Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study / Masoud AMIRI in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1582-1600 Titre : Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Masoud AMIRI, Auteur ; Sander LAMBALLAIS, Auteur ; Eloy GEENJAAR, Auteur ; Laura M. E. BLANKEN, Auteur ; Hanan EL MARROUN, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.1582-1600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre- and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data-driven approach was used to identify a number of pre- and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6-year-old children, a number of pre- and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study [Texte imprimé et/ou numérique] / Masoud AMIRI, Auteur ; Sander LAMBALLAIS, Auteur ; Eloy GEENJAAR, Auteur ; Laura M. E. BLANKEN, Auteur ; Hanan EL MARROUN, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur . - p.1582-1600. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1582-1600 Index. décimale : PER Périodiques Résumé : Abstract A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre- and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data-driven approach was used to identify a number of pre- and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6-year-old children, a number of pre- and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Infant muscle tone and childhood autistic traits: A longitudinal study in the general population / Fadila SERDAREVIC in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.757-768 Titre : Infant muscle tone and childhood autistic traits: A longitudinal study in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Fadila SERDAREVIC, Auteur ; Akhgar GHASSABIAN, Auteur ; Tamara VAN BATENBURG-EDDES, Auteur ; Tonya WHITE, Auteur ; Laura M. E. BLANKEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.757-768 Langues : Anglais (eng) Mots-clés : infant muscle tone  autistic traits  autism spectrum disorder  prospective Index. décimale : PER Périodiques Résumé : In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years. We defined clinical PDP if scores were >98th percentile of the norm population. Diagnosis of autism spectrum disorder (ASD) was clinically confirmed in 30 children. We observed a modest association between overall neuromotor development in infants and autistic traits. Low muscle tone in infancy predicted autistic traits measured by SRS (adjusted beta?=?0.05, 95% CI for B: 0.00–0.02, P?=?0.01), and PDP (adjusted beta?=?0.08, 95% CI for B: 0.04–0.10, P? En ligne : http://dx.doi.org/10.1002/aur.1739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Infant muscle tone and childhood autistic traits: A longitudinal study in the general population [Texte imprimé et/ou numérique] / Fadila SERDAREVIC, Auteur ; Akhgar GHASSABIAN, Auteur ; Tamara VAN BATENBURG-EDDES, Auteur ; Tonya WHITE, Auteur ; Laura M. E. BLANKEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur . - p.757-768. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.757-768 Mots-clés : infant muscle tone  autistic traits  autism spectrum disorder  prospective Index. décimale : PER Périodiques Résumé : In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years. We defined clinical PDP if scores were >98th percentile of the norm population. Diagnosis of autism spectrum disorder (ASD) was clinically confirmed in 30 children. We observed a modest association between overall neuromotor development in infants and autistic traits. Low muscle tone in infancy predicted autistic traits measured by SRS (adjusted beta?=?0.05, 95% CI for B: 0.00–0.02, P?=?0.01), and PDP (adjusted beta?=?0.08, 95% CI for B: 0.04–0.10, P? En ligne : http://dx.doi.org/10.1002/aur.1739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort / Novika Purnama SARI in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 26 p. Titre : Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort Type de document : Texte imprimé et/ou numérique Auteurs : Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/epidemiology  Child  Female  Humans  Male  Maternal Age  Mentalization  Mothers  Netherlands/epidemiology  Pregnancy  Autistic-like traits  Children   Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort [Texte imprimé et/ou numérique] / Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur . - 26 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 26 p. Mots-clés : Autistic Disorder/epidemiology  Child  Female  Humans  Male  Maternal Age  Mentalization  Mothers  Netherlands/epidemiology  Pregnancy  Autistic-like traits  Children   Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

A prospective study of fetal head growth, autistic traits and autism spectrum disorder / Laura M. E. BLANKEN in Autism Research, 11-4 (April 2018)  

