Behavior in childhood is associated with romantic partnering patterns in adulthood / F. VERGUNST in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.842-852 Titre : Behavior in childhood is associated with romantic partnering patterns in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : F. VERGUNST, Auteur ; Y. ZHENG, Auteur ; P. DOMOND, Auteur ; F. VITARO, Auteur ; R. E. TREMBLAY, Auteur ; D. NAGIN, Auteur ; J. PARK, Auteur ; Sylvana M. CÔTÉ, Auteur Article en page(s) : p.842-852 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aggression  Anxiety  Child  Child Behavior  Cohort Studies  Humans  Longitudinal Studies  Problem Behavior  Young Adult  Romantic partner  administrative data  behavior  disruptive behaviors  externalizing disorders  income  marriage  prosociality  tax return  welfare Index. décimale : PER Périodiques Résumé : BACKGROUND: Most people will partner at some point during their lives. Yet little is known about the association between childhood behavior and patterns of long-term romantic partnering in adulthood. METHODS: In this population-based cohort study, behavioral ratings were prospectively obtained from teachers when children (n = 2,960) were aged 10-12 years - for inattention, hyperactivity, aggression-opposition, anxiety, and prosociality - and linked to their tax return records from age 18 to 35 years (1998-2015). We used group-based based trajectory modeling to estimate the probability of partnership (marriage/cohabitation) over time and multinomial logistic regression models to examine the association between childhood behavior and trajectory group membership. The child's sex and family socioeconomic background were adjusted for. RESULTS: Five distinct trajectories of partnering were identified: early-partnered (n = 420, 14.4%), mid-partnered (n = 620, 21.3%), late-partnered (n = 570, 19.2%), early-partnered-separated (n = 460, 15.5%), and delayed-or-unpartnered (n = 890, 30.0%). Participants in the early-partnered-separated and delayed-or-unpartnered trajectories were more likely to have left high school without a diploma and to have lower earnings and higher welfare receipt from age 18 to 35 years. After adjustment for sex and family background, inattention and aggression-opposition were uniquely and additively associated with increased likelihood of following an early-partnered-separated trajectory, while inattention and anxiety were associated with an increased likelihood of following a delayed-or-unpartnered trajectory. Childhood prosocial behaviors were consistently associated with earlier and more sustained patterns of partnership. CONCLUSIONS: Children with behavioral problems are more likely to separate or to be unpartnered across early adulthood. This may have consequences for their psychological health and wellbeing and that of their families. En ligne : http://dx.doi.org/10.1111/jcpp.13329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Behavior in childhood is associated with romantic partnering patterns in adulthood [Texte imprimé et/ou numérique] / F. VERGUNST, Auteur ; Y. ZHENG, Auteur ; P. DOMOND, Auteur ; F. VITARO, Auteur ; R. E. TREMBLAY, Auteur ; D. NAGIN, Auteur ; J. PARK, Auteur ; Sylvana M. CÔTÉ, Auteur . - p.842-852. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.842-852 Mots-clés : Adolescent  Adult  Aggression  Anxiety  Child  Child Behavior  Cohort Studies  Humans  Longitudinal Studies  Problem Behavior  Young Adult  Romantic partner  administrative data  behavior  disruptive behaviors  externalizing disorders  income  marriage  prosociality  tax return  welfare Index. décimale : PER Périodiques Résumé : BACKGROUND: Most people will partner at some point during their lives. Yet little is known about the association between childhood behavior and patterns of long-term romantic partnering in adulthood. METHODS: In this population-based cohort study, behavioral ratings were prospectively obtained from teachers when children (n = 2,960) were aged 10-12 years - for inattention, hyperactivity, aggression-opposition, anxiety, and prosociality - and linked to their tax return records from age 18 to 35 years (1998-2015). We used group-based based trajectory modeling to estimate the probability of partnership (marriage/cohabitation) over time and multinomial logistic regression models to examine the association between childhood behavior and trajectory group membership. The child's sex and family socioeconomic background were adjusted for. RESULTS: Five distinct trajectories of partnering were identified: early-partnered (n = 420, 14.4%), mid-partnered (n = 620, 21.3%), late-partnered (n = 570, 19.2%), early-partnered-separated (n = 460, 15.5%), and delayed-or-unpartnered (n = 890, 30.0%). Participants in the early-partnered-separated and delayed-or-unpartnered trajectories were more likely to have left high school without a diploma and to have lower earnings and higher welfare receipt from age 18 to 35 years. After adjustment for sex and family background, inattention