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Auteur Sally OZONOFF |
Documents disponibles écrits par cet auteur (58)
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Social orienting and initiated joint attention behaviors in 9 to 12 month old children with autism spectrum disorder: A family home movies study / Ruben PALOMO in Autism Research, 15-6 (June 2022)
[article]
Titre : Social orienting and initiated joint attention behaviors in 9 to 12 month old children with autism spectrum disorder: A family home movies study Type de document : Texte imprimé et/ou numérique Auteurs : Ruben PALOMO, Auteur ; Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Mercedes BELINCHÓN CARMONA, Auteur Article en page(s) : p.1109-1119 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications Autistic Disorder Child Humans Infant Motion Pictures Retrospective Studies Social Behavior autism family home movies initiating joint attention joint attention social motivation social orienting Index. décimale : PER Périodiques Résumé : According to the Social Motivation model children with autism show deficits in social orienting (looking at faces and responding to name) at the end of their first year of life. In this model, those deficits are both the earliest behavioral consequences of an alteration in the dopamine reward system balance and the foundation of the social impairments that characterize this neurodevelopmental disorder. The current study tests two of the main predictions of this model: that social orienting deficits are the first behavioral manifestation of autism, and that they are developmentally related to joint attention deficits. We retrospectively analyzed family home movies of 9- to 12-month-old infants, 29 of whom were later diagnosed with autism and 16 of whom were typically developing. After confirming that the videotapes of both groups were similar in content of the scenes recorded (contexts, type of social activity, etc.), we compared their social orienting (social gaze and responding to name) and joint attention behaviors (gaze alternation and gestures). No significant differences between groups were found in looking at faces, but the group with autism showed deficits in responding to name and initiations of joint attention (IJA). Looking at people was not significantly correlated with IJA behaviors, but response to name was. The lack of group differences in looking at faces between 9 and 12?months, and the existence of IJA difficulties in the ASD group without concurrent impairment in looking at faces, do not support predictions of the Social Motivation model. LAY SUMMARY: Various theories have been proposed to explain the emergence of autism symptoms early in life. This study tested two key predictions of the Social Motivation model. Comparing family movies of children 9- to 12-months-old later diagnosed with autism or with typical development, we did not observe difficulties in looking at other people's faces but children with autism responded to name and used gaze and gestures to direct the adult's attention to events of interest less frequently. This absence of difficulties in looking at faces does not fit with what the Social Motivation model of autism predicts and therefore we must develop alternative explanations. En ligne : http://dx.doi.org/10.1002/aur.2695 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-6 (June 2022) . - p.1109-1119[article] Social orienting and initiated joint attention behaviors in 9 to 12 month old children with autism spectrum disorder: A family home movies study [Texte imprimé et/ou numérique] / Ruben PALOMO, Auteur ; Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Mercedes BELINCHÓN CARMONA, Auteur . - p.1109-1119.
Langues : Anglais (eng)
in Autism Research > 15-6 (June 2022) . - p.1109-1119
Mots-clés : Autism Spectrum Disorder/complications Autistic Disorder Child Humans Infant Motion Pictures Retrospective Studies Social Behavior autism family home movies initiating joint attention joint attention social motivation social orienting Index. décimale : PER Périodiques Résumé : According to the Social Motivation model children with autism show deficits in social orienting (looking at faces and responding to name) at the end of their first year of life. In this model, those deficits are both the earliest behavioral consequences of an alteration in the dopamine reward system balance and the foundation of the social impairments that characterize this neurodevelopmental disorder. The current study tests two of the main predictions of this model: that social orienting deficits are the first behavioral manifestation of autism, and that they are developmentally related to joint attention deficits. We retrospectively analyzed family home movies of 9- to 12-month-old infants, 29 of whom were later diagnosed with autism and 16 of whom were typically developing. After confirming that the videotapes of both groups were similar in content of the scenes recorded (contexts, type of social activity, etc.), we compared their social orienting (social gaze and responding to name) and joint attention behaviors (gaze alternation and gestures). No significant differences between groups were found in looking at faces, but the group with autism showed deficits in responding to name and initiations of joint attention (IJA). Looking at people was not significantly correlated with IJA behaviors, but response to name was. The lack of group differences in looking at faces between 9 and 12?months, and the existence of IJA difficulties