Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis / Jane MCGRATH in Autism Research, 5-5 (October 2012)  

Public ISBD [article]  inAutism Research > 5-5 (October 2012) . - p.314-330 Titre : Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis Type de document : texte imprimé Auteurs : Jane MCGRATH, Auteur ; Katherine A. JOHNSON, Auteur ; Christine ECKER, Auteur ; Erik O'HANLON, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Hugh GARAVAN, Auteur Article en page(s) : p.314-330 Langues : Anglais (eng) Mots-clés : autism  functional MRI  visuospatial processing  mental rotation  functional connectivity Index. décimale : PER Périodiques Résumé : Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (“Same Trials”) or mirror-imaged (“Mirror Trials”). Behavioral results revealed a relative advantage of mental rotation in the ASD group—controls were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314–330. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis [texte imprimé] / Jane MCGRATH, Auteur ; Katherine A. JOHNSON, Auteur ; Christine ECKER, Auteur ; Erik O'HANLON, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Hugh GARAVAN, Auteur . - p.314-330. Langues : Anglais (eng) in Autism Research > 5-5 (October 2012) . - p.314-330 Mots-clés : autism  functional MRI  visuospatial processing  mental rotation  functional connectivity Index. décimale : PER Périodiques Résumé : Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (“Same Trials”) or mirror-imaged (“Mirror Trials”). Behavioral results revealed a relative advantage of mental rotation in the ASD group—controls were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314–330. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample / Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1380-1389 Titre : Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample Type de document : texte imprimé Auteurs : Argyris STRINGARIS, Auteur ; Natalie CASTELLANOS-RYAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMAN, Auteur ; Claire LAWRENCE, Auteur ; Frauke NEES, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Tomáš PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Marcella RIETSCHEL, Auteur ; Michael N. SMOLKA, Auteur ; Gunter SCHUMANN, Auteur ; Robert GOODMAN, Auteur ; Patricia J. CONROD, Auteur ; THE IMAGEN CONSORTIUM, Auteur Article en page(s) : p.1380-1389 Langues : Anglais (eng) Mots-clés : Mania  bipolar  intelligence  adolescents  creativity Index. décimale : PER Périodiques Résumé : Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample [texte imprimé] / Argyris STRINGARIS, Auteur ; Natalie CASTELLANOS-RYAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMAN, Auteur ; Claire LAWRENCE, Auteur ; Frauke NEES, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Tomáš PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Marcella RIETSCHEL, Auteur ; Michael N. SMOLKA, Auteur ; Gunter SCHUMANN, Auteur ; Robert GOODMAN, Auteur ; Patricia J. CONROD, Auteur ; THE IMAGEN CONSORTIUM, Auteur . - p.1380-1389. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1380-1389 Mots-clés : Mania  bipolar  intelligence  adolescents  creativity Index. décimale : PER Périodiques Résumé : Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders / Jacqueline FITZGERALD in Autism Research, 8-2 (April 2015)  

