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Auteur Francesca HAPPE |
Documents disponibles écrits par cet auteur (119)
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The Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders / Matthew J. HOLLOCKS in Autism Research, 7-2 (April 2014)
[article]
Titre : The Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Matthew J. HOLLOCKS, Auteur ; Catherine R. G. JONES, Auteur ; Andrew PICKLES, Auteur ; Gillian BAIRD, Auteur ; Francesca HAPPE, Auteur ; Tony CHARMAN, Auteur ; Emily SIMONOFF, Auteur Article en page(s) : p.216-228 Mots-clés : anxiety ASD depression executive functions social cognition neuropsychology Index. décimale : PER Périodiques Résumé : While high levels of anxiety and depression are now recognized as major co-occurring problems in children and young people with an autism spectrum disorder (ASD), research examining possible associations with individual differences in neurocognitive functioning has been limited. This study included 90 adolescents with an ASD aged 14–16 years with a full-scale IQ ?50. Using structural equation modeling, we examined the independent relationships between multiple measures of executive functioning and social cognition on severity of anxiety or depressive symptoms. Results indicated a significant association between poorer executive functioning and higher levels of anxiety, but not depression. In contrast, social cognition ability was not associated with either anxiety or depression. This study is the first to report significant associations between executive functions and anxiety in ASD. This may suggest that poor executive functioning is one factor associated with the high prevalence of anxiety disorder in children and adolescents with ASD. En ligne : http://dx.doi.org/10.1002/aur.1361 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230
in Autism Research > 7-2 (April 2014) . - p.216-228[article] The Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Matthew J. HOLLOCKS, Auteur ; Catherine R. G. JONES, Auteur ; Andrew PICKLES, Auteur ; Gillian BAIRD, Auteur ; Francesca HAPPE, Auteur ; Tony CHARMAN, Auteur ; Emily SIMONOFF, Auteur . - p.216-228.
in Autism Research > 7-2 (April 2014) . - p.216-228
Mots-clés : anxiety ASD depression executive functions social cognition neuropsychology Index. décimale : PER Périodiques Résumé : While high levels of anxiety and depression are now recognized as major co-occurring problems in children and young people with an autism spectrum disorder (ASD), research examining possible associations with individual differences in neurocognitive functioning has been limited. This study included 90 adolescents with an ASD aged 14–16 years with a full-scale IQ ?50. Using structural equation modeling, we examined the independent relationships between multiple measures of executive functioning and social cognition on severity of anxiety or depressive symptoms. Results indicated a significant association between poorer executive functioning and higher levels of anxiety, but not depression. In contrast, social cognition ability was not associated with either anxiety or depression. This study is the first to report significant associations between executive functions and anxiety in ASD. This may suggest that poor executive functioning is one factor associated with the high prevalence of anxiety disorder in children and adolescents with ASD. En ligne : http://dx.doi.org/10.1002/aur.1361 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 The association between theory of mind, executive function, and the symptoms of autism spectrum disorder / Catherine R. G. JONES in Autism Research, 11-1 (January 2018)
[article]
Titre : The association between theory of mind, executive function, and the symptoms of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Catherine R. G. JONES, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur ; Andrew PICKLES, Auteur ; Anita J. S. MARSDEN, Auteur ; Jenifer TREGAY, Auteur ; Francesca HAPPE, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.95-109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : It has been strongly argued that atypical cognitive processes in autism spectrum disorder (ASD) contribute to the expression of behavioural symptoms. Comprehensive investigation of these claims has been limited by small and unrepresentative sample sizes and the absence of wide?ranging task batteries. The current study investigated the cognitive abilities of 100 adolescents with ASD (mean age?=?15 years 6 months), using 10 tasks to measure the domains of theory of mind (ToM) and executive function (EF). We used structural equation modelling as a statistically robust way of exploring the associations between cognition and parent?reported measures of social communication and restricted and repetitive behaviours (RRBs). We found that ToM ability was associated with both social communication symptoms and RRBs. EF was a correlate of ToM but had no direct association with parent?reported symptom expression. Our data suggest that in adolescence ToM ability, but not EF, is directly related to autistic symptom expression. Autism Res 2018, 11: 95–109. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The behaviours that are common to autism spectrum disorder (ASD) have been linked to differences in thinking ability. We assessed autistic adolescents and found that social communication difficulties and the presence of restricted and repetitive behaviours related to difficulties in understanding other peoples’ minds (theory of mind). In contrast, these behaviours were not associated with the general thinking abilities involved in planning and executing tasks (executive function). En ligne : https://doi.org/10.1002/aur.1873 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334
in Autism Research > 11-1 (January 2018) . - p.95-109[article] The association between theory of mind, executive function, and the symptoms of autism spectrum disorder [Texte imprimé et/ou numérique] / Catherine R. G. JONES, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur ; Andrew PICKLES, Auteur ; Anita J. S. MARSDEN, Auteur ; Jenifer TREGAY, Auteur ; Francesca HAPPE, Auteur ; Tony CHARMAN, Auteur . - p.95-109.
