Dépouillements

Atypical Cerebellar Responses are Associated with Altered Neural Habituation during Sensory Stimulation in Autism / Melis E. CAKAR in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70313 Titre : Atypical Cerebellar Responses are Associated with Altered Neural Habituation during Sensory Stimulation in Autism Type de document : texte imprimé Auteurs : Melis E. CAKAR, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur Année de publication : 2026 Article en page(s) : p.e70313 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cerebellum  fMRI  habituation  sensory over-responsivity Index. décimale : PER Périodiques Résumé : ABSTRACT Sensory processing atypicalities are highly prevalent in autistic youth; yet, the neural mechanisms underlying these differences are not well understood. While the cerebellum plays a key role in sensorimotor coordination and is structurally and functionally atypical in the autistic brain, it has been overlooked in research investigating sensory challenges in autism. Previous evidence has linked sensory over-responsivity in autism to altered neural habituation in sensory and limbic regions, but the role of the cerebellum in atypical habituation is as yet unknown. In the current study, we investigated sensory-evoked cerebellar responses in autistic and typically-developing (TD) youth, and how these responses related to sensory-limbic habituation. Fifty-two autistic and 41 TD participants aged 8?18?years underwent fMRI during mildly aversive auditory and tactile stimulation. We found increased activity in the contralateral (to the tactile stimulation) cerebellum in ASD compared to TD. Greater cerebellar activity was associated with more habituation in sensory-limbic regions for TD youth. In contrast, stronger activity in lobule VII (including crus I and II) was associated with less amygdala habituation in ASD. There were no diagnostic group differences in the relationship between cerebellar activation and habituation in sensory cortices. Results inform understanding of the role of the cerebellum in processing aversive sensory information and, taken together, findings of hyper-active cerebellar responses as well as an atypical relationship between cerebellar function and amygdala habituation suggest cerebellar involvement in sensory alterations in autism. En ligne : https://doi.org/10.1002/aur.70313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Atypical Cerebellar Responses are Associated with Altered Neural Habituation during Sensory Stimulation in Autism [texte imprimé] / Melis E. CAKAR, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur . - 2026 . - p.e70313. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70313 Mots-clés : autism spectrum disorder  cerebellum  fMRI  habituation  sensory over-responsivity Index. décimale : PER Périodiques Résumé : ABSTRACT Sensory processing atypicalities are highly prevalent in autistic youth; yet, the neural mechanisms underlying these differences are not well understood. While the cerebellum plays a key role in sensorimotor coordination and is structurally and functionally atypical in the autistic brain, it has been overlooked in research investigating sensory challenges in autism. Previous evidence has linked sensory over-responsivity in autism to altered neural habituation in sensory and limbic regions, but the role of the cerebellum in atypical habituation is as yet unknown. In the current study, we investigated sensory-evoked cerebellar responses in autistic and typically-developing (TD) youth, and how these responses related to sensory-limbic habituation. Fifty-two autistic and 41 TD participants aged 8?18?years underwent fMRI during mildly aversive auditory and tactile stimulation. We found increased activity in the contralateral (to the tactile stimulation) cerebellum in ASD compared to TD. Greater cerebellar activity was associated with more habituation in sensory-limbic regions for TD youth. In contrast, stronger activity in lobule VII (including crus I and II) was associated with less amygdala habituation in ASD. There were no diagnostic group differences in the relationship between cerebellar activation and habituation in sensory cortices. Results inform understanding of the role of the cerebellum in processing aversive sensory information and, taken together, findings of hyper-active cerebellar responses as well as an atypical relationship between cerebellar function and amygdala habituation suggest cerebellar involvement in sensory alterations in autism. En ligne : https://doi.org/10.1002/aur.70313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Inclusion of Participants With Limited English Proficiency in Autism Research / Ava Weiran LU in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70331 Titre : Inclusion of Participants With Limited English Proficiency in Autism Research Type de document : texte imprimé Auteurs : Ava Weiran LU, Auteur ; Cambrynne DEJONG, Auteur ; Mary Grace HARRIS, Auteur ; Mariah Samuelle JOHNSON, Auteur ; Purnima MUDNAL, Auteur ; Luis RIVAS VAZQUEZ, Auteur ; Yanira Belen ESPINOSA, Auteur ; Daniela KOTSONIS, Auteur ; Maya I. RAGAVAN, Auteur ; Sarabeth BRODER-FINGERT, Auteur ; Marijane WHITE, Auteur ; Katharine E. ZUCKERMAN, Auteur Année de publication : 2026 Article en page(s) : p.e70331 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  communication  healthcare disparities  limited english proficiency  quality of health care  research subjects  review Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) and limited English proficiency (LEP), defined as having limited ability to read, write, or understand English, may experience disparities in quality of care and healthcare outcomes. However, little research has described methods and practices for including participants with LEP in ASD research studies. This literature review study investigated (1) the prevalence of LEP inclusion in U.S. research about ASD, (2) the languages included, and (3) the communication methods between research teams and participants with LEP. Using the Covidence Systematic Review Software, we completed a two-round screening of 1007 studies published between 2013 and June 2025 in four major autism journals: Autism, Autism Research, Journal of Autism and Developmental Disorders, and Research in Autism Spectrum Disorders. We limited the sample to U.S.-based original research involving human subjects with ASD and/or their caretakers. Eligible studies were reviewed further to extract relevant study information (e.g., participant demographics, study type, communication methods, and inclusion of LEP participants). Only 61 (19%) among the 326 eligible studies explicitly mentioned the inclusion of participants with LEP and provided information about their inclusion. Other studies may have included LEP participants but did not report their inclusion in the publication. The most common language included was Spanish. Results showed that the most used oral and written communication methods involved communication with, and translation of study materials by a bilingual research team member. The results suggest that LEP participants were underrepresented in ASD research, and future research is needed to advise more inclusive healthcare practices and policies for children and families. En ligne : https://doi.org/10.1002/aur.70331 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Inclusion of Participants With Limited English Proficiency in Autism Research [texte imprimé] / Ava Weiran LU, Auteur ; Cambrynne DEJONG, Auteur ; Mary Grace HARRIS, Auteur ; Mariah Samuelle JOHNSON, Auteur ; Purnima MUDNAL, Auteur ; Luis RIVAS VAZQUEZ, Auteur ; Yanira Belen ESPINOSA, Auteur ; Daniela KOTSONIS, Auteur ; Maya I. RAGAVAN, Auteur ; Sarabeth BRODER-FINGERT, Auteur ; Marijane WHITE, Auteur ; Katharine E. ZUCKERMAN, Auteur . - 2026 . - p.e70331. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70331 Mots-clés : autism spectrum disorder  communication  healthcare disparities  limited english proficiency  quality of health care  research subjects  review Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) and limited English proficiency (LEP), defined as having limited ability to read, write, or understand English, may experience disparities in quality of care and healthcare outcomes. However, little research has described methods and practices for including participants with LEP in ASD research studies. This literature review study investigated (1) the prevalence of LEP inclusion in U.S. research about ASD, (2) the languages included, and (3) the communication methods between research teams and participants with LEP. Using the Covidence Systematic Review Software, we completed a two-round screening of 1007 studies published between 2013 and June 2025 in four major autism journals: Autism, Autism Research, Journal of Autism and Developmental Disorders, and Research in Autism Spectrum Disorders. We limited the sample to U.S.-based original research involving human subjects with ASD and/or their caretakers. Eligible studies were reviewed further to extract relevant study information (e.g., participant demographics, study type, communication methods, and inclusion of LEP participants). Only 61 (19%) among the 326 eligible studies explicitly mentioned the inclusion of participants with LEP and provided information about their inclusion. Other studies may have included LEP participants but did not report their inclusion in the publication. The most common language included was Spanish. Results showed that the most used oral and written communication methods involved communication with, and translation of study materials by a bilingual research team member. The results suggest that LEP participants were underrepresented in ASD research, and future research is needed to advise more inclusive healthcare practices and policies for children and families. En ligne : https://doi.org/10.1002/aur.70331 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Autism Screening in the First Year and Beyond: Comparison of Multiple Measures / Devon N. GANGI in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70340 Titre : Autism Screening in the First Year and Beyond: Comparison of Multiple Measures Type de document : texte imprimé Auteurs : Devon N. GANGI, Auteur ; Chandni PARIKH, Auteur ; Monique Moore HILL, Auteur ; Shyeena MAQBOOL, Auteur ; Rachel NI, Auteur ; Simon DVORAK, Auteur ; Gregory S. YOUNG, Auteur ; Sally OZONOFF, Auteur Année de publication : 2026 Article en page(s) : p.e70340 Langues : Anglais (eng) Mots-clés : autism  early detection  psychometric properties  screening Index. décimale : PER Périodiques Résumé : ABSTRACT Autism screening aids in early detection and diagnosis. Several screeners are available for toddlers 16?months and older, but there is little data on the accuracy of screening measures used in the first year of life. A community sample (N?