Age-related parietal GABA alterations in children with autism spectrum disorder / Marilena M. DEMAYO in Autism Research, 14-5 (May 2021)  

Public ISBD [article]  inAutism Research > 14-5 (May 2021) . - p.859-872 Titre : Age-related parietal GABA alterations in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Marilena M. DEMAYO, Auteur ; Ashley D. HARRIS, Auteur ; Yun Ju C. SONG, Auteur ; Izabella POKORSKI, Auteur ; Rinku THAPA, Auteur ; Shrujna PATEL, Auteur ; Zahava AMBARCHI, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.859-872 Langues : Anglais (eng) Mots-clés : GABA (gamma-aminobutyric acid)  biomarker  children  magnetic resonance spectroscopy (MRS)  neurochemistry  parietal lobe Index. décimale : PER Périodiques Résumé : GABA is the primary inhibitory neurotransmitter in the brain, and is essential to the balance of cortical excitation and inhibition. Reductions in GABA are proposed to result in an overly excitatory cortex that may cause, or contribute to, symptoms of autism spectrum disorder (ASD). This study employed a cross-sectional design to explore GABA+ differences in ASD and the impact of age, comparing 4-12 year olds with ASD (N = 24) to typically developing children (N = 35). GABA+ concentration was measured using edited magnetic resonance spectroscopy in the left parietal lobe. This study used a mixed model to investigate group differences between children with ASD and typically developing children. There was a significant difference in GABA+ levels between the groups, a significant effect of age and interaction between age and diagnostic group. The ASD group showed an association between GABA+ and age, with GABA+ levels gradually increasing with age (r = 0.59, p = 0.003). Typically developing children did not show age-related change in GABA+ concentration (r = 0.09, p = 0.60). By the age of 9, children with ASD showed GABA+ levels that were comparable to their typically developing peers. This study suggests that children with ASD have initially lower levels of GABA+ in the left parietal lobe compared to typically developing children, and that these initially lower levels of GABA+ increase with age in ASD within this region. It is suggested that this developmental shift of GABA+ levels within the left parietal lobe provides a possible explanation for the previously found reductions in childhood that does not persist in adults. LAY SUMMARY: This study measured levels of GABA in the left parietal lobe using magnetic resonance spectroscopy in children with ASD and typically developing children. GABA levels were initially lower in the ASD group, and increased with age, while GABA did not change with age in the typically developing group. This suggests that alterations in GABA signaling may be associated with ASD in childhood. Autism Res 2021, 14: 859-872. © 2021 International Society for Autism Research, Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 [article] Age-related parietal GABA alterations in children with autism spectrum disorder [texte imprimé] / Marilena M. DEMAYO, Auteur ; Ashley D. HARRIS, Auteur ; Yun Ju C. SONG, Auteur ; Izabella POKORSKI, Auteur ; Rinku THAPA, Auteur ; Shrujna PATEL, Auteur ; Zahava AMBARCHI, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur . - p.859-872. Langues : Anglais (eng) in Autism Research > 14-5 (May 2021) . - p.859-872 Mots-clés : GABA (gamma-aminobutyric acid)  biomarker  children  magnetic resonance spectroscopy (MRS)  neurochemistry  parietal lobe Index. décimale : PER Périodiques Résumé : GABA is the primary inhibitory neurotransmitter in the brain, and is essential to the balance of cortical excitation and inhibition. Reductions in GABA are proposed to result in an overly excitatory cortex that may cause, or contribute to, symptoms of autism spectrum disorder (ASD). This study employed a cross-sectional design to explore GABA+ differences in ASD and the impact of age, comparing 4-12 year olds with ASD (N = 24) to typically developing children (N = 35). GABA+ concentration was measured using edited magnetic resonance spectroscopy in the left parietal lobe. This study used a mixed model to investigate group differences between children with ASD and typically developing children. There was a significant difference in GABA+ levels between the groups, a significant effect of age and interaction between age and diagnostic group. The ASD group showed an association between GABA+ and age, with GABA+ levels gradually increasing with age (r = 0.59, p = 0.003). Typically developing children did not show age-related change in GABA+ concentration (r = 0.09, p = 0.60). By the age of 9, children with ASD showed GABA+ levels that were comparable to their typically developing peers. This study suggests that children with ASD have initially lower levels of GABA+ in the left parietal lobe compared to typically developing children, and that these initially lower levels of GABA+ increase with age in ASD within this region. It is suggested that this developmental shift of GABA+ levels within the left parietal lobe provides a possible explanation for the previously found reductions in childhood that does not persist in adults. LAY SUMMARY: This study measured levels of GABA in the left parietal lobe using magnetic resonance spectroscopy in children with ASD and typically developing children. GABA levels were initially lower in the ASD group, and increased with age, while GABA did not change with age in the typically developing group. This suggests that alterations in GABA signaling may be associated with ASD in childhood. Autism Res 2021, 14: 859-872. © 2021 International Society for Autism Research, Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444

Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function / Eleni A. DEMETRIOU in Autism, 25-8 (November 2021)  

Public ISBD [article]  inAutism > 25-8 (November 2021) . - p.2223-2237 Titre : Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function Type de document : texte imprimé Auteurs : Eleni A. DEMETRIOU, Auteur ; Karen L. PEPPER, Auteur ; Shin Ho PARK, Auteur ; Liz PELLICANO, Auteur ; Yun Ju C. SONG, Auteur ; Sharon L. NAISMITH, Auteur ; Ian B. HICKIE, Auteur ; Emma E. THOMAS, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.2223-2237 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Cognition  Executive Function  Female  Humans  Male  Neuropsychological Tests  Self Report  Sex Characteristics  Behavioural Rating Inventory of Executive Function  Cambridge Neuropsychological Test Automated Battery  autism spectrum disorder  executive function  sex differences Index. décimale : PER Périodiques Résumé : Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism. En ligne : http://dx.doi.org/10.1177/13623613211014991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function [texte imprimé] / Eleni A. DEMETRIOU, Auteur ; Karen L. PEPPER, Auteur ; Shin Ho PARK, Auteur ; Liz PELLICANO, Auteur ; Yun Ju C. SONG, Auteur ; Sharon L. NAISMITH, Auteur ; Ian B. HICKIE, Auteur ; Emma E. THOMAS, Auteur ; Adam J. GUASTELLA, Auteur . - p.2223-2237. Langues : Anglais (eng) in Autism > 25-8 (November 2021) . - p.2223-2237 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Cognition  Executive Function  Female  Humans  Male  Neuropsychological Tests  Self Report  Sex Characteristics  Behavioural Rating Inventory of Executive Function  Cambridge Neuropsychological Test Automated Battery  autism spectrum disorder  executive function  sex differences Index. décimale : PER Périodiques Résumé : Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism. En ligne : http://dx.doi.org/10.1177/13623613211014991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress / Shin Ho PARK in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1675-1686 Titre : Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress Type de document : texte imprimé Auteurs : Shin Ho PARK, Auteur ; Yun Ju C. SONG, Auteur ; Eleni A. DEMETRIOU, Auteur ; Karen L. PEPPER, Auteur ; Andrea NORTON, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Daniel F. HERMENS, Auteur ; Nicholas GLOZIER, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.1675-1686 Langues : Anglais (eng) Mots-clés : developmental disorders  distress  health services  mental health  treatment  well being Index. décimale : PER Périodiques Résumé : In this study, we consecutively recruited treatment-seeking young autistic adults without intellectual impairment aged 16-30 years who presented to a mental health service and evaluated general health (distress, quality of life, and disability), functioning (work loss days and social functioning), and mood symptoms (depression, anxiety, and stress) in those diagnosed with autism spectrum disorder (n = 96). This group was compared to young adults presenting to the same service with primary mental health disorders (depression, n = 343; bipolar, n = 132; psychosis, n = 166; and anxiety, n = 303). This study also investigated the influence of mood symptoms on general health and functioning in the autism spectrum disorder group. Young autistic adults reported significant general health and functioning impairments that were of similar degree to those presenting with primary mental health disorders. Interestingly, the autistic group also reported similarly high levels of mood symptoms to those with primary depressive and anxiety disorders. In the autistic group, depressive symptoms were strongly associated with distress, quality of life, and work loss days, while stress symptoms were strongly associated with disability. This study highlights further research, and mental health services are required specifically targeting young autistic adults to address their significant unmet needs. En ligne : http://dx.doi.org/10.1177/1362361318823925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress [texte imprimé] / Shin Ho PARK, Auteur ; Yun Ju C. SONG, Auteur ; Eleni A. DEMETRIOU, Auteur ; Karen L. PEPPER, Auteur ; Andrea NORTON, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Daniel F. HERMENS, Auteur ; Nicholas GLOZIER, Auteur ; Adam J. GUASTELLA, Auteur . - p.1675-1686. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1675-1686 Mots-clés : developmental disorders  distress  health services  mental health  treatment  well being Index. décimale : PER Périodiques Résumé : In this study, we consecutively recruited treatment-seeking young autistic adults without intellectual impairment aged 16-30 years who presented to a mental health service and evaluated general health (distress, quality of life, and disability), functioning (work loss days and social functioning), and mood symptoms (depression, anxiety, and stress) in those diagnosed with autism spectrum disorder (n = 96). This group was compared to young adults presenting to the same service with primary mental health disorders (depression, n = 343; bipolar, n = 132; psychosis, n = 166; and anxiety, n = 303). This study also investigated the influence of mood symptoms on general health and functioning in the autism spectrum disorder group. Young autistic adults reported significant general health and functioning impairments that were of similar degree to those presenting with primary mental health disorders. Interestingly, the autistic group also reported similarly high levels of mood symptoms to those with primary depressive and anxiety disorders. In the autistic group, depressive symptoms were strongly associated with distress, quality of life, and work loss days, while stress symptoms were strongly associated with disability. This study highlights further research, and mental health services are required specifically targeting young autistic adults to address their significant unmet needs. En ligne : http://dx.doi.org/10.1177/1362361318823925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Replication of the psychometric properties of the WHODAS-II in individuals with autism spectrum disorder / Shin Ho PARK in Autism Research, 12-12 (December)  

