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Auteur Geraldine DAWSON |
Documents disponibles écrits par cet auteur (78)
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The autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials / Frederick SHIC in Molecular Autism, 13 (2022)
[article]
Titre : The autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Frederick SHIC, Auteur ; Adam J. NAPLES, Auteur ; Erin C. BARNEY, Auteur ; Shou An CHANG, Auteur ; Beibin LI, Auteur ; Takumi MCALLISTER, Auteur ; Minah KIM, Auteur ; Kelsey J. DOMMER, Auteur ; Simone HASSELMO, Auteur ; Adham ATYABI, Auteur ; Quan WANG, Auteur ; Gerhard HELLEMAN, Auteur ; April R. LEVIN, Auteur ; Helen SEOW, Auteur ; Raphael BERNIER, Auteur ; Katarzyna CHARWASKA, Auteur ; Geraldine DAWSON, Auteur ; James DZIURA, Auteur ; Susan FAJA, Auteur ; Shafali SPURLING JESTE, Auteur ; Scott P. JOHNSON, Auteur ; Michael MURIAS, Auteur ; Charles A. NELSON, Auteur ; Maura SABATOS-DEVITO, Auteur ; Damla SENTURK, Auteur ; Catherine A. SUGAR, Auteur ; Sara J. WEBB, Auteur ; James C. MCPARTLAND, Auteur Article en page(s) : 15 p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/psychology Autistic Disorder/diagnosis Biomarkers Child Eye Movements Eye-Tracking Technology Humans Autism spectrum disorder Biological motion Eye tracking Face processing Gaze pattern Visual attention Index. décimale : PER Périodiques Résumé : BACKGROUND: Eye tracking (ET) is a powerful methodology for studying attentional processes through quantification of eye movements. The precision, usability, and cost-effectiveness of ET render it a promising platform for developing biomarkers for use in clinical trials for autism spectrum disorder (ASD). METHODS: The autism biomarkers consortium for clinical trials conducted a multisite, observational study of 6-11-year-old children with ASD (n=280) and typical development (TD, n=119). The ET battery included: Activity Monitoring, Social Interactive, Static Social Scenes, Biological Motion Preference, and Pupillary Light Reflex tasks. A priori, gaze to faces in Activity Monitoring, Social Interactive, and Static Social Scenes tasks were aggregated into an Oculomotor Index of Gaze to Human Faces (OMI) as the primary outcome measure. This work reports on fundamental biomarker properties (data acquisition rates, construct validity, six-week stability, group discrimination, and clinical relationships) derived from these assays that serve as a base for subsequent development of clinical trial biomarker applications. RESULTS: All tasks exhibited excellent acquisition rates, met expectations for construct validity, had moderate or high six-week stabilities, and highlighted subsets of the ASD group with distinct biomarker performance. Within ASD, higher OMI was associated with increased memory for faces, decreased autism symptom severity, and higher verbal IQ and pragmatic communication skills. LIMITATIONS: No specific interventions were administered in this study, limiting information about how ET biomarkers track or predict outcomes in response to treatment. This study did not consider co-occurrence of psychiatric conditions nor specificity in comparison with non-ASD special populations, therefore limiting our understanding of the applicability of outcomes to specific clinical contexts-of-use. Research-grade protocols and equipment were used; further studies are needed to explore deployment in less standardized contexts. CONCLUSIONS: All ET tasks met expectations regarding biomarker properties, with strongest performance for tasks associated with attention to human faces and weakest performance associated with biological motion preference. Based on these data, the OMI has been accepted to the FDA's Biomarker Qualification program, providing a path for advancing efforts to develop biomarkers for use in clinical trials. En ligne : http://dx.doi.org/10.1186/s13229-021-00482-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Molecular Autism > 13 (2022) . - 15 p.[article] The autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials [Texte imprimé et/ou numérique] / Frederick SHIC, Auteur ; Adam J. NAPLES, Auteur ; Erin C. BARNEY, Auteur ; Shou An CHANG, Auteur ; Beibin LI, Auteur ; Takumi MCALLISTER, Auteur ; Minah KIM, Auteur ; Kelsey J. DOMMER, Auteur ; Simone HASSELMO, Auteur ; Adham ATYABI, Auteur ; Quan WANG, Auteur ; Gerhard HELLEMAN, Auteur ; April R. LEVIN, Auteur ; Helen SEOW, Auteur ; Raphael BERNIER, Auteur ; Katarzyna CHARWASKA, Auteur ; Geraldine DAWSON, Auteur ; James DZIURA, Auteur ; Susan FAJA, Auteur ; Shafali SPURLING JESTE, Auteur ; Scott P. JOHNSON, Auteur ; Michael MURIAS, Auteur ; Charles A. NELSON, Auteur ; Maura SABATOS-DEVITO, Auteur ; Damla SENTURK, Auteur ; Catherine A. SUGAR, Auteur ; Sara J. WEBB, Auteur ; James C. MCPARTLAND, Auteur . - 15 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 15 p.