=?1641) completed three screeners?M-CHAT-R, ITC, VIRSA?online at 6, 9, 12, 18, and 24?months of age (including exploratory use of M-CHAT-R prior to 16?months). At 36?months, outcomes of ASD or Non-ASD were determined by tele-evaluation and outcome surveys. Psychometric properties were assessed for all screeners at all ages, both used individually and in combination. When used in the first year of life (6?12?months), psychometric properties were in the poor range, with area under the curve (AUC) En ligne : https://doi.org/10.1002/aur.70340 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Autism Screening in the First Year and Beyond: Comparison of Multiple Measures [texte imprimé] / Devon N. GANGI, Auteur ; Chandni PARIKH, Auteur ; Monique Moore HILL, Auteur ; Shyeena MAQBOOL, Auteur ; Rachel NI, Auteur ; Simon DVORAK, Auteur ; Gregory S. YOUNG, Auteur ; Sally OZONOFF, Auteur . - 2026 . - p.e70340. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70340 Mots-clés : autism  early detection  psychometric properties  screening Index. décimale : PER Périodiques Résumé : ABSTRACT Autism screening aids in early detection and diagnosis. Several screeners are available for toddlers 16?months and older, but there is little data on the accuracy of screening measures used in the first year of life. A community sample (N?=?1641) completed three screeners?M-CHAT-R, ITC, VIRSA?online at 6, 9, 12, 18, and 24?months of age (including exploratory use of M-CHAT-R prior to 16?months). At 36?months, outcomes of ASD or Non-ASD were determined by tele-evaluation and outcome surveys. Psychometric properties were assessed for all screeners at all ages, both used individually and in combination. When used in the first year of life (6?12?months), psychometric properties were in the poor range, with area under the curve (AUC) En ligne : https://doi.org/10.1002/aur.70340 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Empathy Moderates the Association Between Social Disengagement and Emotion Problems in Autistic Youth / Lacey CHETCUTI in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70341 Titre : Empathy Moderates the Association Between Social Disengagement and Emotion Problems in Autistic Youth Type de document : texte imprimé Auteurs : Lacey CHETCUTI, Auteur ; Emily SPACKMAN, Auteur ; Eva LOTH, Auteur ; Emma BAKER, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVIĆ, Auteur Année de publication : 2026 Article en page(s) : p.e70341 Langues : Anglais (eng) Mots-clés : autism  emotion problems  empathy  shyness  social avoidance  social disengagement  unsociability Index. décimale : PER Périodiques Résumé : ABSTRACT Social disengagement and empathizing difficulties are common in autism and have been linked to various socioemotional outcomes. Yet, their relationship remains understudied. This study addresses this gap by examining associations among different forms of social disengagement and empathy in autistic children and adolescents, as well as their interactive effects in predicting concurrent emotion problems. Parents of 689 autistic youth aged 5?17?years (M [SD]?=?11.23 [3.56]; 76% male) completed questionnaires: the Child Social Preference Scale assessed shyness, unsociability, and social avoidance; the Children's Empathy Quotient measured cognitive and affective empathy; and the Strengths and Difficulties Questionnaire assessed emotion problems. Results showed that all forms of social disengagement were associated with difficulties in both cognitive and affective empathy, with social avoidance showing the strongest associations. Furthermore, the interplay between different forms of social disengagement and empathy contributed to variability in emotion problems. Specifically, the links between unsociability and social avoidance and elevated emotion problems were stronger among youth with higher levels of empathy. In contrast, the positive association between shyness and emotion problems was not influenced by empathy. These findings underscore the importance of considering the multifaceted nature of social disengagement and its association with empathy, offering directions for future research. En ligne : https://doi.org/10.1002/aur.70341 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Empathy Moderates the Association Between Social Disengagement and Emotion Problems in Autistic Youth [texte imprimé] / Lacey CHETCUTI, Auteur ; Emily SPACKMAN, Auteur ; Eva LOTH, Auteur ; Emma BAKER, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVIĆ, Auteur . - 2026 . - p.e70341. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70341 Mots-clés : autism  emotion problems  empathy  shyness  social avoidance  social disengagement  unsociability Index. décimale : PER Périodiques Résumé : ABSTRACT Social disengagement and empathizing difficulties are common in autism and have been linked to various socioemotional outcomes. Yet, their relationship remains understudied. This study addresses this gap by examining associations among different forms of social disengagement and empathy in autistic children and adolescents, as well as their interactive effects in predicting concurrent emotion problems. Parents of 689 autistic youth aged 5?17?years (M [SD]?=?11.23 [3.56]; 76% male) completed questionnaires: the Child Social Preference Scale assessed shyness, unsociability, and social avoidance; the Children's Empathy Quotient measured cognitive and affective empathy; and the Strengths and Difficulties Questionnaire assessed emotion problems. Results showed that all forms of social disengagement were associated with difficulties in both cognitive and affective empathy, with social avoidance showing the strongest associations. Furthermore, the interplay between different forms of social disengagement and empathy contributed to variability in emotion problems. Specifically, the links between unsociability and social avoidance and elevated emotion problems were stronger among youth with higher levels of empathy. In contrast, the positive association between shyness and emotion problems was not influenced by empathy. These findings underscore the importance of considering the multifaceted nature of social disengagement and its association with empathy, offering directions for future research. En ligne : https://doi.org/10.1002/aur.70341 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Characterization of Anticholinergic Medication Use and Its Associations With Everyday Memory Problems and Cognitive Decline in Autistic Adults With Higher Support Needs / Goldie A. MCQUAID in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70342 Titre : Characterization of Anticholinergic Medication Use and Its Associations With Everyday Memory Problems and Cognitive Decline in Autistic Adults With Higher Support Needs Type de document : texte imprimé Auteurs : Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur Année de publication : 2026 Article en page(s) : p.e70342 Langues : Anglais (eng) Mots-clés : adult  anticholinergic  autism  cognition  memory Index. décimale : PER Périodiques Résumé : ABSTRACT Among older adults in the general population, medications with anticholinergic (AC) effects are associated with declines in cognitive functioning and with dementia and Alzheimer's disease. Autistic people have high rates of co-occurring medical conditions and polypharmacy across the lifespan; thus, they may be at particularly high risk of exposure to AC medications and their negative impacts on cognitive functioning, including earlier in adulthood. Consistent with this, a single study has shown AC medication use is prevalent among autistic adults without co-occurring intellectual disability and is associated with self-reported concurrent memory problems and declines in cognition. No study has examined AC medications and their associations with cognition among autistic adults with higher support needs. We therefore characterized AC medication use and its associations with caregiver-rated memory problems and changes in cognition and behavior that have been linked with cognitive decline. Caregivers of autistic adults (18?68?years; Mean ~31?years) recruited via Simons Powering Autism Research's (SPARK) Research Match service reported medication use (N?=?512), memory complaints (N?=?467), and a screener that probes behavior/cognitive changes (N?=?466) that are associated with cognitive decline among persons with an intellectual disability. The majority (66.41%) of autistic adults were taking at least one AC medication and 31% were taking clinically-meaningful levels of these medications. After controlling for age and birth sex, greater potency of AC medications was associated with both caregiver-reported memory challenges and behavioral/cognitive changes associated with cognitive decline. Understanding AC medication use and its potential impacts on cognition among autistic adults with higher support needs is crucial. En ligne : https://doi.org/10.1002/aur.70342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Characterization of Anticholinergic Medication Use and Its Associations With Everyday Memory Problems and Cognitive Decline in Autistic Adults With Higher Support Needs [texte imprimé] / Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur . - 2026 . - p.e70342. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70342 Mots-clés : adult  anticholinergic  autism  cognition  memory Index. décimale : PER Périodiques Résumé : ABSTRACT Among older adults in the general population, medications with anticholinergic (AC) effects are associated with declines in cognitive functioning and with dementia and Alzheimer's disease. Autistic people have high rates of co-occurring medical conditions and polypharmacy across the lifespan; thus, they may be at particularly high risk of exposure to AC medications and their negative impacts on cognitive functioning, including earlier in adulthood. Consistent with this, a single study has shown AC medication use is prevalent among autistic adults without co-occurring intellectual disability and is associated with self-reported concurrent memory problems and declines in cognition. No study has examined AC medications and their associations with cognition among autistic adults with higher support needs. We therefore characterized AC medication use and its associations with caregiver-rated memory problems and changes in cognition and behavior that have been linked with cognitive decline. Caregivers of autistic adults (18?68?years; Mean ~31?years) recruited via Simons Powering Autism Research's (SPARK) Research Match service reported medication use (N?=?512), memory complaints (N?=?467), and a screener that probes behavior/cognitive changes (N?=?466) that are associated with cognitive decline among persons with an intellectual disability. The majority (66.41%) of autistic adults were taking at least one AC medication and 31% were taking clinically-meaningful levels of these medications. After controlling for age and birth sex, greater potency of AC medications was associated with both caregiver-reported memory challenges and behavioral/cognitive changes associated with cognitive decline. Understanding AC medication use and its potential impacts on cognition among autistic adults with higher support needs is crucial. En ligne : https://doi.org/10.1002/aur.70342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation / Michelle PEARL in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70344 Titre : Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation Type de document : texte imprimé Auteurs : Michelle PEARL, Auteur ; Kimberly BERGER, Auteur ; Piera M. CIRILLO, Auteur ; Nickilou Y. KRIGBAUM, Auteur ; Victor POON, Auteur ; Gayle C. WINDHAM, Auteur ; Barbara A. COHN, Auteur Année de publication : 2026 Article en page(s) : p.e70344 Langues : Anglais (eng) Mots-clés : alcoholic beverages  autism spectrum disorder  coffee  grandparents  prenatal exposure delayed effects  smoking  tea Index. décimale : PER Périodiques Résumé : ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD). Pregnant participants (grandparent generation) in the Child Health and Development Studies (CHDS) were interviewed between 1959 and 1967 about their own and their partners' smoking and consumption of alcohol, coffee, and tea. CHDS participant records were linked to 18,053 third-generation California births from 1989 to 2014, from which ASD cases were identified from Department of Developmental Services records. We estimated adjusted relative risk (aRR) of ASD associated with grandparents' smoking and consumption of alcoholic beverages, coffee, and tea from log-binomial regression models adjusted for grandparents' age, education, and grandmother's race. Grandfather's overall tobacco smoking (including pipes and cigars) during their partner's pregnancy was related to grandchild ASD (aRR?=?1.76, 95% confidence interval [1.05, 2.96]), as was grandfathers' cigarette smoking (aRR?=?1.67 [1.01, 2.76]), particularly smoking 20 or more cigarettes per day (aRR?=?1.91 [1.03, 3.55]), relative to no smoking. Alcohol consumption of five or more drinks of hard liquor per week by grandfathers was associated with ASD in grandchildren (aRR?=?2.90 [1.24, 6.79], relative to none), as was total consumption of nine or more total alcoholic drinks (aRR?=?1.87 [1.00, 3.51] relative to En ligne : https://doi.org/10.1002/aur.70344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation [texte imprimé] / Michelle PEARL, Auteur ; Kimberly BERGER, Auteur ; Piera M. CIRILLO, Auteur ; Nickilou Y. KRIGBAUM, Auteur ; Victor POON, Auteur ; Gayle C. WINDHAM, Auteur ; Barbara A. COHN, Auteur . - 2026 . - p.e70344. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70344 Mots-clés : alcoholic beverages  autism spectrum disorder  coffee  grandparents  prenatal exposure delayed effects  smoking  tea Index. décimale : PER Périodiques Résumé : ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD). Pregnant participants (grandparent generation) in the Child Health and Development Studies (CHDS) were interviewed between 1959 and 1967 about their own and their partners' smoking and consumption of alcohol, coffee, and tea. CHDS participant records were linked to 18,053 third-generation California births from 1989 to 2014, from which ASD cases were identified from Department of Developmental Services records. We estimated adjusted relative risk (aRR) of ASD associated with grandparents' smoking and consumption of alcoholic beverages, coffee, and tea from log-binomial regression models adjusted for grandparents' age, education, and grandmother's race. Grandfather's overall tobacco smoking (including pipes and cigars) during their partner's pregnancy was related to grandchild ASD (aRR?=?1.76, 95% confidence interval [1.05, 2.96]), as was grandfathers' cigarette smoking (aRR?=?1.67 [1.01, 2.76]), particularly smoking 20 or more cigarettes per day (aRR?=?1.91 [1.03, 3.55]), relative to no smoking. Alcohol consumption of five or more drinks of hard liquor per week by grandfathers was associated with ASD in grandchildren (aRR?=?2.90 [1.24, 6.79], relative to none), as was total consumption of nine or more total alcoholic drinks (aRR?=?1.87 [1.00, 3.51] relative to En ligne : https://doi.org/10.1002/aur.70344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Social Pain Sensitivity in Autistic Adults: Associations With Gender, Self-Esteem, Cognitive Empathy, and Sensory Sensitivity / Alvin VAN ASSELT in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70345 Titre : Social Pain Sensitivity in Autistic Adults: Associations With Gender, Self-Esteem, Cognitive Empathy, and Sensory Sensitivity Type de document : texte imprimé Auteurs : Alvin VAN ASSELT, Auteur ; Yvette ROKE, Auteur ; Sander BEGEER, Auteur ; Anke SCHEEREN, Auteur Année de publication : 2026 Article en page(s) : p.e70345 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  empathy  gender identity  perception  self-concept  social isolation  social status Index. décimale : PER Périodiques Résumé : ABSTRACT Social pain sensitivity refers to the tendency to detect and react strongly to cues of social exclusion. Frequent social adversities and specific characteristics may make individuals with autism more sensitive to social pain, yet evidence remains inconsistent. To enhance our understanding, autistic adults aged ≥?16?years (n?=?1425; Mage?=?47.3, SD?=?14.2) and allistic adults (n?=?187; Mage?=?51.4, SD?=?14.6) enrolled in the Netherlands Autism Register (NAR) completed the Social Pain Questionnaire (SPQ). A two-way ANOVA demonstrated that autistic adults reported significantly higher social pain sensitivity than allistic adults, with a small effect size (?2p?=?0.02). Women reported higher social pain sensitivity than men across both groups (?2p?=?0.01), and this gender difference was comparable for autistic and allistic adults. Within the autistic group, in a subset of participants with complete data (n?=?234), a hierarchical multiple regression analysis showed that social pain sensitivity was moderately associated with lower self-esteem (??=??0.47), but not with cognitive empathy or sensory sensitivity. Exploratory analyses further indicated that self-esteem fully accounted for the association between autism diagnosis and social pain sensitivity. Consistent with sociometer theory, these results suggest that heightened social pain sensitivity in autistic adults may reflect reduced perceived social acceptance. Our findings highlight the relevance of social adversities for autistic adults and underscore the need for supports that strengthen belonging and reduce socially painful experiences. En ligne : https://doi.org/10.1002/aur.70345 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Social Pain Sensitivity in Autistic Adults: Associations With Gender, Self-Esteem, Cognitive Empathy, and Sensory Sensitivity [texte imprimé] / Alvin VAN ASSELT, Auteur ; Yvette ROKE, Auteur ; Sander BEGEER, Auteur ; Anke SCHEEREN, Auteur . - 2026 . - p.e70345. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70345 Mots-clés : autism spectrum disorder  empathy  gender identity  perception  self-concept  social isolation  social status Index. décimale : PER Périodiques Résumé : ABSTRACT Social pain sensitivity refers to the tendency to detect and react strongly to cues of social exclusion. Frequent social adversities and specific characteristics may make individuals with autism more sensitive to social pain, yet evidence remains inconsistent. To enhance our understanding, autistic adults aged ≥?16?years (n?=?1425; Mage?=?47.3, SD?=?14.2) and allistic adults (n?=?187; Mage?=?51.4, SD?=?14.6) enrolled in the Netherlands Autism Register (NAR) completed the Social Pain Questionnaire (SPQ). A two-way ANOVA demonstrated that autistic adults reported significantly higher social pain sensitivity than allistic adults, with a small effect size (?2p?=?0.02). Women reported higher social pain sensitivity than men across both groups (?2p?=?0.01), and this gender difference was comparable for autistic and allistic adults. Within the autistic group, in a subset of participants with complete data (n?