits  Co-morbidity  Dyspraxia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (ASC) are frequently associated with motor coordination difficulties. However, no studies have explored the prevalence of dyspraxia in a large sample of individuals with and without ASC or associations between dyspraxia and autistic traits in these individuals. METHODS: Two thousand eight hundred seventy-one adults (with ASC) and 10,706 controls (without ASC) self-reported whether they have been diagnosed with dyspraxia. A subsample of participants then completed the Autism Spectrum Quotient (AQ; 1237 ASC and 6765 controls) and the Empathy Quotient (EQ; 1147 ASC and 6129 controls) online through the Autism Research Centre website. The prevalence of dyspraxia was compared between those with and without ASC. AQ and EQ scores were compared across the four groups: (1) adults with ASC with dyspraxia, (2) adults with ASC without dyspraxia, (3) controls with dyspraxia, and (4) controls without dyspraxia. RESULTS: Adults with ASC were significantly more likely to report a diagnosis of dyspraxia (6.9%) than those without ASC (0.8%). In the ASC group, those with co-morbid diagnosis of dyspraxia did not have significantly different AQ or EQ scores than those without co-morbid dyspraxia. However, in the control group (without ASC), those with dyspraxia had significantly higher AQ and lower EQ scores than those without dyspraxia. CONCLUSIONS: Dyspraxia is significantly more prevalent in adults with ASC compared to controls, confirming reports that motor coordination difficulties are significantly more common in this group. Interestingly, in the general population, dyspraxia was associated with significantly higher autistic traits and lower empathy. These results suggest that motor coordination skills are important for effective social skills and empathy. En ligne : http://dx.doi.org/10.1186/s13229-016-0112-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Erratum: A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome / Alexander KOLEVZON in Molecular Autism, (June 2015)  

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Erratum to: Neural selectivity for communicative auditory signals in Phelan-McDermid syndrome / A. Ting WANG in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium / Roseann SCHAAF ; Karla K. AUSDERAU ; Grace T. BARANEK ; D Jonah BARRETT ; Carissa J. CASCIO ; Rachel L. DUMONT ; Ekomobong E. Eyoh ; Michelle D. FAILLA ; Jacob I. FELDMAN ; Jennifer H. FOSS-FEIG ; Heather L. GREEN ; Shulamite A. GREEN ; Jason L. HE ; Elizabeth A. KAPLAN-KAHN ; Bahar KEÇELI-KAYS?L? ; Keren MACLENNAN ; Zoe MAILLOUX ; Elysa J. MARCO ; Lisa E. MASH ; Elizabeth P. MCKERNAN ; Sophie MOLHOLM ; Stewart H. MOSTOFSKY ; Nicolaas A. J. PUTS ; Caroline E. ROBERTSON ; Natalie RUSSO ; Nicole SHEA ; John SIDERIS ; James S. SUTCLIFFE ; Teresa TAVASSOLI ; Mark T. WALLACE ; Ericka L. WODKA ; Tiffany G. WOYNAROSKI in Molecular Autism, 14 (2023)  

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Grandma knows best: Family structure and age of diagnosis of autism spectrum disorder / N. SICHERMAN in Autism, 22-3 (April 2018)  

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In Our Own Words: The Complex Sensory Experiences of Autistic Adults / K. MACLENNAN in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

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Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay / Ozlem BOZDAGI in Molecular Autism, (April 2013)  

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Measuring Sensory Reactivity in Autism Spectrum Disorder: Application and Simplification of a Clinician-Administered Sensory Observation Scale / Teresa TAVASSOLI in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

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Neural selectivity for communicative auditory signals in Phelan-McDermid syndrome / A. Ting WANG in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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Olfactory Detection Thresholds and Adaptation in Adults with Autism Spectrum Condition / Teresa TAVASSOLI in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

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A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome / Alexander KOLEVZON in Molecular Autism, (December 2014)  

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