Public ISBD [article]  inAutism Research > 8-2 (April 2015) . - p.136-152 Titre : Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Jacqueline FITZGERALD, Auteur ; Katherine JOHNSON, Auteur ; Elizabeth KEHOE, Auteur ; Arun L.W. BOKDE, Auteur ; Hugh GARAVAN, Auteur ; Louise GALLAGHER, Auteur ; Jane MCGRATH, Auteur Article en page(s) : p.136-152 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  functional connectivity  attention orienting  attention network  neuroimaging Index. décimale : PER Périodiques Résumé : Background Attention orienting is a cognitive process that facilitates the movement of attention focus from one location to another: this may be impaired in autism spectrum disorder (ASD). Dorsal and ventral attention networks (DAN and VAN) sub-serve the process of attention orienting. This study investigated the functional connectivity of attention orienting in these networks in ASD using the Posner Cueing Task. Method Twenty-one adolescents with ASD and 21 age and IQ matched controls underwent functional magnetic resonance imaging. A psychophysical interaction (PPI) analysis was implemented to investigate task-dependent functional connectivity, measuring synchronicity of brain regions during the task. Regions of interest (ROI) were selected to explore functional connectivity in the DAN during cue-only conditions and in the VAN during invalid and valid trials. Results Behaviourally, the ASD and control groups performed the task in a similar manner. Functional MRI results indicated that the ASD and control groups activated similar brain regions. During invalid trials (VAN), the ASD group showed significant positive functional connectivity to multiple brain regions, whilst the control group demonstrated negative connectivity. During valid trials (VAN), the two groups also showed contrasting patterns of connectivity. In the cue-only conditions (DAN), the ASD group showed weaker functional connectivity. Conclusion The DAN analysis suggests that the ASD group has weaker coherence between brain areas involved in goal-driven, endogenous attention control. The strong positive functional connectivity exhibited by the ASD group in the VAN during the invalid trials suggests that individuals with ASD may generate compensatory mechanisms to achieve neurotypical behaviour. These results support the theory of abnormal cortical connectivity in autism. En ligne : http://dx.doi.org/10.1002/aur.1430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders [texte imprimé] / Jacqueline FITZGERALD, Auteur ; Katherine JOHNSON, Auteur ; Elizabeth KEHOE, Auteur ; Arun L.W. BOKDE, Auteur ; Hugh GARAVAN, Auteur ; Louise GALLAGHER, Auteur ; Jane MCGRATH, Auteur . - p.136-152. Langues : Anglais (eng) in Autism Research > 8-2 (April 2015) . - p.136-152 Mots-clés : autism spectrum disorders  functional connectivity  attention orienting  attention network  neuroimaging Index. décimale : PER Périodiques Résumé : Background Attention orienting is a cognitive process that facilitates the movement of attention focus from one location to another: this may be impaired in autism spectrum disorder (ASD). Dorsal and ventral attention networks (DAN and VAN) sub-serve the process of attention orienting. This study investigated the functional connectivity of attention orienting in these networks in ASD using the Posner Cueing Task. Method Twenty-one adolescents with ASD and 21 age and IQ matched controls underwent functional magnetic resonance imaging. A psychophysical interaction (PPI) analysis was implemented to investigate task-dependent functional connectivity, measuring synchronicity of brain regions during the task. Regions of interest (ROI) were selected to explore functional connectivity in the DAN during cue-only conditions and in the VAN during invalid and valid trials. Results Behaviourally, the ASD and control groups performed the task in a similar manner. Functional MRI results indicated that the ASD and control groups activated similar brain regions. During invalid trials (VAN), the ASD group showed significant positive functional connectivity to multiple brain regions, whilst the control group demonstrated negative connectivity. During valid trials (VAN), the two groups also showed contrasting patterns of connectivity. In the cue-only conditions (DAN), the ASD group showed weaker functional connectivity. Conclusion The DAN analysis suggests that the ASD group has weaker coherence between brain areas involved in goal-driven, endogenous attention control. The strong positive functional connectivity exhibited by the ASD group in the VAN during the invalid trials suggests that individuals with ASD may generate compensatory mechanisms to achieve neurotypical behaviour. These results support the theory of abnormal cortical connectivity in autism. En ligne : http://dx.doi.org/10.1002/aur.1430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Early adolescent gender diversity and mental health in the Adolescent Brain Cognitive Development study / Alexandra POTTER in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.171-179 Titre : Early adolescent gender diversity and mental health in the Adolescent Brain Cognitive Development study Type de document : texte imprimé Auteurs : Alexandra POTTER, Auteur ; Sarahjane DUBE, Auteur ; Nicholas ALLGAIER, Auteur ; Hannah LOSO, Auteur ; Masha Y. IVANOVA, Auteur ; Lisa C BARRIOS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Bader CHAARANI, Auteur ; Julie DUMAS, Auteur ; Sarah FELDSTEIN-EWING, Auteur ; Edward G. FREEDMAN, Auteur ; Hugh GARAVAN, Auteur ; Elizabeth HOFFMAN, Auteur ; Erin MCGLADE, Auteur ; Leah ROBIN, Auteur ; Michelle M. JOHNS, Auteur Année de publication : 2021 Article en page(s) : p.171-179 Langues : Anglais (eng) Mots-clés : Gender diversity  early adolescent  gender expression  