Cortical thickness variations and their relation to social and executive dysfunctions in autism spectrum disorder among an East Asian population: A longitudinal MRI study / Jung-Chi CHANG in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202689 Titre : Cortical thickness variations and their relation to social and executive dysfunctions in autism spectrum disorder among an East Asian population: A longitudinal MRI study Type de document : texte imprimé Auteurs : Jung-Chi CHANG, Auteur ; Yu-Chieh CHEN, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.202689 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  MRI  Cortical thickness  Longitudinal  Daily executive function  Autistic features Index. décimale : PER Périodiques Résumé : Background The longitudinal brain structural changes and their relationships with clinical features have not been comprehensively established in individuals with autism spectrum disorder (ASD), and existing analyses have mainly focused on Western samples. This study compared change rates of cortical thickness between participants with ASD and typically developing control (TDC) and their relationships with dynamic clinical features and executive dysfunction in an East Asian sample. Methods We assessed 86 ASD and 82 TDC participants at two time points with structural MRI and autistic features and executive dysfunction measures. We used surface-based morphometry to identify the differences in developmental patterns between the ASD and TDC groups. We then examined the relationships between specific brain regions that vary developmentally and clinical parameters. Results Seven clusters were identified, showing accelerating cortical thinning in the ASD participants, including the left inferior temporal, pars orbitalis, inferior parietal, pars opercularis, right middle temporal, and bilateral rostral middle frontal regions. Greater thinning rates in the left inferior parietal and left pars opercularis regions correlated with accelerated increases in autistic features in the ASD group. Greater thinning rates in the left inferior parietal region were associated with greater executive deterioration. These structural changes also predicted social and executive dysfunction in follow-up assessments. Exploratory cross-lagged panel modeling further suggested that baseline cortical thickness in the left pars opercularis predicted social challenges at follow-up, independent of baseline autistic features. Our findings indicate that distinct developmental changes in cortical thickness are associated with social and executive dysfunction, indicating potential pseudonormalization processes that occur from adolescence to early adulthood in this population. Conclusions Our study elucidates neurodevelopmental correlates and trajectories of clinical deficits in ASD among Asian individuals, extending our understanding of brain-behavior relationships from adolescence to early adulthood. En ligne : https://doi.org/10.1016/j.reia.2025.202689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Cortical thickness variations and their relation to social and executive dysfunctions in autism spectrum disorder among an East Asian population: A longitudinal MRI study [texte imprimé] / Jung-Chi CHANG, Auteur ; Yu-Chieh CHEN, Auteur ; Susan Shur-Fen GAU, Auteur . - p.202689. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202689 Mots-clés : Autism spectrum disorder  MRI  Cortical thickness  Longitudinal  Daily executive function  Autistic features Index. décimale : PER Périodiques Résumé : Background The longitudinal brain structural changes and their relationships with clinical features have not been comprehensively established in individuals with autism spectrum disorder (ASD), and existing analyses have mainly focused on Western samples. This study compared change rates of cortical thickness between participants with ASD and typically developing control (TDC) and their relationships with dynamic clinical features and executive dysfunction in an East Asian sample. Methods We assessed 86 ASD and 82 TDC participants at two time points with structural MRI and autistic features and executive dysfunction measures. We used surface-based morphometry to identify the differences in developmental patterns between the ASD and TDC groups. We then examined the relationships between specific brain regions that vary developmentally and clinical parameters. Results Seven clusters were identified, showing accelerating cortical thinning in the ASD participants, including the left inferior temporal, pars orbitalis, inferior parietal, pars opercularis, right middle temporal, and bilateral rostral middle frontal regions. Greater thinning rates in the left inferior parietal and left pars opercularis regions correlated with accelerated increases in autistic features in the ASD group. Greater thinning rates in the left inferior parietal region were associated with greater executive deterioration. These structural changes also predicted social and executive dysfunction in follow-up assessments. Exploratory cross-lagged panel modeling further suggested that baseline cortical thickness in the left pars opercularis predicted social challenges at follow-up, independent of baseline autistic features. Our findings indicate that distinct developmental changes in cortical thickness are associated with social and executive dysfunction, indicating potential pseudonormalization processes that occur from adolescence to early adulthood in this population. Conclusions Our study elucidates neurodevelopmental correlates and trajectories of clinical deficits in ASD among Asian individuals, extending our understanding of brain-behavior relationships from adolescence to early adulthood. En ligne : https://doi.org/10.1016/j.reia.2025.202689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Mental health correlates and potential childhood predictors for the wish to be of the opposite sex in young autistic adults / Jung-Chi CHANG in Autism, 26-1 (January 2022)  

