Development of ADHD symptoms in preschool children: Genetic and environmental contributions / Espen M. EILERTSEN in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1299-1305 Titre : Development of ADHD symptoms in preschool children: Genetic and environmental contributions Type de document : texte imprimé Auteurs : Espen M. EILERTSEN, Auteur ; Line C. GJERDE, Auteur ; Kenneth S. KENDLER, Auteur ; Espen RØYSAMB, Auteur ; Steven H. AGGEN, Auteur ; Kristin GUSTAVSON, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Eivind YSTRØM, Auteur Article en page(s) : p.1299-1305 Langues : Anglais (eng) Mots-clés : Norwegian Mother and Child Cohort Study (MoBa)  attention-deficit/hyperactivity disorder symptoms  heritability  longitudinal  twin study Index. décimale : PER Périodiques Résumé : We examined genetic and environmental contributions to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) in preschool children. ADHD symptoms in siblings at 1.5, 3, and 5 years of age were investigated in a population-based sample from the prospective Norwegian Mother and Child Cohort Study. The longitudinal contributions of additive genetic, shared, twin-specific, and unique environmental influences were estimated using biometric structural equation models. Heritability of ADHD symptoms ranged from 54% to 70%. There was evidence of partially new genetic influences at successive ages, with genetic correlations ranging from .58 to .89. Contributions from shared environmental factors and twin-specific factors were minor. The importance of unique environmental effects appeared to increase across ages, and was mostly specific to a given age. There was no evidence suggesting that this pattern differs across males and females. Symptoms of ADHD are highly heritability in young children from as early as 1.5 years of age. Longitudinal stability of ADHD symptoms is mainly attributable to genetic influences, but there is also some evidence for age-specific genetic influences. These findings contribute to our understanding of development of ADHD early in life, and can guide future molecular genetics studies. En ligne : http://dx.doi.org/10.1017/s0954579418000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Development of ADHD symptoms in preschool children: Genetic and environmental contributions [texte imprimé] / Espen M. EILERTSEN, Auteur ; Line C. GJERDE, Auteur ; Kenneth S. KENDLER, Auteur ; Espen RØYSAMB, Auteur ; Steven H. AGGEN, Auteur ; Kristin GUSTAVSON, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Eivind YSTRØM, Auteur . - p.1299-1305. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1299-1305 Mots-clés : Norwegian Mother and Child Cohort Study (MoBa)  attention-deficit/hyperactivity disorder symptoms  heritability  longitudinal  twin study Index. décimale : PER Périodiques Résumé : We examined genetic and environmental contributions to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) in preschool children. ADHD symptoms in siblings at 1.5, 3, and 5 years of age were investigated in a population-based sample from the prospective Norwegian Mother and Child Cohort Study. The longitudinal contributions of additive genetic, shared, twin-specific, and unique environmental influences were estimated using biometric structural equation models. Heritability of ADHD symptoms ranged from 54% to 70%. There was evidence of partially new genetic influences at successive ages, with genetic correlations ranging from .58 to .89. Contributions from shared environmental factors and twin-specific factors were minor. The importance of unique environmental effects appeared to increase across ages, and was mostly specific to a given age. There was no evidence suggesting that this pattern differs across males and females. Symptoms of ADHD are highly heritability in young children from as early as 1.5 years of age. Longitudinal stability of ADHD symptoms is mainly attributable to genetic influences, but there is also some evidence for age-specific genetic influences. These findings contribute to our understanding of development of ADHD early in life, and can guide future molecular genetics studies. En ligne : http://dx.doi.org/10.1017/s0954579418000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Language difficulties and internalizing problems: Bidirectional associations from 18 months to 8 years among boys and girls / Siri Saugestad HELLAND in Development and Psychopathology, 30-4 (October 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-4 (October 2018) . - p.1239-1252 Titre : Language difficulties and internalizing problems: Bidirectional associations from 18 months to 8 years among boys and girls Type de document : texte imprimé Auteurs : Siri Saugestad HELLAND, Auteur ; Espen RØYSAMB, Auteur ; Mari Vaage WANG, Auteur ; Kristin GUSTAVSON, Auteur Article en page(s) : p.1239-1252 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies have shown that early language difficulties are associated with later internalizing problems. Less is known about the nature