Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care / Dominic S. FARERI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1865-1876 Titre : Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care Type de document : texte imprimé Auteurs : Dominic S. FARERI, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Jessica E. FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Daniel S. LUMIAN, Auteur ; Christina CALDERA, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1865-1876 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence. En ligne : http://dx.doi.org/10.1017/S0954579417001456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care [texte imprimé] / Dominic S. FARERI, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Jessica E. FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Daniel S. LUMIAN, Auteur ; Christina CALDERA, Auteur ; Nim TOTTENHAM, Auteur . - p.1865-1876. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1865-1876 Index. décimale : PER Périodiques Résumé : Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence. En ligne : http://dx.doi.org/10.1017/S0954579417001456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Concurrent and prospective associations between fitbit wearable-derived RDoC arousal and regulatory constructs and adolescent internalizing symptoms / Benjamin W. NELSON in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.282-295 Titre : Concurrent and prospective associations between fitbit wearable-derived RDoC arousal and regulatory constructs and adolescent internalizing symptoms Type de document : texte imprimé Auteurs : Benjamin W. NELSON, Auteur ; Jessica E. FLANNERY, Auteur ; John FLOURNOY, Auteur ; Natasha DUELL, Auteur ; Mitchell J. PRINSTEIN, Auteur ; Eva TELZER, Auteur Article en page(s) : p.282-295 Langues : Anglais (eng) Mots-clés : Adolescence  fitbit  heart rate  internalizing symptoms  sleep  steps  wearables Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is characterized by alterations in biobehavioral functioning, during which individuals are at heightened risk for onset of psychopathology, particularly internalizing disorders. Researchers have proposed using digital technologies to index daily biobehavioral functioning, yet there is a dearth of research examining how wearable metrics are associated with mental health. METHODS: We preregistered analyses using the Adolescent Brain Cognitive Development Study dataset using wearable data collection in 5,686 adolescents (123,862 person-days or 2,972,688 person-hours) to determine whether wearable indices of resting heart rate (RHR), step count, and sleep duration and variability in these measures were cross-sectionally associated with internalizing symptomatology. All models were also run controlling for age, sex, body mass index, socioeconomic status, and race. We then performed prospective analyses on a subset of this sample (n = 143) across 25 months that had Fitbit data available at baseline and follow-up in order to explore directionality of effects. RESULTS: Cross-sectional analyses revealed a small, yet significant, effect size (R(2)  = .053) that higher RHR, lower step count and step count variability, and greater variability in sleep duration were associated with greater internalizing symptoms. Cross-lagged panel model analysis revealed that there were no prospective associations between wearable variables and internalizing symptoms (partial R(2)  = .026), but greater internalizing symptoms and higher RHR predicted lower step count 25 months later (partial R(2)  = .010), while higher RHR also predicted lower step count variability 25 months later (partial R(2)  = .008). CONCLUSIONS: Findings indicate that wearable indices concurrently associate with internalizing symptoms during early adolescence, while a larger sample size is likely required to accurately assess prospective or directional effects between wearable indices and mental health. Future research should capitalize on the temporal resolution provided by wearable devices to determine the intensive longitudinal relations between biobehavioral risk factors and acute changes in mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13471 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Concurrent and prospective associations between fitbit wearable-derived RDoC arousal and regulatory constructs and adolescent internalizing symptoms [texte imprimé] / Benjamin W. NELSON, Auteur ; Jessica E. FLANNERY, Auteur ; John FLOURNOY, Auteur ; Natasha DUELL, Auteur ; Mitchell J. PRINSTEIN, Auteur ; Eva TELZER, Auteur . - p.282-295. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.282-295 Mots-clés : Adolescence  fitbit  heart rate  internalizing symptoms  sleep  steps  wearables Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is characterized by alterations in biobehavioral functioning, during which individuals are at heightened risk for onset of psychopathology, particularly internalizing disorders. Researchers have proposed using digital technologies to index daily biobehavioral functioning, yet there is a dearth of research examining how wearable metrics are associated with mental health. METHODS: We preregistered analyses using the Adolescent Brain Cognitive Development Study dataset using wearable data collection in 5,686 adolescents (123,862 person-days or 2,972,688 person-hours) to determine whether wearable indices of resting heart rate (RHR), step count, and sleep duration and variability in these measures were cross-sectionally associated with