Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample / Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1380-1389 Titre : Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample Type de document : texte imprimé Auteurs : Argyris STRINGARIS, Auteur ; Natalie CASTELLANOS-RYAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÃœCHEL, Auteur ; Mira FAUTH-BÃœHLER, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMAN, Auteur ; Claire LAWRENCE, Auteur ; Frauke NEES, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Tomáš PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Marcella RIETSCHEL, Auteur ; Michael N. SMOLKA, Auteur ; Gunter SCHUMANN, Auteur ; Robert GOODMAN, Auteur ; Patricia J. CONROD, Auteur ; THE IMAGEN CONSORTIUM,, Auteur Article en page(s) : p.1380-1389 Langues : Anglais (eng) Mots-clés : Mania  bipolar  intelligence  adolescents  creativity Index. décimale : PER Périodiques Résumé : Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample [texte imprimé] / Argyris STRINGARIS, Auteur ; Natalie CASTELLANOS-RYAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÃœCHEL, Auteur ; Mira FAUTH-BÃœHLER, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMAN, Auteur ; Claire LAWRENCE, Auteur ; Frauke NEES, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Tomáš PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Marcella RIETSCHEL, Auteur ; Michael N. SMOLKA, Auteur ; Gunter SCHUMANN, Auteur ; Robert GOODMAN, Auteur ; Patricia J. CONROD, Auteur ; THE IMAGEN CONSORTIUM,, Auteur . - p.1380-1389. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1380-1389 Mots-clés : Mania  bipolar  intelligence  adolescents  creativity Index. décimale : PER Périodiques Résumé : Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways / Luiza K. AXELRUD in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.408-416 Titre : Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways Type de document : texte imprimé Auteurs : Luiza K. AXELRUD, Auteur ; Mauricio S. HOFFMANN, Auteur ; Daniel E. VOSBERG, Auteur ; Marcos SANTORO, Auteur ; Pedro M. PAN, Auteur ; Ary GADELHA, Auteur ; Sintia I. BELANGERO, Auteur ; Euripedes C. MIGUEL, Auteur ; Jean SHIN, Auteur ; Anita THAPAR, Auteur ; Jordan W. SMOLLER, Auteur ; Zdenka PAUSOVA, Auteur ; Luis A. ROHDE, Auteur ; Matthew C. KELLER, Auteur ; Tomáš PAUS, Auteur ; Giovanni A. SALUM, Auteur Article en page(s) : p.408-416 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. Methods Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores (PGS) for cognition, educational attainment, attention-deficit hyperactivity disorder (ADHD), and schizophrenia for the trios. Phenotypes studied included educational and cognitive measures, ADHD and psychotic symptoms. We used a stepwise approach and multiple mediation models to analyze the effect of parental PGS on offspring traits via offspring PGS and parental phenotype. Significant results were replicated in a sample of 1,029 adolescents, 363 mothers, and 307 fathers. Results Maternal and paternal PGS for cognition influenced offspring general intelligence and executive function via offspring PGS (genetic pathway) and parental education (phenotypic pathway). Similar results were found for parental PGS for educational attainment and offspring reading and writing skills. These pathways fully explained associations between parental PGS and offspring phenotypes, without residual direct association. Associations with maternal, but not paternal, PGS were replicated. No associations were found between parental PGS for psychopathology and offspring specific symptoms. Conclusions Our findings indicate that parental genetics influences offspring cognition and educational attainment by genetic and phenotypic pathways, suggesting the expression of parental phenotypes partially explain the association between parental genetic risk and offspring outcomes. Multiple mediations might represent an effective approach to disentangle distinct pathways for intergenerational transmission of behavioral traits. En ligne : https://doi.org/10.1111/jcpp.13708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways [texte imprimé] / Luiza K. AXELRUD, Auteur ; Mauricio S. HOFFMANN, Auteur ; Daniel E. VOSBERG, Auteur ; Marcos SANTORO, Auteur ; Pedro M. PAN, Auteur ; Ary GADELHA, Auteur ; Sintia I. BELANGERO, Auteur ; Euripedes C. MIGUEL, Auteur ; Jean SHIN, Auteur ; Anita THAPAR, Auteur ; Jordan W. SMOLLER, Auteur ; Zdenka PAUSOVA, Auteur ; Luis A. ROHDE, Auteur ; Matthew C. KELLER, Auteur ; Tomáš PAUS, Auteur ; Giovanni A. SALUM, Auteur . - p.408-416. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.408-416 Index. décimale : PER Périodiques Résumé : Background Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. Methods Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores (PGS) for cognition, educational attainment, attention-deficit hyperactivity disorder (ADHD), and schizophrenia for the trios. Phenotypes studied included educational and cognitive measures, ADHD and psychotic symptoms. We used a stepwise approach and multiple mediation models to analyze the effect of parental PGS on offspring traits via offspring PGS and parental phenotype. Significant results were replicated in a sample of 1,029 adolescents, 363 mothers, and 307 fathers. Results Maternal and paternal PGS for cognition influenced offspring general intelligence and executive function via offspring PGS (genetic pathway) and parental education (phenotypic pathway). Similar results were found for parental PGS for educational attainment and offspring reading and writing skills. These pathways fully explained associations between parental PGS and offspring phenotypes, without residual direct association. Associations with maternal, but not paternal, PGS were replicated. No associations were found between parental PGS for psychopathology and offspring specific symptoms. Conclusions Our findings indicate that parental genetics influences offspring cognition and educational attainment by genetic and phenotypic pathways, suggesting the expression of parental phenotypes partially explain the association between parental genetic risk and offspring outcomes. Multiple mediations might represent an effective approach to disentangle distinct pathways for intergenerational transmission of behavioral traits. En ligne : https://doi.org/10.1111/jcpp.13708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder / A. RAZNAHAN in Journal of Neurodevelopmental Disorders, 1-3 (September 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.215-23 Titre : A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder Type de document : texte imprimé Auteurs : A. RAZNAHAN, Auteur ; R. TORO, Auteur ; P. PROITSI, Auteur ; J. POWELL, Auteur ; Tomáš PAUS, Auteur ; Patrick BOLTON, Auteur ; D. G. MURPHY, Auteur Article en page(s) : p.215-23 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with both (i) post-mortem and neuroimaging evidence of abnormal cortical development, and (ii) altered signalling in Brain Derived Neurotrophic Factor (BDNF) pathways - which regulate neuroproliferative and neuroplastic processes. In healthy controls genotype at a single nucleotide polymorphism that alters BDNF signalling (Val66met) has been related to regional cortical volume. It is not known however if this influence on brain development is intact in ASD. Therefore we compared the relationship between genotype and cortical anatomy (as measured using in vivo Magnetic Resonance Imaging) in 41 people with ASD and 30 healthy controls. We measured cortical volume, and its two sole determinants - cortical thickness and surface area - which reflect differing neurodevelopmental processes. We found "Group-by-Genotype" interactions for cortical volume in medial (caudal anterior cingulate, posterior cingulate) and lateral (rostral middle, lateral orbitofrontal, pars orbitalis and pars triangularis) frontal cortices. Furthermore, within (only) these regions "Group-by-Genotype" interactions were also found for surface area. No effects were found for cortical thickness in any region. Our preliminary findings suggest that people with ASD have differences from controls in the relationship between BDNF val66met genotype and regional (especially frontal) cortical volume and surface area, but not cortical thickness. Therefore alterations in the relationship between BDNF val66met genotype and surface area in ASD may drive the findings for volume. If correct, this suggests ASD is associated with a distorted relationship between BDNF val66met genotype and the determinants of regional cortical surface area - gyrification and/or sulcal positioning. En ligne : http://dx.doi.org/10.1007/s11689-009-9012-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder [texte imprimé] / A. RAZNAHAN, Auteur ; R. TORO, Auteur ; P. PROITSI, Auteur ; J. POWELL, Auteur ; Tomáš PAUS, Auteur ; Patrick BOLTON, Auteur ; D. G. MURPHY, Auteur . - p.215-23. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.215-23 Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with both (i) post-mortem and neuroimaging evidence of abnormal cortical development, and (ii) altered signalling in Brain Derived Neurotrophic Factor (BDNF) pathways - which regulate neuroproliferative and neuroplastic processes. In healthy controls genotype at a single nucleotide polymorphism that alters BDNF signalling (Val66met) has been related to regional cortical volume. It is not known however if this influence on brain development is intact in ASD. Therefore we compared the relationship between genotype and cortical anatomy (as measured using in vivo Magnetic Resonance Imaging) in 41 people with ASD and 30 healthy controls. We measured cortical