of the association: the bidirectional relationship over time, the role of different types of language difficulties, and gender differences. The present study examined bidirectional longitudinal associations between parent-rated language difficulties and internalizing problems in a four-wave cross-lagged model from 18 months to 8 years. Data from the Norwegian Mother and Child Cohort Study were used (N = 114,000). Gender-specific dichotomized language variables were created, and associations were investigated uniquely for boys and girls. Logistic regression analyses showed that all cross-lagged associations from 18 months to 5 years were significant for girls (odds ratios [ORs] = 1.48–1.94). For boys, only internalizing problems at 3 years predicted change in language difficulties (OR = 2.33). From 5 to 8 years, the cross-lagged associations between semantic language difficulties and internalizing problems were significant and strong for girls (ORs = 1.92–2.97) and nonsignificant for boys. The results suggest that the associations between language difficulties and internalizing problems are bidirectional from an early age, and that girls are especially vulnerable for developing co-occurring language difficulties and internalizing problems during the years of transition to school. En ligne : http://dx.doi.org/10.1017/S0954579417001559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Language difficulties and internalizing problems: Bidirectional associations from 18 months to 8 years among boys and girls [texte imprimé] / Siri Saugestad HELLAND, Auteur ; Espen RØYSAMB, Auteur ; Mari Vaage WANG, Auteur ; Kristin GUSTAVSON, Auteur . - p.1239-1252. Langues : Anglais (eng) in Development and Psychopathology > 30-4 (October 2018) . - p.1239-1252 Index. décimale : PER Périodiques Résumé : Studies have shown that early language difficulties are associated with later internalizing problems. Less is known about the nature of the association: the bidirectional relationship over time, the role of different types of language difficulties, and gender differences. The present study examined bidirectional longitudinal associations between parent-rated language difficulties and internalizing problems in a four-wave cross-lagged model from 18 months to 8 years. Data from the Norwegian Mother and Child Cohort Study were used (N = 114,000). Gender-specific dichotomized language variables were created, and associations were investigated uniquely for boys and girls. Logistic regression analyses showed that all cross-lagged associations from 18 months to 5 years were significant for girls (odds ratios [ORs] = 1.48–1.94). For boys, only internalizing problems at 3 years predicted change in language difficulties (OR = 2.33). From 5 to 8 years, the cross-lagged associations between semantic language difficulties and internalizing problems were significant and strong for girls (ORs = 1.92–2.97) and nonsignificant for boys. The results suggest that the associations between language difficulties and internalizing problems are bidirectional from an early age, and that girls are especially vulnerable for developing co-occurring language difficulties and internalizing problems during the years of transition to school. En ligne : http://dx.doi.org/10.1017/S0954579417001559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Maternal perinatal and concurrent depressive symptoms and child behavior problems: a sibling comparison study / Line C. GJERDE in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.779-786 Titre : Maternal perinatal and concurrent depressive symptoms and child behavior problems: a sibling comparison study Type de document : texte imprimé Auteurs : Line C. GJERDE, Auteur ; Espen M. EILERTSEN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Tom A. MCADAMS, Auteur ; Henrik Daae ZACHRISSON, Auteur ; Imac Maria ZAMBRANA, Auteur ; Espen RØYSAMB, Auteur ; Kenneth S. KENDLER, Auteur ; Eivind YSTRØM, Auteur Article en page(s) : p.779-786 Langues : Anglais (eng) Mots-clés : Behavior problems  Child Behavior Checklist  depression  MoBa  prenatal  postnatal Index. décimale : PER Périodiques Résumé : Background Previous studies have found significant associations between maternal prenatal and postpartum depression and child behavior problems (CBP). The present study investigates whether associations remain in a prospective, longitudinal design adjusted for familial confounding. Methods The sample comprised 11,599 families including 17,830 siblings from the Norwegian Mother and Child Cohort study. Mothers reported depressive symptoms at gestational weeks 17 and 30, as well as 6 months, 1.5, 3, and 5 years postpartum. Fathers’ depression was measured at gestational week 17. At the last three time-points, child internalizing and externalizing problems were concurrently assessed. We performed multilevel analyses for internalizing and externalizing problems separately, using parental depression as predictors. Analyses were repeated using a sibling comparison design to