internalizing symptomatology. All models were also run controlling for age, sex, body mass index, socioeconomic status, and race. We then performed prospective analyses on a subset of this sample (n = 143) across 25 months that had Fitbit data available at baseline and follow-up in order to explore directionality of effects. RESULTS: Cross-sectional analyses revealed a small, yet significant, effect size (R(2)  = .053) that higher RHR, lower step count and step count variability, and greater variability in sleep duration were associated with greater internalizing symptoms. Cross-lagged panel model analysis revealed that there were no prospective associations between wearable variables and internalizing symptoms (partial R(2)  = .026), but greater internalizing symptoms and higher RHR predicted lower step count 25 months later (partial R(2)  = .010), while higher RHR also predicted lower step count variability 25 months later (partial R(2)  = .008). CONCLUSIONS: Findings indicate that wearable indices concurrently associate with internalizing symptoms during early adolescence, while a larger sample size is likely required to accurately assess prospective or directional effects between wearable indices and mental health. Future research should capitalize on the temporal resolution provided by wearable devices to determine the intensive longitudinal relations between biobehavioral risk factors and acute changes in mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13471 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation / Shulamite A. GREEN in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1135-1144 Titre : Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation Type de document : texte imprimé Auteurs : Shulamite A. GREEN, Auteur ; Bonnie GOFF, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Jessica E. FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Jennifer LOUIE, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1135-1144 Langues : Anglais (eng) Mots-clés : Amygdala development  parents  stress  institutional rearing  separation anxiety  social Index. décimale : PER Périodiques Résumé : Background Significant disruption in caregiving is associated with increased internalizing symptoms, most notably heightened separation anxiety symptoms during childhood. It is also associated with altered functional development of the amygdala, a neurobiological correlate of anxious behavior. However, much less is known about how functional alterations of amygdala predict individual differences in anxiety. Here, we probed amygdala function following institutional caregiving using very subtle social-affective stimuli (trustworthy and untrustworthy faces), which typically result in large differences in amygdala signal, and change in separation anxiety behaviors over a 2-year period. We hypothesized that the degree of differentiation of amygdala signal to trustworthy versus untrustworthy face stimuli would predict separation anxiety symptoms. Methods Seventy-four youths mean (SD) age = 9.7 years (2.64) with and without previous institutional care, who were all living in families at the time of testing, participated in an fMRI task designed to examine differential amygdala response to trustworthy versus untrustworthy faces. Parents reported on their children's separation anxiety symptoms at the time of scan and again 2 years later. Results Previous institutional care was associated with diminished amygdala signal differences and behavioral differences to the contrast of untrustworthy and trustworthy faces. Diminished differentiation of these stimuli types predicted more severe separation anxiety symptoms 2 years later. Older age at adoption was associated with diminished differentiation of amygdala responses. Conclusions A history of institutional care is associated with reduced differential amygdala responses to social-affective cues of trustworthiness that are typically exhibited by comparison samples. Individual differences in the degree of amygdala differential responding to these cues predict the severity of separation anxiety symptoms over a 2-year period. These findings provide a biological mechanism to explain the associations between early caregiving adversity and individual differences in internalizing symptomology during development, thereby contributing to individualized predictions of future clinical outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation [texte imprimé] / Shulamite A. GREEN, Auteur ; Bonnie GOFF, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Jessica E. FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Jennifer LOUIE, Auteur ; Nim TOTTENHAM, Auteur . - p.1135-1144. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1135-1144 Mots-clés : Amygdala development  parents  stress  institutional rearing  separation anxiety  social Index. décimale : PER Périodiques Résumé : Background Significant disruption in caregiving is associated with increased internalizing symptoms, most notably heightened separation anxiety symptoms during childhood. It is also associated with altered functional development of the amygdala, a neurobiological correlate of anxious behavior. However, much less is known about how functional alterations of amygdala predict individual differences in anxiety. Here, we probed amygdala function following institutional caregiving using very subtle social-affective stimuli (trustworthy and untrustworthy faces), which typically result in large differences in amygdala signal, and change in