Dépouillements

Inaccurate prevalence estimates impacts autism policy: A letter to the editor in relation to "Global prevalence of autism: A systematic review update" by Zeidan et al. (2022) / Andres ROMAN-URRESTARAZU in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1184-1186 Titre : Inaccurate prevalence estimates impacts autism policy: A letter to the editor in relation to "Global prevalence of autism: A systematic review update" by Zeidan et al. (2022) Type de document : Texte imprimé et/ou numérique Auteurs : Andres ROMAN-URRESTARAZU, Auteur ; Robin VAN KESSEL, Auteur Article en page(s) : p.1184-1186 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2734 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Inaccurate prevalence estimates impacts autism policy: A letter to the editor in relation to "Global prevalence of autism: A systematic review update" by Zeidan et al. (2022) [Texte imprimé et/ou numérique] / Andres ROMAN-URRESTARAZU, Auteur ; Robin VAN KESSEL, Auteur . - p.1184-1186. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1184-1186 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2734 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

The time has come for living systematic reviews in autism research / Mayada ELSABBAGH in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1187-1188 Titre : The time has come for living systematic reviews in autism research Type de document : Texte imprimé et/ou numérique Auteurs : Mayada ELSABBAGH, Auteur ; Afiqah YUSUF, Auteur ; Jinan ZEIDAN, Auteur ; Julie SCORAH, Auteur ; Eric FOMBONNE, Auteur ; Maureen S. DURKIN, Auteur ; Shekhar SAXENA, Auteur ; Andy SHIH, Auteur Article en page(s) : p.1187-1188 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] The time has come for living systematic reviews in autism research [Texte imprimé et/ou numérique] / Mayada ELSABBAGH, Auteur ; Afiqah YUSUF, Auteur ; Jinan ZEIDAN, Auteur ; Julie SCORAH, Auteur ; Eric FOMBONNE, Auteur ; Maureen S. DURKIN, Auteur ; Shekhar SAXENA, Auteur ; Andy SHIH, Auteur . - p.1187-1188. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1187-1188 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities / Stephania ASSIMOPOULOS in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1189-1208 Titre : Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities Type de document : Texte imprimé et/ou numérique Auteurs : Stephania ASSIMOPOULOS, Auteur ; Christopher HAMMILL, Auteur ; Darren J. FERNANDES, Auteur ; Tara LEIGH SPENCER NOAKES, Auteur ; Yu-Qing ZHOU, Auteur ; Lauryl M J. NUTTER, Auteur ; Jacob ELLEGOOD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; John G. SLED, Auteur ; Jason P. LERCH, Auteur Article en page(s) : p.1189-1208 Langues : Anglais (eng) Mots-clés : autism  cardiac phenotype/cardiology  comorbidities  genetic mouse models  phenotyping  ultrasound biomicroscopy Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b((+/-)) , Chd8((+/-)) , 16p11.2 (deletion), Sgsh((+/-)) , Sgsh((-/-)) , Shank3 ?exon 4-9((+/-)) , Shank3 ?exon 4-9((-/-)) , Fmr1((-/-)) , Vps13b((+/-)) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small-scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion), Fmr1((-/-)) , Arid1b((+/-)) . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion), Sgsh((+/-)) , Fmr1((-/-)) . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non-lethal abnormalities impact normal development. LAY SUMMARY: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD-related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non-lethal cardiac abnormalities can impact development. En ligne : http://dx.doi.org/10.1002/aur.2728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities [Texte imprimé et/ou numérique] / Stephania ASSIMOPOULOS, Auteur ; Christopher HAMMILL, Auteur ; Darren J. FERNANDES, Auteur ; Tara LEIGH SPENCER NOAKES, Auteur ; Yu-Qing ZHOU, Auteur ; Lauryl M J. NUTTER, Auteur ; Jacob ELLEGOOD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; John G. SLED, Auteur ; Jason P. LERCH, Auteur . - p.1189-1208. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1189-1208 Mots-clés : autism  cardiac phenotype/cardiology  comorbidities  genetic mouse models  phenotyping  ultrasound biomicroscopy Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b((+/-)) , Chd8((+/-)) , 16p11.2 (deletion), Sgsh((+/-)) , Sgsh((-/-)) , Shank3 ?exon 4-9((+/-)) , Shank3 ?exon 4-9((-/-)) , Fmr1((-/-)) , Vps13b((+/-)) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small-scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion), Fmr1((-/-)) , Arid1b((+/-)) . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion), Sgsh((+/-)) , Fmr1((-/-)) . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non-lethal abnormalities impact normal development. LAY SUMMARY: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD-related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non-lethal cardiac abnormalities can impact development. En ligne : http://dx.doi.org/10.1002/aur.2728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Gray matter volume alteration is associated with insistence on sameness and cognitive flexibility in autistic youth / Guan-Jye SENG in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1209-1221 Titre : Gray matter volume alteration is associated with insistence on sameness and cognitive flexibility in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Guan-Jye SENG, Auteur ; Meng-Chuan LAI, Auteur ; Joshua Oon Soo GOH, Auteur ; Wen-Yih Issac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1209-1221 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cognitive flexibility  gray matter volume  insistence on sameness  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are hallmark characteristics of autism spectrum disorder (ASD). Previous studies suggest that insistence on sameness (IS) characterized as higher-order RRBs may be a promising subgrouping variable for ASD. Cognitive inflexibility may underpin IS behaviors. However, the neuroanatomical correlates of IS and associated cognitive functions remain unclear. We analyzed data from 140 autistic youth and 124 typically developing (TD) youth (mean age = 15.8?years). Autistic youth were stratified by median-split based on three current IS items in the autism diagnostic interview-revised into two groups (high, HIS, n = 70, and low, LIS, n = 70). Differences in cognitive flexibility were assessed by the Cambridge neuropsychological test automated battery (CANTAB). T1-weighted brain structural images were analyzed using voxel-based morphometry (VBM) to identify differences in gray matter (GM) volume among the three groups. GM volume of regions showing group differences was then correlated with cognitive flexibility. The HIS group showed decreased GM volumes in the left supramarginal gyrus compared to the LIS group and increased GM volumes in the vermis VIII and left cerebellar lobule VIII compared to TD individuals. We did not find significant correlations between regional GM volumes and extra-dimensional shift errors. IS may be a unique RRB component and a potentially valuable stratifier of ASD. However, the neurocognitive underpinnings require further clarification. LAY SUMMARY: The present study found parietal, temporal and cerebellar gray matter volume alterations in autistic youth with greater insistence on sameness. The findings suggest that insistence on sameness may be a useful feature to parse the heterogeneity of the autism spectrum yet further research investigating the underlying neurocognitive mechanism is warranted. En ligne : http://dx.doi.org/10.1002/aur.2732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Gray matter volume alteration is associated with insistence on sameness and cognitive flexibility in autistic youth [Texte imprimé et/ou numérique] / Guan-Jye SENG, Auteur ; Meng-Chuan LAI, Auteur ; Joshua Oon Soo GOH, Auteur ; Wen-Yih Issac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1209-1221. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1209-1221 Mots-clés : autism spectrum disorder  cognitive flexibility  gray matter volume  insistence on sameness  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are hallmark characteristics of autism spectrum disorder (ASD). Previous studies suggest that insistence on sameness (IS) characterized as higher-order RRBs may be a promising subgrouping variable for ASD. Cognitive inflexibility may underpin IS behaviors. However, the neuroanatomical correlates of IS and associated cognitive functions remain unclear. We analyzed data from 140 autistic youth and 124 typically developing (TD) youth (mean age = 15.8?years). Autistic youth were stratified by median-split based on three current IS items in the autism diagnostic interview-revised into two groups (high, HIS, n = 70, and low, LIS, n = 70). Differences in cognitive flexibility were assessed by the Cambridge neuropsychological test automated battery (CANTAB). T1-weighted brain structural images were analyzed using voxel-based morphometry (VBM) to identify differences in gray matter (GM) volume among the three groups. GM volume of regions showing group differences was then correlated with cognitive flexibility. The HIS group showed decreased GM volumes in the left supramarginal gyrus compared to the LIS group and increased GM volumes in the vermis VIII and left cerebellar lobule VIII compared to TD individuals. We did not find significant correlations between regional GM volumes and extra-dimensional shift errors. IS may be a unique RRB component and a potentially valuable stratifier of ASD. However, the neurocognitive underpinnings require further clarification. LAY SUMMARY: The present study found parietal, temporal and cerebellar gray matter volume alterations in autistic youth with greater insistence on sameness. The findings suggest that insistence on sameness may be a useful feature to parse the heterogeneity of the autism spectrum yet further research investigating the underlying neurocognitive mechanism is warranted. En ligne : http://dx.doi.org/10.1002/aur.2732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Increased prefrontal GABA concentrations in adults with autism spectrum disorders / Simon MAIER in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1222-1236 Titre : Increased prefrontal GABA concentrations in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Simon MAIER, Auteur ; Ansgard Lena DÜPPERS, Auteur ; Kimon RUNGE, Auteur ; Michael DACKO, Auteur ; Thomas LANGE, Auteur ; Thomas FANGMEIER, Auteur ; Andreas RIEDEL, Auteur ; Dieter EBERT, Auteur ; Dominique ENDRES, Auteur ; Katharina DOMSCHKE, Auteur ; Evgeniy PERLOV, Auteur ; Kathrin NICKEL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur Article en page(s) : p.1222-1236 Langues : Anglais (eng) Mots-clés : Gaba  anterior cingulate cortex  autism spectrum disorder  dorsolateral prefrontal cortex  gamma-aminobutyric acid  glutamate Index. décimale : PER Périodiques Résumé : The excitatory-inhibitory imbalance hypothesis postulates dysregulation of the gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common underlying deficit in individuals with autism spectrum disorders (ASD). Previous studies suggest an important role of these systems in the pathophysiology of ASD, including a study of our group reporting decreased glutamate concentrations in the pregenual anterior cingulate cortex (ACC) of adults with ASD. The aim of this study was to replicate our previous findings of impaired glutamate metabolism in ASD in a new sample and to additionally quantify GABA in the ACC and dorsolateral prefrontal cortex (dlPFC). Concentrations of GABA and glutamate-glutamine (Glx; combined glutamate and glutamine signal) were quantified in the ACC and dlPFC of 43 adults with ASD and 43 neurotypical controls (NTC) by magnetic resonance spectroscopy (MRS). The ASD group showed increased absolute GABA concentrations and elevated GABA/creatine ratios in the left dlPFC compared to NTC, while no group differences were detected in the pregenual and dorsal ACC. Previous findings of altered Glx concentration in the pregenual ACC of the ASD group could not be replicated. Regarding Glx concentrations and Glx/creatine ratios, there were no significant differences in the dlPFC and ACC either. The study supports the hypothesis of an altered GABA and glutamate equilibrium, indicating an imbalance between excitatory and inhibitory metabolism in ASD patients. However, inconsistent results across studies and brain regions suggest a complex underlying phenomenon. LAY SUMMARY: Adults of the autism spectrum exhibit elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Increased prefrontal GABA concentrations in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Simon MAIER, Auteur ; Ansgard Lena DÜPPERS, Auteur ; Kimon RUNGE, Auteur ; Michael DACKO, Auteur ; Thomas LANGE, Auteur ; Thomas FANGMEIER, Auteur ; Andreas RIEDEL, Auteur ; Dieter EBERT, Auteur ; Dominique ENDRES, Auteur ; Katharina DOMSCHKE, Auteur ; Evgeniy PERLOV, Auteur ; Kathrin NICKEL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur . - p.1222-1236. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1222-1236 Mots-clés : Gaba  anterior cingulate cortex  autism spectrum disorder  dorsolateral prefrontal cortex  gamma-aminobutyric acid  glutamate Index. décimale : PER Périodiques Résumé : The excitatory-inhibitory imbalance hypothesis postulates dysregulation of the gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common underlying deficit in individuals with autism spectrum disorders (ASD). Previous studies suggest an important role of these systems in the pathophysiology of ASD, including a study of our group reporting decreased glutamate concentrations in the pregenual anterior cingulate cortex (ACC) of adults with ASD. The aim of this study was to replicate our previous findings of impaired glutamate metabolism in ASD in a new sample and to additionally quantify GABA in the ACC and dorsolateral prefrontal cortex (dlPFC). Concentrations of GABA and glutamate-glutamine (Glx; combined glutamate and glutamine signal) were quantified in the ACC and dlPFC of 43 adults with ASD and 43 neurotypical controls (NTC) by magnetic resonance spectroscopy (MRS). The ASD group showed increased absolute GABA concentrations and elevated GABA/creatine ratios in the left dlPFC compared to NTC, while no group differences were detected in the pregenual and dorsal ACC. Previous findings of altered Glx concentration in the pregenual ACC of the ASD group could not be replicated. Regarding Glx concentrations and Glx/creatine ratios, there were no significant differences in the dlPFC and ACC either. The study supports the hypothesis of an altered GABA and glutamate equilibrium, indicating an imbalance between excitatory and inhibitory metabolism in ASD patients. However, inconsistent results across studies and brain regions suggest a complex underlying phenomenon. LAY SUMMARY: Adults of the autism spectrum exhibit elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

A mixed methods evaluation of the acceptability of therapy using LEGO® bricks (LEGO® based therapy) in mainstream primary and secondary education / Amy BARR in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1237-1248 Titre : A mixed methods evaluation of the acceptability of therapy using LEGO® bricks (LEGO® based therapy) in mainstream primary and secondary education Type de document : Texte imprimé et/ou numérique Auteurs : Amy BARR, Auteur ; Elizabeth COATES, Auteur ; Ellen KINGSLEY, Auteur ; Gina GOMEZ DE LA CUESTA, Auteur ; Katie BIGGS, Auteur ; Ann LE COUTEUR, Auteur ; Barry WRIGHT, Auteur Article en page(s) : p.1237-1248 Langues : Anglais (eng) Mots-clés : Lego®  autism  play brick therapy  qualitative research  questionnaires  social communication Index. décimale : PER Périodiques Résumé : Many autistic children and young people need extra support with social skills. Social skills programmes, such as LEGO® based therapy (LBT), are commonly used to help with these difficulties. The aim of this study was to examine the acceptability of LBT using qualitative interviews and questionnaires with facilitators and parents/guardians on behalf of autistic children and young people. Acceptability was measured in line with constructs of the Theoretical Framework of Acceptability. Questionnaires were analyzed descriptively and between group comparisons were undertaken using the Mann-Whitney U Test. Telephone interviews were undertaken with a sub-sample of facilitators. All interviews were recorded, transcribed verbatim, and framework analysis was performed by two researchers supported by NVivo. The questionnaire response rate was 80% for facilitators and 77% for parents/guardians. Overall acceptability, measured on a 1-5 (minimum-maximum) scale, was high for both facilitators and parents/guardians with a median (range) of 5 (4-5) and 4 (3-5), respectively. Facilitators rated the acceptability of the programme significantly higher overall than parents (p En ligne : http://dx.doi.org/10.1002/aur.2725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] A mixed methods evaluation of the acceptability of therapy using LEGO® bricks (LEGO® based therapy) in mainstream primary and secondary education [Texte imprimé et/ou numérique] / Amy BARR, Auteur ; Elizabeth COATES, Auteur ; Ellen KINGSLEY, Auteur ; Gina GOMEZ DE LA CUESTA, Auteur ; Katie BIGGS, Auteur ; Ann LE COUTEUR, Auteur ; Barry WRIGHT, Auteur . - p.1237-1248. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1237-1248 Mots-clés : Lego®  autism  play brick therapy  qualitative research  questionnaires  social communication Index. décimale : PER Périodiques Résumé : Many autistic children and young people need extra support with social skills. Social skills programmes, such as LEGO® based therapy (LBT), are commonly used to help with these difficulties. The aim of this study was to examine the acceptability of LBT using qualitative interviews and questionnaires with facilitators and parents/guardians on behalf of autistic children and young people. Acceptability was measured in line with constructs of the Theoretical Framework of Acceptability. Questionnaires were analyzed descriptively and between group comparisons were undertaken using the Mann-Whitney U Test. Telephone interviews were undertaken with a sub-sample of facilitators. All interviews were recorded, transcribed verbatim, and framework analysis was performed by two researchers supported by NVivo. The questionnaire response rate was 80% for facilitators and 77% for parents/guardians. Overall acceptability, measured on a 1-5 (minimum-maximum) scale, was high for both facilitators and parents/guardians with a median (range) of 5 (4-5) and 4 (3-5), respectively. Facilitators rated the acceptability of the programme significantly higher overall than parents (p En ligne : http://dx.doi.org/10.1002/aur.2725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Associations between sleep problems and domains relevant to daytime functioning and clinical symptomatology in autism: A meta-analysis / Gloria T. HAN in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1249-1260 Titre : Associations between sleep problems and domains relevant to daytime functioning and clinical symptomatology in autism: A meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Gloria T. HAN, Auteur ; Dominic A. TREVISAN, Auteur ; Emily A. ABEL, Auteur ; Elise M. CUMMINGS, Auteur ; Carter CARLOS, Auteur ; Armen BAGDASAROV, Auteur ; Shashwat KALA, Auteur ; Termara PARKER, Auteur ; Craig CANAPARI, Auteur ; James C. MCPARTLAND, Auteur Article en page(s) : p.1249-1260 Langues : Anglais (eng) Mots-clés : autism  daytime functioning  meta-analysis  sleep Index. décimale : PER Périodiques Résumé : Autistic individuals experience significantly higher rates of sleep problems compared to the general population, which negatively impacts various aspects of daytime functioning. The strength of associations across domains of functioning has not yet been summarized across studies. The present meta-analysis examined the strength of associations between sleep problems and various domains of daytime functioning in autistic individuals. Searches were conducted in EMBASE, PubMed, Web of Science, and Google Scholar through May 2020. Inclusion criteria were: an index of sleep disturbance in individuals diagnosed with autism spectrum disorder (ASD); data collected prior to any sleep-related intervention; statistical data indicating relations between sleep problems and outcomes relevant to behavior, cognition, and physical or mental health. Exclusion criteria were: statistics characterizing the relationship between sleep disturbance and outcome variables that partialled out covariates; studies examining correlations between different measures of sleep disturbance. Participants totaled 15,074 from 49 published articles and 51 samples, yielding 209 effect sizes. Sleep problems were significantly associated with more clinical symptomatology and worse daytime functioning. Subgroup analyses demonstrated that sleep problems were most strongly associated with internalizing and externalizing symptoms and executive functioning, followed by core autism symptoms, family factors, and adaptive functioning. Findings highlight the far-reaching consequences of sleep problems on daytime functioning for autistic individuals and support the continued prioritization of sleep as a target for intervention through integrated care models to improve wellbeing. LAY SUMMARY: Autistic individuals experience higher rates of sleep problems, such as difficulty falling asleep and staying asleep, compared to the general population. We quantitatively summarized the literature about how sleep problems are related to different aspects of daytime functioning to identify areas that may be most affected by sleep. Sleep problems were related to all areas assessed, with the strongest associations for mood and anxiety symptoms. We recommend prioritizing sleep health in autistic individuals to improve wellbeing and quality of life. En ligne : http://dx.doi.org/10.1002/aur.2758 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Associations between sleep problems and domains relevant to daytime functioning and clinical symptomatology in autism: A meta-analysis [Texte imprimé et/ou numérique] / Gloria T. HAN, Auteur ; Dominic A. TREVISAN, Auteur ; Emily A. ABEL, Auteur ; Elise M. CUMMINGS, Auteur ; Carter CARLOS, Auteur ; Armen BAGDASAROV, Auteur ; Shashwat KALA, Auteur ; Termara PARKER, Auteur ; Craig CANAPARI, Auteur ; James C. MCPARTLAND, Auteur . - p.1249-1260. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1249-1260 Mots-clés : autism  daytime functioning  meta-analysis  sleep Index. décimale : PER Périodiques Résumé : Autistic individuals experience significantly higher rates of sleep problems compared to the general population, which negatively impacts various aspects of daytime functioning. The strength of associations across domains of functioning has not yet been summarized across studies. The present meta-analysis examined the strength of associations between sleep problems and various domains of daytime functioning in autistic individuals. Searches were conducted in EMBASE, PubMed, Web of Science, and Google Scholar through May 2020. Inclusion criteria were: an index of sleep disturbance in individuals diagnosed with autism spectrum disorder (ASD); data collected prior to any sleep-related intervention; statistical data indicating relations between sleep problems and outcomes relevant to behavior, cognition, and physical or mental health. Exclusion criteria were: statistics characterizing the relationship between sleep disturbance and outcome variables that partialled out covariates; studies examining correlations between different measures of sleep disturbance. Participants totaled 15,074 from 49 published articles and 51 samples, yielding 209 effect sizes. Sleep problems were significantly associated with more clinical symptomatology and worse daytime functioning. Subgroup analyses demonstrated that sleep problems were most strongly associated with internalizing and externalizing symptoms and executive functioning, followed by core autism symptoms, family factors, and adaptive functioning. Findings highlight the far-reaching consequences of sleep problems on daytime functioning for autistic individuals and support the continued prioritization of sleep as a target for intervention through integrated care models to improve wellbeing. LAY SUMMARY: Autistic individuals experience higher rates of sleep problems, such as difficulty falling asleep and staying asleep, compared to the general population. We quantitatively summarized the literature about how sleep problems are related to different aspects of daytime functioning to identify areas that may be most affected by sleep. Sleep problems were related to all areas assessed, with the strongest associations for mood and anxiety symptoms. We recommend prioritizing sleep health in autistic individuals to improve wellbeing and quality of life. En ligne : http://dx.doi.org/10.1002/aur.2758 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Beyond group differences: Exploring the preliminary signals of target engagement of an executive function training for autistic children / Sarah R. EDMUNDS in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1261-1273 Titre : Beyond group differences: Exploring the preliminary signals of target engagement of an executive function training for autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Sarah R. EDMUNDS, Auteur ; Gabrielle A. MACNAUGHTON, Auteur ; M. Rosario RUEDA, Auteur ; Lina M. COMBITA, Auteur ; Susan FAJA, Auteur Article en page(s) : p.1261-1273 Langues : Anglais (eng) Mots-clés : Adhd  anxiety  autism spectrum disorders  executive function training  inhibitory control  moderation  target engagement Index. décimale : PER Périodiques Résumé : Understanding both for whom and how interventions work is a crucial next step in providing personalized care to children with autism spectrum disorder (ASD). Autistic children present with heterogeneity both within core ASD criteria and with respect to co-occurring mental health challenges, which may affect their ability to benefit from intervention. In a secondary data analysis of a randomized control trial evaluating an executive function (EF) training with 70 7- to 11-year-old autistic children, we explored: (1) whether co-occurring attention-deficit/hyperactivity disorder (ADHD) features or anxiety features at baseline moderated the extent to which children benefited from the EF training. In other words, we asked, "For whom is training effective?" We also explored: (2) the extent to which changes in a brain-based measure of target engagement predicted the clinical outcomes of the EF training. This is a step towards asking, "How is training effective?" We found that EF training improved behavioral inhibition only for children with clinically significant co-occurring ADHD features. Anxiety features, while prevalent, did not moderate EF training efficacy. Finally, for the EF training group only, there was a significant correlation between pre-to-post change in an EEG-based measure of target engagement, N2 incongruent amplitude during a flanker task, and change in repetitive behaviors, a behavioral outcome that was reported in