Public ISBD [article]  inAutism > 26-1 (January 2022) . - p.146-159 Titre : Mental health correlates and potential childhood predictors for the wish to be of the opposite sex in young autistic adults Type de document : texte imprimé Auteurs : Jung-Chi CHANG, Auteur ; Meng-Chuan LAI, Auteur ; Yueh-Ming TAI, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.146-159 Langues : Anglais (eng) Mots-clés : autism  follow-up study  gender dysphoria  mental health Index. décimale : PER Périodiques Résumé : Autistic people/people with autism spectrum disorder are more likely to experience gender dysphoria. However, the possible longitudinal predictors and underlying mechanisms of this co-occurrence are unclear. To fill this knowledge gap, we assessed 88 people with autism spectrum disorder and 42 typically developing individuals at their average ages of 13.0 (baseline, childhood/adolescence) and 20.2 years old (follow-up, adulthood). At follow-up, their endorsement on the item "I wish I was the opposite sex" was used to evaluate gender dysphoric symptoms. We compared mental health symptoms between adults with and without this item endorsement at the follow-up assessment. We explored parent-reported family and autism characteristics-related predictors in childhood/adolescence to this item endorsement in adulthood. We found that more autistic adults reported the wish to be of the opposite sex than did typically developing individuals. Autistic adults who endorsed this item experienced more mental health challenges, more school bullying and cyberbullying, more suicidal ideation, and worse quality of life. Moreover, parent-reported lower family support and more stereotyped/repetitive behaviors during childhood/adolescence predicted the self-reported wish to be of the opposite sex in adulthood in autistic individuals. More attention and support should be provided to autistic people regarding gender development and related mental health and quality of life impact, especially during the transition period to young adulthood. En ligne : http://dx.doi.org/10.1177/13623613211024098 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Mental health correlates and potential childhood predictors for the wish to be of the opposite sex in young autistic adults [texte imprimé] / Jung-Chi CHANG, Auteur ; Meng-Chuan LAI, Auteur ; Yueh-Ming TAI, Auteur ; Susan Shur-Fen GAU, Auteur . - p.146-159. Langues : Anglais (eng) in Autism > 26-1 (January 2022) . - p.146-159 Mots-clés : autism  follow-up study  gender dysphoria  mental health Index. décimale : PER Périodiques Résumé : Autistic people/people with autism spectrum disorder are more likely to experience gender dysphoria. However, the possible longitudinal predictors and underlying mechanisms of this co-occurrence are unclear. To fill this knowledge gap, we assessed 88 people with autism spectrum disorder and 42 typically developing individuals at their average ages of 13.0 (baseline, childhood/adolescence) and 20.2 years old (follow-up, adulthood). At follow-up, their endorsement on the item "I wish I was the opposite sex" was used to evaluate gender dysphoric symptoms. We compared mental health symptoms between adults with and without this item endorsement at the follow-up assessment. We explored parent-reported family and autism characteristics-related predictors in childhood/adolescence to this item endorsement in adulthood. We found that more autistic adults reported the wish to be of the opposite sex than did typically developing individuals. Autistic adults who endorsed this item experienced more mental health challenges, more school bullying and cyberbullying, more suicidal ideation, and worse quality of life. Moreover, parent-reported lower family support and more stereotyped/repetitive behaviors during childhood/adolescence predicted the self-reported wish to be of the opposite sex in adulthood in autistic individuals. More attention and support should be provided to autistic people regarding gender development and related mental health and quality of life impact, especially during the transition period to young adulthood. En ligne : http://dx.doi.org/10.1177/13623613211024098 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities / Chun-Hung YEH in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 21 p. Titre : White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities Type de document : texte imprimé Auteurs : Chun-Hung YEH, Auteur ; Rung-Yu TSENG, Auteur ; Hsing-Chang NI, Auteur ; Luca COCCHI, Auteur ; Jung-Chi CHANG, Auteur ; Mei-Yun HSU, Auteur ; En-Nien TU, Auteur ; Yu-Yu WU, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : 21 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Autistic Disorder/diagnostic imaging/pathology  Brain/diagnostic imaging/pathology  Corpus Callosum/diagnostic imaging  Diffusion Magnetic Resonance Imaging/methods  Humans  White Matter/diagnostic imaging/pathology  Autism spectrum disorder  Cerebellum  Diffusion MRI  Fixel-based analysis  Intellectual disabilities  Minimally verbal status Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimage literature of autism spectrum disorder (ASD) has a moderate-to-high risk of bias, partially because those combined with intellectual impairment (II) and/or minimally verbal (MV) status are generally ignored. We aimed to provide more comprehensive insights into white matter alterations of ASD, inclusive of individuals with II (ASD-II-Only) or MV expression (ASD-MV). METHODS: Sixty-five participants with