Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study / Yong Zhang ; Fang Xie ; Sheng LI ; Ying LI ; Liting Yang ; Zhen Wang ; Jinlin Lei ; Huailan Guo in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.427-436 Titre : Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Yong Zhang, Auteur ; Fang Xie, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting Yang, Auteur ; Zhen Wang, Auteur ; Jinlin Lei, Auteur ; Huailan Guo, Auteur Article en page(s) : p.427-436 Langues : Anglais (eng) Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research [Texte imprimé et/ou numérique] / Yong Zhang, Auteur ; Fang Xie, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting Yang, Auteur ; Zhen Wang, Auteur ; Jinlin Lei, Auteur ; Huailan Guo, Auteur . - p.427-436. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.427-436 Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder / Han-Xue YANG in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.729-739 Titre : Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Han-Xue YANG, Auteur ; Han-Yu ZHOU, Auteur ; Ying LI, Auteur ; Yong-Hua CUI, Auteur ; Yang XIANG, Auteur ; Rong-Man YUAN, Auteur ; Simon S. Y. LUI, Auteur ; Raymond C. K. CHAN, Auteur Article en page(s) : p.729-739 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with  Hyperactivity/complications/diagnosis/epidemiology  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Autistic Disorder  Child  Comorbidity  Humans  Interoception  autism spectrum disorders  autistic traits  eye-tracking Index. décimale : PER Périodiques Résumé : Interoception refers to the awareness of internal physiological state. Several previous studies reported that people with autism spectrum disorders (ASD) and adults with attention-deficit/hyperactivity disorder (ADHD) have diverse patterns of interoception, but the extent of literature is limited and inconsistent. This study aimed to investigate the interoceptive accuracy (IA) in children with ASD, children with comorbid ASD and ADHD, and typically developing (TD) children with high and low levels of autistic traits. We administered the eye-tracking interoceptive accuracy task (EIAT) to 30 children with ASD, 20 children with comorbid ASD and ADHD, and 63 TD controls with high and low levels of autistic traits. Parent-report scales concerning ASD and ADHD symptoms were collected. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. Reduced IA was also found in TD children with high-autistic traits relative to those with low-autistic traits. IA was negatively correlated with autistic and ADHD symptoms. Atypical cardiac interoception could be found in children with ASD. Difficulties in sensing and comprehending internal bodily signals in childhood may be related to both ASD and ADHD symptoms. LAY SUMMARY: The present study examined interoceptive accuracy (IA) in children with autism spectrum disorders (ASD), children with comorbid ASD and attention-deficit/hyperactivity disorder (ADHD), and typically developing (TD) children with high and low levels of autistic traits. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. TD children with high-autistic traits exhibited decreased IA compared to those with low-autistic traits. These results have implications for understanding sensory atypicality found in ASD and ADHD. En ligne : https://dx.doi.org/10.1002/aur.2679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Han-Xue YANG, Auteur ; Han-Yu ZHOU, Auteur ; Ying LI, Auteur ; Yong-Hua CUI, Auteur ; Yang XIANG, Auteur ; Rong-Man YUAN, Auteur ; Simon S. Y. LUI, Auteur ; Raymond C. K. CHAN, Auteur . - p.729-739. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.729-739 Mots-clés : Adult  Attention Deficit Disorder with  Hyperactivity/complications/diagnosis/epidemiology  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Autistic Disorder  Child  Comorbidity  Humans  Interoception  autism spectrum disorders  autistic traits  eye-tracking Index. décimale : PER Périodiques Résumé : Interoception refers to the awareness of internal physiological state. Several previous studies reported that people with autism spectrum disorders (ASD) and adults with attention-deficit/hyperactivity disorder (ADHD) have diverse patterns of interoception, but the extent of literature is limited and inconsistent. This study aimed to investigate the interoceptive accuracy (IA) in children with ASD, children with comorbid ASD and ADHD, and typically developing (TD) children with high and low levels of autistic traits. We administered the eye-tracking interoceptive accuracy task (EIAT) to 30 children with ASD, 20 children with comorbid ASD and ADHD, and 63 TD controls with high and low levels of autistic traits. Parent-report scales concerning ASD and ADHD symptoms were collected. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. Reduced IA was also found in TD children with high-autistic traits relative to those with low-autistic traits. IA was negatively correlated with autistic and ADHD symptoms. Atypical cardiac interoception could be found in children with ASD. Difficulties in sensing and comprehending internal bodily signals in childhood may be related to both ASD and ADHD symptoms. LAY SUMMARY: The present study examined interoceptive accuracy (IA) in children with autism spectrum disorders (ASD), children with comorbid ASD and attention-deficit/hyperactivity disorder (ADHD), and typically developing (TD) children with high and low levels of autistic traits. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. TD children with high-autistic traits exhibited decreased IA compared to those with low-autistic traits. These results have implications for understanding sensory atypicality found in ASD and ADHD. En ligne : https://dx.doi.org/10.1002/aur.2679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

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