the parent RCT to have improved with training compared to waitlist control. This study provides preliminary evidence that EF training may differentially affect subgroups of autistic children and that changes at the neural level may precede changes in behavior. LAY SUMMARY: Understanding both for whom and how interventions work will help us provide personalized care to children with autism spectrum disorder (ASD). Autistic children present with many different strengths and challenges. Co-occurring mental health challenges may affect how much autistic children benefit from intervention. We analyzed secondary data from a rigorously designed pilot intervention study, a randomized control trial (RCT), that enrolled 70 7- to 11-year-old autistic children to assess whether a set of computer-based executive function (EF) training games improved their performance. Executive functions include being able to shift between tasks, inhibit a response, and keep information in working memory. In the current study, we explored: (1) whether children's co-occurring attention-deficit/hyperactivity disorder (ADHD) features or anxiety features, measured before the EF training began, affected how much they benefited from the EF training. In other words, we asked, "For whom is training effective?" We also explored: (2) whether children's brain-based changes in EF predicted their performance in everyday life (e.g., parent report on a survey). This is a step toward asking, "How is training effective?" We found that EF training improved children's inhibition ability, but only for children with clinically significant ADHD features. While many children in our sample also had anxiety features, we found that anxiety levels did not affect how well the EF training worked. Finally, for children who received the EF training, changes in a brain-based measure of conflict monitoring (i.e., being able to noticing differences in stimuli) predicted changes in children's repetitive behaviors. This study provides early evidence that EF training may be more effective for some autistic children than others, especially those with ADHD features. En ligne : http://dx.doi.org/10.1002/aur.2735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Beyond group differences: Exploring the preliminary signals of target engagement of an executive function training for autistic children [Texte imprimé et/ou numérique] / Sarah R. EDMUNDS, Auteur ; Gabrielle A. MACNAUGHTON, Auteur ; M. Rosario RUEDA, Auteur ; Lina M. COMBITA, Auteur ; Susan FAJA, Auteur . - p.1261-1273. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1261-1273 Mots-clés : Adhd  anxiety  autism spectrum disorders  executive function training  inhibitory control  moderation  target engagement Index. décimale : PER Périodiques Résumé : Understanding both for whom and how interventions work is a crucial next step in providing personalized care to children with autism spectrum disorder (ASD). Autistic children present with heterogeneity both within core ASD criteria and with respect to co-occurring mental health challenges, which may affect their ability to benefit from intervention. In a secondary data analysis of a randomized control trial evaluating an executive function (EF) training with 70 7- to 11-year-old autistic children, we explored: (1) whether co-occurring attention-deficit/hyperactivity disorder (ADHD) features or anxiety features at baseline moderated the extent to which children benefited from the EF training. In other words, we asked, "For whom is training effective?" We also explored: (2) the extent to which changes in a brain-based measure of target engagement predicted the clinical outcomes of the EF training. This is a step towards asking, "How is training effective?" We found that EF training improved behavioral inhibition only for children with clinically significant co-occurring ADHD features. Anxiety features, while prevalent, did not moderate EF training efficacy. Finally, for the EF training group only, there was a significant correlation between pre-to-post change in an EEG-based measure of target engagement, N2 incongruent amplitude during a flanker task, and change in repetitive behaviors, a behavioral outcome that was reported in the parent RCT to have improved with training compared to waitlist control. This study provides preliminary evidence that EF training may differentially affect subgroups of autistic children and that changes at the neural level may precede changes in behavior. LAY SUMMARY: Understanding both for whom and how interventions work will help us provide personalized care to children with autism spectrum disorder (ASD). Autistic children present with many different strengths and challenges. Co-occurring mental health challenges may affect how much autistic children benefit from intervention. We analyzed secondary data from a rigorously designed pilot intervention study, a randomized control trial (RCT), that enrolled 70 7- to 11-year-old autistic children to assess whether a set of computer-based executive function (EF) training games improved their performance. Executive functions include being able to shift between tasks, inhibit a response, and keep information in working memory. In the current study, we explored: (1) whether children's co-occurring attention-deficit/hyperactivity disorder (ADHD) features or anxiety features, measured before the EF training began, affected how much they benefited from the EF training. In other words, we asked, "For whom is training effective?" We also explored: (2) whether children's brain-based changes in EF predicted their performance in everyday life (e.g., parent report on a survey). This is a step toward asking, "How is training effective?" We found that EF training improved children's inhibition ability, but only for children with clinically significant ADHD features. While many children in our sample also had anxiety features, we found that anxiety levels did not affect how well the EF training worked. Finally, for children who received the EF training, changes in a brain-based measure of conflict monitoring (i.e., being able to noticing differences in stimuli) predicted changes in children's repetitive behaviors. This study provides early evidence that EF training may be more effective for some autistic children than others, especially those with ADHD features. En ligne : http://dx.doi.org/10.1002/aur.2735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Clinical and behavioral attributes leading to sleep disorders in children on the autism spectrum / Anne MASI in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1274-1287 Titre : Clinical and behavioral attributes leading to sleep disorders in children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Anne MASI, Auteur ; Mohammod Ali MONI, Auteur ; Syeda Ishra AZIM, Auteur ; Byungkuk CHOI, Auteur ; Helen S. HEUSSLER, Auteur ; Ping-I LIN, Auteur ; Antonio Mendoza DIAZ, Auteur ; Valsamma EAPEN, Auteur Article en page(s) : p.1274-1287 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  behavioral problems  children  clinical phenotypes  sleep disorders Index. décimale : PER Périodiques Résumé : Sleep disorders are a common comorbid condition in children diagnosed with autism spectrum disorder ("autism"). However, the relationship between the clinical features of autism and sleep disorders remains unclear. A better understanding of the inherent autism-related characteristics linked to comorbid sleep disorders would improve comprehensive assessment and management. This study examined the relationship between sociodemographics, autism symptoms, sleep problems, cognitive status, behavioral attributes, and sensory profiles. Using data from 1268 participants who took part in the Australian Autism Biobank, sleep-related measurements using the Child Sleep Habits Questionnaire (CSHQ) were compared between autistic children aged 2 to 17 (N =?969), their siblings (N =?188), and unrelated children without an autism diagnosis (N =?111). The known relationship between sleep problems and autism was further explored by including scores from the Autism Diagnostic Observation Schedule-2, Mullen Scales of Early Learning, Vineland Adaptive Behavioral Scale-II and the Short Sensory Profile-2; which were included in analyses for autistic participants who had a completed CSHQ. Multiple regression models were used to identify clinical/behavioral variables associated with CSHQ subscales. The autism group had a significantly higher total CSHQ score than the sibling and comparison groups (p En ligne : http://dx.doi.org/10.1002/aur.2745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Clinical and behavioral attributes leading to sleep disorders in children on the autism spectrum [Texte imprimé et/ou numérique] / Anne MASI, Auteur ; Mohammod Ali MONI, Auteur ; Syeda Ishra AZIM, Auteur ; Byungkuk CHOI, Auteur ; Helen S. HEUSSLER, Auteur ; Ping-I LIN, Auteur ; Antonio Mendoza DIAZ, Auteur ; Valsamma EAPEN, Auteur . - p.1274-1287. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1274-1287 Mots-clés : autism spectrum disorder  behavioral problems  children  clinical phenotypes  sleep disorders Index. décimale : PER Périodiques Résumé : Sleep disorders are a common comorbid condition in children diagnosed with autism spectrum disorder ("autism"). However, the relationship between the clinical features of autism and sleep disorders remains unclear. A better understanding of the inherent autism-related characteristics linked to comorbid sleep disorders would improve comprehensive assessment and management. This study examined the relationship between sociodemographics, autism symptoms, sleep problems, cognitive status, behavioral attributes, and sensory profiles. Using data from 1268 participants who took part in the Australian Autism Biobank, sleep-related measurements using the Child Sleep Habits Questionnaire (CSHQ) were compared between autistic children aged 2 to 17 (N =?969), their siblings (N =?188), and unrelated children without an autism diagnosis (N =?111). The known relationship between sleep problems and autism was further explored by including scores from the Autism Diagnostic Observation Schedule-2, Mullen Scales of Early Learning, Vineland Adaptive Behavioral Scale-II and the Short Sensory Profile-2; which were included in analyses for autistic participants who had a completed CSHQ. Multiple regression models were used to identify clinical/behavioral variables associated with CSHQ subscales. The autism group had a significantly higher total CSHQ score than the sibling and comparison groups (p En ligne : http://dx.doi.org/10.1002/aur.2745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Combining voice and language features improves automated autism detection / Heather MACFARLANE in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1288-1300 Titre : Combining voice and language features improves automated autism detection Type de document : Texte imprimé et/ou numérique Auteurs : Heather MACFARLANE, Auteur ; Alexandra C. SALEM, Auteur ; Liu CHEN, Auteur ; Meysam ASGARI, Auteur ; Eric FOMBONNE, Auteur Article en page(s) : p.1288-1300 Langues : Anglais (eng) Mots-clés : autism  automated measures  communication  disfluency  natural language processing  pragmatic language  prosody  voice Index. décimale : PER Périodiques Résumé : Variability in expressive and receptive language, difficulty with pragmatic language, and prosodic difficulties are all features of autism spectrum disorder (ASD). Quantifying language and voice characteristics is an important step for measuring outcomes for autistic people, yet clinical measurement is cumbersome and costly. Using natural language processing (NLP) methods and a harmonic model of speech, we analyzed language transcripts and audio recordings to automatically classify individuals as ASD or non-ASD. One-hundred fifty-eight participants (88 ASD, 70 non-ASD) ages 7 to 17 were evaluated with the autism diagnostic observation schedule (ADOS-2), module 3. The ADOS-2 was transcribed following modified SALT guidelines. Seven automated language measures (ALMs) and 10 automated voice measures (AVMs) for each participant were generated from the transcripts and audio of one ADOS-2 task. The measures were analyzed using support vector machine (SVM; a binary classifier) and receiver operating characteristic (ROC). The AVM model resulted in an ROC area under the curve (AUC) of 0.7800, the ALM model an AUC of 0.8748, and the combined model a significantly improved AUC of 0.9205. The ALM model better detected ASD participants who were younger and had lower language skills and shorter activity time. ASD participants detected by the AVM model had better language profiles than those detected by the language model. In combination, automated measurement of language and voice characteristics successfully differentiated children with and without autism. This methodology could help design robust outcome measures for future research. LAY SUMMARY: People with autism often struggle with communication differences which traditional clinical measures and language tests cannot fully capture. Using language transcripts and audio recordings from 158 children ages 7 to 17, we showed that automated, objective language and voice measurements successfully predict the child's diagnosis. This methodology could help design improved outcome measures for research. En ligne : http://dx.doi.org/10.1002/aur.2733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Combining voice and language features improves automated autism detection [Texte imprimé et/ou numérique] / Heather MACFARLANE, Auteur ; Alexandra C. SALEM, Auteur ; Liu CHEN, Auteur ; Meysam ASGARI, Auteur ; Eric FOMBONNE, Auteur . - p.1288-1300. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1288-1300 Mots-clés : autism  automated measures  communication  disfluency  natural language processing  pragmatic language  prosody  voice Index. décimale : PER Périodiques Résumé : Variability in expressive and receptive language, difficulty with pragmatic language, and prosodic difficulties are all features of autism spectrum disorder (ASD). Quantifying language and voice characteristics is an important step for measuring outcomes for autistic people, yet clinical measurement is cumbersome and costly. Using natural language processing (NLP) methods and a harmonic model of speech, we analyzed language transcripts and audio recordings to automatically classify individuals as ASD or non-ASD. One-hundred fifty-eight participants (88 ASD, 70 non-ASD) ages 7 to 17 were evaluated with the autism diagnostic observation schedule (ADOS-2), module 3. The ADOS-2 was transcribed following modified SALT guidelines. Seven automated language measures (ALMs) and 10 automated voice measures (AVMs) for each participant were generated from the transcripts and audio of one ADOS-2 task. The measures were analyzed using support vector machine (SVM; a binary classifier) and receiver operating characteristic (ROC). The AVM model resulted in an ROC area under the curve (AUC) of 0.7800, the ALM model an AUC of 0.8748, and the combined model a significantly improved AUC of 0.9205. The ALM model better detected ASD participants who were younger and had lower language skills and shorter activity time. ASD participants detected by the AVM model had better language profiles than those detected by the language model. In combination, automated measurement of language and voice characteristics successfully differentiated children with and without autism. This methodology could help design robust outcome measures for future research. LAY SUMMARY: People with autism often struggle with communication differences which traditional clinical measures and language tests cannot fully capture. Using language transcripts and audio recordings from 158 children ages 7 to 17, we showed that automated, objective language and voice measurements successfully predict the child's diagnosis. This methodology could help design improved outcome measures for research. En ligne : http://dx.doi.org/10.1002/aur.2733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Developmental profiles of children at risk for autism spectrum disorder at school entry / Angie IP in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1301-1310 Titre : Developmental profiles of children at risk for autism spectrum disorder at school entry Type de document : Texte imprimé et/ou numérique Auteurs : Angie IP, Auteur ; Brenda T. POON, Auteur ; Gillian HANLEY, Auteur ; Martin GUHN, Auteur ; Tim F. OBERLANDER, Auteur Article en page(s) : p.1301-1310 Langues : Anglais (eng) Mots-clés : attention deficit disorder  autism spectrum disorder  child development  cohort studies  diagnosis  functional status  health equity Index. décimale : PER Périodiques Résumé : Functional abilities in children with autism spectrum disorder (ASD) are highly heterogenous, and impairments can overlap with non-ASD neurodevelopmental disorders. We compared the profiles of children assessed for ASD with and without an ASD diagnosis using a retrospective cohort study of 101,739 children born in British Columbia (2000-2008). The children were grouped into the following five comparison groups: (1) ASD- (n = 1131), (2) ASD+ (n = 1583), (3) Ministry of Education designated ASD+ (n = 654), (4) special need other than ASD (n = 11,663), and (5) typically developing (n = 86,708). Five developmental domains were assessed using the Early Development Instrument. ANCOVA was used to control for covariates, Tukey's HSD test for multiple comparisons, and Cohen's d for effect size. The ASD- group had slightly higher scores than the ASD+ group with small to medium effect sizes in all domains (d = 0.20-0.48). The ASD- group had slightly higher scores than the Ministry of Education ASD+ group in only three domains with small effect sizes (d = 0.21-0.25). The ASD- group had lower scores in all domains compared to the typically developing group with large effect sizes in all domains (d = 1.12-1.77). The ASD- group received less education funding at school entry than both ASD+ groups. Overall, only small to medium differences in development were detected between the ASD- and ASD+ groups. While these children differ diagnostically, they share similar functional profiles and have substantially more difficulties than typically developing children. Therefore, differences in levels of support at school entry raise critical questions of equity. LAY SUMMARY: Comparison of children in British Columbia who have been referred for an autism assessment, with or without a diagnosis, shows similarities in their functional and developmental profiles in kindergarten. Furthermore, both groups of children have more difficulties than typically developing children. However, children who have been referred for assessment without an autism diagnosis receive less financial support at school entry, raising important questions on equity. En ligne : http://dx.doi.org/10.1002/aur.2742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Developmental profiles of children at risk for autism spectrum disorder at school entry [Texte imprimé et/ou numérique] / Angie IP, Auteur ; Brenda T. POON, Auteur ; Gillian HANLEY, Auteur ; Martin GUHN, Auteur ; Tim F. OBERLANDER, Auteur . - p.1301-1310. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1301-1310 Mots-clés : attention deficit disorder  autism spectrum disorder  child development  cohort studies  diagnosis  functional status  health equity Index. décimale : PER Périodiques Résumé : Functional abilities in children with autism spectrum disorder (ASD) are highly heterogenous, and impairments can overlap with non-ASD neurodevelopmental disorders. We compared the profiles of children assessed for ASD with and without an ASD diagnosis using a retrospective cohort study of 101,739 children born in British Columbia (2000-2008). The children were grouped into the following five comparison groups: (1) ASD- (n = 1131), (2) ASD+ (n = 1583), (3) Ministry of Education designated ASD+ (n = 654), (4) special need other than ASD (n = 11,663), and (5) typically developing (n = 86,708). Five developmental domains were assessed using the Early Development Instrument. ANCOVA was used to control for covariates, Tukey's HSD test for multiple comparisons, and Cohen's d for effect size. The ASD- group had slightly higher scores than the ASD+ group with small to medium effect sizes in all domains (d = 0.20-0.48). The ASD- group had slightly higher scores than the Ministry of Education ASD+ group in only three domains with small effect sizes (d = 0.21-0.25). The ASD- group had lower scores in all domains compared to the typically developing group with large effect sizes in all domains (d = 1.12-1.77). The ASD- group received less education funding at school entry than both ASD+ groups. Overall, only small to medium differences in development were detected between the ASD- and ASD+ groups. While these children differ diagnostically, they share similar functional profiles and have substantially more difficulties than typically developing children. Therefore, differences in levels of support at school entry raise critical questions of equity. LAY SUMMARY: Comparison of children in British Columbia who have been referred for an autism assessment, with or without a diagnosis, shows similarities in their functional and developmental profiles in kindergarten. Furthermore, both groups of children have more difficulties than typically developing children. However, children who have been referred for assessment without an autism diagnosis receive less financial support at school entry, raising important questions on equity. En ligne : http://dx.doi.org/10.1002/aur.2742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Do children with and without autism spectrum disorder use different visuospatial processing skills to perform the Rey-Osterrieth complex figure test? / Ramona CARDILLO in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1311-1323 Titre : Do children with and without autism spectrum disorder use different visuospatial processing skills to perform the Rey-Osterrieth complex figure test? Type de document : Texte imprimé et/ou numérique Auteurs : Ramona CARDILLO, Auteur ; Rachele LIEVORE, Auteur ; Irene C. MAMMARELLA, Auteur Article en page(s) : p.1311-1323 Langues : Anglais (eng) Mots-clés : Rey-Osterrieth complex figure  autism spectrum disorder  local/global processing  visuospatial organization abilities  visuospatial skills Index. décimale : PER Périodiques Résumé : Visuospatial organization abilities are closely related to other visuospatial processing skills, such as visuomotor coordination, perceptual abilities, mental rotation, and working memory (WM). One task that enables visuospatial organization abilities to be investigated is the Rey-Osterrieth complex figure test (ROCFT). When examining visuospatial functioning, individuals with autism spectrum disorder (ASD) have proved capable of operating both locally and globally, depending on the sub-domain embraced, with a preference for a locally-oriented processing of visuospatial information. The present research aimed to establish whether different underlying visuospatial skills might account for performance in the ROCFT in children and adolescents with ASD, compared with typically developing (TD), by considering the role of local/global visuospatial processing. The study involved 39 participants who have ASD without intellectual disability, and 57 TD aged 8-16?years. The participants were administered tasks assessing visuospatial organization abilities, manual dexterity, visual perception, mental rotation, spatial-sequential, spatial-simultaneous WM, and visuospatial processing. Our results suggest that manual dexterity and visuospatial processing similarly explain performance in both groups, while differences in visuospatial WM account for the two groups' visuospatial organization abilities. Spatial-simultaneous WM predicted performance in copy and recall conditions in the TD group but not in the ASD group, while spatial-sequential WM only did so in the latter group, reinforcing the tendency of children with ASD towards local bias in the visuospatial organization domain. The implications of these findings are discussed. LAY SUMMARY: The visuospatial organization abilities of children and adolescents with and without autism were compared, considering their underlying visuospatial skills. Visuospatial organization impairments emerged for children with autism, who differed from typically developing children in the underlying visuospatial skills involved. Given the crucial role of visuospatial organization abilities in everyday life, our results could inspire practitioners to develop training interventions that take into account the strengths and weaknesses of individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.2717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Do children with and without autism spectrum disorder use different visuospatial processing skills to perform the Rey-Osterrieth complex figure test? [Texte imprimé et/ou numérique] / Ramona CARDILLO, Auteur ; Rachele LIEVORE, Auteur ; Irene C. MAMMARELLA, Auteur . - p.1311-1323. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1311-1323 Mots-clés : Rey-Osterrieth complex figure  autism spectrum disorder  local/global processing  visuospatial organization abilities  visuospatial skills Index. décimale : PER Périodiques Résumé : Visuospatial organization abilities are closely related to other visuospatial processing skills, such as visuomotor coordination, perceptual abilities, mental rotation, and working memory (WM). One task that enables visuospatial organization abilities to be investigated is the Rey-Osterrieth complex figure test (ROCFT). When examining visuospatial functioning, individuals with autism spectrum disorder (ASD) have proved capable of operating both locally and globally, depending on the sub-domain embraced, with a preference for a locally-oriented processing of visuospatial information. The present research aimed to establish whether different underlying visuospatial skills might account for performance in the ROCFT in children and adolescents with ASD, compared with typically developing (TD), by considering the role of local/global visuospatial processing. The study involved 39 participants who have ASD without intellectual disability, and 57 TD aged 8-16?years. The participants were administered tasks assessing visuospatial organization abilities, manual dexterity, visual perception, mental rotation, spatial-sequential, spatial-simultaneous WM, and visuospatial processing. Our results suggest that manual dexterity and visuospatial processing similarly explain performance in both groups, while differences in visuospatial WM account for the two groups' visuospatial organization abilities. Spatial-simultaneous WM predicted performance in copy and recall conditions in the TD group but not in the ASD group, while spatial-sequential WM only did so in the latter group, reinforcing the tendency of children with ASD towards local bias in the visuospatial organization domain. The implications of these findings are discussed. LAY SUMMARY: The visuospatial organization abilities of children and adolescents with and without autism were compared, considering their underlying visuospatial skills. Visuospatial