nonconformity  suicidality  transgender  that they have no competing or potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: There are known associations between mental health symptoms and transgender identity among adults. Whether this relationship extends to early adolescents and to gender domains other than identity is unclear. This study measured dimensions of gender in a large, diverse, sample of youth, and examined associations between diverse gender experiences and mental health. METHODS: The ABCD study is an ongoing, longitudinal, US cohort study. Baseline data (release 2.0) include 11,873 youth age 9/10 (48% female); and the 4,951 1-year follow-up visits (age 10/11; 48% female) completed prior to data release. A novel gender survey at the 1-year visit assessed felt-gender, gender noncontentedness, and gender nonconformity using a 5-point scale. Mental health measures included youth- and parent-reports. RESULTS: Roughly half a percent of 9/10-year-olds (n = 58) responded 'yes' or 'maybe' when asked, 'Are you transgender' at baseline. Recurrent thoughts of death were more prevalent among these youth compared to the rest of the cohort (19.6% vs. 6.4%, χ(2)  = 16.0, p < .001). At the 1-year visit, when asked about the three dimensions of gender on a 5-point scale, 33.2% (n = 1,605) provided responses that were not exclusively and totally aligned with one gender. Significant relationships were observed between mental health symptoms and gender diversity for all dimensions assessed. CONCLUSIONS: Similar to adult studies, early adolescents identifying as transgender reported increased mental health symptoms. Results also point to considerable diversity in other dimensions of gender (felt-gender, gender noncontentedness, gender nonconformity) among 10/11-year-olds, and find this diversity to be related to critical mental health symptoms. These findings add to our limited understanding of the relationship between dimensions of gender and wellness for youth. En ligne : http://dx.doi.org/10.1111/jcpp.13248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Early adolescent gender diversity and mental health in the Adolescent Brain Cognitive Development study [texte imprimé] / Alexandra POTTER, Auteur ; Sarahjane DUBE, Auteur ; Nicholas ALLGAIER, Auteur ; Hannah LOSO, Auteur ; Masha Y. IVANOVA, Auteur ; Lisa C BARRIOS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Bader CHAARANI, Auteur ; Julie DUMAS, Auteur ; Sarah FELDSTEIN-EWING, Auteur ; Edward G. FREEDMAN, Auteur ; Hugh GARAVAN, Auteur ; Elizabeth HOFFMAN, Auteur ; Erin MCGLADE, Auteur ; Leah ROBIN, Auteur ; Michelle M. JOHNS, Auteur . - 2021 . - p.171-179. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.171-179 Mots-clés : Gender diversity  early adolescent  gender expression  nonconformity  suicidality  transgender  that they have no competing or potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: There are known associations between mental health symptoms and transgender identity among adults. Whether this relationship extends to early adolescents and to gender domains other than identity is unclear. This study measured dimensions of gender in a large, diverse, sample of youth, and examined associations between diverse gender experiences and mental health. METHODS: The ABCD study is an ongoing, longitudinal, US cohort study. Baseline data (release 2.0) include 11,873 youth age 9/10 (48% female); and the 4,951 1-year follow-up visits (age 10/11; 48% female) completed prior to data release. A novel gender survey at the 1-year visit assessed felt-gender, gender noncontentedness, and gender nonconformity using a 5-point scale. Mental health measures included youth- and parent-reports. RESULTS: Roughly half a percent of 9/10-year-olds (n = 58) responded 'yes' or 'maybe' when asked, 'Are you transgender' at baseline. Recurrent thoughts of death were more prevalent among these youth compared to the rest of the cohort (19.6% vs. 6.4%, χ(2)  = 16.0, p < .001). At the 1-year visit, when asked about the three dimensions of gender on a 5-point scale, 33.2% (n = 1,605) provided responses that were not exclusively and totally aligned with one gender. Significant relationships were observed between mental health symptoms and gender diversity for all dimensions assessed. CONCLUSIONS: Similar to adult studies, early adolescents identifying as transgender reported increased mental health symptoms. Results also point to considerable diversity in other dimensions of gender (felt-gender, gender noncontentedness, gender nonconformity) among 10/11-year-olds, and find this diversity to be related to critical mental health symptoms. These findings add to our limited understanding of the relationship between dimensions of gender and wellness for youth. En ligne : http://dx.doi.org/10.1111/jcpp.13248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / Barbara RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : texte imprimé Auteurs : Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [texte imprimé] / Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

A review of neuropsychological and neuroimaging research in autistic spectrum disorders: Attention, inhibition and cognitive flexibility / Jane SANDERS in Research in Autism Spectrum Disorders, 2-1 (January/March 2008)  

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Structural brain correlates of adolescent resilience / Keith B. BURT in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

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Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

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White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study / Jane MCGRATH in Autism Research, 6-5 (October 2013)  

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