and aggression-opposition were uniquely and additively associated with increased likelihood of following an early-partnered-separated trajectory, while inattention and anxiety were associated with an increased likelihood of following a delayed-or-unpartnered trajectory. Childhood prosocial behaviors were consistently associated with earlier and more sustained patterns of partnership. CONCLUSIONS: Children with behavioral problems are more likely to separate or to be unpartnered across early adulthood. This may have consequences for their psychological health and wellbeing and that of their families. En ligne : http://dx.doi.org/10.1111/jcpp.13329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Early childhood child care and disruptive behavior problems during adolescence: a 17-year population-based propensity score study / M. ORRI in Journal of Child Psychology and Psychiatry, 60-11 (November 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1174-1182 Titre : Early childhood child care and disruptive behavior problems during adolescence: a 17-year population-based propensity score study Type de document : Texte imprimé et/ou numérique Auteurs : M. ORRI, Auteur ; R. E. TREMBLAY, Auteur ; C. JAPEL, Auteur ; Michel BOIVIN, Auteur ; F. VITARO, Auteur ; T. LOSIER, Auteur ; M. R. BRENDGEN, Auteur ; B. FALISSARD, Auteur ; M. MELCHIOR, Auteur ; Sylvana M. CÔTÉ, Auteur Article en page(s) : p.1174-1182 Langues : Anglais (eng) Mots-clés : Early childhood education  adolescence  child care  disruptive problems  externalising behaviour  family adversity  longitudinal  opposition  physical aggression  poverty  prevention  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Child-care services during early childhood provide opportunities for social interactions that may facilitate children's learning of acceptable social behaviors. Furthermore, they may reduce exposure to family adversity for some children. The aim of this study was to determine whether intensity of exposure to child-care services prior to age 5 years has a beneficial effect on disruptive behavior problems during adolescence, and whether the effect is more pronounced for children from low socioeconomic families. METHODS: N = 1,588 participants from the Quebec Longitudinal Study of Child Development were assessed 14 times from 5 months to 17 years. Intensity of child-care exposure was measured from 5 months to 5 years of age. Main outcomes were self-reported physical aggression and opposition from age 12 to 17 years. Family socioeconomic status (SES) was measured at 5 months. Factors explaining differences in child-care use were controlled using propensity score weights (PSW). RESULTS: Children exposed to moderate-intensity child-care services (part-time child-care services before 1(1/2) years and full time afterward) reported lower levels of physical aggression (d = -.11, p = .056) and opposition (d = -.14, p = .029) during adolescence compared to children exposed to low-intensity child-care services. A significant child care by SES interaction (p = .017) for physical aggression indicated that the moderate-intensity child-care effect was specific to children from low SES families (d = -.36, p = .002). No interaction with socioeconomic status was found for opposition. CONCLUSIONS: Moderate-intensity child-care services from infancy to school entry may prevent disruptive behavior during adolescence, especially for disadvantaged children. En ligne : http://dx.doi.org/10.1111/jcpp.13065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Early childhood child care and disruptive behavior problems during adolescence: a 17-year population-based propensity score study [Texte imprimé et/ou numérique] / M. ORRI, Auteur ; R. E. TREMBLAY, Auteur ; C. JAPEL, Auteur ; Michel BOIVIN, Auteur ; F. VITARO, Auteur ; T. LOSIER, Auteur ; M. R. BRENDGEN, Auteur ; B. FALISSARD, Auteur ; M. MELCHIOR, Auteur ; Sylvana M. CÔTÉ, Auteur . - p.1174-1182. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1174-1182 Mots-clés : Early childhood education  adolescence  child care  disruptive problems  externalising behaviour  family adversity  longitudinal  opposition  physical aggression  poverty  prevention  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Child-care services during early childhood provide opportunities for social interactions that may facilitate children's learning of acceptable social behaviors. Furthermore, they may reduce exposure to family adversity for some children. The aim of this study was to determine whether intensity of exposure to child-care services prior to age 5 years has a beneficial effect on disruptive behavior problems during adolescence, and whether the effect is more pronounced for children from low socioeconomic families. METHODS: N = 1,588 participants from the Quebec Longitudinal Study of Child Development were assessed 14 times from 5 months to 17 years. Intensity of child-care exposure was measured from 5 months to 5 years of age. Main outcomes were self-reported