Mots-clés : Autism Spectrum Disorder/diagnosis/psychology Autistic Disorder/diagnosis Biomarkers Child Eye Movements Eye-Tracking Technology Humans Autism spectrum disorder Biological motion Eye tracking Face processing Gaze pattern Visual attention Index. décimale : PER Périodiques Résumé : BACKGROUND: Eye tracking (ET) is a powerful methodology for studying attentional processes through quantification of eye movements. The precision, usability, and cost-effectiveness of ET render it a promising platform for developing biomarkers for use in clinical trials for autism spectrum disorder (ASD). METHODS: The autism biomarkers consortium for clinical trials conducted a multisite, observational study of 6-11-year-old children with ASD (n=280) and typical development (TD, n=119). The ET battery included: Activity Monitoring, Social Interactive, Static Social Scenes, Biological Motion Preference, and Pupillary Light Reflex tasks. A priori, gaze to faces in Activity Monitoring, Social Interactive, and Static Social Scenes tasks were aggregated into an Oculomotor Index of Gaze to Human Faces (OMI) as the primary outcome measure. This work reports on fundamental biomarker properties (data acquisition rates, construct validity, six-week stability, group discrimination, and clinical relationships) derived from these assays that serve as a base for subsequent development of clinical trial biomarker applications. RESULTS: All tasks exhibited excellent acquisition rates, met expectations for construct validity, had moderate or high six-week stabilities, and highlighted subsets of the ASD group with distinct biomarker performance. Within ASD, higher OMI was associated with increased memory for faces, decreased autism symptom severity, and higher verbal IQ and pragmatic communication skills. LIMITATIONS: No specific interventions were administered in this study, limiting information about how ET biomarkers track or predict outcomes in response to treatment. This study did not consider co-occurrence of psychiatric conditions nor specificity in comparison with non-ASD special populations, therefore limiting our understanding of the applicability of outcomes to specific clinical contexts-of-use. Research-grade protocols and equipment were used; further studies are needed to explore deployment in less standardized contexts. CONCLUSIONS: All ET tasks met expectations regarding biomarker properties, with strongest performance for tasks associated with attention to human faces and weakest performance associated with biological motion preference. Based on these data, the OMI has been accepted to the FDA's Biomarker Qualification program, providing a path for advancing efforts to develop biomarkers for use in clinical trials. En ligne : http://dx.doi.org/10.1186/s13229-021-00482-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 The Broader Autism Phenotype in Simplex and Multiplex Families / Jennifer GERDTS in Journal of Autism and Developmental Disorders, 43-7 (July 2013)
[article]
Titre : The Broader Autism Phenotype in Simplex and Multiplex Families Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer GERDTS, Auteur ; Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur ; Annette ESTES, Auteur Année de publication : 2013 Article en page(s) : p.1597-1605 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Simplex Multiplex Broader autism phenotype Index. décimale : PER Périodiques Résumé : Mothers, fathers, and siblings from 87 multiplex (M-mothers, M-fathers, and M-siblings) and 41 simplex (S-mothers, S-fathers, and S-siblings) Autism spectrum disorder families were assessed using the Broader Phenotype Autism Symptom Scale. S-mothers, S-fathers, and S-siblings showed more social interest and were more expressive in their use of nonverbal communication compared to M-mothers, M-fathers, and M-siblings. Conversational skills were also improved in S-fathers and S-siblings compared to M-fathers and M-siblings. S-siblings showed significantly lower rigidity and intense interests compared to M-siblings. The decreased number and intensity of broader autism phenotype traits observed in parents and siblings within simplex families provide behavioral evidence consistent with findings of increased de novo genetic events in simplex families. En ligne : http://dx.doi.org/10.1007/s10803-012-1706-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Journal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1597-1605[article] The Broader Autism Phenotype in Simplex and Multiplex Families [Texte imprimé et/ou numérique] / Jennifer GERDTS, Auteur ; Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur ; Annette ESTES, Auteur . - 2013 . - p.1597-1605.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1597-1605