ASD (ASD-Whole; 16.6+5.9 years; comprising 34 intellectually able youth, ASD-IA, and 31 intellectually impaired youth, ASD-II, including 24 ASD-II-Only plus 7 ASD-MV) and 38 demographic-matched typically developing controls (TDC; 17.3+5.6 years) were scanned in accelerated diffusion-weighted MRI. Fixel-based analysis was undertaken to investigate the categorical differences in fiber density (FD), fiber cross section (FC), and a combined index (FDC), and brain symptom/cognition associations. RESULTS: ASD-Whole had reduced FD in the anterior and posterior corpus callosum and left cerebellum Crus I, and smaller FDC in right cerebellum Crus II, compared to TDC. ASD-IA, relative to TDC, had no significant discrepancies, while ASD-II showed almost identical alterations to those from ASD-Whole vs. TDC. ASD-II-Only had greater FD/FDC in the isthmus splenium of callosum than ASD-MV. Autistic severity negatively correlated with FC in right Crus I. Nonverbal full-scale IQ positively correlated with FC/FDC in cerebellum VI. FD/FDC of the right dorsolateral prefrontal cortex showed a diagnosis-by-executive function interaction. LIMITATIONS: We could not preclude the potential effects of age and sex from the ASD cohort, although statistical tests suggested that these factors were not influential. Our results could be confounded by variable psychiatric comorbidities and psychotropic medication uses in our ASD participants recruited from outpatient clinics, which is nevertheless closer to a real-world presentation of ASD. The outcomes related to ASD-MV were considered preliminaries due to the small sample size within this subgroup. Finally, our study design did not include intellectual impairment-only participants without ASD to disentangle the mixture of autistic and intellectual symptoms. CONCLUSIONS: ASD-associated white matter alterations appear driven by individuals with II and potentially further by MV. Results suggest that changes in the corpus callosum and cerebellum are key for psychopathology and cognition associated with ASD. Our work highlights an essential to include understudied subpopulations on the spectrum in research. En ligne : http://dx.doi.org/10.1186/s13229-022-00499-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities [texte imprimé] / Chun-Hung YEH, Auteur ; Rung-Yu TSENG, Auteur ; Hsing-Chang NI, Auteur ; Luca COCCHI, Auteur ; Jung-Chi CHANG, Auteur ; Mei-Yun HSU, Auteur ; En-Nien TU, Auteur ; Yu-Yu WU, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiang-Yuan LIN, Auteur . - 21 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 21 p. Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Autistic Disorder/diagnostic imaging/pathology  Brain/diagnostic imaging/pathology  Corpus Callosum/diagnostic imaging  Diffusion Magnetic Resonance Imaging/methods  Humans  White Matter/diagnostic imaging/pathology  Autism spectrum disorder  Cerebellum  Diffusion MRI  Fixel-based analysis  Intellectual disabilities  Minimally verbal status Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimage literature of autism spectrum disorder (ASD) has a moderate-to-high risk of bias, partially because those combined with intellectual impairment (II) and/or minimally verbal (MV) status are generally ignored. We aimed to provide more comprehensive insights into white matter alterations of ASD, inclusive of individuals with II (ASD-II-Only) or MV expression (ASD-MV). METHODS: Sixty-five participants with ASD (ASD-Whole; 16.6+5.9 years; comprising 34 intellectually able youth, ASD-IA, and 31 intellectually impaired youth, ASD-II, including 24 ASD-II-Only plus 7 ASD-MV) and 38 demographic-matched typically developing controls (TDC; 17.3+5.6 years) were scanned in accelerated diffusion-weighted MRI. Fixel-based analysis was undertaken to investigate the categorical differences in fiber density (FD), fiber cross section (FC), and a combined index (FDC), and brain symptom/cognition associations. RESULTS: ASD-Whole had reduced FD in the anterior and posterior corpus callosum and left cerebellum Crus I, and smaller FDC in right cerebellum Crus II, compared to TDC. ASD-IA, relative to TDC, had no significant discrepancies, while ASD-II showed almost identical alterations to those from ASD-Whole vs. TDC. ASD-II-Only had greater FD/FDC in the isthmus splenium of callosum than ASD-MV. Autistic severity negatively correlated with FC in right Crus I. Nonverbal full-scale IQ positively correlated with FC/FDC in cerebellum VI. FD/FDC of the right dorsolateral prefrontal cortex showed a diagnosis-by-executive function interaction. LIMITATIONS: We could not preclude the potential effects of age and sex from the ASD cohort, although statistical tests suggested that these factors were not influential. Our results could be confounded by variable psychiatric comorbidities and psychotropic medication uses in our ASD participants recruited from outpatient clinics, which is nevertheless closer to a real-world presentation of ASD. The outcomes related to ASD-MV were considered preliminaries due to the small sample size within this subgroup. Finally, our study design did not include intellectual impairment-only participants without ASD to disentangle the mixture of autistic and intellectual symptoms. CONCLUSIONS: ASD-associated white matter alterations appear driven by individuals with II and potentially further by MV. Results suggest that changes in the corpus callosum and cerebellum are key for psychopathology and cognition associated with ASD. Our work highlights an essential to include understudied subpopulations on the spectrum in research. En ligne : http://dx.doi.org/10.1186/s13229-022-00499-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

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