Could Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females / Ericka L. WODKA ; Richard A. E. EDDEN ; Stewart H. MOSTOFSKY ; Nicolaas A. J. PUTS ; Jason L. HE in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.239-255 Titre : Could Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females Type de document : Texte imprimé et/ou numérique Auteurs : Ericka L. WODKA, Auteur ; Richard A. E. EDDEN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. J. PUTS, Auteur ; Jason L. HE, Auteur Article en page(s) : p.239-255 Index. décimale : PER Périodiques Résumé : Sensory differences are highly prevalent in autistic individuals. However, few studies have compared their presentation between autistic males and autistic females. We used psychophysics to assess and compare tactile perceptual sensitivity between autistic and non-autistic boys and girls aged between 8 and 12 years of age. While there were sex-differences of amplitude discrimination, frequency discrimination and order judgement thresholds, these sex-differences were not autism-specific. Mean RTs and detection thresholds were elevated in autism but were comparable between the sexes. Tactile sensitivity measures that are elevated in autism but are otherwise comparable between autistic males and autistic females suggest the possibility that certain sensory features could be used as sex-indifferent markers of autism. Further investigation with larger and more representative samples should be conducted before any stronger conclusions are made. En ligne : https://doi.org/10.1007/s10803-022-05787-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] Could Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females [Texte imprimé et/ou numérique] / Ericka L. WODKA, Auteur ; Richard A. E. EDDEN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. J. PUTS, Auteur ; Jason L. HE, Auteur . - p.239-255. in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.239-255 Index. décimale : PER Périodiques Résumé : Sensory differences are highly prevalent in autistic individuals. However, few studies have compared their presentation between autistic males and autistic females. We used psychophysics to assess and compare tactile perceptual sensitivity between autistic and non-autistic boys and girls aged between 8 and 12 years of age. While there were sex-differences of amplitude discrimination, frequency discrimination and order judgement thresholds, these sex-differences were not autism-specific. Mean RTs and detection thresholds were elevated in autism but were comparable between the sexes. Tactile sensitivity measures that are elevated in autism but are otherwise comparable between autistic males and autistic females suggest the possibility that certain sensory features could be used as sex-indifferent markers of autism. Further investigation with larger and more representative samples should be conducted before any stronger conclusions are made. En ligne : https://doi.org/10.1007/s10803-022-05787-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium / Roseann SCHAAF ; Karla K. AUSDERAU ; Grace T. BARANEK ; D Jonah BARRETT ; Carissa J. CASCIO ; Rachel L. DUMONT ; Ekomobong E. Eyoh ; Michelle D. FAILLA ; Jacob I. FELDMAN ; Jennifer H. FOSS-FEIG ; Heather L. GREEN ; Shulamite A. GREEN ; Jason L. HE ; Elizabeth A. KAPLAN-KAHN ; Bahar KEÇELI-KAYS?L? ; Keren MACLENNAN ; Zoe MAILLOUX ; Elysa J. MARCO ; Lisa E. MASH ; Elizabeth P. MCKERNAN ; Sophie MOLHOLM ; Stewart H. MOSTOFSKY ; Nicolaas A. J. PUTS ; Caroline E. ROBERTSON ; Natalie RUSSO ; Nicole SHEA ; John SIDERIS ; James S. SUTCLIFFE ; Teresa TAVASSOLI ; Mark T. WALLACE ; Ericka L. WODKA ; Tiffany G. WOYNAROSKI in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 31 p. Titre : Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium Type de document : Texte imprimé et/ou numérique Auteurs : Roseann SCHAAF, Auteur ; Karla K. AUSDERAU, Auteur ; Grace T. BARANEK, Auteur ; D Jonah BARRETT, Auteur ; Carissa J. CASCIO, Auteur ; Rachel L. DUMONT, Auteur ; Ekomobong E. Eyoh, Auteur ; Michelle D. FAILLA, Auteur ; Jacob I. FELDMAN, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Heather L. GREEN, Auteur ; Shulamite A. GREEN, Auteur ; Jason L. HE, Auteur ; Elizabeth A. KAPLAN-KAHN, Auteur ; Bahar KEÇELI-KAYS?L?, Auteur ; Keren MACLENNAN, Auteur ; Zoe MAILLOUX, Auteur ; Elysa J. MARCO, Auteur ; Lisa E. MASH, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Sophie MOLHOLM, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. J. PUTS, Auteur ; Caroline E. ROBERTSON, Auteur ; Natalie RUSSO, Auteur ; Nicole SHEA, Auteur ; John SIDERIS, Auteur ; James S. SUTCLIFFE, Auteur ; Teresa TAVASSOLI, Auteur ; Mark T. WALLACE, Auteur ; Ericka L. WODKA, Auteur ; Tiffany G. WOYNAROSKI, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Differences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these "supra-modal" traits in the autistic population. METHODS: Leveraging a combined sample of 3868 autistic youth drawn from 12 distinct data sources (ages 3-18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a "general response pattern" factor for each supra-modal construct and determine the added value of "modality-specific response pattern" scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO, and SEEK (sub)constructs. RESULTS: All modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses supported the validity of a supra-modal HYPER construct (?