Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder / Leticia RIBEIRO DE OLIVEIRA in Research in Autism Spectrum Disorders, 73 (May 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 73 (May 2019) . - 101548 Titre : Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Leticia RIBEIRO DE OLIVEIRA, Auteur ; Jessica BRIAN, Auteur ; Elizabeth KELLEY, Auteur ; Deryk BEAL, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Alana IABONI, Auteur ; Susan Day FRAGIADAKIS, Auteur ; Leanne RISTIC, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Teenu SANJEEVAN, Auteur Article en page(s) : 101548 Langues : Anglais (eng) Mots-clés : ASD  Verbal intelligence quotient  Receptive language  Expressive language  Wechsler scales  Oral and Written Language Scales – Second Edition Index. décimale : PER Périodiques Résumé : Background There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the Oral Written Language Scales – Second Edition (OWLS-II) of 714 participants aged 3–21 years: 488 with ASD and 226 with TD. Results Regression analyses revealed that VIQ scores predicted greater variance in receptive and expressive language scores in males with ASD relative to males with TD, and predicted less variance in receptive and expressive language scores in females with ASD relative to females with TD. Overall, VIQ accounted for a small proportion of variance in receptive and expressive language scores. Conclusions Our findings indicate that the VIQ does not accurately capture language form and content evaluated by language measures like the OWLS-II, but may perhaps be used as a proxy for language content only. En ligne : https://doi.org/10.1016/j.rasd.2020.101548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder [Texte imprimé et/ou numérique] / Leticia RIBEIRO DE OLIVEIRA, Auteur ; Jessica BRIAN, Auteur ; Elizabeth KELLEY, Auteur ; Deryk BEAL, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Alana IABONI, Auteur ; Susan Day FRAGIADAKIS, Auteur ; Leanne RISTIC, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Teenu SANJEEVAN, Auteur . - 101548. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101548 Mots-clés : ASD  Verbal intelligence quotient  Receptive language  Expressive language  Wechsler scales  Oral and Written Language Scales – Second Edition Index. décimale : PER Périodiques Résumé : Background There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the Oral Written Language Scales – Second Edition (OWLS-II) of 714 participants aged 3–21 years: 488 with ASD and 226 with TD. Results Regression analyses revealed that VIQ scores predicted greater variance in receptive and expressive language scores in males with ASD relative to males with TD, and predicted less variance in receptive and expressive language scores in females with ASD relative to females with TD. Overall, VIQ accounted for a small proportion of variance in receptive and expressive language scores. Conclusions Our findings indicate that the VIQ does not accurately capture language form and content evaluated by language measures like the OWLS-II, but may perhaps be used as a proxy for language content only. En ligne : https://doi.org/10.1016/j.rasd.2020.101548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study / Danielle A. BARIBEAU in Autism Research, 16-8 (August 2023)  

Public ISBD [article]  inAutism Research > 16-8 (August 2023) . - p.1600-1608 Titre : Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study Type de document : Texte imprimé et/ou numérique Auteurs : Danielle A. BARIBEAU, Auteur ; Jasleen ARNEJA, Auteur ; Xuesong WANG, Auteur ; Jennifer HOWE, Auteur ; John R. MCLAUGHLIN, Auteur ; Karen TU, Auteur ; Jun GUAN, Auteur ; Alana IABONI, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Stephen W. SCHERER, Auteur ; Susan E. BRONSKILL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer D. BROOKS, Auteur Article en page(s) : p.1600-1608 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Whether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism-associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3-year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism-associated gene (n=83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p=0.01; outpatient mental health visit: 66% vs. 77%, p=0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p=0.4) and genetic status was not associated with odds of being a high-cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism-associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions. En ligne : https://doi.org/10.1002/aur.2999 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study [Texte imprimé et/ou numérique] / Danielle A. BARIBEAU, Auteur ; Jasleen ARNEJA, Auteur ; Xuesong WANG, Auteur ; Jennifer HOWE, Auteur ; John R. MCLAUGHLIN, Auteur ; Karen TU, Auteur ; Jun GUAN, Auteur ; Alana IABONI, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Stephen W. SCHERER, Auteur ; Susan E. BRONSKILL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer D. BROOKS, Auteur . - p.1600-1608. Langues : Anglais (eng) in Autism Research > 16-8 (August 2023) . - p.1600-1608 Index. décimale : PER Périodiques Résumé : Abstract Whether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism-associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3-year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism-associated gene (n=83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p=0.01; outpatient mental health visit: 66% vs. 77%, p=0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p=0.4) and genetic status was not associated with odds of being a high-cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism-associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions. En ligne : https://doi.org/10.1002/aur.2999 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism / Deepali MANKAD in Molecular Autism, (March 2015)  

Public ISBD [article]  inMolecular Autism > (March 2015) . - p.1-11 Titre : A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Deepali MANKAD, Auteur ; Annie DUPUIS, Auteur ; Sharon SMILE, Auteur ; Wendy ROBERTS, Auteur ; Jessica BRIAN, Auteur ; Toni LUI, Auteur ; Lisa GENORE, Auteur ; Dina ZAGHLOUL, Auteur ; Alana IABONI, Auteur ; Peggy Margaret A. MARCON, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting more than 1% of children. It is characterized by social communication deficits and repetitive behaviors/restricted interests. In the absence of any medications known to improve core symptom domains, parents often use complementary alternative treatments, including omega-3 fatty acid supplements. En ligne : http://dx.doi.org/10.1186/s13229-015-0010-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism [Texte imprimé et/ou numérique] / Deepali MANKAD, Auteur ; Annie DUPUIS, Auteur ; Sharon SMILE, Auteur ; Wendy ROBERTS, Auteur ; Jessica BRIAN, Auteur ; Toni LUI, Auteur ; Lisa GENORE, Auteur ; Dina ZAGHLOUL, Auteur ; Alana IABONI, Auteur ; Peggy Margaret A. MARCON, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (March 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting more than 1% of children. It is characterized by social communication deficits and repetitive behaviors/restricted interests. In the absence of any medications known to improve core symptom domains, parents often use complementary alternative treatments, including omega-3 fatty acid supplements. En ligne : http://dx.doi.org/10.1186/s13229-015-0010-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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