=?234), a hierarchical multiple regression analysis showed that social pain sensitivity was moderately associated with lower self-esteem (??=??0.47), but not with cognitive empathy or sensory sensitivity. Exploratory analyses further indicated that self-esteem fully accounted for the association between autism diagnosis and social pain sensitivity. Consistent with sociometer theory, these results suggest that heightened social pain sensitivity in autistic adults may reflect reduced perceived social acceptance. Our findings highlight the relevance of social adversities for autistic adults and underscore the need for supports that strengthen belonging and reduce socially painful experiences. En ligne : https://doi.org/10.1002/aur.70345 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Maternal Thyroid Dysfunction During Pregnancy and Childhood Autism or Other Developmental Outcomes / Zoe B. KAPLAN in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70346 Titre : Maternal Thyroid Dysfunction During Pregnancy and Childhood Autism or Other Developmental Outcomes Type de document : texte imprimé Auteurs : Zoe B. KAPLAN, Auteur ; Elizabeth N. PEARCE, Auteur ; Meghan MILLER, Auteur ; Daniel TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Hyeong-Moo SHIN, Auteur ; Rebecca J. SCHMIDT, Auteur Année de publication : 2026 Article en page(s) : p.e70346 Langues : Anglais (eng) Mots-clés : autism  child development disorders  developmental origins of health and disease  epidemiologic methods  T4 thyroid hormone  thyroid-stimulating hormone Index. décimale : PER Périodiques Résumé : ABSTRACT Overt maternal hypothyroidism during pregnancy has been associated with cognitive impairment in offspring, but less is known about effects of subclinical hypothyroidism and other maternal thyroid conditions on autism spectrum disorder (ASD). This study examined the relationships between maternal thyroid dysfunction during pregnancy and child neurodevelopmental outcomes. Participants were from a high ASD likelihood pregnancy cohort (MARBLES). Maternal thyroid dysfunction (hypothyroid or hyperthyroid compared to euthyroid) was measured in up to one blood sample per trimester. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) were also examined as exposures. Outcomes were child ASD diagnosis, non-typical development (non-TD), typical development and standardized scores from the Social Responsiveness Scale (SRS). Outcomes were confirmed by study psychometricians. Multinomial logistic and quintile regressions were used to examine associations of maternal thyroid dysfunction (using trimester-specific reference ranges) with developmental outcomes and SRS scores. Among 285 pregnancies, 83.9% were categorized as euthyroid, 9.5% hypothyroid, and 6.7% hyperthyroid. Of 285 children included in analyses, 28.8% were diagnosed with ASD (n?=?82; female?=?27) and 14.7% with non-TD (n?=?42; female?=?19). Maternal hypothyroid conditions were associated with increased ASD:TD odds (adjusted RRR?=?3.40, 95% CI: 1.22, 9.45; p?=?0.02). Significant relationships were also found between hypothyroid conditions and non-TD, and between first trimester TSH and ASD. There was no evidence of a relationship between either TSH or FT4 and preschool SRS scores. Findings suggest that maternal hypothyroid conditions during pregnancy are associated with greater chances of their children developing ASD and other neurodevelopmental differences among children with high familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.70346 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Maternal Thyroid Dysfunction During Pregnancy and Childhood Autism or Other Developmental Outcomes [texte imprimé] / Zoe B. KAPLAN, Auteur ; Elizabeth N. PEARCE, Auteur ; Meghan MILLER, Auteur ; Daniel TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Hyeong-Moo SHIN, Auteur ; Rebecca J. SCHMIDT, Auteur . - 2026 . - p.e70346. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70346 Mots-clés : autism  child development disorders  developmental origins of health and disease  epidemiologic methods  T4 thyroid hormone  thyroid-stimulating hormone Index. décimale : PER Périodiques Résumé : ABSTRACT Overt maternal hypothyroidism during pregnancy has been associated with cognitive impairment in offspring, but less is known about effects of subclinical hypothyroidism and other maternal thyroid conditions on autism spectrum disorder (ASD). This study examined the relationships between maternal thyroid dysfunction during pregnancy and child neurodevelopmental outcomes. Participants were from a high ASD likelihood pregnancy cohort (MARBLES). Maternal thyroid dysfunction (hypothyroid or hyperthyroid compared to euthyroid) was measured in up to one blood sample per trimester. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) were also examined as exposures. Outcomes were child ASD diagnosis, non-typical development (non-TD), typical development and standardized scores from the Social Responsiveness Scale (SRS). Outcomes were confirmed by study psychometricians. Multinomial logistic and quintile regressions were used to examine associations of maternal thyroid dysfunction (using trimester-specific reference ranges) with developmental outcomes and SRS scores. Among 285 pregnancies, 83.9% were categorized as euthyroid, 9.5% hypothyroid, and 6.7% hyperthyroid. Of 285 children included in analyses, 28.8% were diagnosed with ASD (n?=?82; female?=?27) and 14.7% with non-TD (n?=?42; female?=?19). Maternal hypothyroid conditions were associated with increased ASD:TD odds (adjusted RRR?=?3.40, 95% CI: 1.22, 9.45; p?=?0.02). Significant relationships were also found between hypothyroid conditions and non-TD, and between first trimester TSH and ASD. There was no evidence of a relationship between either TSH or FT4 and preschool SRS scores. Findings suggest that maternal hypothyroid conditions during pregnancy are associated with greater chances of their children developing ASD and other neurodevelopmental differences among children with high familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.70346 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Impaired Motor Competence in Children and Adolescents With Autism Spectrum Disorder: Evidence From a Systematic Review and Meta-Analysis / Nerea BLANCO-MARTÍNEZ in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70347 Titre : Impaired Motor Competence in Children and Adolescents With Autism Spectrum Disorder: Evidence From a Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Nerea BLANCO-MARTÍNEZ, Auteur ; Daniel GONZÁLEZ-DEVESA, Auteur ; Silvia VARELA, Auteur ; Rocío CARBALLO-AFONSO, Auteur ; Carlos AYÁN-PÉREZ, Auteur Année de publication : 2026 Article en page(s) : p.e70347 Langues : Anglais (eng) Mots-clés : adolescents  autism spectrum disorder  children  meta-analysis  motor competence  motor skills Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is frequently associated with motor difficulties that may affect daily functioning, participation in physical activity, and developmental outcomes. Although motor impairments have been widely reported in this population, comparative evidence against typically developing (TD) peers remains fragmented across studies and assessment tools. This systematic review and meta-analysis aimed to examine whether children and adolescents with ASD show lower motor competence than TD peers and to identify the most affected motor domains. A systematic search was conducted in Scopus, Web of Science, PubMed, and SPORTDiscus up to December 10, 2025. Studies were eligible if they included children or adolescents with ASD and TD controls and assessed motor competence using standardized instruments. A total of 42 studies involving 3142 participants were included. The most frequently used tools were the Movement Assessment Battery for Children, the Bruininks?Oseretsky Test of Motor Proficiency, and the Test of Gross Motor Development. Across studies, children and adolescents with ASD consistently showed poorer performance than TD peers in manual dexterity, aiming and catching, balance, locomotor skills, and object control. Meta-analytic findings also indicated that participants with ASD had greater odds of presenting motor difficulty and being classified within the at-risk range. Despite heterogeneity and methodological limitations, the overall evidence supports a broad pattern of lower motor competence in ASD. These findings reinforce the importance of early motor assessment and targeted intervention in clinical and educational contexts. En ligne : https://doi.org/10.1002/aur.70347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Impaired Motor Competence in Children and Adolescents With Autism Spectrum Disorder: Evidence From a Systematic Review and Meta-Analysis [texte imprimé] / Nerea BLANCO-MARTÍNEZ, Auteur ; Daniel GONZÁLEZ-DEVESA, Auteur ; Silvia VARELA, Auteur ; Rocío CARBALLO-AFONSO, Auteur ; Carlos AYÁN-PÉREZ, Auteur . - 2026 . - p.e70347. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70347 Mots-clés : adolescents  autism spectrum disorder  children  meta-analysis  motor competence  motor skills Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is frequently associated with motor difficulties that may affect daily functioning, participation in physical activity, and developmental outcomes. Although motor impairments have been widely reported in this population, comparative evidence against typically developing (TD) peers remains fragmented across studies and assessment tools. This systematic review and meta-analysis aimed to examine whether children and adolescents with ASD show lower motor competence than TD peers and to identify the most affected motor domains. A systematic search was conducted in Scopus, Web of Science, PubMed, and SPORTDiscus up to December 10, 2025. Studies were eligible if they included children or adolescents with ASD and TD controls and assessed motor competence using standardized instruments. A total of 42 studies involving 3142 participants were included. The most frequently used tools were the Movement Assessment Battery for Children, the Bruininks?Oseretsky Test of Motor Proficiency, and the Test of Gross Motor Development. Across studies, children and adolescents with ASD consistently showed poorer performance than TD peers in manual dexterity, aiming and catching, balance, locomotor skills, and object control. Meta-analytic findings also indicated that participants with ASD had greater odds of presenting motor difficulty and being classified within the at-risk range. Despite heterogeneity and methodological limitations, the overall evidence supports a broad pattern of lower motor competence in ASD. These findings reinforce the importance of early motor assessment and targeted intervention in clinical and educational contexts. En ligne : https://doi.org/10.1002/aur.70347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Quality of Life in Autism: A Systematic Review and Meta-Analysis of Patients and Caregivers / Kamila CASTRO in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70348 Titre : Quality of Life in Autism: A Systematic Review and Meta-Analysis of Patients and Caregivers Type de document : texte imprimé Auteurs : Kamila CASTRO, Auteur ; Camila Kümmel DUARTE, Auteur ; Eduarda SILVA, Auteur ; Laura HOFFMANN, Auteur ; Jenifer Lopes BORCHARDT, Auteur ; Laura POHL, Auteur ; Josiane LUÇARDO, Auteur ; Myrella LAPSCHIES, Auteur ; Andreia Morales CASCAES, Auteur ; Ana Amélia FREITAS-VILELA, Auteur ; Adriane CENCI, Auteur ; Juliana S. VAZ, Auteur Année de publication : 2026 Article en page(s) : p.e70348 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition associated with significant challenges in daily functioning and well-being. Caregivers often experience substantial psychological and physical burden. However, comprehensive synthesis of quality of life (QoL) outcomes for both individuals with ASD and their caregivers remains limited. This study evaluated QoL in individuals with ASD and their caregivers and examined key psychological, social, and economic determinants. A systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO: CRD42024538872). PubMed, Scopus, Embase, PsycINFO, and preprint repositories were searched for studies published between January 2013 and July 2025. Eligible studies assessed QoL using validated instruments in individuals with ASD aged ≤?19?years and/or their caregivers. Random-effects meta-analysis was used to estimate pooled mean differences. Of 14,368 records identified, 216 studies were included. Quantitative meta-analyses included up to 173 studies, depending on the outcome and availability of comparable data. Individuals with ASD scored 21.7 points lower than peers (95% CI: ?26.9 to ?16.5; p? En ligne : https://doi.org/10.1002/aur.70348 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Quality of Life in Autism: A Systematic Review and Meta-Analysis of Patients and Caregivers [texte imprimé] / Kamila CASTRO, Auteur ; Camila Kümmel DUARTE, Auteur ; Eduarda SILVA, Auteur ; Laura HOFFMANN, Auteur ; Jenifer Lopes BORCHARDT, Auteur ; Laura POHL, Auteur ; Josiane LUÇARDO, Auteur ; Myrella LAPSCHIES, Auteur ; Andreia Morales CASCAES, Auteur ; Ana Amélia FREITAS-VILELA, Auteur ; Adriane CENCI, Auteur ; Juliana S. VAZ, Auteur . - 2026 . - p.e70348. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70348 Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition associated with significant challenges in daily functioning and well-being. Caregivers often experience substantial psychological and physical burden. However, comprehensive synthesis of quality of life (QoL) outcomes for both individuals with ASD and their caregivers remains limited. This study evaluated QoL in individuals with ASD and their caregivers and examined key psychological, social, and economic determinants. A systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO: CRD42024538872). PubMed, Scopus, Embase, PsycINFO, and preprint repositories were searched for studies published between January 2013 and July 2025. Eligible studies assessed QoL using validated instruments in individuals with ASD aged ≤?19?years and/or their caregivers. Random-effects meta-analysis was used to estimate pooled mean differences. Of 14,368 records identified, 216 studies were included. Quantitative meta-analyses included up to 173 studies, depending on the outcome and availability of comparable data. Individuals with ASD scored 21.7 points lower than peers (95% CI: ?26.9 to ?16.5; p? En ligne : https://doi.org/10.1002/aur.70348 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Long-Term Risk of Rheumatoid Arthritis in Individuals With Autism Spectrum Disorder: A Population-Based Matched Cohort Study / Evora Hailin ZHU in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70349 Titre : Long-Term Risk of Rheumatoid Arthritis in Individuals With Autism Spectrum Disorder: A Population-Based Matched Cohort Study Type de document : texte imprimé Auteurs : Evora Hailin ZHU, Auteur ; Stephen Z. LEVINE, Auteur ; Matilda MORIN, Auteur ; Weiyao YIN, Auteur ; Benjamin CHRISTOFFERSEN, Auteur ; Johan ASKLING, Auteur ; Natalia RIVERA, Auteur ; Abraham REICHENBERG, Auteur ; Joseph D. BUXBAUM, Auteur ; Sven SANDIN, Auteur ; Benjamin Hon Kei YIP, Auteur Année de publication : 2026 Article en page(s) : p.e70349 Langues : Anglais (eng) Mots-clés : autism  autoimmune  comorbidity  population-based cohort  rheumatoid arthritis Index. décimale : PER Périodiques Résumé : ABSTRACT To investigate the long-term risk of rheumatoid arthritis (RA) among individuals with autism spectrum disorder (ASD), addressing potential immune comorbidity in ASD populations. A population-based matched cohort was assembled using Swedish registers, including 46,164 individuals diagnosed with ASD between 1987 and 2017, matched to 4,634,895 controls by sex and birth year. Cohort members were followed from age 18 until RA diagnosis, death, emigration, or end of follow-up, providing up to 30?years of observation into adulthood. Cox proportional hazards models estimated hazard ratios (HR) for RA, with sensitivity analyses adjusting for parental autoimmune, psychiatric history, and socioeconomic status. RA diagnosis rates were similar between individuals with ASD (n?=?58, 0.13%) and controls (n?=?5484, 0.12%), with no increased risk: overall HR?=?1.06 (95% CI 0.82?1.37), seropositive HR?=?1.00 (0.67?1.48), and seronegative HR?=?1.12 (0.79?1.57). Complementary analyses adjusting for parental psychiatric history, autoimmune conditions, and socioeconomic factors yielded consistent null findings (HR?=?1.34, 95% CI 0.97?1.84). Sensitivity analyses, including accelerated failure time models and alternative RA subtype definitions, confirmed these results. This large-scale population study does not suggest an increased RA risk in individuals with ASD. Despite suggested immune dysfunction in ASD and shared genetic pathways with autoimmune conditions, we did not observe evidence that ASD is associated with elevated RA risk during adulthood; In conclusion, these findings inform understanding of autoimmune comorbidity patterns in autism and may guide evidence-based clinical monitoring for autistic adults. En ligne : https://doi.org/10.1002/aur.70349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Long-Term Risk of Rheumatoid Arthritis in Individuals With Autism Spectrum Disorder: A Population-Based Matched Cohort Study [texte imprimé] / Evora Hailin ZHU, Auteur ; Stephen Z. LEVINE, Auteur ; Matilda MORIN, Auteur ; Weiyao YIN, Auteur ; Benjamin CHRISTOFFERSEN, Auteur ; Johan ASKLING, Auteur ; Natalia RIVERA, Auteur ; Abraham REICHENBERG, Auteur ; Joseph D. BUXBAUM, Auteur ; Sven SANDIN, Auteur ; Benjamin Hon Kei YIP, Auteur . - 2026 . - p.e70349. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70349 Mots-clés : autism  autoimmune  comorbidity  population-based cohort  rheumatoid arthritis Index. décimale : PER Périodiques Résumé : ABSTRACT To investigate the long-term risk of rheumatoid arthritis (RA) among individuals with autism spectrum disorder (ASD), addressing potential immune comorbidity in ASD populations. A population-based matched cohort was assembled using Swedish registers, including 46,164 individuals diagnosed with ASD between 1987 and 2017, matched to 4,634,895 controls by sex and birth year. Cohort members were followed from age 18 until RA diagnosis, death, emigration, or end of follow-up, providing up to 30?years of observation into adulthood. Cox proportional hazards models estimated hazard ratios (HR) for RA, with sensitivity analyses adjusting for parental autoimmune, psychiatric history, and socioeconomic status. RA diagnosis rates were similar between individuals with ASD (n?=?58, 0.13%) and controls (n?=?5484, 0.12%), with no increased risk: overall HR?=?1.06 (95% CI 0.82?1.37), seropositive HR?=?1.00 (0.67?1.48), and seronegative HR?=?1.12 (0.79?1.57). Complementary analyses adjusting for parental psychiatric history, autoimmune conditions, and socioeconomic factors yielded consistent null findings (HR?