separation anxiety behaviors over a 2-year period. We hypothesized that the degree of differentiation of amygdala signal to trustworthy versus untrustworthy face stimuli would predict separation anxiety symptoms. Methods Seventy-four youths mean (SD) age = 9.7 years (2.64) with and without previous institutional care, who were all living in families at the time of testing, participated in an fMRI task designed to examine differential amygdala response to trustworthy versus untrustworthy faces. Parents reported on their children's separation anxiety symptoms at the time of scan and again 2 years later. Results Previous institutional care was associated with diminished amygdala signal differences and behavioral differences to the contrast of untrustworthy and trustworthy faces. Diminished differentiation of these stimuli types predicted more severe separation anxiety symptoms 2 years later. Older age at adoption was associated with diminished differentiation of amygdala responses. Conclusions A history of institutional care is associated with reduced differential amygdala responses to social-affective cues of trustworthiness that are typically exhibited by comparison samples. Individual differences in the degree of amygdala differential responding to these cues predict the severity of separation anxiety symptoms over a 2-year period. These findings provide a biological mechanism to explain the associations between early caregiving adversity and individual differences in internalizing symptomology during development, thereby contributing to individualized predictions of future clinical outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Friendship and social functioning following early institutional rearing: The role of ADHD symptoms / Kathryn L. HUMPHREYS in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1477-1487 Titre : Friendship and social functioning following early institutional rearing: The role of ADHD symptoms Type de document : texte imprimé Auteurs : Kathryn L. HUMPHREYS, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Eva H. TELZER, Auteur ; Jessica E. FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Valentina PARK, Auteur ; Steve S. LEE, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1477-1487 Langues : Anglais (eng) Mots-clés : Adhd  institutional care  institutional rearing  social problems Index. décimale : PER Périodiques Résumé : Early institutional rearing is associated with increased risk for subsequent peer relationship difficulties, but the underlying mechanisms have not been identified. Friendship characteristics, social behaviors with peers, normed assessments of social problems, and social cue use were assessed in 142 children (mean age = 10.06, SD = 2.02; range 7-13 years), of whom 67 were previously institutionalized (PI), and 75 were raised by their biological families. Anxiety and attention-deficit/hyperactivity disorder (ADHD) symptoms, often elevated among PI children, were examined as potential mediators of PI status and baseline social functioning and longitudinal follow-ups (2 and 4 years later). Twenty-seven percent of PI children fell above the Child Behavior Checklist Social Problems cutoff. An examination of specific social behaviors with peers indicated that PI and comparison children did not differ in empathic concern or peer social approach, though parents were more likely to endorse aggression/overarousal as a reason that PI children might struggle with friendships. Comparison children outperformed PI children in computerized testing of social cue use learning. Finally, across these measures, social difficulties exhibited in the PI group were mediated by ADHD symptoms with predicted social problems assessed 4 years later. These findings show that, when PI children struggle with friendships, mechanisms involving attention and behavior regulation are likely contributors. En ligne : http://dx.doi.org/10.1017/s0954579418001050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Friendship and social functioning following early institutional rearing: The role of ADHD symptoms [texte imprimé] / Kathryn L. HUMPHREYS, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Eva H. TELZER, Auteur ; Jessica E. FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Valentina PARK, Auteur ; Steve S. LEE, Auteur ; Nim TOTTENHAM, Auteur . - p.1477-1487. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1477-1487 Mots-clés : Adhd  institutional care  institutional rearing  social problems Index. décimale : PER Périodiques Résumé : Early institutional rearing is associated with increased risk for subsequent peer relationship difficulties, but the underlying mechanisms have not been identified. Friendship characteristics, social behaviors with peers, normed assessments of social problems, and social cue use were assessed in 142 children (mean age = 10.06, SD = 2.02; range 7-13 years), of whom 67 were previously institutionalized (PI), and 75 were raised by their biological families. Anxiety and attention-deficit/hyperactivity disorder (ADHD) symptoms, often elevated among PI children, were examined as potential mediators of PI status and baseline social functioning and longitudinal follow-ups (2 and 4 years later). Twenty-seven percent of PI children fell above the Child Behavior Checklist Social Problems cutoff. An examination of specific social behaviors with peers indicated that PI and comparison children did not differ in empathic concern or peer social approach, though parents were more likely to endorse