Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial / Yun WANG in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Titre : Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial Type de document : texte imprimé Auteurs : Yun WANG, Auteur ; Ellen M. KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy E. MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.1381-1391 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial [texte imprimé] / Yun WANG, Auteur ; Ellen M. KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy E. MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur . - p.1381-1391. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Homotypic and heterotypic continuity of internalizing and externalizing symptoms from ages 3 to 12: The moderating role of diurnal cortisol / Allison FROST in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.789-798 Titre : Homotypic and heterotypic continuity of internalizing and externalizing symptoms from ages 3 to 12: The moderating role of diurnal cortisol Type de document : texte imprimé Auteurs : Allison FROST, Auteur ; Ellen M. KESSEL, Auteur ; Sarah R. BLACK, Auteur ; Brandon L. GOLDSTEIN, Auteur ; Kristin BERNARD, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.789-798 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychological symptoms that arise in early childhood can follow a multitude of patterns into adolescence, including homotypic continuity (i.e., similar symptoms over time) and heterotypic continuity (i.e., a shift in symptoms over time). However, we know very little about the factors that distinguish homotypic vs. heterotypic continuity of early internalizing and externalizing symptoms over development. In a separate line of research, diurnal cortisol has been shown to predict later internalizing and externalizing problems. In the current study, we tested whether diurnal cortisol patterns moderated the course of internalizing and externalizing symptoms from preschool to early adolescence. 554 children (54% male) and parents participated in a longitudinal study. Parents reported on their children’s internalizing and externalizing symptoms at ages 3 and 12, and children collected diurnal saliva samples at age 9. Results showed that a steeper cortisol decline at age 9 combined with high internalizing or externalizing problems at age 3 predicted higher internalizing problems at age 12. A more blunted cortisol decline combined with early internalizing or externalizing problems predicted higher externalizing problems in early adolescence. These results illustrate the moderating role of stress system functioning in homotypic and heterotypic patterns of psychopathology from preschool to early adolescence. En ligne : http://dx.doi.org/10.1017/S0954579418000573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Homotypic and heterotypic continuity of internalizing and externalizing symptoms from ages 3 to 12: The moderating role of diurnal cortisol [texte imprimé] / Allison FROST, Auteur ; Ellen M. KESSEL, Auteur ; Sarah R. BLACK, Auteur ; Brandon L. GOLDSTEIN, Auteur ; Kristin BERNARD, Auteur ; Daniel N. KLEIN, Auteur . - p.789-798. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.789-798 Index. décimale : PER Périodiques Résumé : Psychological symptoms that arise in early childhood can follow a multitude of patterns into adolescence, including homotypic continuity (i.e., similar symptoms over time) and heterotypic continuity (i.e., a shift in symptoms over time). However, we know very little about the factors that distinguish homotypic vs. heterotypic continuity of early internalizing and externalizing symptoms over development. In a separate line of research, diurnal cortisol has been shown to predict later internalizing and externalizing problems. In the current study, we tested whether diurnal cortisol patterns moderated the course of internalizing and externalizing symptoms from preschool to early adolescence. 554 children (54% male) and parents participated in a longitudinal study. Parents reported on their children’s internalizing and externalizing symptoms at ages 3 and 12, and children collected diurnal saliva samples at age 9. Results showed that a steeper cortisol decline at age 9 combined with high internalizing or externalizing problems at age 3 predicted higher internalizing problems at age 12. A more blunted cortisol decline combined with early internalizing or externalizing problems predicted higher externalizing problems in early adolescence. These results illustrate the moderating role of stress system functioning in homotypic and heterotypic patterns of psychopathology from preschool to early adolescence. En ligne : http://dx.doi.org/10.1017/S0954579418000573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Neural reactivity to monetary rewards and losses differentiates social from generalized anxiety in children / Ellen M. KESSEL in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.792-800 Titre : Neural reactivity to monetary rewards and losses differentiates social from generalized anxiety in children Type de document : texte imprimé Auteurs : Ellen M. KESSEL, Auteur ; Autumn KUJAWA, Auteur ; Greg HAJCAK PROUDFIT, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.792-800 Langues : Anglais (eng) Mots-clés : Anxiety  reward processing  children  event-related potentials Index. décimale : PER Périodiques Résumé : Background The relationship between reward sensitivity and pediatric anxiety is poorly understood. Evidence suggests that alterations in reward processing are more characteristic of depressive than anxiety disorders. However, some studies have reported that anxiety disorders are also associated with perturbations in reward processing. Heterogeneity in the forms of anxiety studied may account for the differences between studies. We used the feedback-negativity, an event-related potential sensitive to monetary gains versus losses (ΔFN), to examine whether different forms of youth anxiety symptoms were uniquely associated