Public ISBD [article]  inAutism Research > 12-12 (December) . - p.1726-1727 Titre : Replication of the psychometric properties of the WHODAS-II in individuals with autism spectrum disorder Type de document : texte imprimé Auteurs : Shin Ho PARK, Auteur ; Eleni A. DEMETRIOU, Auteur ; Karen L. PEPPER, Auteur ; Yun Ju C. SONG, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Nicholas GLOZIER, Auteur ; Adam J. GUASTELLA, Auteur Année de publication : 2019 Article en page(s) : p.1726-1727 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2216 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] Replication of the psychometric properties of the WHODAS-II in individuals with autism spectrum disorder [texte imprimé] / Shin Ho PARK, Auteur ; Eleni A. DEMETRIOU, Auteur ; Karen L. PEPPER, Auteur ; Yun Ju C. SONG, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Nicholas GLOZIER, Auteur ; Adam J. GUASTELLA, Auteur . - 2019 . - p.1726-1727. Langues : Anglais (eng) in Autism Research > 12-12 (December) . - p.1726-1727 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2216 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder / Marilena M. DEMAYO in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1211-1222 Titre : The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Marilena M. DEMAYO, Auteur ; Izabella POKORSKI, Auteur ; Yun Ju C. SONG, Auteur ; Rinku THAPA, Auteur ; Shrujna PATEL, Auteur ; Zahava AMBARCHI, Auteur ; Domenic SOLIGO, Auteur ; Indra SADELI, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.1211-1222 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain  Child  Child, Preschool  Feasibility Studies  Humans  Magnetic Resonance Imaging/methods  Autism spectrum disorders  Biomarkers  Brain function  Brain structure  Clinical trial  Interventions–pharmacologic  Magnetic resonance imaging  Neuroimaging  Pre-school children  School-age children Index. décimale : PER Périodiques Résumé : There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3-12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial. En ligne : http://dx.doi.org/10.1007/s10803-021-05028-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder [texte imprimé] / Marilena M. DEMAYO, Auteur ; Izabella POKORSKI, Auteur ; Yun Ju C. SONG, Auteur ; Rinku THAPA, Auteur ; Shrujna PATEL, Auteur ; Zahava AMBARCHI, Auteur ; Domenic SOLIGO, Auteur ; Indra SADELI, Auteur ; Emma E. THOMAS, Auteur ; Ian B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur . - p.1211-1222. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1211-1222 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain  Child  Child, Preschool  Feasibility Studies  Humans  Magnetic Resonance Imaging/methods  Autism spectrum disorders  Biomarkers  Brain function  Brain structure  Clinical trial  Interventions–pharmacologic  Magnetic resonance imaging  Neuroimaging  Pre-school children  School-age children Index. décimale : PER Périodiques Résumé : There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3-12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial. En ligne : http://dx.doi.org/10.1007/s10803-021-05028-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Validation of the 36-item and 12-item self-report World Health Organization Disability Assessment Schedule II (WHODAS-II) in individuals with autism spectrum disorder / Shin Ho PARK in Autism Research, 12-7 (July 2019)  

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