organization impairments emerged for children with autism, who differed from typically developing children in the underlying visuospatial skills involved. Given the crucial role of visuospatial organization abilities in everyday life, our results could inspire practitioners to develop training interventions that take into account the strengths and weaknesses of individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.2717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study / Meredith PECUKONIS in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1324-1335 Titre : Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study Type de document : Texte imprimé et/ou numérique Auteurs : Meredith PECUKONIS, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Mayada ELSABBAGH, Auteur ; Jana M. IVERSON, Auteur ; Shafali JESTE, Auteur ; Rebecca LANDA, Auteur ; Daniel S. MESSINGER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Sara Jane WEBB, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.1324-1335 Langues : Anglais (eng) Mots-clés : gesture  infant sibling  language  maternal education  motor  nonverbal cognition Index. décimale : PER Périodiques Résumé : While previous work has identified the early predictors of language skills in infants at elevated familial risk (ER) and low familial risk (LR) for autism spectrum disorder (ASD), no studies to date have explored whether these predictors vary based on diagnostic outcome of ASD or no ASD. The present study used a large, multisite dataset to examine associations between a set of commonly studied predictor variables (infant gesture abilities, fine motor skills, nonverbal cognition, and maternal education level), measured at 12?months, and language skills, measured at 3?years, across three diagnostic outcome groups-infants with ASD ("ASD"), ER infants without ASD ("ER-no ASD"), and LR infants without ASD ("LR-no ASD"). Findings revealed that the predictors of language skills differed across groups, as gesture abilities were positively associated with language skills in the ER-no ASD group but negatively associated with language skills in the ASD group. Furthermore, maternal education level was positively associated with language skills in the ASD and LR-no ASD groups only. Variability in these early predictors may help explain why language skills are heterogeneous across the autism spectrum, and, with further study, may help clinicians identify those in need of additional and/or specialized intervention services that support language development. LAY SUMMARY: The present study identified predictors of language skills in infants with and without autism spectrum disorder (ASD). Maternal education level and 12-month gesture abilities predicted 3-year language skills in infants with ASD. Measuring these predictors early in life may help identify infants and families in need of additional and/or specialized intervention services that support language development. En ligne : http://dx.doi.org/10.1002/aur.2760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study [Texte imprimé et/ou numérique] / Meredith PECUKONIS, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Mayada ELSABBAGH, Auteur ; Jana M. IVERSON, Auteur ; Shafali JESTE, Auteur ; Rebecca LANDA, Auteur ; Daniel S. MESSINGER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Sara Jane WEBB, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.1324-1335. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1324-1335 Mots-clés : gesture  infant sibling  language  maternal education  motor  nonverbal cognition Index. décimale : PER Périodiques Résumé : While previous work has identified the early predictors of language skills in infants at elevated familial risk (ER) and low familial risk (LR) for autism spectrum disorder (ASD), no studies to date have explored whether these predictors vary based on diagnostic outcome of ASD or no ASD. The present study used a large, multisite dataset to examine associations between a set of commonly studied predictor variables (infant gesture abilities, fine motor skills, nonverbal cognition, and maternal education level), measured at 12?months, and language skills, measured at 3?years, across three diagnostic outcome groups-infants with ASD ("ASD"), ER infants without ASD ("ER-no ASD"), and LR infants without ASD ("LR-no ASD"). Findings revealed that the predictors of language skills differed across groups, as gesture abilities were positively associated with language skills in the ER-no ASD group but negatively associated with language skills in the ASD group. Furthermore, maternal education level was positively associated with language skills in the ASD and LR-no ASD groups only. Variability in these early predictors may help explain why language skills are heterogeneous across the autism spectrum, and, with further study, may help clinicians identify those in need of additional and/or specialized intervention services that support language development. LAY SUMMARY: The present study identified predictors of language skills in infants with and without autism spectrum disorder (ASD). Maternal education level and 12-month gesture abilities predicted 3-year language skills in infants with ASD. Measuring these predictors early in life may help identify infants and families in need of additional and/or specialized intervention services that support language development. En ligne : http://dx.doi.org/10.1002/aur.2760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder / Kelly POWELL in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1336-1347 Titre : Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kelly POWELL, Auteur ; Suzanne MACARI, Auteur ; Emma BRENNAN-WYDRA, Auteur ; Hannah FEINER, Auteur ; Maureen BUTLER, Auteur ; Diogo GONCALVES FORTES, Auteur ; Alexandra BOXBERGER, Auteur ; Mariana TORRES-VISO, Auteur ; Chelsea MORGAN, Auteur ; Megan LYONS, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1336-1347 Langues : Anglais (eng) Mots-clés : autism  executive function  sibling  toddlers Index. décimale : PER Périodiques Résumé : Executive functioning (EF) deficits co-occur frequently with autism spectrum disorder (ASD) and have a long-term detrimental impact on quality of life of children and their families. Timely identification of risk for EF vulnerabilities may hasten access to early intervention and alleviate their long-term consequences. This study examines (1) if EF deficits are elevated in toddlers with ASD compared to nonautistic siblings of children with ASD, typically developing (TYP) toddlers, and toddlers with atypical developmental presentation; and (2) if EF deficits have a detrimental effect on adaptive functioning in ASD. Participants were recruited between September 2014 and October 2019 and included 73 toddlers with ASD, 33 nonautistic siblings of children with ASD, 35 toddlers with atypical development, and 28 TYP toddlers matched on chronological age (M = 39.01?months, SD = 3.11). EF deficits were measured using the BRIEF-P; adaptive skills were measured using the VABS-II. Whenever appropriate, analyses were controlled for MSEL verbal and nonverbal developmental quotient, ADOS-2 autism severity scores, and sex. Analyses revealed that toddlers with ASD exhibited elevated BRIEF-P scores across all domains compared to each of the three comparison groups. Higher BRIEF-P scores were associated with lower adaptive social, communication, and daily living skills while controlling for symptom severity, verbal and nonverbal functioning, and sex. In conclusion, marked vulnerabilities in EF are already present in 3-year-old toddlers with ASD and are predictive of the level of adaptive functioning in ASD. EF vulnerabilities in toddlers should be targeted for intervention to improve long-term outcomes in ASD. LAY SUMMARY: Many children with autism experience vulnerabilities in executive functioning (EF), which may include challenges with inhibition, working memory, cognitive flexibility, and planning. The study shows that these vulnerabilities can already be detected at age three and that their presence is linked with lower social, communication, and daily living skills. Screening children with ASD for EF challenges and helping those who have difficulties may improve their long-term outcomes. En ligne : http://dx.doi.org/10.1002/aur.2715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder [Texte imprimé et/ou numérique] / Kelly POWELL, Auteur ; Suzanne MACARI, Auteur ; Emma BRENNAN-WYDRA, Auteur ; Hannah FEINER, Auteur ; Maureen BUTLER, Auteur ; Diogo GONCALVES FORTES, Auteur ; Alexandra BOXBERGER, Auteur ; Mariana TORRES-VISO, Auteur ; Chelsea MORGAN, Auteur ; Megan LYONS, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1336-1347. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1336-1347 Mots-clés : autism  executive function  sibling  toddlers Index. décimale : PER Périodiques Résumé : Executive functioning (EF) deficits co-occur frequently with autism spectrum disorder (ASD) and have a long-term detrimental impact on quality of life of children and their families. Timely identification of risk for EF vulnerabilities may hasten access to early intervention and alleviate their long-term consequences. This study examines (1) if EF deficits are elevated in toddlers with ASD compared to nonautistic siblings of children with ASD, typically developing (TYP) toddlers, and toddlers with atypical developmental presentation; and (2) if EF deficits have a detrimental effect on adaptive functioning in ASD. Participants were recruited between September 2014 and October 2019 and included 73 toddlers with ASD, 33 nonautistic siblings of children with ASD, 35 toddlers with atypical development, and 28 TYP toddlers matched on chronological age (M = 39.01?months, SD = 3.11). EF deficits were measured using the BRIEF-P; adaptive skills were measured using the VABS-II. Whenever appropriate, analyses were controlled for MSEL verbal and nonverbal developmental quotient, ADOS-2 autism severity scores, and sex. Analyses revealed that toddlers with ASD exhibited elevated BRIEF-P scores across all domains compared to each of the three comparison groups. Higher BRIEF-P scores were associated with lower adaptive social, communication, and daily living skills while controlling for symptom severity, verbal and nonverbal functioning, and sex. In conclusion, marked vulnerabilities in EF are already present in 3-year-old toddlers with ASD and are predictive of the level of adaptive functioning in ASD. EF vulnerabilities in toddlers should be targeted for intervention to improve long-term outcomes in ASD. LAY SUMMARY: Many children with autism experience vulnerabilities in executive functioning (EF), which may include challenges with inhibition, working memory, cognitive flexibility, and planning. The study shows that these vulnerabilities can already be detected at age three and that their presence is linked with lower social, communication, and daily living skills. Screening children with ASD for EF challenges and helping those who have difficulties may improve their long-term outcomes. En ligne : http://dx.doi.org/10.1002/aur.2715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability / Ning PAN in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1348-1357 Titre : Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur Article en page(s) : p.1348-1357 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD?+?ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD?+?ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12?years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD?+?ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p? En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability [Texte imprimé et/ou numérique] / Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur . - p.1348-1357. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1348-1357 Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD?+?ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD?+?ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12?years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD?+?ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p? En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Diagnosing autism in low-income countries: Clinical record-based analysis in Sri Lanka / Hashan PEIRIS in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1358-1367 Titre : Diagnosing autism in low-income countries: Clinical record-based analysis in Sri Lanka Type de document : Texte imprimé et/ou numérique Auteurs : Hashan PEIRIS, Auteur ; Darshana Chitraka WICKRAMARACHCHI, Auteur ; Pradeepa SAMARASINGHE, Auteur ; Philip VANCE, Auteur ; Dulangi DAHANAYAKE, Auteur ; Veerandi KULASEKARA, Auteur ; Madhuka NADEESHANI, Auteur Article en page(s) : p.1358-1367 Langues : Anglais (eng) Mots-clés : Asd  ASD diagnosing standards  ASD predictors  Cars  autism  classification  cultural factors  logistic regression  low-income countries Index. décimale : PER Périodiques Résumé : Use of autism diagnosing standards in low-income countries (LICs) are restricted due to the high price and unavailability of trained health professionals. Furthermore, these standards are heavily skewed towards developed countries and LICs are underrepresented. Due to such constraints, many LICs use their own ways of assessing autism. This is the first retrospective study to analyze such local practices in Sri Lanka. The study was conducted at Ward 19B of Lady Ridgeway Hospital (LRH) using the clinical forms filled for diagnosing ASD. In this study, 356 records were analyzed, from which 79.5% were boys and the median age was 33?months. For each child, the clinical form together with the Childhood Autism Rating Scale (CARS) value were recorded. In this study, a Clinically Derived Autism Score (CDAS) is obtained from the clinical forms. Scatter plot and Pearson product moment correlation coefficient were used to benchmark CDAS with CARS, and it was found CDAS to be positively and moderately correlated with CARS. In identifying the significant variables, a logistic regression model was built based on clinically observed data and it evidenced that "Eye Contact," "Interaction with Others," "Pointing," "Flapping of Hands," "Request for Needs," "Rotate Wheels," and "Line up Things" variables as the most significant variables in diagnosing autism. Based on these significant predictors, the classification tree was built. The pruned tree depicts a set of rules, which could be used in similar clinical environments to screen for autism. LAY SUMMARY: Screening and diagnosing autism in low-income countries such as Sri Lanka has always been a challenge due to limited resources and not being able to afford global standards. Due to these challenges, locally developed clinical forms have been used. This study is the first to analyze a clinical record set for autism in Sri Lanka to benchmark the local clinic form with a global standard. Furthermore, this study identifies the most significant diagnostic symptoms for children and based on these significant features, a simple set of IF-THEN rules are derived which could be used for screening autism in a similar clinical environment by health officials in the absence of consultants. En ligne : http://dx.doi.org/10.1002/aur.2765 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Diagnosing autism in low-income countries: Clinical record-based analysis in Sri Lanka [Texte imprimé et/ou numérique] / Hashan PEIRIS, Auteur ; Darshana Chitraka WICKRAMARACHCHI, Auteur ; Pradeepa SAMARASINGHE, Auteur ; Philip VANCE, Auteur ; Dulangi DAHANAYAKE, Auteur ; Veerandi KULASEKARA, Auteur ; Madhuka NADEESHANI, Auteur . - p.1358-1367. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1358-1367 Mots-clés : Asd  ASD diagnosing standards  ASD predictors  Cars  autism  classification  cultural factors  logistic regression  low-income countries Index. décimale : PER Périodiques Résumé : Use of autism diagnosing standards in low-income countries (LICs) are restricted due to the high price and unavailability of trained health professionals. Furthermore, these standards are heavily skewed towards developed countries and LICs are underrepresented. Due to such constraints, many LICs use their own ways of assessing autism. This is the first retrospective study to analyze such local practices in Sri Lanka. The study was conducted at Ward 19B of Lady Ridgeway Hospital (LRH) using the clinical forms filled for diagnosing ASD. In this study, 356 records were analyzed, from which 79.5% were boys and the median age was 33?months. For each child, the clinical form together with the Childhood Autism Rating Scale (CARS) value were recorded. In this study, a Clinically Derived Autism Score (CDAS) is obtained from the clinical forms. Scatter plot and Pearson product moment correlation coefficient were used to benchmark CDAS with CARS, and it was found CDAS to be positively and moderately correlated with CARS. In identifying the significant variables, a logistic regression model was built based on clinically observed data and it evidenced that "Eye Contact," "Interaction with Others," "Pointing," "Flapping of Hands," "Request for Needs," "Rotate Wheels," and "Line up Things" variables as the most significant variables in diagnosing autism. Based on these significant predictors, the classification tree was built. The pruned tree depicts a set of rules, which could be used in similar clinical environments to screen for autism. LAY SUMMARY: Screening and diagnosing autism in low-income countries such as Sri Lanka has always been a challenge due to limited resources and not being able to afford global standards. Due to these challenges, locally developed clinical forms have been used. This study is the first to analyze a clinical record set for autism in Sri Lanka to benchmark the local clinic form with a global standard. Furthermore, this study identifies the most significant diagnostic symptoms for children and based on these significant features, a simple set of IF-THEN rules are derived which could be used for screening autism in a similar clinical environment by health officials in the absence of consultants. En ligne : http://dx.doi.org/10.1002/aur.2765 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477