physical aggression and opposition from age 12 to 17 years. Family socioeconomic status (SES) was measured at 5 months. Factors explaining differences in child-care use were controlled using propensity score weights (PSW). RESULTS: Children exposed to moderate-intensity child-care services (part-time child-care services before 1(1/2) years and full time afterward) reported lower levels of physical aggression (d = -.11, p = .056) and opposition (d = -.14, p = .029) during adolescence compared to children exposed to low-intensity child-care services. A significant child care by SES interaction (p = .017) for physical aggression indicated that the moderate-intensity child-care effect was specific to children from low SES families (d = -.36, p = .002). No interaction with socioeconomic status was found for opposition. CONCLUSIONS: Moderate-intensity child-care services from infancy to school entry may prevent disruptive behavior during adolescence, especially for disadvantaged children. En ligne : http://dx.doi.org/10.1111/jcpp.13065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood / J. HENRY in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1282-1288 Titre : Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood Type de document : Texte imprimé et/ou numérique Auteurs : J. HENRY, Auteur ; G. DIONNE, Auteur ; E. VIDING, Auteur ; F. VITARO, Auteur ; M. BRENDGEN, Auteur ; R. E. TREMBLAY, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.1282-1288 Langues : Anglais (eng) Mots-clés : Callous-unemotional traits  gene-environment interaction  twin studies  warm/rewarding parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous gene-environment interaction studies of CU traits have relied on the candidate gene approach, which does not account for the entire genetic load of complex phenotypes. Moreover, these studies have not examined the role of positive environmental factors such as warm/rewarding parenting. The aim of the present study was to determine whether early warm/rewarding parenting moderates the genetic contributions (i.e., heritability) to callous-unemotional (CU) traits at school age. METHODS: Data were collected in a population sample of 662 twin pairs (Quebec Newborn Twin Study - QNTS). Mothers reported on their warm/rewarding parenting. Teachers assessed children's CU traits. These reports were subjected to twin modeling. RESULTS: Callous-unemotional traits were highly heritable, with the remaining variance accounted for by nonshared environmental factors. Warm/rewarding parenting significantly moderated the role of genes in CU traits; heritability was lower when children received high warm/rewarding parenting than when they were exposed to low warm/rewarding parenting. CONCLUSIONS: High warm/rewarding parenting may partly impede the genetic expression of CU traits. Developmental models of CU traits need to account for such gene-environment processes. En ligne : http://dx.doi.org/10.1111/jcpp.12918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood [Texte imprimé et/ou numérique] / J. HENRY, Auteur ; G. DIONNE, Auteur ; E. VIDING, Auteur ; F. VITARO, Auteur ; M. BRENDGEN, Auteur ; R. E. TREMBLAY, Auteur ; Michel BOIVIN, Auteur . - p.1282-1288. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1282-1288 Mots-clés : Callous-unemotional traits  gene-environment interaction  twin studies  warm/rewarding parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous gene-environment interaction studies of CU traits have relied on the candidate gene approach, which does not account for the entire genetic load of complex phenotypes. Moreover, these studies have not examined the role of positive environmental factors such as warm/rewarding parenting. The aim of the present study was to determine whether early warm/rewarding parenting moderates the genetic contributions (i.e., heritability) to callous-unemotional (CU) traits at school age. METHODS: Data were collected in a population sample of 662 twin pairs (Quebec Newborn Twin Study - QNTS). Mothers reported on their warm/rewarding parenting. Teachers assessed children's CU traits. These reports were subjected to twin modeling. RESULTS: Callous-unemotional traits were highly heritable, with the remaining variance accounted for by nonshared environmental factors. Warm/rewarding parenting significantly moderated the role of genes in CU traits; heritability was lower when children received high warm/rewarding parenting than when they were exposed to low warm/rewarding parenting. CONCLUSIONS: High warm/rewarding parenting may partly impede the genetic expression of CU traits. Developmental models of CU traits need to account for such gene-environment processes. En ligne : http://dx.doi.org/10.1111/jcpp.12918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Identifying environmental pathways between irritability during childhood and suicidal ideation and attempt in adolescence: findings from a 20-year population-based study / A. FORTE in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1402-1411 