Mots-clés : Autism spectrum disorder Simplex Multiplex Broader autism phenotype Index. décimale : PER Périodiques Résumé : Mothers, fathers, and siblings from 87 multiplex (M-mothers, M-fathers, and M-siblings) and 41 simplex (S-mothers, S-fathers, and S-siblings) Autism spectrum disorder families were assessed using the Broader Phenotype Autism Symptom Scale. S-mothers, S-fathers, and S-siblings showed more social interest and were more expressive in their use of nonverbal communication compared to M-mothers, M-fathers, and M-siblings. Conversational skills were also improved in S-fathers and S-siblings compared to M-fathers and M-siblings. S-siblings showed significantly lower rigidity and intense interests compared to M-siblings. The decreased number and intensity of broader autism phenotype traits observed in parents and siblings within simplex families provide behavioral evidence consistent with findings of increased de novo genetic events in simplex families. En ligne : http://dx.doi.org/10.1007/s10803-012-1706-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 The Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders / Benjamin AARONSON in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : The Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin AARONSON, Auteur ; Annette ESTES, Auteur ; Sally J ROGERS, Auteur ; Geraldine DAWSON, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.3304-3313 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Cognition Early Intervention, Educational Humans Parents Autism spectrum disorders Eeg Early start denver model Mu rhythm Index. décimale : PER Périodiques Résumé : We examined the relationship between the Early start Denver model (ESDM) intervention and mu rhythm attenuation, an EEG paradigm reflecting neural processes associated with action perception and social information processing. Children were assigned to either receive comprehensive ESDM intervention for two years, or were encouraged to pursue resources in the community. Two years after intervention, EEG was collected during the execution and observation of grasping actions performed by familiar and unfamiliar agents. The ESDM group showed significantly greater attenuation when viewing a parent or caregiver executing a grasping action, compared with an unfamiliar individual executing the same action. Our findings suggest that the ESDM may have a unique impact on neural circuitry underlying social cognition and familiarity. En ligne : http://dx.doi.org/10.1007/s10803-021-05190-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3304-3313[article] The Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Benjamin AARONSON, Auteur ; Annette ESTES, Auteur ; Sally J ROGERS, Auteur ; Geraldine DAWSON, Auteur ; Raphael BERNIER, Auteur . - p.3304-3313.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3304-3313
Mots-clés : Autism Spectrum Disorder Child Cognition Early Intervention, Educational Humans Parents Autism spectrum disorders Eeg Early start denver model Mu rhythm Index. décimale : PER Périodiques Résumé : We examined the relationship between the Early start Denver model (ESDM) intervention and mu rhythm attenuation, an EEG paradigm reflecting neural processes associated with action perception and social information processing. Children were assigned to either receive comprehensive ESDM intervention for two years, or were encouraged to pursue resources in the community. Two years after intervention, EEG was collected during the execution and observation of grasping actions performed by familiar and unfamiliar agents. The ESDM group showed significantly greater attenuation when viewing a parent or caregiver executing a grasping action, compared with an unfamiliar individual executing the same action. Our findings suggest that the ESDM may have a unique impact on neural circuitry underlying social cognition and familiarity. En ligne : http://dx.doi.org/10.1007/s10803-021-05190-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 The Effects of Face Expertise Training on the Behavioral Performance and Brain Activity of Adults with High Functioning Autism Spectrum Disorders / Susan FAJA in Journal of Autism and Developmental Disorders, 42-2 (February 2012)
[article]