=?1.34, 95% CI 0.97?1.84). Sensitivity analyses, including accelerated failure time models and alternative RA subtype definitions, confirmed these results. This large-scale population study does not suggest an increased RA risk in individuals with ASD. Despite suggested immune dysfunction in ASD and shared genetic pathways with autoimmune conditions, we did not observe evidence that ASD is associated with elevated RA risk during adulthood; In conclusion, these findings inform understanding of autoimmune comorbidity patterns in autism and may guide evidence-based clinical monitoring for autistic adults. En ligne : https://doi.org/10.1002/aur.70349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Predictors of Change in Severity of Self-Injurious Behaviors in Preschool-Aged Autistic Children / Joseph BOYLE in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70350 Titre : Predictors of Change in Severity of Self-Injurious Behaviors in Preschool-Aged Autistic Children Type de document : texte imprimé Auteurs : Joseph BOYLE, Auteur ; Andrew DAKOPOLOS, Auteur ; Olivia SURGENT, Auteur ; Joshua K. LEE, Auteur ; Derek S. ANDREWS, Auteur ; Brianna HEATH, Auteur ; Jason SMUCNY, Auteur ; Marjorie SOLOMON, Auteur ; Sally J. ROGERS, Auteur ; Christine Wu NORDAHL, Auteur Année de publication : 2026 Article en page(s) : p.e70350 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Self-injurious behaviors (SIBs) affect up to 50% of autistic individuals and significantly impact quality of life and everyday functioning. Cross-sectional studies link the presence of SIB to lower IQ, altered sensory responsivity, and poor emotion regulation, yet their effect on changes in SIB severity from early childhood to school age in autism remains poorly understood. We examined SIBs in 325 autistic children assessed at age 2?5?years (T1) and 161 autistic children at 4?9?years (T3). This included a subset of 122 autistic children evaluated longitudinally at both time points. SIBs were classified into subgroups based on severity of SIB (no-SIB, mild, moderate, severe). We assessed cognitive ability, dysregulation, and sensory features at each time point. Cross-sectional and longitudinal analyses were used to examine group differences. At T1, 74% of the sample were characterized as having mild, moderate, or severe SIB. At T3, 67% had mild, moderate, or severe SIB. There was substantial variability in SIB severity subgroup membership across time; however, only 9% did not have SIBs at either timepoint. At both timepoints, children with more severe SIBs had increased dysregulation (p? En ligne : https://doi.org/10.1002/aur.70350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Predictors of Change in Severity of Self-Injurious Behaviors in Preschool-Aged Autistic Children [texte imprimé] / Joseph BOYLE, Auteur ; Andrew DAKOPOLOS, Auteur ; Olivia SURGENT, Auteur ; Joshua K. LEE, Auteur ; Derek S. ANDREWS, Auteur ; Brianna HEATH, Auteur ; Jason SMUCNY, Auteur ; Marjorie SOLOMON, Auteur ; Sally J. ROGERS, Auteur ; Christine Wu NORDAHL, Auteur . - 2026 . - p.e70350. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70350 Index. décimale : PER Périodiques Résumé : ABSTRACT Self-injurious behaviors (SIBs) affect up to 50% of autistic individuals and significantly impact quality of life and everyday functioning. Cross-sectional studies link the presence of SIB to lower IQ, altered sensory responsivity, and poor emotion regulation, yet their effect on changes in SIB severity from early childhood to school age in autism remains poorly understood. We examined SIBs in 325 autistic children assessed at age 2?5?years (T1) and 161 autistic children at 4?9?years (T3). This included a subset of 122 autistic children evaluated longitudinally at both time points. SIBs were classified into subgroups based on severity of SIB (no-SIB, mild, moderate, severe). We assessed cognitive ability, dysregulation, and sensory features at each time point. Cross-sectional and longitudinal analyses were used to examine group differences. At T1, 74% of the sample were characterized as having mild, moderate, or severe SIB. At T3, 67% had mild, moderate, or severe SIB. There was substantial variability in SIB severity subgroup membership across time; however, only 9% did not have SIBs at either timepoint. At both timepoints, children with more severe SIBs had increased dysregulation (p? En ligne : https://doi.org/10.1002/aur.70350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

DSM-5-TR Severity Levels for Autism Spectrum Disorder (ASD): Agreement Between Clinicians Using Telehealth and In-Person Assessment Procedures / Michael J. MORRIER in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70351 Titre : DSM-5-TR Severity Levels for Autism Spectrum Disorder (ASD): Agreement Between Clinicians Using Telehealth and In-Person Assessment Procedures Type de document : texte imprimé Auteurs : Michael J. MORRIER, Auteur ; Allison J. SCHWARTZ, Auteur Année de publication : 2026 Article en page(s) : p.e70351 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  clinician agreement  diagnostic assessment  DSM-5-TR  severity ratings Index. décimale : PER Périodiques Résumé : ABSTRACT The DSM-5/DSM-5-TR includes clinician-reported severity levels to help individualize autism spectrum disorder (ASD) diagnoses. Severity levels for the two core autism domains of social communication and interaction (SCI) and restricted and repetitive behaviors (RRBs) are assigned using a 3-point Likert scale, with higher levels indicating greater symptom severity. Research examining the consistency of DSM-5-TR severity-rating agreement has been limited. Four doctoral-level clinicians independently evaluated 49 toddlers, ages 16?31?months, with each child receiving both a telehealth and an in-person (IPA) comprehensive diagnostic assessment. Previous research using this cohort demonstrated high agreement between clinicians for overall ASD diagnostic outcome. The present study examined agreement in clinician-assigned DSM-5-TR severity levels. Agreement between assessment protocols was fair for SCI (??=?0.318, 95% CI [?0.114, 0.352]) and slight for RRB (??=?0.195, 95% CI [?0.046, 0.436]). Further analyses revealed no significant differences in severity ratings based on individual clinician, clinical team, or assessment protocol. These findings suggest that factors beyond the core ASD symptom domains may influence clinicians' assignment of DSM-5-TR severity levels despite guidance that ratings should reflect impairment within SCI and RRB. The relatively low agreement observed for severity ratings, despite previously demonstrated high agreement for ASD diagnostic classification, suggests that assigning a diagnosis and determining the level of support needed represent distinct clinical decisions. Improving the consistency and transparency of DSM-5-TR severity level assignment may strengthen clinical communication, treatment planning, and equitable access to services while enhancing the reliability and clinical utility of these specifiers across diagnostic settings. En ligne : https://doi.org/10.1002/aur.70351 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] DSM-5-TR Severity Levels for Autism Spectrum Disorder (ASD): Agreement Between Clinicians Using Telehealth and In-Person Assessment Procedures [texte imprimé] / Michael J. MORRIER, Auteur ; Allison J. SCHWARTZ, Auteur . - 2026 . - p.e70351. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70351 Mots-clés : autism spectrum disorder  clinician agreement  diagnostic assessment  DSM-5-TR  severity ratings Index. décimale : PER Périodiques Résumé : ABSTRACT The DSM-5/DSM-5-TR includes clinician-reported severity levels to help individualize autism spectrum disorder (ASD) diagnoses. Severity levels for the two core autism domains of social communication and interaction (SCI) and restricted and repetitive behaviors (RRBs) are assigned using a 3-point Likert scale, with higher levels indicating greater symptom severity. Research examining the consistency of DSM-5-TR severity-rating agreement has been limited. Four doctoral-level clinicians independently evaluated 49 toddlers, ages 16?31?months, with each child receiving both a telehealth and an in-person (IPA) comprehensive diagnostic assessment. Previous research using this cohort demonstrated high agreement between clinicians for overall ASD diagnostic outcome. The present study examined agreement in clinician-assigned DSM-5-TR severity levels. Agreement between assessment protocols was fair for SCI (??=?0.318, 95% CI [?0.114, 0.352]) and slight for RRB (??=?0.195, 95% CI [?0.046, 0.436]). Further analyses revealed no significant differences in severity ratings based on individual clinician, clinical team, or assessment protocol. These findings suggest that factors beyond the core ASD symptom domains may influence clinicians' assignment of DSM-5-TR severity levels despite guidance that ratings should reflect impairment within SCI and RRB. The relatively low agreement observed for severity ratings, despite previously demonstrated high agreement for ASD diagnostic classification, suggests that assigning a diagnosis and determining the level of support needed represent distinct clinical decisions. Improving the consistency and transparency of DSM-5-TR severity level assignment may strengthen clinical communication, treatment planning, and equitable access to services while enhancing the reliability and clinical utility of these specifiers across diagnostic settings. En ligne : https://doi.org/10.1002/aur.70351 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Methodological Considerations for Interpreting a Short Eye-Tracking Paradigm for Autism Screening / Ashith TRIPATHI in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70352 Titre : Methodological Considerations for Interpreting a Short Eye-Tracking Paradigm for Autism Screening Type de document : texte imprimé Auteurs : Ashith TRIPATHI, Auteur ; Raj KUMAR, Auteur ; Krishan KUMAR, Auteur Année de publication : 2026 Article en page(s) : p.e70352 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Methodological Considerations for Interpreting a Short Eye-Tracking Paradigm for Autism Screening [texte imprimé] / Ashith TRIPATHI, Auteur ; Raj KUMAR, Auteur ; Krishan KUMAR, Auteur . - 2026 . - p.e70352. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70352 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Effects of Cannabidiol-Rich Cannabis Oil on Facial Expression Recognition and Theory of Mind in Children With Autism Spectrum Disorder: A Randomized Clinical Trial / Wandersonia Moreira Brito MEDEIROS in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70353 Titre : Effects of Cannabidiol-Rich Cannabis Oil on Facial Expression Recognition and Theory of Mind in Children With Autism Spectrum Disorder: A Randomized Clinical Trial Type de document : texte imprimé Auteurs : Wandersonia Moreira Brito MEDEIROS, Auteur ; Estácio Amaro DA SILVA JUNIOR, Auteur ; Katy Lísias Gondim Dias DE ALBUQUERQUE, Auteur ; Marine Diniz DA ROSA, Auteur ; Amanda Gleiciane DE LIMA OLIVEIRA, Auteur ; Maycon Jônatas DA SILVA, Auteur ; João Vitor Andrade FERNANDES, Auteur ; Emily Caroline Costa VIEIRA, Auteur ; João Paulo Mendes DOS SANTOS, Auteur ; Thais Cavalcanti BORGES, Auteur ; Ana Hermínia Andrade E SILVA, Auteur ; Carlos Espínola Neto SEGUNDO, Auteur ; Nelson TORRO-ALVES, Auteur Année de publication : 2026 Article en page(s) : p.e70353 Langues : Anglais (eng) Mots-clés : anxiety  autism spectrum disorder  cannabidiol  children  randomized controlled trial Index. décimale : PER Périodiques Résumé : ABSTRACT To evaluate, in a post hoc subanalysis, the effects of cannabidiol (CBD)-rich cannabis oil on facial expression recognition and theory of mind in children with autism spectrum disorder (ASD). This post hoc subanalysis included children from a double-blind, randomized, placebo-controlled trial who completed social cognition assessments at baseline and after treatment. Participants received CBD-rich cannabis oil or placebo for 12?weeks. Facial expression recognition and theory of mind were assessed using neuropsychological tasks. Between-group differences were evaluated using the Mann?Whitney U test, whereas within-group changes were assessed using the Wilcoxon signed-rank test. Nineteen Brazilian children with ASD were included (72.7% male; mean age, 7.82?years). Within-group analyses showed significant improvements in facial expression recognition (p?=?0.030) and verbal theory of mind (p?=?0.016) after treatment in the CBD group, whereas corresponding changes in the placebo group were not statistically significant. However, between-group comparisons showed no significant differences after treatment in facial expression recognition (p?=?0.527) or verbal theory of mind (p?=?0.901). Total theory of mind scores improved significantly within both groups, with no significant between-group difference (p?=?0.967). Although significant within-group improvements in facial expression recognition and verbal theory of mind were observed following CBD-rich cannabis oil treatment, these changes were not significantly different from those observed with placebo. Given the small sample size and exploratory post hoc design, these findings should be interpreted cautiously and do not establish a treatment effect of CBD on social cognition in children with ASD. Trial Registration Brazilian Clinical Trials Registry (ReBEC), RBR-5wr2cqq (UTN: U1111-1261-4178), accessible at https://ensaiosclinicos.gov.br/rg/RBR-5wr2cqq En ligne : https://doi.org/10.1002/aur.70353 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Effects of Cannabidiol-Rich Cannabis Oil on Facial Expression Recognition and Theory of Mind in Children With Autism Spectrum Disorder: A Randomized Clinical Trial [texte imprimé] / Wandersonia Moreira Brito MEDEIROS, Auteur ; Estácio Amaro DA SILVA JUNIOR, Auteur ; Katy Lísias Gondim Dias DE ALBUQUERQUE, Auteur ; Marine Diniz DA ROSA, Auteur ; Amanda Gleiciane DE LIMA OLIVEIRA, Auteur ; Maycon Jônatas DA SILVA, Auteur ; João Vitor Andrade FERNANDES, Auteur ; Emily Caroline Costa VIEIRA, Auteur ; João Paulo Mendes DOS SANTOS, Auteur ; Thais Cavalcanti BORGES, Auteur ; Ana Hermínia Andrade E SILVA, Auteur ; Carlos Espínola Neto SEGUNDO, Auteur ; Nelson TORRO-ALVES, Auteur . - 2026 . - p.e70353. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70353 Mots-clés : anxiety  autism spectrum disorder  cannabidiol  children  randomized controlled trial Index. décimale : PER Périodiques Résumé : ABSTRACT To evaluate, in a post hoc subanalysis, the effects of cannabidiol (CBD)-rich cannabis oil on facial expression recognition and theory of mind in children with autism spectrum disorder (ASD). This post hoc subanalysis included children from a double-blind, randomized, placebo-controlled trial who completed social cognition assessments at baseline and after treatment. Participants received CBD-rich cannabis oil or placebo for 12?weeks. Facial expression recognition and theory of mind were assessed using neuropsychological tasks. Between-group differences were evaluated using the Mann?Whitney U test, whereas within-group changes were assessed using the Wilcoxon signed-rank test. Nineteen Brazilian children with ASD were included (72.7% male; mean age, 7.82?years). Within-group analyses showed significant improvements in facial expression recognition (p?=?0.030) and verbal theory of mind (p?=?0.016) after treatment in the CBD group, whereas corresponding changes in the placebo group were not statistically significant. However, between-group comparisons showed no significant differences after treatment in facial expression recognition (p?=?0.527) or verbal theory of mind (p?=?0.901). Total theory of mind scores improved significantly within both groups, with no significant between-group difference (p?=?0.967). Although significant within-group improvements in facial expression recognition and verbal theory of mind were observed following CBD-rich cannabis oil treatment, these changes were not significantly different from those observed with placebo. Given the small sample size and exploratory post hoc design, these findings should be interpreted cautiously and do not establish a treatment effect of CBD on social cognition in children with ASD. Trial Registration Brazilian Clinical Trials Registry (ReBEC), RBR-5wr2cqq (UTN: U1111-1261-4178), accessible at https://ensaiosclinicos.gov.br/rg/RBR-5wr2cqq En ligne : https://doi.org/10.1002/aur.70353 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Correction to “Specialization of Anterior and Posterior Hippocampal Functional Connectivity Differs in Autism” in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70355 Titre : Correction to “Specialization of Anterior and Posterior Hippocampal Functional Connectivity Differs in Autism” Type de document : texte imprimé Année de publication : 2026 Article en page(s) : p.e70355 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70355 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Correction to “Specialization of Anterior and Posterior Hippocampal Functional Connectivity Differs in Autism” [texte imprimé] . - 2026 . - p.e70355. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70355 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70355 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Sex and Cognitive Ability-Based Stratification of Social Attention in Autism / Jason W. GRIFFIN in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70356 Titre : Sex and Cognitive Ability-Based Stratification of Social Attention in Autism Type de document : texte imprimé Auteurs : Jason W. GRIFFIN, Auteur ; Frederick SHIC, Auteur ; Adam NAPLES, Auteur ; Kelsey DOMMER, Auteur ; Geraldine DAWSON, Auteur ; Susan FAJA, Auteur ; Shafali JESTE, Auteur ; Natalia KLEINHANS, Auteur ; James DZIURA, Auteur ; Catherine SUGAR, Auteur ; Damla SENTURK, Auteur ; Gerhard HELLEMANN, Auteur ; Sara Jane WEBB, Auteur ; James C. MCPARTLAND, Auteur ; Trials THE AUTISM BIOMARKERS CONSORTIUM FOR CLINICAL, Auteur Année de publication : 2026 Article en page(s) : p.e70356 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Reduced social attention (SA) is a hallmark feature of autism that is foundational to social communication and interaction. However, emerging evidence suggests that reduced SA may not be uniformly expressed across the autism spectrum. Sex and cognitive ability (IQ) have been identified as relevant stratification variables, potentially moderating SA in autistic children. We examined differential patterns of SA stratified by sex and cognitive ability in a large, longitudinal sample of autistic and neurotypical (NT) children (ages 6?11?years) from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT), examining SA across four measurement timepoints (Baseline, 6?weeks, 6?months, and 4?years). SA was measured using the oculomotor index of gaze to human faces (OMI) derived from standardized eye-tracking (ET) assays, with children stratified by sex (male, female) and IQ (IQ?≥?85, IQ? En ligne : https://doi.org/10.1002/aur.70356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Sex and Cognitive Ability-Based Stratification of Social Attention in Autism [texte imprimé] / Jason W. GRIFFIN, Auteur ; Frederick SHIC, Auteur ; Adam NAPLES, Auteur ; Kelsey DOMMER, Auteur ; Geraldine DAWSON, Auteur ; Susan FAJA, Auteur ; Shafali JESTE, Auteur ; Natalia KLEINHANS, Auteur ; James DZIURA, Auteur ; Catherine SUGAR, Auteur ; Damla SENTURK, Auteur ; Gerhard HELLEMANN, Auteur ; Sara Jane WEBB, Auteur ; James C. MCPARTLAND, Auteur ; Trials THE AUTISM BIOMARKERS CONSORTIUM FOR CLINICAL, Auteur . - 2026 . - p.e70356. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70356 Index. décimale : PER Périodiques Résumé : ABSTRACT Reduced social attention (SA) is a hallmark feature of autism that is foundational to social communication and interaction. However, emerging evidence suggests that reduced SA may not be uniformly expressed across the autism spectrum. Sex and cognitive ability (IQ) have been identified as relevant stratification variables, potentially moderating SA in autistic children. We examined differential patterns of SA stratified by sex and cognitive ability in a large, longitudinal sample of autistic and neurotypical (NT) children (ages 6?11?years) from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT), examining SA across four measurement timepoints (Baseline, 6?weeks, 6?months, and 4?years). SA was measured using the oculomotor index of gaze to human faces (OMI) derived from standardized eye-tracking (ET) assays, with children stratified by sex (male, female) and IQ (IQ?≥?85, IQ? En ligne : https://doi.org/10.1002/aur.70356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