Titre : Identifying environmental pathways between irritability during childhood and suicidal ideation and attempt in adolescence: findings from a 20-year population-based study Type de document : Texte imprimé et/ou numérique Auteurs : A. FORTE, Auteur ; M. ORRI, Auteur ; G. TURECKI, Auteur ; C. GALERA, Auteur ; M. POMPILI, Auteur ; Michel BOIVIN, Auteur ; R. E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; M. C. GEOFFROY, Auteur Article en page(s) : p.1402-1411 Langues : Anglais (eng) Mots-clés : Adolescent  Child  Female  Humans  Irritable Mood  Longitudinal Studies  Risk Factors  Suicidal Ideation  Suicide, Attempted  Irritability  adolescence  birth cohort  longitudinal  suicide attempt Index. décimale : PER Périodiques Résumé : BACKGROUND: Irritable children are at increased risk of suicidal ideation and suicide attempt, but the underlying environmental mechanisms accounting for these associations are largely unknown. We aimed to investigate the mediating role of peer victimization and harsh parenting in the association between childhood irritability and adolescent suicidal ideation and attempt. METHOD: N?=?1,483 participants from the Québec Longitudinal Study of Child Development followed up from 5?months until 20?years of age (2018) with annual or biannual assessments. Irritability was operationalized using assessments of teacher-reported temper tantrums and reactive aggression. Suicidal ideation and suicide attempt at ages 13, 15, 17, and 20?years were self-reported. Peer victimization (self-reported at age 13) and harsh parenting (mothers reported at age 13) were considered as potential mediators. RESULTS: We identified four trajectories of teacher-reported irritability symptoms from 6 to 12?years: low (74.8%), rising (12.9%), declining (7.3%), and persistent (4.9%). In adjusted models, children in the persistent and rising trajectories had, respectively, 2.81-fold (CI, 1.27-6.22) and 2.14-fold (CI, 1.20-3.81) increased odds of suicide attempt in adolescence, but not suicidal ideation. We found that a significant proportion of the association between irritability trajectories and suicide attempt was mediated by peer victimization (33% and 35% for rising and persistent, respectively), but there was no mediation via harsh parenting. CONCLUSIONS: Our findings suggest that peer victimization may be a key mechanism explaining the increased suicide attempt risk of children presenting with persistently high or increasing irritability. Interventions to reduce peer victimization may be helpful to reduce suicide risk among irritable children. En ligne : http://dx.doi.org/10.1111/jcpp.13411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Identifying environmental pathways between irritability during childhood and suicidal ideation and attempt in adolescence: findings from a 20-year population-based study [Texte imprimé et/ou numérique] / A. FORTE, Auteur ; M. ORRI, Auteur ; G. TURECKI, Auteur ; C. GALERA, Auteur ; M. POMPILI, Auteur ; Michel BOIVIN, Auteur ; R. E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; M. C. GEOFFROY, Auteur . - p.1402-1411. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1402-1411 Mots-clés : Adolescent  Child  Female  Humans  Irritable Mood  Longitudinal Studies  Risk Factors  Suicidal Ideation  Suicide, Attempted  Irritability  adolescence  birth cohort  longitudinal  suicide attempt Index. décimale : PER Périodiques Résumé : BACKGROUND: Irritable children are at increased risk of suicidal ideation and suicide attempt, but the underlying environmental mechanisms accounting for these associations are largely unknown. We aimed to investigate the mediating role of peer victimization and harsh parenting in the association between childhood irritability and adolescent suicidal ideation and attempt. METHOD: N?=?1,483 participants from the Québec Longitudinal Study of Child Development followed up from 5?months until 20?years of age (2018) with annual or biannual assessments. Irritability was operationalized using assessments of teacher-reported temper tantrums and reactive aggression. Suicidal ideation and suicide attempt at ages 13, 15, 17, and 20?years were self-reported. Peer victimization (self-reported at age 13) and harsh parenting (mothers reported at age 13) were considered as potential mediators. RESULTS: We identified four trajectories of teacher-reported irritability symptoms from 6 to 12?years: low (74.8%), rising (12.9%), declining (7.3%), and persistent (4.9%). In adjusted models, children in the persistent and rising trajectories had, respectively, 2.81-fold (CI, 1.27-6.22) and 2.14-fold (CI, 1.20-3.81) increased odds of suicide attempt in adolescence, but not suicidal ideation. We found that a significant proportion of the association between irritability trajectories and suicide attempt was mediated by peer victimization (33% and 35% for rising and persistent, respectively), but there was no mediation via harsh parenting. CONCLUSIONS: Our findings suggest