in the ASD group without concurrent impairment in looking at faces, do not support predictions of the Social Motivation model. LAY SUMMARY: Various theories have been proposed to explain the emergence of autism symptoms early in life. This study tested two key predictions of the Social Motivation model. Comparing family movies of children 9- to 12-months-old later diagnosed with autism or with typical development, we did not observe difficulties in looking at other people's faces but children with autism responded to name and used gaze and gestures to direct the adult's attention to events of interest less frequently. This absence of difficulties in looking at faces does not fit with what the Social Motivation model of autism predicts and therefore we must develop alternative explanations. En ligne : http://dx.doi.org/10.1002/aur.2695 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism / Kristen LYALL in Autism Research, 13-6 (June 2020)
[article]
Titre : The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Lanxin SONG, Auteur ; Kelly N. BOTTERON, Auteur ; Lisa A. CROEN, Auteur ; Stephen R. DAGER, Auteur ; M. Daniele FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; Elizabeth KAUFFMAN, Auteur ; Rebecca LANDA, Auteur ; Christine LADD-ACOSTA, Auteur ; Daniel S. MESSINGER, Auteur ; Sally OZONOFF, Auteur ; Juhi PANDEY, Auteur ; Joseph PIVEN, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robert T. SCHULTZ, Auteur ; Wendy L. STONE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Heather E. VOLK, Auteur Article en page(s) : p.998-1010 Langues : Anglais (eng) Mots-clés : autism autism-related traits high familial risk parental age Index. décimale : PER Périodiques Résumé : Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age?30?years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30?years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted ? = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted ? associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism. En ligne : http://dx.doi.org/10.1002/aur.2303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Autism Research > 13-6 (June 2020) . - p.998-1010[article] The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Lanxin SONG, Auteur ; Kelly N. BOTTERON, Auteur ; Lisa A. CROEN, Auteur ; Stephen R. DAGER, Auteur ; M. Daniele FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; Elizabeth KAUFFMAN, Auteur ; Rebecca LANDA, Auteur ; Christine LADD-ACOSTA, Auteur ; Daniel S. MESSINGER, Auteur ; Sally OZONOFF, Auteur ; Juhi PANDEY, Auteur ; Joseph PIVEN, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robert T. SCHULTZ, Auteur ; Wendy L. STONE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Heather E. VOLK, Auteur . - p.998-1010.
Langues : Anglais (eng)
in Autism Research > 13-6 (June 2020) . - p.998-1010
Mots-clés : autism autism-related traits high familial risk parental age Index. décimale : PER Périodiques Résumé : Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age?30?years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30?years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted ? = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted ? associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism. En ligne : http://dx.doi.org/10.1002/aur.2303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 The Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age / Amy M. WETHERBY in Autism, 26-7 (October 2022)
[article]
Titre : The Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age Type de document : Texte imprimé et/ou numérique Auteurs : Amy M. WETHERBY, Auteur ; Whitney GUTHRIE, Auteur ; Jessica L HOOKER, Auteur ; Abigail D. DELEHANTY, Auteur ; Taylor N. DAY, Auteur ; Juliann WOODS, Auteur ; Karen PIERCE, Auteur ; Stacy S. MANWARING, Auteur ; Audrey THURM, Auteur ; Sally OZONOFF, Auteur ; Eva PETKOVA, Auteur ; Catherine LORD, Auteur Article en page(s) : p.2112-2123 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child Child, Preschool Communication Disorders/diagnosis Humans Infant Mass Screening Sensitivity and Specificity Early Screening for Autism and Communication Disorders autism spectrum disorder field-testing screening validation potential conflicts of interest with respect to the research, authorship, and/or publication of this article: A.M.W. is co-author of the Communication and Symbolic Behavior Scales and receives royalties but not from this study. Catherine Lord is author of the Autism Diagnostic Observation Schedule–Second Edition (ADOS-2). C.L. and W.G. are authors of the ADOS Toddler Module (ADOS-T). They receive royalties from use of the ADOS-2/ADOS-T, but not from this study. The remaining authors have no financial relationships relevant to this article to disclose. Index. décimale : PER Périodiques Résumé : There is a critical need for accurate screening tools for autism spectrum disorder in very young children so families can access tailored intervention services as early as possible. However, there are few screeners designed for children 18-24months. Developing screeners that pick up on the signs of autism spectrum disorder in very young children has proved even more challenging. In this study, we examined a new autism-specific parent-report screening tool, the Early Screening for Autism and Communication Disorders for children between 12 and 36months of age. Field-testing was done in five sites with 471 children screened for communication delays in primary care or referred for familial risk or concern for autism spectrum