with reward sensitivity as indexed by neural reactivity to the receipt of positive and negative monetary outcomes. Method Participants were 390, eight- to ten-year-old children (175 females) from a large community sample. The ΔFN was measured during a monetary reward task. Self-reports of child anxiety and depression symptoms and temperamental positive emotionality (PE) were obtained. Results Multiple regression analysis revealed that social anxiety and generalized anxiety symptoms were unique predictors of reward sensitivity after accounting for concurrent depressive symptoms and PE. While social anxiety was associated with a greater ΔFN, generalized anxiety was associated with a reduced ΔFN. Conclusions Different symptom dimensions of child anxiety are differentially related to alterations in reward sensitivity. This may, in part, explain inconsistent findings in the literature regarding reward processing in anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12355 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Neural reactivity to monetary rewards and losses differentiates social from generalized anxiety in children [texte imprimé] / Ellen M. KESSEL, Auteur ; Autumn KUJAWA, Auteur ; Greg HAJCAK PROUDFIT, Auteur ; Daniel N. KLEIN, Auteur . - p.792-800. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.792-800 Mots-clés : Anxiety  reward processing  children  event-related potentials Index. décimale : PER Périodiques Résumé : Background The relationship between reward sensitivity and pediatric anxiety is poorly understood. Evidence suggests that alterations in reward processing are more characteristic of depressive than anxiety disorders. However, some studies have reported that anxiety disorders are also associated with perturbations in reward processing. Heterogeneity in the forms of anxiety studied may account for the differences between studies. We used the feedback-negativity, an event-related potential sensitive to monetary gains versus losses (ΔFN), to examine whether different forms of youth anxiety symptoms were uniquely associated with reward sensitivity as indexed by neural reactivity to the receipt of positive and negative monetary outcomes. Method Participants were 390, eight- to ten-year-old children (175 females) from a large community sample. The ΔFN was measured during a monetary reward task. Self-reports of child anxiety and depression symptoms and temperamental positive emotionality (PE) were obtained. Results Multiple regression analysis revealed that social anxiety and generalized anxiety symptoms were unique predictors of reward sensitivity after accounting for concurrent depressive symptoms and PE. While social anxiety was associated with a greater ΔFN, generalized anxiety was associated with a reduced ΔFN. Conclusions Different symptom dimensions of child anxiety are differentially related to alterations in reward sensitivity. This may, in part, explain inconsistent findings in the literature regarding reward processing in anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12355 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles / Daniel C. KOPALA-SIBLEY in Development and Psychopathology, 29-4 (October 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-4 (October 2017) . - p.1469-1482 Titre : Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles Type de document : texte imprimé Auteurs : Daniel C. KOPALA-SIBLEY, Auteur ; Caitlin JELINEK, Auteur ; Ellen M. KESSEL, Auteur ; Allison FROST, Auteur ; Anna E.S. ALLMANN, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.1469-1482 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The link between parental depressive history and parenting styles is well established, as is the association of parenting with child psychopathology. However, little research has examined whether a depressive history in one parent predicts the parenting style of the other parent. As well, relatively little research has tested transactional models of the parenting–child psychopathology relationship in the context of parents' depressive histories. In this study, mothers and fathers of 392 children were assessed for a lifetime history of major depression when their children were 3 years old. They then completed measures of permissiveness and authoritarianism and their child's internalizing and externalizing symptoms when children were 3, 6, and 9 years old. The results showed that a depressive history in one parent predicted the other parent's permissiveness. Analyses then showed that child externalizing symptoms at age 3 predicted maternal permissiveness and authoritarianism and paternal permissiveness at age 6. Maternal permissiveness at age 6 predicted child externalizing symptoms at age 9. No relationships in either direction were found between parenting styles and child internalizing symptoms. The results highlight the importance of considering both parents' depressive histories when understanding parenting styles, and support transactional models of parenting styles and child externalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579417000396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313 [article] Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles [texte imprimé] / Daniel C. KOPALA-SIBLEY, Auteur ; Caitlin JELINEK, Auteur ; Ellen M. KESSEL, Auteur ; Allison FROST, Auteur ; Anna E.S. ALLMANN, Auteur ; Daniel N. KLEIN, Auteur . - p.1469-1482. Langues : Anglais (eng) in Development and Psychopathology > 29-4 (October 2017) . - p.1469-1482 Index. décimale : PER Périodiques Résumé : Abstract The link between parental depressive history and parenting styles is well established, as is the association of parenting with child psychopathology. However, little research has examined whether a depressive history in one parent predicts the parenting style of the other parent. As well, relatively little research has tested transactional models of the parenting–child psychopathology relationship in the context of parents' depressive histories. In