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Early communication deficits in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context / A. Özge SUNGUR in Autism Research, 9-6 (June 2016)
[article]
Titre : Early communication deficits in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context Type de document : Texte imprimé et/ou numérique Auteurs : A. Özge SUNGUR, Auteur ; Rainer K. W. SCHWARTING, Auteur ; Markus WÖHR, Auteur Article en page(s) : p.696-709 Langues : Anglais (eng) Mots-clés : animal model postsynaptic density neurodevelopmental disorders autism communication ultrasonic vocalization social context Index. décimale : PER Périodiques Résumé : Alterations in SHANK genes were repeatedly reported in autism spectrum disorder (ASD). ASD is a group of neurodevelopmental disorders diagnosed by persistent deficits in social communication/interaction across multiple contexts, with restricted/repetitive patterns of behavior. To date, diagnostic criteria for ASD are purely behaviorally defined and reliable biomarkers have still not been identified. The validity of mouse models for ASD therefore strongly relies on their behavioral phenotype. Here, we studied communication by means of isolation-induced pup ultrasonic vocalizations (USV) in the Shank1 mouse model for ASD by comparing Shank1?/? null mutant, Shank1+/? heterozygous, and Shank1+/+ wildtype littermate controls. The first aim of the present study was to evaluate the effects of Shank1 deletions on developmental aspects of communication in order to see whether ASD-related communication deficits are due to general impairment or delay in development. Second, we focused on social context effects on USV production. We show that Shank1?/? pups vocalized less and displayed a delay in the typical inverted U-shaped developmental USV emission pattern with USV rates peaking on postnatal day (PND) 9, resulting in a prominent genotype difference on PND6. Moreover, testing under social conditions revealed even more prominently genotype-dependent deficits regardless of the familiarity of the social context. As communication by definition serves a social function, introducing a social component to the typically nonsocial test environment could therefore help to reveal communication deficits in mouse models for ASD. Together, these results indicate that SHANK1 is involved in acoustic communication across species, with genetic alterations in SHANK1 resulting in social communication/interaction deficits. Autism Res 2016, 9: 696–709. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Autism Research > 9-6 (June 2016) . - p.696-709[article] Early communication deficits in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context [Texte imprimé et/ou numérique] / A. Özge SUNGUR, Auteur ; Rainer K. W. SCHWARTING, Auteur ; Markus WÖHR, Auteur . - p.696-709.
Langues : Anglais (eng)
in Autism Research > 9-6 (June 2016) . - p.696-709
Mots-clés : animal model postsynaptic density neurodevelopmental disorders autism communication ultrasonic vocalization social context Index. décimale : PER Périodiques Résumé : Alterations in SHANK genes were repeatedly reported in autism spectrum disorder (ASD). ASD is a group of neurodevelopmental disorders diagnosed by persistent deficits in social communication/interaction across multiple contexts, with restricted/repetitive patterns of behavior. To date, diagnostic criteria for ASD are purely behaviorally defined and reliable biomarkers have still not been identified. The validity of mouse models for ASD therefore strongly relies on their behavioral phenotype. Here, we studied communication by means of isolation-induced pup ultrasonic vocalizations (USV) in the Shank1 mouse model for ASD by comparing Shank1?/? null mutant, Shank1+/? heterozygous, and Shank1+/+ wildtype littermate controls. The first aim of the present study was to evaluate the effects of Shank1 deletions on developmental aspects of communication in order to see whether ASD-related communication deficits are due to general impairment or delay in development. Second, we focused on social context effects on USV production. We show that Shank1?/? pups vocalized less and displayed a delay in the typical inverted U-shaped developmental USV emission pattern with USV rates peaking on postnatal day (PND) 9, resulting in a prominent genotype difference on PND6. Moreover, testing under social conditions revealed even more prominently genotype-dependent deficits regardless of the familiarity of the social context. As communication by definition serves a social function, introducing a social component to the typically nonsocial test environment could therefore help to reveal communication deficits in mouse models for ASD. Together, these results indicate that SHANK1 is involved in acoustic communication across species, with genetic alterations in SHANK1 resulting in social communication/interaction deficits. Autism Res 2016, 9: 696–709. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect / Jeroen VAN OOSTERHOUT in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect Type de document : Texte imprimé et/ou numérique Auteurs : Jeroen VAN OOSTERHOUT, Auteur ; Kim VAN DER LINDEN, Auteur ; Claudia J. P. SIMONS, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Machteld MARCELIS, Auteur Article en page(s) : p.1366-1375 Langues : Anglais (eng) Mots-clés : Adult Affect Autism Spectrum Disorder/psychology Autistic Disorder Cross-Sectional Studies Humans Neuroticism Social Environment Stress, Psychological/psychology autism momentary assessment social context stress reactivity Index. décimale : PER Périodiques Résumé : Neuroticism is associated with increased stress reactivity. In autism spectrum disorders (ASD), emotional stress reactivity is increased and there is some evidence for an increased negative affect (NA) when with less familiar people. The aim of this study was to compare adults with ASD and controls on levels of neuroticism and on interactions between neuroticism and appraised stress or social context in models of NA. This is a cross-sectional observational study comprising a group of 50 adults with ASD and 51 controls. Experience sampling method (ESM) reports were collected for 10 days to measure daily life stress, mood, and social context. Multilevel regression analyses revealed significantly higher neuroticism levels in ASD than in controls. Adults with ASD who scored high on neuroticism showed a significantly stronger association between activity/social stress and NA (i.e., higher stress reactivity) than those with low scores. Furthermore, the association between neuroticism and NA was stronger when adults with ASD were with less familiar people compared with being alone or with familiar people. No consistent corresponding significant interactions were found in the control group. In conclusion, in ASD, neuroticism moderates the association between appraised stress and NA as well as the association between social context and NA. En ligne : http://dx.doi.org/10.1017/s0954579420002278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Development and Psychopathology > 34-4 (October 2022) . - p.1366-1375[article] Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect [Texte imprimé et/ou numérique] / Jeroen VAN OOSTERHOUT, Auteur ; Kim VAN DER LINDEN, Auteur ; Claudia J. P. SIMONS, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Machteld MARCELIS, Auteur . - p.1366-1375.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1366-1375
Mots-clés : Adult Affect Autism Spectrum Disorder/psychology Autistic Disorder Cross-Sectional Studies Humans Neuroticism Social Environment Stress, Psychological/psychology autism momentary assessment social context stress reactivity Index. décimale : PER Périodiques Résumé : Neuroticism is associated with increased stress reactivity. In autism spectrum disorders (ASD), emotional stress reactivity is increased and there is some evidence for an increased negative affect (NA) when with less familiar people. The aim of this study was to compare adults with ASD and controls on levels of neuroticism and on interactions between neuroticism and appraised stress or social context in models of NA. This is a cross-sectional observational study comprising a group of 50 adults with ASD and 51 controls. Experience sampling method (ESM) reports were collected for 10 days to measure daily life stress, mood, and social context. Multilevel regression analyses revealed significantly higher neuroticism levels in ASD than in controls. Adults with ASD who scored high on neuroticism showed a significantly stronger association between activity/social stress and NA (i.e., higher stress reactivity) than those with low scores. Furthermore, the association between neuroticism and NA was stronger when adults with ASD were with less familiar people compared with being alone or with familiar people. No consistent corresponding significant interactions were found in the control group. In conclusion, in ASD, neuroticism moderates the association between appraised stress and NA as well as the association between social context and NA. En ligne : http://dx.doi.org/10.1017/s0954579420002278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing / K. F. JANKOWSKI in Journal of Autism and Developmental Disorders, 51-10 (October 2021)
[article]
Titre : Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing Type de document : Texte imprimé et/ou numérique Auteurs : K. F. JANKOWSKI, Auteur ; J. H. PFEIFER, Auteur Article en page(s) : p.3514-3532 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Emotions Empathy Humans Mentalization Autism Perspective-taking Self-conscious emotions Social context Social emotions Index. décimale : PER Périodiques Résumé : Autistic adolescents experience a secondary wave of social cognitive challenges which impact interpersonal success. We investigated self-conscious emotion (SCE) processing in autistic and neurotypical adolescents. Participants watched videos of peers acting embarrassed and proud and rated inferred and empathic SCEs. We compared intensity ratings across groups and conducted correlations with social cognitive abilities and autistic features. Autistic adolescents recognized SCEs and felt empathic SCEs; however, they made atypical emotion attributions when perspective-taking demands were high, which more strongly reflected the situational context. Atypical attributions were associated with perspective-taking difficulties and autistic feature intensity. An over-reliance on contextual cues may reflect a strict adherence to learned social rules, possibly compensating for less reflexive mentalizing, which may underlie interpersonal challenges in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04808-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3514-3532[article] Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing [Texte imprimé et/ou numérique] / K. F. JANKOWSKI, Auteur ; J. H. PFEIFER, Auteur . - p.3514-3532.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3514-3532
Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Emotions Empathy Humans Mentalization Autism Perspective-taking Self-conscious emotions Social context Social emotions Index. décimale : PER Périodiques Résumé : Autistic adolescents experience a secondary wave of social cognitive challenges which impact interpersonal success. We investigated self-conscious emotion (SCE) processing in autistic and neurotypical adolescents. Participants watched videos of peers acting embarrassed and proud and rated inferred and empathic SCEs. We compared intensity ratings across groups and conducted correlations with social cognitive abilities and autistic features. Autistic adolescents recognized SCEs and felt empathic SCEs; however, they made atypical emotion attributions when perspective-taking demands were high, which more strongly reflected the situational context. Atypical attributions were associated with perspective-taking difficulties and autistic feature intensity. An over-reliance on contextual cues may reflect a strict adherence to learned social rules, possibly compensating for less reflexive mentalizing, which may underlie interpersonal challenges in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04808-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 Emotional Processing in Autism Spectrum Disorders: Effects of Age, Emotional Valence, and Social Engagement on Emotional Language Use / E. J. TEH in Journal of Autism and Developmental Disorders, 48-12 (December 2018)
[article]
Titre : Emotional Processing in Autism Spectrum Disorders: Effects of Age, Emotional Valence, and Social Engagement on Emotional Language Use Type de document : Texte imprimé et/ou numérique Auteurs : E. J. TEH, Auteur ; M. J. YAP, Auteur ; S. J. RICKARD LIOW, Auteur Article en page(s) : p.4138-4154 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Emotion deficits Emotional development Emotional language Picture descriptions Social context Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) show deficits in reporting others' emotions (Lartseva et al. in Front Hum Neurosci 8:991, 2015) and in deriving meaning in social contexts (Klin et al. in Handbook of autism and pervasive developmental disorders, Wiley, Hoboken, 2005). However, researchers often use stimuli that conflate salient emotional and social information. Using a matched-pairs design, the impact of emotional and social information on emotional language in pre-school and school-age children, with and without ASD, was assessed with a picture description task comprising rated stimuli from the Pictures with Social Contexts and Emotional Scenes database (Teh et al. in Behav Res Methods, https://doi.org/10.3758/s13428-017-0947-x , 2017). Results showed both groups with ASD produced fewer emotional terms than typically developing children, but the effects were moderated by valence, social engagement, and age. Implications for theory and clinical practice are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3659-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4138-4154[article] Emotional Processing in Autism Spectrum Disorders: Effects of Age, Emotional Valence, and Social Engagement on Emotional Language Use [Texte imprimé et/ou numérique] / E. J. TEH, Auteur ; M. J. YAP, Auteur ; S. J. RICKARD LIOW, Auteur . - p.4138-4154.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4138-4154
Mots-clés : Autism spectrum disorders Emotion deficits Emotional development Emotional language Picture descriptions Social context Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) show deficits in reporting others' emotions (Lartseva et al. in Front Hum Neurosci 8:991, 2015) and in deriving meaning in social contexts (Klin et al. in Handbook of autism and pervasive developmental disorders, Wiley, Hoboken, 2005). However, researchers often use stimuli that conflate salient emotional and social information. Using a matched-pairs design, the impact of emotional and social information on emotional language in pre-school and school-age children, with and without ASD, was assessed with a picture description task comprising rated stimuli from the Pictures with Social Contexts and Emotional Scenes database (Teh et al. in Behav Res Methods, https://doi.org/10.3758/s13428-017-0947-x , 2017). Results showed both groups with ASD produced fewer emotional terms than typically developing children, but the effects were moderated by valence, social engagement, and age. Implications for theory and clinical practice are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3659-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371