adjust for familial confounding. Results All parental depressive time-points were significantly and positively associated with child internalizing and externalizing problems. After sibling comparison, however, only concurrent maternal depression was significantly associated with internalizing [estimate = 2.82 (1.91–3.73, 95% CI)] and externalizing problems [estimate = 2.40 (1.56–3.23, 95% CI)]. The effect of concurrent maternal depression on internalizing problems increased with child age. Conclusions Our findings do not support the notion that perinatal maternal depression is particularly detrimental to children's psychological development, as the most robust effects were found for maternal depression occurring during preschool years. En ligne : http://dx.doi.org/10.1111/jcpp.12704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Maternal perinatal and concurrent depressive symptoms and child behavior problems: a sibling comparison study [texte imprimé] / Line C. GJERDE, Auteur ; Espen M. EILERTSEN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Tom A. MCADAMS, Auteur ; Henrik Daae ZACHRISSON, Auteur ; Imac Maria ZAMBRANA, Auteur ; Espen RØYSAMB, Auteur ; Kenneth S. KENDLER, Auteur ; Eivind YSTRØM, Auteur . - p.779-786. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.779-786 Mots-clés : Behavior problems  Child Behavior Checklist  depression  MoBa  prenatal  postnatal Index. décimale : PER Périodiques Résumé : Background Previous studies have found significant associations between maternal prenatal and postpartum depression and child behavior problems (CBP). The present study investigates whether associations remain in a prospective, longitudinal design adjusted for familial confounding. Methods The sample comprised 11,599 families including 17,830 siblings from the Norwegian Mother and Child Cohort study. Mothers reported depressive symptoms at gestational weeks 17 and 30, as well as 6 months, 1.5, 3, and 5 years postpartum. Fathers’ depression was measured at gestational week 17. At the last three time-points, child internalizing and externalizing problems were concurrently assessed. We performed multilevel analyses for internalizing and externalizing problems separately, using parental depression as predictors. Analyses were repeated using a sibling comparison design to adjust for familial confounding. Results All parental depressive time-points were significantly and positively associated with child internalizing and externalizing problems. After sibling comparison, however, only concurrent maternal depression was significantly associated with internalizing [estimate = 2.82 (1.91–3.73, 95% CI)] and externalizing problems [estimate = 2.40 (1.56–3.23, 95% CI)]. The effect of concurrent maternal depression on internalizing problems increased with child age. Conclusions Our findings do not support the notion that perinatal maternal depression is particularly detrimental to children's psychological development, as the most robust effects were found for maternal depression occurring during preschool years. En ligne : http://dx.doi.org/10.1111/jcpp.12704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families / Espen M. EILERTSEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1186-1195 Titre : On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families Type de document : texte imprimé Auteurs : Espen M. EILERTSEN, Auteur ; Rosa CHEESMAN, Auteur ; Ziada AYORECH, Auteur ; Espen RØYSAMB, Auteur ; Jean-Baptiste PINGAULT, Auteur ; PÃ¥l R. NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; Alexandra HAVDAHL, Auteur ; Tom A. MCADAMS, Auteur ; Fartein A. TORVIK, Auteur ; Eivind YSTRØM, Auteur Année de publication : 2022 Article en page(s) : p.1186-1195 Langues : Anglais (eng) Mots-clés : Child  Cohort Studies  Humans  Parenting  Parents  Problem Behavior  Externalizing disorders  MoBa  gene-environment correlation  indirect genetic effects  parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Theoretical models of the development of childhood externalizing disorders emphasize the role of parents. Empirical studies have not been able to identify specific aspects of parental behaviors explaining a considerable proportion of the observed individual differences in externalizing problems. The problem is complicated by the contribution of genetic factors to externalizing problems, as parents provide both genes and environments to their children. We studied the joint contributions of direct genetic effects of children and the indirect genetic effects of parents through the environment on externalizing problems. METHODS: The study used genome-wide single nucleotide polymorphism data from 9,675 parent-offspring trios participating in the Norwegian Mother Father and child cohort study. Based on genomic relatedness matrices, we estimated the contribution of direct genetic effects and indirect maternal and paternal genetic effects on ADHD, conduct and disruptive behaviors at 8years of age. RESULTS: Models including indirect parental