this study, mothers and fathers of 392 children were assessed for a lifetime history of major depression when their children were 3 years old. They then completed measures of permissiveness and authoritarianism and their child's internalizing and externalizing symptoms when children were 3, 6, and 9 years old. The results showed that a depressive history in one parent predicted the other parent's permissiveness. Analyses then showed that child externalizing symptoms at age 3 predicted maternal permissiveness and authoritarianism and paternal permissiveness at age 6. Maternal permissiveness at age 6 predicted child externalizing symptoms at age 9. No relationships in either direction were found between parenting styles and child internalizing symptoms. The results highlight the importance of considering both parents' depressive histories when understanding parenting styles, and support transactional models of parenting styles and child externalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579417000396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313

Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children / Ellen M. KESSEL in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1589-1598 Titre : Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children Type de document : texte imprimé Auteurs : Ellen M. KESSEL, Auteur ; Brady D. NELSON, Auteur ; Megan FINSAAS, Auteur ; Autumn KUJAWA, Auteur ; Alexandria MEYER, Auteur ; Evelyn BROMET, Auteur ; Gabrielle A. CARLSON, Auteur ; Greg HAJCAK, Auteur ; Roman KOTOV, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.1589-1598 Langues : Anglais (eng) Mots-clés : brain development  event-related potentials  natural disaster  parenting Index. décimale : PER Périodiques Résumé : Little is known about the effect of natural disasters on children's neural development. Additionally, despite evidence that stress and parenting may both influence the development of neural systems underlying reward and threat processing, few studies have brought together these areas of research. The current investigation examined the effect of parenting styles and hurricane-related stress on the development of neural reactivity to reward and threat in children. Approximately 8 months before and 9 months after Hurricane Sandy, 74 children experiencing high and low levels of hurricane-related stress completed tasks that elicited the reward positivity and error-related negativity, event-related potentials indexing sensitivity to reward and threat, respectively. At the post-Hurricane assessment, children completed a self-report questionnaire to measure promotion- and prevention-focused parenting styles. Among children exposed to high levels of hurricane-related stress, lower levels of promotion-focused, but not prevention-focused, parenting were associated with a reduced post-Sandy reward positivity. In addition, in children with high stress exposure, greater prevention-focused, but not promotion-focused, parenting was associated with a larger error-related negativity after Hurricane Sandy. These findings highlight the need to consider contextual variables such as parenting when examining how exposure to stress alters the development of neural reactivity to reward and threat in children. En ligne : http://dx.doi.org/10.1017/s0954579418001347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children [texte imprimé] / Ellen M. KESSEL, Auteur ; Brady D. NELSON, Auteur ; Megan FINSAAS, Auteur ; Autumn KUJAWA, Auteur ; Alexandria MEYER, Auteur ; Evelyn BROMET, Auteur ; Gabrielle A. CARLSON, Auteur ; Greg HAJCAK, Auteur ; Roman KOTOV, Auteur ; Daniel N. KLEIN, Auteur . - p.1589-1598. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1589-1598 Mots-clés : brain development  event-related potentials  natural disaster  parenting Index. décimale : PER Périodiques Résumé : Little is known about the effect of natural disasters on children's neural development. Additionally, despite evidence that stress and parenting may both influence the development of neural systems underlying reward and threat processing, few studies have brought together these areas of research. The current investigation examined the effect of parenting styles and hurricane-related stress on the development of neural reactivity to reward and threat in children. Approximately 8 months before and 9 months after Hurricane Sandy, 74 children experiencing high and low levels of hurricane-related stress completed tasks that elicited the reward positivity and error-related negativity, event-related potentials indexing sensitivity to reward and threat, respectively. At the post-Hurricane assessment, children completed a self-report questionnaire to measure promotion- and prevention-focused parenting styles. Among children exposed to high levels of hurricane-related stress, lower levels of promotion-focused, but not prevention-focused, parenting were associated with a reduced post-Sandy reward positivity. In addition, in children with high stress exposure, greater prevention-focused, but not promotion-focused, parenting was associated with a larger error-related negativity after Hurricane Sandy. These findings highlight the need to consider contextual variables such as parenting when examining how exposure to stress alters the development of neural reactivity to reward and threat in children. En ligne : http://dx.doi.org/10.1017/s0954579418001347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Preschool irritability predicts child psychopathology, functional impairment, and service use at age nine / Lea R. DOUGHERTY in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

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Transdiagnostic factors and pathways to multifinality: The error-related negativity predicts whether preschool irritability is associated with internalizing versus externalizing symptoms at age 9 / Ellen M. KESSEL in Development and Psychopathology, 28-4 pt1 (November 2016)  

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