disorder. The Early Screening for Autism and Communication Disorders was tested in three age groups: 12-17, 18-23, and 24-36months. A best-estimate diagnosis of autism spectrum disorder, developmental delay, or typical development was made. Analyses examined all 46 items and identified 30 items that best discriminated autism spectrum disorder from the non-spectrum groups. Cutoffs were established for each age group with good sensitivity and specificity. Results provide preliminary support for the accuracy of the Early Screening for Autism and Communication Disorders as an autism-specific screener in children 12-36months with elevated risk of communication delay or autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/13623613211012526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Autism > 26-7 (October 2022) . - p.2112-2123[article] The Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age [Texte imprimé et/ou numérique] / Amy M. WETHERBY, Auteur ; Whitney GUTHRIE, Auteur ; Jessica L HOOKER, Auteur ; Abigail D. DELEHANTY, Auteur ; Taylor N. DAY, Auteur ; Juliann WOODS, Auteur ; Karen PIERCE, Auteur ; Stacy S. MANWARING, Auteur ; Audrey THURM, Auteur ; Sally OZONOFF, Auteur ; Eva PETKOVA, Auteur ; Catherine LORD, Auteur . - p.2112-2123.
Langues : Anglais (eng)
in Autism > 26-7 (October 2022) . - p.2112-2123
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child Child, Preschool Communication Disorders/diagnosis Humans Infant Mass Screening Sensitivity and Specificity Early Screening for Autism and Communication Disorders autism spectrum disorder field-testing screening validation potential conflicts of interest with respect to the research, authorship, and/or publication of this article: A.M.W. is co-author of the Communication and Symbolic Behavior Scales and receives royalties but not from this study. Catherine Lord is author of the Autism Diagnostic Observation Schedule–Second Edition (ADOS-2). C.L. and W.G. are authors of the ADOS Toddler Module (ADOS-T). They receive royalties from use of the ADOS-2/ADOS-T, but not from this study. The remaining authors have no financial relationships relevant to this article to disclose. Index. décimale : PER Périodiques Résumé : There is a critical need for accurate screening tools for autism spectrum disorder in very young children so families can access tailored intervention services as early as possible. However, there are few screeners designed for children 18-24months. Developing screeners that pick up on the signs of autism spectrum disorder in very young children has proved even more challenging. In this study, we examined a new autism-specific parent-report screening tool, the Early Screening for Autism and Communication Disorders for children between 12 and 36months of age. Field-testing was done in five sites with 471 children screened for communication delays in primary care or referred for familial risk or concern for autism spectrum disorder. The Early Screening for Autism and Communication Disorders was tested in three age groups: 12-17, 18-23, and 24-36months. A best-estimate diagnosis of autism spectrum disorder, developmental delay, or typical development was made. Analyses examined all 46 items and identified 30 items that best discriminated autism spectrum disorder from the non-spectrum groups. Cutoffs were established for each age group with good sensitivity and specificity. Results provide preliminary support for the accuracy of the Early Screening for Autism and Communication Disorders as an autism-specific screener in children 12-36months with elevated risk of communication delay or autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/13623613211012526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 The onset of autism: patterns of symptom emergence in the first years of life / Sally OZONOFF in Autism Research, 1-6 (December 2008)
[article]
Titre : The onset of autism: patterns of symptom emergence in the first years of life Type de document : Texte imprimé et/ou numérique Auteurs : Sally OZONOFF, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Kelly HEUNG, Auteur ; Robert BYRD, Auteur ; David J. HANSEN, Auteur Année de publication : 2008 Article en page(s) : p.320-328 Langues : Anglais (eng) Mots-clés : onset regression infancy early-identification Index. décimale : PER Périodiques Résumé : Previous conceptualizations of autism have suggested that symptoms are evident either early in the first year of life or later in the second year, after a loss of previously acquired skills. New research suggests, however, that these two patterns do not capture all the different ways autism can emerge. For example, some children show a developmental plateau marked by failure to progress, while other children display mixed features, with both early delays and later losses evident. This article reviews the literature on autism onset, discusses problems with the traditional ways in which onset has been conceptualized, and provides recommendations for future research. We suggest that onset is better thought of as a dimensional process rather than dichotomous categories. En ligne : http://dx.doi.org/10.1002/aur.53 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934
in Autism Research > 1-6 (December 2008) . - p.320-328[article] The onset of autism: patterns of symptom emergence in the first years of life [Texte imprimé et/ou numérique] / Sally OZONOFF, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Kelly HEUNG, Auteur ; Robert BYRD, Auteur ; David J. HANSEN, Auteur . - 2008 . - p.320-328.
