Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study / Yong ZHANG ; Fang XIE ; Sheng LI ; Ying LI ; Liting YANG ; Zhen WANG ; Jinlin LEI ; Huailan GUO in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.427-436 Titre : Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research Type de document : texte imprimé Auteurs : Yong ZHANG, Auteur ; Fang XIE, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting YANG, Auteur ; Zhen WANG, Auteur ; Jinlin LEI, Auteur ; Huailan GUO, Auteur Article en page(s) : p.427-436 Langues : Anglais (eng) Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research [texte imprimé] / Yong ZHANG, Auteur ; Fang XIE, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting YANG, Auteur ; Zhen WANG, Auteur ; Jinlin LEI, Auteur ; Huailan GUO, Auteur . - p.427-436. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.427-436 Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder / Han-Xue YANG in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.729-739 Titre : Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Han-Xue YANG, Auteur ; Han-Yu ZHOU, Auteur ; Ying LI, Auteur ; Yong-Hua CUI, Auteur ; Yang XIANG, Auteur ; Rong-Man YUAN, Auteur ; Simon S.Y. LUI, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : p.729-739 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with  Hyperactivity/complications/diagnosis/epidemiology  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Autistic Disorder  Child  Comorbidity  Humans  Interoception  autism spectrum disorders  autistic traits  eye-tracking Index. décimale : PER Périodiques Résumé : Interoception refers to the awareness of internal physiological state. Several previous studies reported that people with autism spectrum disorders (ASD) and adults with attention-deficit/hyperactivity disorder (ADHD) have diverse patterns of interoception, but the extent of literature is limited and inconsistent. This study aimed to investigate the interoceptive accuracy (IA) in children with ASD, children with comorbid ASD and ADHD, and typically developing (TD) children with high and low levels of autistic traits. We administered the eye-tracking interoceptive accuracy task (EIAT) to 30 children with ASD, 20 children with comorbid ASD and ADHD, and 63 TD controls with high and low levels of autistic traits. Parent-report scales concerning ASD and ADHD symptoms were collected. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. Reduced IA was also found in TD children with high-autistic traits relative to those with low-autistic traits. IA was negatively correlated with autistic and ADHD symptoms. Atypical cardiac interoception could be found in children with ASD. Difficulties in sensing and comprehending internal bodily signals in childhood may be related to both ASD and ADHD symptoms. LAY SUMMARY: The present study examined interoceptive accuracy (IA) in children with autism spectrum disorders (ASD), children with comorbid ASD and attention-deficit/hyperactivity disorder (ADHD), and typically developing (TD) children with high and low levels of autistic traits. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. TD children with high-autistic traits exhibited decreased IA compared to those with low-autistic traits. These results have implications for understanding sensory atypicality found in ASD and ADHD. En ligne : https://dx.doi.org/10.1002/aur.2679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder [texte imprimé] / Han-Xue YANG, Auteur ; Han-Yu ZHOU, Auteur ; Ying LI, Auteur ; Yong-Hua CUI, Auteur ; Yang XIANG, Auteur ; Rong-Man YUAN, Auteur ; Simon S.Y. LUI, Auteur ; Raymond C.K. CHAN, Auteur . - p.729-739. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.729-739 Mots-clés : Adult  Attention Deficit Disorder with  Hyperactivity/complications/diagnosis/epidemiology  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Autistic Disorder  Child  Comorbidity  Humans  Interoception  autism spectrum disorders  autistic traits  eye-tracking Index. décimale : PER Périodiques Résumé : Interoception refers to the awareness of internal physiological state. Several previous studies reported that people with autism spectrum disorders (ASD) and adults with attention-deficit/hyperactivity disorder (ADHD) have diverse patterns of interoception, but the extent of literature is limited and inconsistent. This study aimed to investigate the interoceptive accuracy (IA) in children with ASD, children with comorbid ASD and ADHD, and typically developing (TD) children with high and low levels of autistic traits. We administered the eye-tracking interoceptive accuracy task (EIAT) to 30 children with ASD, 20 children with comorbid ASD and ADHD, and 63 TD controls with high and low levels of autistic traits. Parent-report scales concerning ASD and ADHD symptoms were collected. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. Reduced IA was also found in TD children with high-autistic traits relative to those with low-autistic traits. IA was negatively correlated with autistic and ADHD symptoms. Atypical cardiac interoception could be found in children with ASD. Difficulties in sensing and comprehending internal bodily signals in childhood may be related to both ASD and ADHD symptoms. LAY SUMMARY: The present study examined interoceptive accuracy (IA) in children with autism spectrum disorders (ASD), children with comorbid ASD and attention-deficit/hyperactivity disorder (ADHD), and typically developing (TD) children with high and low levels of autistic traits. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. TD children with high-autistic traits exhibited decreased IA compared to those with low-autistic traits. These results have implications for understanding sensory atypicality found in ASD and ADHD. En ligne : https://dx.doi.org/10.1002/aur.2679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17,524 individuals / Fenghua LI in Journal of Child Psychology and Psychiatry, 63-1 (January 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.34-46 Titre : Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17,524 individuals Type de document : texte imprimé Auteurs : Fenghua LI, Auteur ; Yonghua CUI, Auteur ; Ying LI, Auteur ; Lanting GUO, Auteur ; Xiaoyan KE, Auteur ; Jing LIU, Auteur ; Xuerong LUO, Auteur ; Yi ZHENG, Auteur ; James F. LECKMAN, Auteur Année de publication : 2022 Article en page(s) : p.34-46 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit and Disruptive Behavior Disorders  Child  China/epidemiology  Comorbidity  Depressive Disorder, Major  Diagnostic and Statistical Manual of Mental Disorders  Female  Humans  Male  Mental Disorders/diagnosis/epidemiology  Prevalence  China  adolescents  children  mental disorder  prevalence Index. décimale : PER Périodiques Résumé : BACKGROUND: To date, no national-scale psychiatric epidemiological survey for children and adolescents has been conducted in China. In order to inform government officials and policymakers and to develop a comprehensive plan for service providers, there was a clear need to conduct an up-to-date systematic nationwide psychiatric epidemiological survey. METHODS: We conducted a two-stage large-scale psychiatric point prevalence survey. Multistage cluster stratified random sampling was used as the sampling strategy. Five provinces were selected by comprehensively considering geographical partition, economic development, and rural/urban factors. In Stage 1, the Child Behavior Checklist was used as the screening tool. In Stage 2, Mini-International Neuropsychiatric Interview for Children and Adolescents and a diagnostic process based on the Diagnostic and Statistical Manual were used to make the diagnoses. Sampling weights and poststratification weights were employed to match the population distributions. Exploratory analyses were also performed using socio-demographic factors. Prevalence in socio-demographic factor subgroups and overall were estimated. Rao-Scott adjusted chi-square tests were utilized to determine if between-group differences were present. Factor interactions were checked by logistic regression analyses. RESULTS: A total of 73,992 participants aged 6-16 years of age were selected in Stage 1. In Stage 2, 17,524 individuals were screened and diagnosed. The weighted prevalence of any disorder was 17.5% (95% CI: 17.2-18.0). Statistically significant differences in prevalence of any psychiatric disorder were observed between sexes [χ(2) (1, N = 71,929) = 223.0, p < .001], age groups [χ(2) (1, N = 71,929) = 18.6, p < .001] and developed vs. developing areas [χ(2) (1, N = 71,929) = 2,129.6, p < .001], while no difference was found between rural and urban areas [χ(2) (1, N = 71,929) = 1.4, p = .239]. Male, younger individuals, children, and adolescents from developed areas had higher prevalence of any psychiatric disorder. The prevalence of any psychiatric disorder was found to