Langues : Anglais (eng)
in Autism Research > 11-1 (January 2018) . - p.95-109
Index. décimale : PER Périodiques Résumé : It has been strongly argued that atypical cognitive processes in autism spectrum disorder (ASD) contribute to the expression of behavioural symptoms. Comprehensive investigation of these claims has been limited by small and unrepresentative sample sizes and the absence of wide?ranging task batteries. The current study investigated the cognitive abilities of 100 adolescents with ASD (mean age?=?15 years 6 months), using 10 tasks to measure the domains of theory of mind (ToM) and executive function (EF). We used structural equation modelling as a statistically robust way of exploring the associations between cognition and parent?reported measures of social communication and restricted and repetitive behaviours (RRBs). We found that ToM ability was associated with both social communication symptoms and RRBs. EF was a correlate of ToM but had no direct association with parent?reported symptom expression. Our data suggest that in adolescence ToM ability, but not EF, is directly related to autistic symptom expression. Autism Res 2018, 11: 95–109. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The behaviours that are common to autism spectrum disorder (ASD) have been linked to differences in thinking ability. We assessed autistic adolescents and found that social communication difficulties and the presence of restricted and repetitive behaviours related to difficulties in understanding other peoples’ minds (theory of mind). In contrast, these behaviours were not associated with the general thinking abilities involved in planning and executing tasks (executive function). En ligne : https://doi.org/10.1002/aur.1873 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism / Gavin R. STEWART in Autism Research, 13-4 (April 2020)
[article]
Titre : The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism Type de document : Texte imprimé et/ou numérique Auteurs : Gavin R. STEWART, Auteur ; Anne CORBETT, Auteur ; Clive BALLARD, Auteur ; Byron CREESE, Auteur ; Dag AARSLAND, Auteur ; Adam HAMPSHIRE, Auteur ; Rebecca A. CHARLTON, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.641-654 Langues : Anglais (eng) Mots-clés : Asd Bap aging autism broad autism phenotype mental health older adults physical health psychiatric conditions Index. décimale : PER Périodiques Résumé : Autism commonly aggregates in families, with twin studies estimating heritability to be around 80%. Subclinical autism-like characteristics have also been found at elevated rates in relatives of autistic probands. Physical and psychiatric conditions have been reported at elevated rates in autistic children and adults, and also in their relatives. However, to date, there has been no exploration of how aging may affect this pattern. This study examined cross-sectional data from the ongoing online PROTECT study. A total of 20,220 adults aged 50 years and older reported whether they have an autistic first-degree relative. In total, 739 older adults reported having an autistic first-degree relative (AFDR group) and 11,666 were identified as having no family history of any neurodevelopmental disorder (NFD group). The AFDR group demonstrated significantly higher frequencies of self-reported psychiatric diagnoses and a greater total number of co-occurring psychiatric diagnoses than the NFD group. Furthermore, the AFDR group reported elevated current self-report symptoms of depression, anxiety, traumatic experience, and post-traumatic stress than the NFD group. By contrast, few differences between AFDR and NFD groups were observed in physical health conditions, and no differences were observed in the total number of co-occurring physical health diagnoses. These findings suggest that adults who have an AFDR may be at greater risk of poor mental, but not physical, health in later life. Older adults with autistic relatives may benefit from close monitoring to mitigate this susceptibility and to provide timely intervention. Autism Res 2020, 13: 641-654. (c) 2020 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Children and adults with an autistic relative have been found to experience more psychiatric difficulties than those with no family links to autism. However, a few studies have explored what happens when these individuals get older. Examining over 20,000 adults age 50+, we found that older adults with an autistic relative experienced elevated rates of most psychiatric conditions but not physical conditions. Older adults with autistic relatives may benefit from close monitoring to mitigate this susceptibility and to provide timely intervention. En ligne : http://dx.doi.org/10.1002/aur.2277 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Autism Research > 13-4 (April 2020) . - p.641-654[article] The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism [Texte imprimé et/ou numérique] / Gavin R. STEWART, Auteur ; Anne CORBETT, Auteur ; Clive BALLARD, Auteur ; Byron CREESE, Auteur ; Dag AARSLAND, Auteur ; Adam HAMPSHIRE, Auteur ; Rebecca A. CHARLTON, Auteur ; Francesca HAPPE, Auteur . - p.641-654.