Langues : Anglais (eng)
in Autism Research > 1-6 (December 2008) . - p.320-328
Mots-clés : onset regression infancy early-identification Index. décimale : PER Périodiques Résumé : Previous conceptualizations of autism have suggested that symptoms are evident either early in the first year of life or later in the second year, after a loss of previously acquired skills. New research suggests, however, that these two patterns do not capture all the different ways autism can emerge. For example, some children show a developmental plateau marked by failure to progress, while other children display mixed features, with both early delays and later losses evident. This article reviews the literature on autism onset, discusses problems with the traditional ways in which onset has been conceptualized, and provides recommendations for future research. We suggest that onset is better thought of as a dimensional process rather than dichotomous categories. En ligne : http://dx.doi.org/10.1002/aur.53 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934 The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum / Mikle SOUTH in Autism, 11-5 (September 2007)
[article]
Titre : The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Mikle SOUTH, Auteur ; Sally OZONOFF, Auteur ; William M. MCMAHON, Auteur Année de publication : 2007 Article en page(s) : p.437-451 Langues : Anglais (eng) Mots-clés : Autism Central-coherence Executive-function Repetitive-behavior Index. décimale : PER Périodiques Résumé : This study examined the relationship between everyday repetitive behavior (primary symptoms of autism) and performance on neuropsychological tests of executive function and central coherence (secondary symptoms). It was hypothesized that the frequency and intensity of repetitive behavior would be positively correlated with laboratory measures of cognitive rigidity and weak central coherence. Participants included 19 individuals (ages 10—19) with high-functioning autism spectrum disorders (ASD group) and 18 age- and IQ-matched typically developing controls (TD group). There was partial support in the ASD group for the link between repetitive behavior and executive performance (the Wisconsin Card Sorting Task). There was no support for a link between repetitive behavior and measures of central coherence (a Gestalt Closure test and the Embedded Figures Test). Further research on repetitive behaviors in autism may benefit from a focus on narrow behavioral and cognitive constructs rather than general categories. En ligne : http://dx.doi.org/10.1177/1362361307079606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177
in Autism > 11-5 (September 2007) . - p.437-451[article] The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum [Texte imprimé et/ou numérique] / Mikle SOUTH, Auteur ; Sally OZONOFF, Auteur ; William M. MCMAHON, Auteur . - 2007 . - p.437-451.
Langues : Anglais (eng)
in Autism > 11-5 (September 2007) . - p.437-451
Mots-clés : Autism Central-coherence Executive-function Repetitive-behavior Index. décimale : PER Périodiques Résumé : This study examined the relationship between everyday repetitive behavior (primary symptoms of autism) and performance on neuropsychological tests of executive function and central coherence (secondary symptoms). It was hypothesized that the frequency and intensity of repetitive behavior would be positively correlated with laboratory measures of cognitive rigidity and weak central coherence. Participants included 19 individuals (ages 10—19) with high-functioning autism spectrum disorders (ASD group) and 18 age- and IQ-matched typically developing controls (TD group). There was partial support in the ASD group for the link between repetitive behavior and executive performance (the Wisconsin Card Sorting Task). There was no support for a link between repetitive behavior and measures of central coherence (a Gestalt Closure test and the Embedded Figures Test). Further research on repetitive behaviors in autism may benefit from a focus on narrow behavioral and cognitive constructs rather than general categories. En ligne : http://dx.doi.org/10.1177/1362361307079606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 The Very Early Autism Phenotype / Nurit YIRMIYA in Journal of Autism and Developmental Disorders, 37-1 (January 2007)
PermalinkVisual Fixation Patterns during Reciprocal Social Interaction Distinguish a Subgroup of 6-Month-Old Infants At-Risk for Autism from Comparison Infants / Noah MERIN in Journal of Autism and Developmental Disorders, 37-1 (January 2007)
PermalinkWhat will my child's future hold? phenotypes of intellectual development in 2–8?year?olds with autism spectrum disorder / Marjorie SOLOMON in Autism Research, 11-1 (January 2018)
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