decrease with the age in the male group, while the female group increased with the age. Individuals diagnosed with attention-deficit hyperactivity disorder, oppositional defiant disorder, a tic disorder, conduct disorder, and major depression disorder had the highest rates of comorbidity. CONCLUSIONS: The prevalence of any psychiatric disorder we found is the highest ever reported in China. These results urgently need to be addressed by public mental health service providers and policymakers in order to provide access to the necessary treatments and to reduce the long-term negative impact of these conditions on families and the society as a whole. En ligne : http://dx.doi.org/10.1111/jcpp.13445 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17,524 individuals [texte imprimé] / Fenghua LI, Auteur ; Yonghua CUI, Auteur ; Ying LI, Auteur ; Lanting GUO, Auteur ; Xiaoyan KE, Auteur ; Jing LIU, Auteur ; Xuerong LUO, Auteur ; Yi ZHENG, Auteur ; James F. LECKMAN, Auteur . - 2022 . - p.34-46. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.34-46 Mots-clés : Adolescent  Attention Deficit and Disruptive Behavior Disorders  Child  China/epidemiology  Comorbidity  Depressive Disorder, Major  Diagnostic and Statistical Manual of Mental Disorders  Female  Humans  Male  Mental Disorders/diagnosis/epidemiology  Prevalence  China  adolescents  children  mental disorder  prevalence Index. décimale : PER Périodiques Résumé : BACKGROUND: To date, no national-scale psychiatric epidemiological survey for children and adolescents has been conducted in China. In order to inform government officials and policymakers and to develop a comprehensive plan for service providers, there was a clear need to conduct an up-to-date systematic nationwide psychiatric epidemiological survey. METHODS: We conducted a two-stage large-scale psychiatric point prevalence survey. Multistage cluster stratified random sampling was used as the sampling strategy. Five provinces were selected by comprehensively considering geographical partition, economic development, and rural/urban factors. In Stage 1, the Child Behavior Checklist was used as the screening tool. In Stage 2, Mini-International Neuropsychiatric Interview for Children and Adolescents and a diagnostic process based on the Diagnostic and Statistical Manual were used to make the diagnoses. Sampling weights and poststratification weights were employed to match the population distributions. Exploratory analyses were also performed using socio-demographic factors. Prevalence in socio-demographic factor subgroups and overall were estimated. Rao-Scott adjusted chi-square tests were utilized to determine if between-group differences were present. Factor interactions were checked by logistic regression analyses. RESULTS: A total of 73,992 participants aged 6-16 years of age were selected in Stage 1. In Stage 2, 17,524 individuals were screened and diagnosed. The weighted prevalence of any disorder was 17.5% (95% CI: 17.2-18.0). Statistically significant differences in prevalence of any psychiatric disorder were observed between sexes [χ(2) (1, N = 71,929) = 223.0, p < .001], age groups [χ(2) (1, N = 71,929) = 18.6, p < .001] and developed vs. developing areas [χ(2) (1, N = 71,929) = 2,129.6, p < .001], while no difference was found between rural and urban areas [χ(2) (1, N = 71,929) = 1.4, p = .239]. Male, younger individuals, children, and adolescents from developed areas had higher prevalence of any psychiatric disorder. The prevalence of any psychiatric disorder was found to decrease with the age in the male group, while the female group increased with the age. Individuals diagnosed with attention-deficit hyperactivity disorder, oppositional defiant disorder, a tic disorder, conduct disorder, and major depression disorder had the highest rates of comorbidity. CONCLUSIONS: The prevalence of any psychiatric disorder we found is the highest ever reported in China. These results urgently need to be addressed by public mental health service providers and policymakers in order to provide access to the necessary treatments and to reduce the long-term negative impact of these conditions on families and the society as a whole. En ligne : http://dx.doi.org/10.1111/jcpp.13445 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Refractive Status and Amblyopia Risk Factors in Chinese Children with Autism Spectrum Disorder / Jing WANG in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1530-1536 