Public ISBD [article]  inAutism Research > 11-4 (April 2018) . - p.602-612 Titre : A prospective study of fetal head growth, autistic traits and autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laura M. E. BLANKEN, Auteur ; A. DASS, Auteur ; Gail A. ALVARES, Auteur ; J. VAN DER ENDE, Auteur ; Nikita K. SCHOEMAKER, Auteur ; H. EL MARROUN, Auteur ; M. HICKEY, Auteur ; C. PENNELL, Auteur ; S. WHITE, Auteur ; M. T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Vincent W.V. JADDOE, Auteur ; F. C. VERHULST, Auteur ; H. TIEMEIER, Auteur ; W. MCINTOSH, Auteur ; T. WHITE, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.602-612 Langues : Anglais (eng) Mots-clés : brain growth  head circumference  pregnancy  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism-Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602-612. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. En ligne : http://dx.doi.org/10.1002/aur.1921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] A prospective study of fetal head growth, autistic traits and autism spectrum disorder [Texte imprimé et/ou numérique] / Laura M. E. BLANKEN, Auteur ; A. DASS, Auteur ; Gail A. ALVARES, Auteur ; J. VAN DER ENDE, Auteur ; Nikita K. SCHOEMAKER, Auteur ; H. EL MARROUN, Auteur ; M. HICKEY, Auteur ; C. PENNELL, Auteur ; S. WHITE, Auteur ; M. T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Vincent W.V. JADDOE, Auteur ; F. C. VERHULST, Auteur ; H. TIEMEIER, Auteur ; W. MCINTOSH, Auteur ; T. WHITE, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.602-612. Langues : Anglais (eng) in Autism Research > 11-4 (April 2018) . - p.602-612 Mots-clés : brain growth  head circumference  pregnancy  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism-Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602-612. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. En ligne : http://dx.doi.org/10.1002/aur.1921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Psychotic experiences and future school performance in childhood: a population-based cohort study / Lisa R STEENKAMP in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.357-365 Titre : Psychotic experiences and future school performance in childhood: a population-based cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Lisa R STEENKAMP, Auteur ; Koen BOLHUIS, Auteur ; Laura M. E. BLANKEN, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Manon H. J. HILLEGERS, Auteur ; Steven A. KUSHNER, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.357-365 Langues : Anglais (eng) Mots-clés : Psychosis  cognitive impairment  intelligence  school children  school performance Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychotic experiences are common in childhood and an important risk indicator of adverse mental health outcomes. However, little is known about the association of psychotic experiences with functional outcomes in childhood, particularly regarding school performance. The aim of the present study was to examine whether psychotic experiences were prospectively related to school performance in childhood. METHODS: This study was embedded in the population-based Generation R Study (N = 2,362). Psychotic experiences were assessed using self-reports on hallucinations at age 10 years. School performance was assessed using a standardized national school performance test at age 12 years. We considered the total school performance score, as well as language and mathematics subscales. Analyses were adjusted for sociodemographic characteristics, maternal nonverbal IQ, nonverbal IQ at age 6 years and co-occurring psychopathology at age 10 years. RESULTS: Psychotic experiences were prospectively associated with poorer school performance scores (B = -0.61, 95% CI [-0.98;-0.25], p = .001), as well as poorer language (B(percentile rank score)  = -2.00, 95% CI [-3.20;-0.79], p = .001) and mathematical ability (B(percentile rank score)  = -1.75, 95% CI [-2.99;-0.51], p = .006). These associations remained after additional adjustment for nonverbal IQ at age 6 years (B = -0.51, 95% CI [-0.86;-0.16], p = .005), and co-occurring internalizing (B = -0.40, 95% CI [-0.77;-0.03], p = .036) and externalizing problems (B = -0.40, 95% CI [-0.75;-0.04], p = .029), but not attention problems (B = -0.10, 95% CI [-0.47;0.26], p = .57). CONCLUSIONS: Children with psychotic experiences had lower school performance scores than their nonaffected peers. The finding was independent of sociodemographic characteristics, intelligence and co-occurring internalizing and externalizing problems, but not attention problems. This study suggests that psychotic experiences are associated with childhood functional impairments, although the relatively small effects and the role of attention problems warrant further exploration. En ligne : http://dx.doi.org/10.1111/jcpp.13281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Psychotic experiences and future school performance in childhood: a population-based cohort study [Texte imprimé et/ou numérique] / Lisa R STEENKAMP, Auteur ; Koen BOLHUIS, Auteur ; Laura M. E. BLANKEN, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Manon H. J. HILLEGERS, Auteur ; Steven A. KUSHNER, Auteur ; Henning TIEMEIER, Auteur . - p.357-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.357-365 Mots-clés : Psychosis  cognitive impairment  intelligence  school children  school performance Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychotic experiences are common in childhood and an important risk indicator of adverse mental health outcomes. However, little is known about the association of psychotic experiences with functional outcomes in childhood, particularly regarding school performance. The aim of the present study was to examine whether psychotic experiences were prospectively related to school performance in childhood. METHODS: This study was embedded in the population-based Generation R Study (N = 2,362). Psychotic experiences were assessed using self-reports on hallucinations at age 10 years. School performance was assessed using a standardized national school performance test at age 12 years. We considered the total school performance score, as well as language and mathematics subscales. Analyses were adjusted for sociodemographic characteristics, maternal nonverbal IQ, nonverbal IQ at age 6 years and co-occurring psychopathology at age 10 years. RESULTS: Psychotic experiences were prospectively associated with poorer school performance scores (B = -0.61, 95% CI [-0.98;-0.25], p = .001), as well as poorer language (B(percentile rank score)  = -2.00, 95% CI [-3.20;-0.79], p = .001) and mathematical ability (B(percentile rank score)  = -1.75, 95% CI [-2.99;-0.51], p = .006). These associations remained after additional adjustment for nonverbal IQ at age 6 years (B = -0.51, 95% CI [-0.86;-0.16], p = .005), and co-occurring internalizing (B = -0.40, 95% CI [-0.77;-0.03], p = .036) and externalizing problems (B = -0.40, 95% CI [-0.75;-0.04], p = .029), but not attention problems (B = -0.10, 95% CI [-0.47;0.26], p = .57). CONCLUSIONS: Children with psychotic experiences had lower school performance scores than their nonaffected peers. The finding was independent of sociodemographic characteristics, intelligence and co-occurring internalizing and externalizing problems, but not attention problems. This study suggests that psychotic experiences are associated with childhood functional impairments, although the relatively small effects and the role of attention problems warrant further exploration. En ligne : http://dx.doi.org/10.1111/jcpp.13281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study / M. E. VERHOEFF in Molecular Autism, 9 (2018)  

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