(H)=.800) but not a supra-modal HYPO construct (?(H)=.653), and supra-modal SEEK models suggested a more limited version of the construct that excluded some sensory modalities (?(H)=.800; 4/7 modalities). Modality-specific subscales demonstrated significant added value for all response patterns. Meta-analytic correlations varied by construct, although sensory features tended to correlate most with other domains of core autism features and co-occurring psychiatric symptoms (with general HYPER and speech HYPO demonstrating the largest numbers of practically significant correlations). LIMITATIONS: Conclusions may not be generalizable beyond the specific pool of items used in the current study, which was limited to caregiver report of observable behaviors and excluded multisensory items that reflect many "real-world" sensory experiences. CONCLUSION: Of the three sensory response patterns, only HYPER demonstrated sufficient evidence for valid interpretation at the supra-modal level, whereas supra-modal HYPO/SEEK constructs demonstrated substantial psychometric limitations. For clinicians and researchers seeking to characterize sensory reactivity in autism, modality-specific response pattern scores may represent viable alternatives that overcome many of these limitations. En ligne : http://dx.doi.org/10.1186/s13229-023-00563-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium [Texte imprimé et/ou numérique] / Roseann SCHAAF, Auteur ; Karla K. AUSDERAU, Auteur ; Grace T. BARANEK, Auteur ; D Jonah BARRETT, Auteur ; Carissa J. CASCIO, Auteur ; Rachel L. DUMONT, Auteur ; Ekomobong E. Eyoh, Auteur ; Michelle D. FAILLA, Auteur ; Jacob I. FELDMAN, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Heather L. GREEN, Auteur ; Shulamite A. GREEN, Auteur ; Jason L. HE, Auteur ; Elizabeth A. KAPLAN-KAHN, Auteur ; Bahar KEÇELI-KAYS?L?, Auteur ; Keren MACLENNAN, Auteur ; Zoe MAILLOUX, Auteur ; Elysa J. MARCO, Auteur ; Lisa E. MASH, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Sophie MOLHOLM, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. J. PUTS, Auteur ; Caroline E. ROBERTSON, Auteur ; Natalie RUSSO, Auteur ; Nicole SHEA, Auteur ; John SIDERIS, Auteur ; James S. SUTCLIFFE, Auteur ; Teresa TAVASSOLI, Auteur ; Mark T. WALLACE, Auteur ; Ericka L. WODKA, Auteur ; Tiffany G. WOYNAROSKI, Auteur . - 31 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 31 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Differences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these "supra-modal" traits in the autistic population. METHODS: Leveraging a combined sample of 3868 autistic youth drawn from 12 distinct data sources (ages 3-18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a "general response pattern" factor for each supra-modal construct and determine the added value of "modality-specific response pattern" scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO, and SEEK (sub)constructs. RESULTS: All modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses supported the validity of a supra-modal HYPER construct (?(H)=.800) but not a supra-modal HYPO construct (?(H)=.653), and supra-modal SEEK models suggested a more limited version of the construct that excluded some sensory modalities (?(H)=.800; 4/7 modalities). Modality-specific subscales demonstrated significant added value for all response patterns. Meta-analytic correlations varied by construct, although sensory features tended to correlate most with other domains of core autism features and co-occurring psychiatric symptoms (with general HYPER and speech HYPO demonstrating the largest numbers of practically significant correlations). LIMITATIONS: Conclusions may not be generalizable beyond the specific pool of items used in the current study, which was limited to caregiver report of observable behaviors and excluded multisensory items that reflect many "real-world" sensory experiences. CONCLUSION: Of the three sensory response patterns, only HYPER demonstrated sufficient evidence for valid interpretation at the supra-modal level, whereas supra-modal HYPO/SEEK constructs demonstrated substantial psychometric limitations. For clinicians and researchers seeking to characterize sensory reactivity in autism, modality-specific response pattern scores may represent viable alternatives that overcome many of these limitations. En ligne : http://dx.doi.org/10.1186/s13229-023-00563-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Perceptual alterations in the relationship between