Titre : Refractive Status and Amblyopia Risk Factors in Chinese Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Jing WANG, Auteur ; Gang DING, Auteur ; Ying LI, Auteur ; Ning HUA, Auteur ; Nan WEI, Auteur ; Xiaoli QI, Auteur ; Yuxian NING, Auteur ; Ying ZHANG, Auteur ; Xue LI, Auteur ; Jun LI, Auteur ; Linlin SONG, Auteur ; Xuehan QIAN, Auteur Année de publication : 2018 Article en page(s) : p.1530-1536 Langues : Anglais (eng) Mots-clés : Amblyopia  Autism  Children  Refractive status  Risk factor  Strabismus Index. décimale : PER Périodiques Résumé : Amblyopia risk factors in children with autism spectrum disorders (ASD) are usually hard to detect in early childhood due to poor cooperation and has not been reported in the Chinese population. We screened 168 Chinese children with ASD, aged between 3 and 8 years, and 264 age-matched neurotypical children with Spot photoscreener and basic ophthalmologic examinations. Children with ASD were found to have normal refractive status but significantly higher incidence of strabismus (16.1%), compared with control children (1.5%) (p < 0.01). Most of the cases of strabismus found in children with ASD were classified as esodeviation. Strabismus in children with ASD should be considered more seriously as an amblyopia risk factor by ophthalmologists and other healthcare professionals. En ligne : http://dx.doi.org/10.1007/s10803-017-3387-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Refractive Status and Amblyopia Risk Factors in Chinese Children with Autism Spectrum Disorder [texte imprimé] / Jing WANG, Auteur ; Gang DING, Auteur ; Ying LI, Auteur ; Ning HUA, Auteur ; Nan WEI, Auteur ; Xiaoli QI, Auteur ; Yuxian NING, Auteur ; Ying ZHANG, Auteur ; Xue LI, Auteur ; Jun LI, Auteur ; Linlin SONG, Auteur ; Xuehan QIAN, Auteur . - 2018 . - p.1530-1536. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1530-1536 Mots-clés : Amblyopia  Autism  Children  Refractive status  Risk factor  Strabismus Index. décimale : PER Périodiques Résumé : Amblyopia risk factors in children with autism spectrum disorders (ASD) are usually hard to detect in early childhood due to poor cooperation and has not been reported in the Chinese population. We screened 168 Chinese children with ASD, aged between 3 and 8 years, and 264 age-matched neurotypical children with Spot photoscreener and basic ophthalmologic examinations. Children with ASD were found to have normal refractive status but significantly higher incidence of strabismus (16.1%), compared with control children (1.5%) (p < 0.01). Most of the cases of strabismus found in children with ASD were classified as esodeviation. Strabismus in children with ASD should be considered more seriously as an amblyopia risk factor by ophthalmologists and other healthcare professionals. En ligne : http://dx.doi.org/10.1007/s10803-017-3387-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder / Kimberly BERGER in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.2017-2026 Titre : The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Kimberly BERGER, Auteur ; Michelle PEARL, Auteur ; Martin KHARRAZI, Auteur ; Ying LI, Auteur ; Josephine DEGUZMAN, Auteur ; Jianwen SHE, Auteur ; Paramjit BEHNIWAL, Auteur ; Kristen LYALL, Auteur ; Gayle WINDHAM, Auteur Année de publication : 2021 Article en page(s) : p.2017-2026 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Child  Cotinine  Female  Humans  Maternal Exposure/adverse effects  Pregnancy  Smoking  Tobacco Smoke Pollution/adverse effects/analysis  Autism Spectrum Disorder  cotinine  pregnancy  smoking  tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (≥3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder [texte imprimé] / Kimberly BERGER, Auteur ; Michelle PEARL, Auteur ; Martin KHARRAZI, Auteur ; Ying LI, Auteur ; Josephine DEGUZMAN, Auteur ; Jianwen SHE, Auteur ; Paramjit BEHNIWAL, Auteur ; Kristen LYALL, Auteur ; Gayle WINDHAM, Auteur . - 2021 . - p.2017-2026. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.2017-2026 Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Child  Cotinine  Female  Humans  Maternal Exposure/adverse effects  Pregnancy  Smoking  Tobacco Smoke Pollution/adverse effects/analysis  Autism Spectrum Disorder  cotinine  pregnancy  smoking  tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (≥3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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