aggression/overarousal as a reason that PI children might struggle with friendships. Comparison children outperformed PI children in computerized testing of social cue use learning. Finally, across these measures, social difficulties exhibited in the PI group were mediated by ADHD symptoms with predicted social problems assessed 4 years later. These findings show that, when PI children struggle with friendships, mechanisms involving attention and behavior regulation are likely contributors. En ligne : http://dx.doi.org/10.1017/s0954579418001050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity / Bridget L. CALLAGHAN in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.309-328 Titre : Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity Type de document : texte imprimé Auteurs : Bridget L. CALLAGHAN, Auteur ; Andrea FIELDS, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Christina CALDERA, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Bonnie GOFF, Auteur ; Jessica E. FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Mor SHAPIRO, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.309-328 Langues : Anglais (eng) Mots-clés : anxiety  development  functional magnetic resonance imaging  gastrointestinal distress  microbiome Index. décimale : PER Périodiques Résumé : Gastrointestinal and mental disorders are highly comorbid, and animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain and bacteria that live within the gastrointestinal system (the microbiome) underlie adversity-gastrointestinal-anxiety interactions, but these links have not been investigated during human development. In this study, we utilized data from a population of 344 youth (3-18 years old) who were raised with their biological parents or were exposed to early adverse caregiving experiences (i.e., institutional or foster care followed by international adoption) to explore adversity-gastrointestinal-anxiety associations. In Study 1, we demonstrated that previous adverse care experiences were associated with increased incidence of gastrointestinal symptoms in youth. Gastrointestinal symptoms were also associated with concurrent and future anxiety (measured across 5 years), and those gastrointestinal symptoms mediated the adversity-anxiety association at Time 1. In a subsample of children who provided both stool samples and functional magnetic resonance imaging of the brain (Study 2, which was a "proof-of-principle"), adversity was associated with changes in diversity (both alpha and beta) of microbial communities, and bacteria levels (adversity-associated and adversity-independent) were correlated with prefrontal cortex activation to emotional faces. Implications of these data for supporting youth mental health are discussed. En ligne : http://dx.doi.org/10.1017/s0954579419000087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity [texte imprimé] / Bridget L. CALLAGHAN, Auteur ; Andrea FIELDS, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Christina CALDERA, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Bonnie GOFF, Auteur ; Jessica E. FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Mor SHAPIRO, Auteur ; Nim TOTTENHAM, Auteur . - p.309-328. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.309-328 Mots-clés : anxiety  development  functional magnetic resonance imaging  gastrointestinal distress  microbiome Index. décimale : PER Périodiques Résumé : Gastrointestinal and mental disorders are highly comorbid, and animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain and bacteria that live within the gastrointestinal system (the microbiome) underlie adversity-gastrointestinal-anxiety interactions, but these links have not been investigated during human development. In this study, we utilized data from a population of 344 youth (3-18 years old) who were raised with their biological parents or were exposed to early adverse caregiving experiences (i.e., institutional or foster care followed by international adoption) to explore adversity-gastrointestinal-anxiety associations. In Study 1, we demonstrated that previous adverse care experiences were associated with increased incidence of gastrointestinal symptoms in youth. Gastrointestinal symptoms were also associated with concurrent and future anxiety (measured across 5 years), and those gastrointestinal symptoms mediated the adversity-anxiety association at Time 1. In a subsample of children who provided both stool samples and functional magnetic resonance imaging of the brain (Study 2, which was a "proof-of-principle"), adversity was associated with changes in diversity (both alpha and beta) of microbial communities, and bacteria levels (adversity-associated and adversity-independent) were correlated with prefrontal cortex activation to emotional faces. Implications of these data for supporting youth mental health are discussed. En ligne : http://dx.doi.org/10.1017/s0954579419000087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

Positive valence bias and parent–child relationship security moderate the association between early institutional caregiving and internalizing symptoms / Michelle R. VANTIEGHEM in Development and Psychopathology, 29-2 (May 2017)  

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Working memory moderates the association between early institutional care and separation anxiety symptoms in late childhood and adolescence / Laura Alicia ALBA in Development and Psychopathology, 31-3 (August 2019)  

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