that peer victimization may be a key mechanism explaining the increased suicide attempt risk of children presenting with persistently high or increasing irritability. Interventions to reduce peer victimization may be helpful to reduce suicide risk among irritable children. En ligne : http://dx.doi.org/10.1111/jcpp.13411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood / Geneviève MORNEAU-VAILLANCOURT in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1320-1329 Titre : Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F. M. ANDLAUER, Auteur ; I. OUELLET-MORIN, Auteur ; S. PAQUIN, Auteur ; M. R. BRENDGEN, Auteur ; F. VITARO, Auteur ; Jean-Philippe GOUIN, Auteur ; Jean R. SEGUIN, Auteur ; É GAGNON, Auteur ; Rosa CHEESMAN, Auteur ; N. FORGET-DUBOIS, Auteur ; G. A. ROULEAU, Auteur ; G. TURECKI, Auteur ; R. E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; G. DIONNE, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.1320-1329 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Child  Humans  Infant, Newborn  Loneliness  Longitudinal Studies  Multifactorial Inheritance/genetics  Prospective Studies  Social withdrawal  polygenic scores  preference for solitude  social wariness  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study were (a) to identify high-risk trajectories for social wariness and preference for solitude in childhood and (b) to examine whether falling on these high-risk trajectories can be predicted by specific polygenic scores for mental health traits and disorders and by a general polygenic predisposition to these traits. METHODS: Teachers evaluated 971 genotyped children at five occasions (age 6 to 12 years) from two prospective longitudinal studies, the Quebec Newborn Twin Study and the Quebec Longitudinal Study of Child Development. Developmental trajectories for social wariness and preference for solitude were identified. We tested whether polygenic scores for attention deficit hyperactivity disorder, autism spectrum disorder, depression, loneliness, and subjective well-being, as well as a general mental health genetic risk score derived across these traits, were associated with the developmental trajectories. RESULTS: Polygenic scores differentially predicted social wariness and preference for solitude. Only the loneliness polygenic score significantly predicted the high trajectory for social wariness. By contrast, the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude. CONCLUSIONS: Distinct associations were uncovered between the polygenic scores, social wariness, and preference for solitude. En ligne : http://dx.doi.org/10.1111/jcpp.13459 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood [Texte imprimé et/ou numérique] / Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F. M. ANDLAUER, Auteur ; I. OUELLET-MORIN, Auteur ; S. PAQUIN, Auteur ; M. R. BRENDGEN, Auteur ; F. VITARO, Auteur ; Jean-Philippe GOUIN, Auteur ; Jean R. SEGUIN, Auteur ; É GAGNON, Auteur ; Rosa CHEESMAN, Auteur ; N. FORGET-DUBOIS, Auteur ; G. A. ROULEAU, Auteur ; G. TURECKI, Auteur ; R. E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; G. DIONNE, Auteur ; Michel BOIVIN, Auteur . - p.1320-1329. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1320-1329 Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Child  Humans  Infant, Newborn  Loneliness  Longitudinal Studies  Multifactorial Inheritance/genetics  Prospective Studies  Social withdrawal  polygenic scores  preference for solitude  social wariness  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study were (a) to identify high-risk trajectories for social wariness and preference for solitude in childhood and (b) to examine whether falling on these high-risk trajectories can be predicted by specific polygenic scores for mental health traits and disorders and by a general polygenic predisposition to these traits. METHODS: Teachers evaluated 971 genotyped children at five occasions (age 6 to 12 years) from two prospective longitudinal studies, the Quebec Newborn Twin Study and the Quebec Longitudinal Study of Child Development. Developmental trajectories for social wariness and preference for solitude were identified. We tested whether polygenic scores for attention deficit hyperactivity disorder, autism spectrum disorder, depression, loneliness, and subjective well-being, as well as a general mental health genetic risk score derived across these traits, were associated with the developmental trajectories. RESULTS: Polygenic scores differentially predicted social wariness and preference for solitude. Only the loneliness polygenic score significantly predicted the high trajectory for social wariness. By contrast, the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude. CONCLUSIONS: Distinct associations were uncovered between the polygenic scores, social wariness, and preference for solitude. En ligne : http://dx.doi.org/10.1111/jcpp.13459 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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