genetic effects were preferred for the ADHD symptoms of inattention and hyperactivity, and conduct problems, but not oppositional defiant behaviors. Direct genetic effects accounted for 11% to 24% of the variance, whereas indirect parental genetic effects accounted for 0% to 16% in ADHD symptoms and conduct problems. The correlation between direct and indirect genetic effects, or gene-environment correlations, decreased the variance with 16% and 13% for conduct and inattention problems, and increased the variance with 6% for hyperactivity problems. CONCLUSIONS: This study provides empirical support to the notion that parents have a significant role in the development of childhood externalizing behaviors. The parental contribution to decrease in variation of inattention and conduct problems by gene-environment correlations would limit the number of children reaching clinical ranges in symptoms. Not accounting for indirect parental genetic effects can lead to both positive and negative bias when identifying genetic variants for childhood externalizing behaviors. En ligne : http://dx.doi.org/10.1111/jcpp.13654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families [texte imprimé] / Espen M. EILERTSEN, Auteur ; Rosa CHEESMAN, Auteur ; Ziada AYORECH, Auteur ; Espen RØYSAMB, Auteur ; Jean-Baptiste PINGAULT, Auteur ; PÃ¥l R. NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; Alexandra HAVDAHL, Auteur ; Tom A. MCADAMS, Auteur ; Fartein A. TORVIK, Auteur ; Eivind YSTRØM, Auteur . - 2022 . - p.1186-1195. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1186-1195 Mots-clés : Child  Cohort Studies  Humans  Parenting  Parents  Problem Behavior  Externalizing disorders  MoBa  gene-environment correlation  indirect genetic effects  parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Theoretical models of the development of childhood externalizing disorders emphasize the role of parents. Empirical studies have not been able to identify specific aspects of parental behaviors explaining a considerable proportion of the observed individual differences in externalizing problems. The problem is complicated by the contribution of genetic factors to externalizing problems, as parents provide both genes and environments to their children. We studied the joint contributions of direct genetic effects of children and the indirect genetic effects of parents through the environment on externalizing problems. METHODS: The study used genome-wide single nucleotide polymorphism data from 9,675 parent-offspring trios participating in the Norwegian Mother Father and child cohort study. Based on genomic relatedness matrices, we estimated the contribution of direct genetic effects and indirect maternal and paternal genetic effects on ADHD, conduct and disruptive behaviors at 8years of age. RESULTS: Models including indirect parental genetic effects were preferred for the ADHD symptoms of inattention and hyperactivity, and conduct problems, but not oppositional defiant behaviors. Direct genetic effects accounted for 11% to 24% of the variance, whereas indirect parental genetic effects accounted for 0% to 16% in ADHD symptoms and conduct problems. The correlation between direct and indirect genetic effects, or gene-environment correlations, decreased the variance with 16% and 13% for conduct and inattention problems, and increased the variance with 6% for hyperactivity problems. CONCLUSIONS: This study provides empirical support to the notion that parents have a significant role in the development of childhood externalizing behaviors. The parental contribution to decrease in variation of inattention and conduct problems by gene-environment correlations would limit the number of children reaching clinical ranges in symptoms. Not accounting for indirect parental genetic effects can lead to both positive and negative bias when identifying genetic variants for childhood externalizing behaviors. En ligne : http://dx.doi.org/10.1111/jcpp.13654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

The Strengths and Difficulties Questionnaire (SDQ) – Self-Report. An analysis of its structure in a multiethnic urban adolescent sample / Jörg RICHTER in Journal of Child Psychology and Psychiatry, 52-9 (September 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-9 (September 2011) . - p.1002-1011 Titre : The Strengths and Difficulties Questionnaire (SDQ) – Self-Report. An analysis of its structure in a multiethnic urban adolescent sample Type de document : texte imprimé Auteurs : Jörg RICHTER, Auteur ; Ase SAGATUN, Auteur ; Sonja HEYERDAHL, Auteur ; Brit OPPEDAL, Auteur ; Espen RØYSAMB, Auteur Année de publication : 2011 Article en page(s) : p.1002-1011 Langues : Anglais (eng) Mots-clés : Self-report SDQ  factor structure  CFA  adolescents  ethnic minorities Index. décimale : PER Périodiques Résumé : Background:  The SDQ is currently one of the internationally most frequently used screening instruments for child and adolescent mental health purposes. However, its structure, cross-cultural