volume, and its two sole determinants - cortical thickness and surface area - which reflect differing neurodevelopmental processes. We found "Group-by-Genotype" interactions for cortical volume in medial (caudal anterior cingulate, posterior cingulate) and lateral (rostral middle, lateral orbitofrontal, pars orbitalis and pars triangularis) frontal cortices. Furthermore, within (only) these regions "Group-by-Genotype" interactions were also found for surface area. No effects were found for cortical thickness in any region. Our preliminary findings suggest that people with ASD have differences from controls in the relationship between BDNF val66met genotype and regional (especially frontal) cortical volume and surface area, but not cortical thickness. Therefore alterations in the relationship between BDNF val66met genotype and surface area in ASD may drive the findings for volume. If correct, this suggests ASD is associated with a distorted relationship between BDNF val66met genotype and the determinants of regional cortical surface area - gyrification and/or sulcal positioning. En ligne : http://dx.doi.org/10.1007/s11689-009-9012-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / B. RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : texte imprimé Auteurs : B. RUGGERI, Auteur ; C. MACARE, Auteur ; S. STOPPONI, Auteur ; T. JIA, Auteur ; F. M. CARVALHO, Auteur ; G. ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; A. CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; H. FLOR, Auteur ; V. FROUIN, Auteur ; J. GALLINAT, Auteur ; H. GARAVAN, Auteur ; P. GOWLAND, Auteur ; A. HEINZ, Auteur ; B. ITTERMANN, Auteur ; J. L. MARTINOT, Auteur ; M. P. MARTINOT, Auteur ; F. NEES, Auteur ; D. PAPADOPOULOS-ORFANOS, Auteur ; Tomáš PAUS, Auteur ; L. POUSTKA, Auteur ; M. N. SMOLKA, Auteur ; N. C. VETTER, Auteur ; H. WALTER, Auteur ; R. WHELAN, Auteur ; W. H. SOMMER, Auteur ; G. BAKALKIN, Auteur ; R. CICCOCIOPPO, Auteur ; G. SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [texte imprimé] / B. RUGGERI, Auteur ; C. MACARE, Auteur ; S. STOPPONI, Auteur ; T. JIA, Auteur ; F. M. CARVALHO, Auteur ; G. ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; A. CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; H. FLOR, Auteur ; V. FROUIN, Auteur ; J. GALLINAT, Auteur ; H. GARAVAN, Auteur ; P. GOWLAND, Auteur ; A. HEINZ, Auteur ; B. ITTERMANN, Auteur ; J. L. MARTINOT, Auteur ; M. P. MARTINOT, Auteur ; F. NEES, Auteur ; D. PAPADOPOULOS-ORFANOS, Auteur ; Tomáš PAUS, Auteur ; L. POUSTKA, Auteur ; M. N. SMOLKA, Auteur ; N. C. VETTER, Auteur ; H. WALTER, Auteur ; R. WHELAN, Auteur ; W. H. SOMMER, Auteur ; G. BAKALKIN, Auteur ; R. CICCOCIOPPO, Auteur ; G. SCHUMANN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Structural brain correlates of adolescent resilience / Keith B. BURT in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1287-1296 Titre : Structural brain correlates of adolescent resilience Type de document : texte imprimé Auteurs : Keith B. BURT, Auteur ; Robert WHELAN, Auteur ; Patricia J. CONROD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÃœCHEL, Auteur ; Mira FAUTH-BÃœHLER, Auteur ; Herta FLOR, Auteur ; André GALINOWSKI, Auteur ; Juergen GALLINAT, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Karl MANN, Auteur ; Frauke NEES, Auteur ; Dimitrios PAPADOPOULOS, Auteur ; Tomáš PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Luise POUSTKA, Auteur ; Marcella RIETSCHEL, Auteur ; Trevor W. ROBBINS, Auteur ; Michael N. SMOLKA, Auteur ; Andreas STRÖHLE, Auteur ; Gunter SCHUMANN, Auteur ; Hugh GARAVAN, Auteur ; Imagen Consortium THE, Auteur Article en page(s) : p.1287-1296 Langues : Anglais (eng) Mots-clés : Imaging  resilience  adolescence  competence  adversity  IMAGEN study Index. décimale : PER Périodiques Résumé : Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Structural brain correlates of adolescent resilience [texte imprimé] / Keith B. BURT, Auteur ; Robert WHELAN, Auteur ; Patricia J. CONROD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÃœCHEL, Auteur ; Mira FAUTH-BÃœHLER, Auteur ; Herta FLOR, Auteur ; André GALINOWSKI, Auteur ; Juergen GALLINAT, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Karl MANN, Auteur ; Frauke NEES, Auteur ; Dimitrios PAPADOPOULOS, Auteur ; Tomáš PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Luise POUSTKA, Auteur ; Marcella RIETSCHEL, Auteur ; Trevor W. ROBBINS, Auteur ; Michael N. SMOLKA, Auteur ; Andreas STRÖHLE, Auteur ; Gunter SCHUMANN, Auteur ; Hugh GARAVAN, Auteur ; Imagen Consortium THE, Auteur . - p.1287-1296. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1287-1296 Mots-clés : Imaging  resilience  adolescence  competence  adversity  IMAGEN study Index. décimale : PER Périodiques Résumé : Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

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