The Effect of a Parent Advocacy Intervention on Service Access for Autistic Youth: The Moderating Role of Baseline Advocacy Ability / Carly MOSER in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70357 Titre : The Effect of a Parent Advocacy Intervention on Service Access for Autistic Youth: The Moderating Role of Baseline Advocacy Ability Type de document : texte imprimé Auteurs : Carly MOSER, Auteur ; Leann Smith DAWALT, Auteur ; Meghan M. BURKE, Auteur ; Julie Lounds TAYLOR, Auteur Année de publication : 2026 Article en page(s) : p.e70357 Langues : Anglais (eng) Mots-clés : adult disability services  autism  parent advocacy  transition to adulthood  treatment moderators Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic youth face significant challenges accessing adult disability services as they transition out of school-based services. Advocating for Supports to Improve Service Transitions (ASSIST), a group-based program, was developed to address this issue by teaching parents about the service system and how to advocate for services for their youth. Through a randomized controlled trial, previous findings showed that ASSIST improved parent advocacy ability and increased access to government programs for youth who had exited high school. To identify which families may benefit most from ASSIST, the current study used a baseline target moderation framework to examine whether parents' baseline levels of advocacy ability (i.e., knowledge of adult services, perceived advocacy skills, and empowerment) modified the effect of intervention modality (ASSIST vs. written materials) on the primary outcome. The primary outcome for this study was having one or more service needs met at the 6- or 12-month follow-up. Participants included 138 parents of transition-aged autistic youth who received the ASSIST program or comprehensive written materials on disability services. We found that parents taking ASSIST who reported high levels of perceived advocacy skills and empowerment at baseline were more likely to have a service need met compared to those who received written materials. These findings help clarify which families are most likely to benefit from a parent advocacy program and underscore the importance of parental empowerment and perceived advocacy skills in securing needed services for their autistic youth. En ligne : https://doi.org/10.1002/aur.70357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] The Effect of a Parent Advocacy Intervention on Service Access for Autistic Youth: The Moderating Role of Baseline Advocacy Ability [texte imprimé] / Carly MOSER, Auteur ; Leann Smith DAWALT, Auteur ; Meghan M. BURKE, Auteur ; Julie Lounds TAYLOR, Auteur . - 2026 . - p.e70357. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70357 Mots-clés : adult disability services  autism  parent advocacy  transition to adulthood  treatment moderators Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic youth face significant challenges accessing adult disability services as they transition out of school-based services. Advocating for Supports to Improve Service Transitions (ASSIST), a group-based program, was developed to address this issue by teaching parents about the service system and how to advocate for services for their youth. Through a randomized controlled trial, previous findings showed that ASSIST improved parent advocacy ability and increased access to government programs for youth who had exited high school. To identify which families may benefit most from ASSIST, the current study used a baseline target moderation framework to examine whether parents' baseline levels of advocacy ability (i.e., knowledge of adult services, perceived advocacy skills, and empowerment) modified the effect of intervention modality (ASSIST vs. written materials) on the primary outcome. The primary outcome for this study was having one or more service needs met at the 6- or 12-month follow-up. Participants included 138 parents of transition-aged autistic youth who received the ASSIST program or comprehensive written materials on disability services. We found that parents taking ASSIST who reported high levels of perceived advocacy skills and empowerment at baseline were more likely to have a service need met compared to those who received written materials. These findings help clarify which families are most likely to benefit from a parent advocacy program and underscore the importance of parental empowerment and perceived advocacy skills in securing needed services for their autistic youth. En ligne : https://doi.org/10.1002/aur.70357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Letter to the Editor: Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors / Laust Vind KNUDSEN in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70358 Titre : Letter to the Editor: Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors Type de document : texte imprimé Auteurs : Laust Vind KNUDSEN, Auteur ; Manouchehr Seyedi VAFAEE, Auteur ; Tanja Maria MICHEL, Auteur Année de publication : 2026 Article en page(s) : p.e70358 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70358 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Letter to the Editor: Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors [texte imprimé] / Laust Vind KNUDSEN, Auteur ; Manouchehr Seyedi VAFAEE, Auteur ; Tanja Maria MICHEL, Auteur . - 2026 . - p.e70358. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70358 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70358 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population-Based Cohort Study Using Clinical Practice Research Datalink Aurum / Aws SADIK in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70360 Titre : Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population-Based Cohort Study Using Clinical Practice Research Datalink Aurum Type de document : texte imprimé Auteurs : Aws SADIK, Auteur ; Golam M. KHANDAKER, Auteur ; Antonio F. PARDIÑAS, Auteur ; Michael LUNDBERG, Auteur ; Brian K. LEE, Auteur ; Cecilia MAGNUSSON, Auteur ; Dheeraj RAI, Auteur ; Paul MADLEY-DOWD, Auteur Année de publication : 2026 Article en page(s) : p.e70360 Langues : Anglais (eng) Mots-clés : antidepressive agents  anxiety  depression  pharmacoepidemiology  primary health care Index. décimale : PER Périodiques Résumé : ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Using population-representative UK primary care records, we defined three autistic groups?autistic adults with intellectual disability (ID), autistic adults without ID and all autistic adults?and four non-autistic groups. In each calendar year we calculated: annual, lifetime and new antidepressant prescribing; indications for serotonin-selective reuptake inhibitor initiation; average doses prescribed for citalopram, fluoxetine, and sertraline; and the proportion of courses that lasted over 1, 2, and 3?years. We also repeated analyses with sex-stratification. In all, 34,173,295 non-autistic adults and 172,242 autistic adults were included (47,011 with ID and 125,231 without ID). 30% of autistic adults and 14.7% of non-autistic adults were prescribed an antidepressant in 2023. Prescriptions, doses and course durations increased over time for all groups. Prescriptions were highest in autistic adults without ID and females, whereas course durations were highest in autistic adults with ID. Recording of depression and anxiety as indications was lower for those with ID. Antidepressant prescribing has increased more for autistic adults than non-autistic adults since 1997, with more new starters, higher doses and longer course durations. This potentially increases the risk of adverse medication effects for autistic adults and emphasizes the need for stronger evidence around the effectiveness and tolerability of mental health interventions and the reasons for systematic differences in prescribing. En ligne : https://doi.org/10.1002/aur.70360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population-Based Cohort Study Using Clinical Practice Research Datalink Aurum [texte imprimé] / Aws SADIK, Auteur ; Golam M. KHANDAKER, Auteur ; Antonio F. PARDIÑAS, Auteur ; Michael LUNDBERG, Auteur ; Brian K. LEE, Auteur ; Cecilia MAGNUSSON, Auteur ; Dheeraj RAI, Auteur ; Paul MADLEY-DOWD, Auteur . - 2026 . - p.e70360. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70360 Mots-clés : antidepressive agents  anxiety  depression  pharmacoepidemiology  primary health care Index. décimale : PER Périodiques Résumé : ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Using population-representative UK primary care records, we defined three autistic groups?autistic adults with intellectual disability (ID), autistic adults without ID and all autistic adults?and four non-autistic groups. In each calendar year we calculated: annual, lifetime and new antidepressant prescribing; indications for serotonin-selective reuptake inhibitor initiation; average doses prescribed for citalopram, fluoxetine, and sertraline; and the proportion of courses that lasted over 1, 2, and 3?years. We also repeated analyses with sex-stratification. In all, 34,173,295 non-autistic adults and 172,242 autistic adults were included (47,011 with ID and 125,231 without ID). 30% of autistic adults and 14.7% of non-autistic adults were prescribed an antidepressant in 2023. Prescriptions, doses and course durations increased over time for all groups. Prescriptions were highest in autistic adults without ID and females, whereas course durations were highest in autistic adults with ID. Recording of depression and anxiety as indications was lower for those with ID. Antidepressant prescribing has increased more for autistic adults than non-autistic adults since 1997, with more new starters, higher doses and longer course durations. This potentially increases the risk of adverse medication effects for autistic adults and emphasizes the need for stronger evidence around the effectiveness and tolerability of mental health interventions and the reasons for systematic differences in prescribing. En ligne : https://doi.org/10.1002/aur.70360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594