Langues : Anglais (eng)
in Autism Research > 13-4 (April 2020) . - p.641-654
Mots-clés : Asd Bap aging autism broad autism phenotype mental health older adults physical health psychiatric conditions Index. décimale : PER Périodiques Résumé : Autism commonly aggregates in families, with twin studies estimating heritability to be around 80%. Subclinical autism-like characteristics have also been found at elevated rates in relatives of autistic probands. Physical and psychiatric conditions have been reported at elevated rates in autistic children and adults, and also in their relatives. However, to date, there has been no exploration of how aging may affect this pattern. This study examined cross-sectional data from the ongoing online PROTECT study. A total of 20,220 adults aged 50 years and older reported whether they have an autistic first-degree relative. In total, 739 older adults reported having an autistic first-degree relative (AFDR group) and 11,666 were identified as having no family history of any neurodevelopmental disorder (NFD group). The AFDR group demonstrated significantly higher frequencies of self-reported psychiatric diagnoses and a greater total number of co-occurring psychiatric diagnoses than the NFD group. Furthermore, the AFDR group reported elevated current self-report symptoms of depression, anxiety, traumatic experience, and post-traumatic stress than the NFD group. By contrast, few differences between AFDR and NFD groups were observed in physical health conditions, and no differences were observed in the total number of co-occurring physical health diagnoses. These findings suggest that adults who have an AFDR may be at greater risk of poor mental, but not physical, health in later life. Older adults with autistic relatives may benefit from close monitoring to mitigate this susceptibility and to provide timely intervention. Autism Res 2020, 13: 641-654. (c) 2020 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Children and adults with an autistic relative have been found to experience more psychiatric difficulties than those with no family links to autism. However, a few studies have explored what happens when these individuals get older. Examining over 20,000 adults age 50+, we found that older adults with an autistic relative experienced elevated rates of most psychiatric conditions but not physical conditions. Older adults with autistic relatives may benefit from close monitoring to mitigate this susceptibility and to provide timely intervention. En ligne : http://dx.doi.org/10.1002/aur.2277 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample / Sara MORUZZI in Journal of Autism and Developmental Disorders, 41-12 (December 2011)
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Titre : The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample Type de document : Texte imprimé et/ou numérique Auteurs : Sara MORUZZI, Auteur ; Anna OGLIARI, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur Année de publication : 2011 Article en page(s) : p.1665-1674 Langues : Anglais (eng) Mots-clés : Clumsiness Autistic traits CBCL Comorbidity Twin study Index. décimale : PER Périodiques Résumé : While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8–17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63. En ligne : http://dx.doi.org/10.1007/s10803-011-1199-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1665-1674[article] The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample [Texte imprimé et/ou numérique] / Sara MORUZZI, Auteur ; Anna OGLIARI, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur . - 2011 . - p.1665-1674.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1665-1674
Mots-clés : Clumsiness Autistic traits CBCL Comorbidity Twin study Index. décimale : PER Périodiques Résumé : While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8–17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63. En ligne : http://dx.doi.org/10.1007/s10803-011-1199-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 The Neuropsychology of Male Adults With High-Functioning Autism or Asperger Syndrome / C. Ellie WILSON in Autism Research, 7-5 (October 2014)
[article]
Titre : The Neuropsychology of Male Adults With High-Functioning Autism or Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : C. Ellie WILSON, Auteur ; Francesca HAPPE, Auteur ; Sally J. WHEELWRIGHT, Auteur ; Christine ECKER, Auteur ; Michael V. LOMBARDO, Auteur ; Patrick JOHNSTON, Auteur ; Eileen DALY, Auteur ; Clodagh M. MURPHY, Auteur ; Debbie SPAIN, Auteur ; Meng-Chuan LAI, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Disa A. SAUTER, Auteur ; CONSORTIUM MRC AIMS,, Auteur ; Simon BARON-COHEN, Auteur ; Declan G. M. MURPHY, Auteur Article en page(s) : p.568-581 Langues : Anglais (eng) Mots-clés : autism spectrum disorder cognitive profiles autistic symptomatology comorbid psychopathology support vector machine classification autistic subtypes Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with ASD. One hundred seventy-eight high-functioning male adults, half with ASD and half without, completed tasks assessing IQ, a broad range of cognitive skills, and autistic and comorbid symptomatology. The aims of the study were, first, to determine whether significant differences existed between cases and controls on cognitive tasks, and whether cognitive profiles, derived