sensory reactivity, intolerance of uncertainty, and anxiety in autistic children with and without ADHD / Helen J. Powell ; Jason L. HE ; Nermin Khalil ; Ericka L. WODKA ; Alyssa DeRonda ; Richard A. E. EDDEN ; Roma A. VASA ; Stewart H. MOSTOFSKY ; Nicolaas A. PUTS in Development and Psychopathology, 37-1 (February 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-1 (February 2025) . - p.16-28 Titre : Perceptual alterations in the relationship between sensory reactivity, intolerance of uncertainty, and anxiety in autistic children with and without ADHD : Development and Psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Helen J. Powell, Auteur ; Jason L. HE, Auteur ; Nermin Khalil, Auteur ; Ericka L. WODKA, Auteur ; Alyssa DeRonda, Auteur ; Richard A. E. EDDEN, Auteur ; Roma A. VASA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. PUTS, Auteur Article en page(s) : p.16-28 Langues : Anglais (eng) Mots-clés : anxiety  autism  intolerance of uncertainty  perception  sensory Index. décimale : PER Périodiques Résumé : Sensory differences and anxiety disorders are highly prevalent in autistic individuals with and without ADHD. Studies have shown that sensory differences and anxiety are associated and that intolerance of uncertainty (IU) plays an important role in this relationship. However, it is unclear as to how different levels of the sensory processing pathway (i.e., perceptual, affective, or behavioral) contribute. Here, we used psychophysics to assess how alterations in tactile perception contribute to questionnaire measures of sensory reactivity, IU, and anxiety. Thirty-eight autistic children (aged 8-12 years; 27 with co-occurring ADHD) were included. Consistent with previous findings, mediation analyses showed that child-reported IU fully mediated an association between parent-reported sensory reactivity and parent-reported anxiety and that anxiety partially mediated an association between sensory reactivity and IU. Of the vibrotactile thresholds, only simultaneous frequency discrimination (SFD) thresholds correlated with sensory reactivity. Interestingly, we found that sensory reactivity fully mediated an association between SFD threshold and anxiety, and between SFD threshold and IU. Taken together, those findings suggest a mechanistic pathway whereby tactile perceptual alterations contribute to sensory reactivity at the affective level, leading in turn to increased IU and anxiety. This stepwise association can inform potential interventions for IU and anxiety in autism. En ligne : https://dx.doi.org/10.1017/S0954579423001360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Perceptual alterations in the relationship between sensory reactivity, intolerance of uncertainty, and anxiety in autistic children with and without ADHD : Development and Psychopathology [Texte imprimé et/ou numérique] / Helen J. Powell, Auteur ; Jason L. HE, Auteur ; Nermin Khalil, Auteur ; Ericka L. WODKA, Auteur ; Alyssa DeRonda, Auteur ; Richard A. E. EDDEN, Auteur ; Roma A. VASA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. PUTS, Auteur . - p.16-28. Langues : Anglais (eng) in Development and Psychopathology > 37-1 (February 2025) . - p.16-28 Mots-clés : anxiety  autism  intolerance of uncertainty  perception  sensory Index. décimale : PER Périodiques Résumé : Sensory differences and anxiety disorders are highly prevalent in autistic individuals with and without ADHD. Studies have shown that sensory differences and anxiety are associated and that intolerance of uncertainty (IU) plays an important role in this relationship. However, it is unclear as to how different levels of the sensory processing pathway (i.e., perceptual, affective, or behavioral) contribute. Here, we used psychophysics to assess how alterations in tactile perception contribute to questionnaire measures of sensory reactivity, IU, and anxiety. Thirty-eight autistic children (aged 8-12 years; 27 with co-occurring ADHD) were included. Consistent with previous findings, mediation analyses showed that child-reported IU fully mediated an association between parent-reported sensory reactivity and parent-reported anxiety and that anxiety partially mediated an association between sensory reactivity and IU. Of the vibrotactile thresholds, only simultaneous frequency discrimination (SFD) thresholds correlated with sensory reactivity. Interestingly, we found that sensory reactivity fully mediated an association between SFD threshold and anxiety, and between SFD threshold and IU. Taken together, those findings suggest a mechanistic pathway whereby tactile perceptual alterations contribute to sensory reactivity at the affective level, leading in turn to increased IU and anxiety. This stepwise association can inform potential interventions for IU and anxiety in autism. En ligne : https://dx.doi.org/10.1017/S0954579423001360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

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