Titre : The Effects of Face Expertise Training on the Behavioral Performance and Brain Activity of Adults with High Functioning Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Susan FAJA, Auteur ; Sara Jane WEBB, Auteur ; Emily A. JONES, Auteur ; Kristen MERKLE, Auteur ; Dana KAMARA, Auteur ; Joshua BAVARO, Auteur ; Elizabeth H. AYLWARD, Auteur ; Geraldine DAWSON, Auteur Année de publication : 2012 Article en page(s) : p.278-293 Langues : Anglais (eng) Mots-clés : ASD Face processing Training Intervention ERPs N170 Index. décimale : PER Périodiques Résumé : The effect of expertise training with faces was studied in adults with ASD who showed initial impairment in face recognition. Participants were randomly assigned to a computerized training program involving either faces or houses. Pre- and post-testing included standardized and experimental measures of behavior and event-related brain potentials (ERPs), as well as interviews after training. After training, all participants met behavioral criteria for expertise with the specific stimuli on which they received training. Scores on standardized measures improved after training for both groups, but only the face training group showed an increased face inversion effect behaviorally and electrophysiological changes to faces in the P100 component. These findings suggest that individuals with ASD can gain expertise in face processing through training. En ligne : http://dx.doi.org/10.1007/s10803-011-1243-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.278-293[article] The Effects of Face Expertise Training on the Behavioral Performance and Brain Activity of Adults with High Functioning Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Susan FAJA, Auteur ; Sara Jane WEBB, Auteur ; Emily A. JONES, Auteur ; Kristen MERKLE, Auteur ; Dana KAMARA, Auteur ; Joshua BAVARO, Auteur ; Elizabeth H. AYLWARD, Auteur ; Geraldine DAWSON, Auteur . - 2012 . - p.278-293.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.278-293
Mots-clés : ASD Face processing Training Intervention ERPs N170 Index. décimale : PER Périodiques Résumé : The effect of expertise training with faces was studied in adults with ASD who showed initial impairment in face recognition. Participants were randomly assigned to a computerized training program involving either faces or houses. Pre- and post-testing included standardized and experimental measures of behavior and event-related brain potentials (ERPs), as well as interviews after training. After training, all participants met behavioral criteria for expertise with the specific stimuli on which they received training. Scores on standardized measures improved after training for both groups, but only the face training group showed an increased face inversion effect behaviorally and electrophysiological changes to faces in the P100 component. These findings suggest that individuals with ASD can gain expertise in face processing through training. En ligne : http://dx.doi.org/10.1007/s10803-011-1243-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire The Impact of Parent-Delivered Intervention on Parents of Very Young Children with Autism / Annette ESTES in Journal of Autism and Developmental Disorders, 44-2 (February 2014)
PermalinkThe Relationship Between Early Neural Responses to Emotional Faces at Age 3 and Later Autism and Anxiety Symptoms in Adolescents with Autism / Emily NEUHAUS in Journal of Autism and Developmental Disorders, 46-7 (July 2016)
PermalinkThe role of abnormal hemispheric specialization in autism / Geraldine DAWSON
PermalinkThe Role of Face Familiarity in Eye Tracking of Faces by Individuals with Autism Spectrum Disorders / Lindsey STERLING in Journal of Autism and Developmental Disorders, 38-9 (October 2008)
PermalinkThe Role of Mirror Neuron Dysfunction in Autism / Raphael BERNIER
PermalinkThe Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study / Erin C. BARNEY ; Adam J. NAPLES ; Kelsey J. DOMMER ; Shou An CHANG ; Beibin LI ; Takumi MCALLISTER ; Adham ATYABI ; Quan WANG ; Raphael BERNIER ; Geraldine DAWSON ; James DZIURA ; Susan FAJA ; Shafali Spurling JESTE ; Michael MURIAS ; Scott P. JOHNSON ; Maura SABATOS-DEVITO ; Gerhard HELLEMAN ; Damla SENTURK ; Catherine A. SUGAR ; Sara Jane WEBB ; James C. MCPARTLAND ; Katarzyna CHAWARSKA ; The Autism Biomarkers Consortium for Clinical TRIALS in Autism Research, 16-11 (November 2023)
PermalinkTrajectories of maternal depression over 7 years: Relations with child psychophysiology and behavior and role of contextual risks / Sharon B. ASHMAN in Development and Psychopathology, 20-1 (Winter 2008)
PermalinkLes troubles du spectre de l’autisme : un aperçu des données récentes sur les causes, le diagnostic et l’intervention / Geraldine DAWSON in Bulletin Scientifique de l'arapi (Le), 32 (Automne 2013)
PermalinkValidation of eye?tracking measures of social attention as a potential biomarker for autism clinical trials / Michael MURIAS in Autism Research, 11-1 (January 2018)
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