using a multivariate classification method with data from multiple cognitive tasks, could distinguish between the two groups. Second, to establish whether cognitive skill level was correlated with degree of autistic symptom severity, and third, whether cognitive skill level was correlated with degree of comorbid psychopathology. Fourth, cognitive characteristics of individuals with Asperger Syndrome (AS) and high-functioning autism (HFA) were compared. After controlling for IQ, ASD and control groups scored significantly differently on tasks of social cognition, motor performance, and executive function (P's??0.05). To investigate cognitive profiles, 12 variables were entered into a support vector machine (SVM), which achieved good classification accuracy (81%) at a level significantly better than chance (P??0.0001). After correcting for multiple correlations, there were no significant associations between cognitive performance and severity of either autistic or comorbid symptomatology. There were no significant differences between AS and HFA groups on the cognitive tasks. Cognitive classification models could be a useful aid to the diagnostic process when used in conjunction with other data sources—including clinical history. Autism Res 2014, 7: 568–581. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Autism Research > 7-5 (October 2014) . - p.568-581[article] The Neuropsychology of Male Adults With High-Functioning Autism or Asperger Syndrome [Texte imprimé et/ou numérique] / C. Ellie WILSON, Auteur ; Francesca HAPPE, Auteur ; Sally J. WHEELWRIGHT, Auteur ; Christine ECKER, Auteur ; Michael V. LOMBARDO, Auteur ; Patrick JOHNSTON, Auteur ; Eileen DALY, Auteur ; Clodagh M. MURPHY, Auteur ; Debbie SPAIN, Auteur ; Meng-Chuan LAI, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Disa A. SAUTER, Auteur ; CONSORTIUM MRC AIMS,, Auteur ; Simon BARON-COHEN, Auteur ; Declan G. M. MURPHY, Auteur . - p.568-581.
Langues : Anglais (eng)
in Autism Research > 7-5 (October 2014) . - p.568-581
Mots-clés : autism spectrum disorder cognitive profiles autistic symptomatology comorbid psychopathology support vector machine classification autistic subtypes Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with ASD. One hundred seventy-eight high-functioning male adults, half with ASD and half without, completed tasks assessing IQ, a broad range of cognitive skills, and autistic and comorbid symptomatology. The aims of the study were, first, to determine whether significant differences existed between cases and controls on cognitive tasks, and whether cognitive profiles, derived using a multivariate classification method with data from multiple cognitive tasks, could distinguish between the two groups. Second, to establish whether cognitive skill level was correlated with degree of autistic symptom severity, and third, whether cognitive skill level was correlated with degree of comorbid psychopathology. Fourth, cognitive characteristics of individuals with Asperger Syndrome (AS) and high-functioning autism (HFA) were compared. After controlling for IQ, ASD and control groups scored significantly differently on tasks of social cognition, motor performance, and executive function (P's??0.05). To investigate cognitive profiles, 12 variables were entered into a support vector machine (SVM), which achieved good classification accuracy (81%) at a level significantly better than chance (P??0.0001). After correcting for multiple correlations, there were no significant associations between cognitive performance and severity of either autistic or comorbid symptomatology. There were no significant differences between AS and HFA groups on the cognitive tasks. Cognitive classification models could be a useful aid to the diagnostic process when used in conjunction with other data sources—including clinical history. Autism Res 2014, 7: 568–581. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 The persistence and stability of psychiatric problems in adolescents with autism spectrum disorders / Emily SIMONOFF in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)
PermalinkThe role of alexithymia and autistic traits in predicting quality of life in an online sample / David MASON in Research in Autism Spectrum Disorders, 90 (February 2022)
PermalinkThe Weak Central Coherence Account of Autism / Francesca HAPPE
PermalinkTheory of Mind in Autism / Francesca HAPPE
Permalink“This may be a really good opportunity to make the world a more autism friendly place”: Professionals’ perspectives on the effects of COVID-19 on autistic individuals / Debbie SPAIN in Research in Autism Spectrum Disorders, 83 (May 2021)
PermalinkTime perception in autism spectrum disorders / Gregory L. WALLACE in Research in Autism Spectrum Disorders, 2-3 (July / September 2008)
PermalinkVariety is Not the Spice of Life for People with Autism Spectrum Disorders: Frequency Ratings of Central, Variable and Inappropriate Aspects of Common Real-life Events / Eva LOTH in Journal of Autism and Developmental Disorders, 40-6 (June 2010)
PermalinkWhat Did I Say? Versus What Did I Think? Attributing False Beliefs to Self Amongst Children With and Without Autism / David WILLIAMS in Journal of Autism and Developmental Disorders, 39-6 (June 2009)
PermalinkWhat is “Weak Central Coherence”? / Francesca HAPPE
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