equivalence, and its applicability in ethnic minority groups is still a matter of discussion. Methods:  SDQ self-report data of 5,379 ethnic Norwegian and 865 ethnic minority adolescents with a variety of national origins was analysed by means of confirmatory factor analysis (CFA). Multi-group comparisons considering equal thresholds combined with more in-depth analyses on factor loadings, residuals, composite reliability, and average amount of variance explained by indicators of respective constructs were performed. Results:  CFA suggested a good fit of the five-factor model of the SDQ self-report in the subsample of ethnic Norwegian adolescents and an acceptable fit in ethnic minority subsamples without substantial differences between ethnic Norwegian SDQ data and data of Pakistani or those of ‘other ethnic minority’ adolescents. When assuming equal thresholds between response categories of the items as well as equal factor loadings the structure in the data significantly differed between ethnic Norwegian and both ethnic minority samples. Some factor loadings and some correlations between constructs significantly differed between ethnic Norwegian and both ethnic minority samples. The correlation coefficients between the hyperactivity factor and the conduct problems factor were too high in all three subsamples in order to establish distinct constructs. Composite reliability and average explained variance of the emotional symptoms factor were good in all samples, whereas they were low for some of the other factors. Conclusions:  To some extent the theoretically proposed five-factor structure of the Norwegian version of the SDQ self-report was supported in 15- to 16-year-old adolescents. However, the results of more detailed analyses raise questions about the interpretation of some subscales. When applying this screening method to Norwegian adolescents, our results suggest that the use of the total difficulty score of the SDQ in screening youth should be preferred over the subscale scores. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02372.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] The Strengths and Difficulties Questionnaire (SDQ) – Self-Report. An analysis of its structure in a multiethnic urban adolescent sample [texte imprimé] / Jörg RICHTER, Auteur ; Ase SAGATUN, Auteur ; Sonja HEYERDAHL, Auteur ; Brit OPPEDAL, Auteur ; Espen RØYSAMB, Auteur . - 2011 . - p.1002-1011. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-9 (September 2011) . - p.1002-1011 Mots-clés : Self-report SDQ  factor structure  CFA  adolescents  ethnic minorities Index. décimale : PER Périodiques Résumé : Background:  The SDQ is currently one of the internationally most frequently used screening instruments for child and adolescent mental health purposes. However, its structure, cross-cultural equivalence, and its applicability in ethnic minority groups is still a matter of discussion. Methods:  SDQ self-report data of 5,379 ethnic Norwegian and 865 ethnic minority adolescents with a variety of national origins was analysed by means of confirmatory factor analysis (CFA). Multi-group comparisons considering equal thresholds combined with more in-depth analyses on factor loadings, residuals, composite reliability, and average amount of variance explained by indicators of respective constructs were performed. Results:  CFA suggested a good fit of the five-factor model of the SDQ self-report in the subsample of ethnic Norwegian adolescents and an acceptable fit in ethnic minority subsamples without substantial differences between ethnic Norwegian SDQ data and data of Pakistani or those of ‘other ethnic minority’ adolescents. When assuming equal thresholds between response categories of the items as well as equal factor loadings the structure in the data significantly differed between ethnic Norwegian and both ethnic minority samples. Some factor loadings and some correlations between constructs significantly differed between ethnic Norwegian and both ethnic minority samples. The correlation coefficients between the hyperactivity factor and the conduct problems factor were too high in all three subsamples in order to establish distinct constructs. Composite reliability and average explained variance of the emotional symptoms factor were good in all samples, whereas they were low for some of the other factors. Conclusions:  To some extent the theoretically proposed five-factor structure of the Norwegian version of the SDQ self-report was supported in 15- to 16-year-old adolescents. However, the results of more detailed analyses raise questions about the interpretation of some subscales. When applying this screening method to Norwegian adolescents, our results suggest that the use of the total difficulty score of the SDQ in screening youth should be preferred over the subscale scores. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02372.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

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