An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits / Ellen M. HOWERTON in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits Type de document : texte imprimé Auteurs : Ellen M. HOWERTON, Auteur ; Valerie MORRILL, Auteur ; Rose SCHROTT, Auteur ; Jason DANIELS, Auteur ; Ashley Y. SONG, Auteur ; Kelly BENKE, Auteur ; Heather VOLK, Auteur ; Homayoon FARZADEGAN, Auteur ; Aimee ANIDO ALEXANDER, Auteur ; Amanda L. TAPIA, Auteur ; Gabriel S. DICHTER, Auteur ; Lisa A. CROEN, Auteur ; Lisa WIGGINS, Auteur ; Genevieve WOJCIK, Auteur ; M. Daniele FALLIN, Auteur ; Christine LADD-ACOSTA, Auteur Langues : Anglais (eng) Mots-clés : Humans  DNA Methylation/genetics  Male  Female  Case-Control Studies  Genome-Wide Association Study  Autism Spectrum Disorder/genetics  Child, Preschool  DNA-Binding Proteins/genetics  Transcription Factors/genetics  Epigenome  Quantitative Trait Loci  Repressor Proteins  Autism  DNA methylation  Quantitative trait  Social Responsiveness Scale  by the institutional review boards (IRBs) at each SEED site. SEED 1 recruitment  was approved by the IRB of each recruitment site: IRB-C, CDC Human Research  Protection Office  Kaiser Foundation Research Institute (KFRI) Kaiser Permanente  Northern California IRB, Colorado Multiple IRB, Emory University IRB, Georgia  Department of Public Health IRB, Maryland Department of Health and Mental Hygiene  IRB, Johns Hopkins Bloomberg School of Public Health IRB, University of North  Carolina IRB and Office of Human Research Ethics, IRB of The Children’s Hospital  of Philadelphia, and IRB of the University of Pennsylvania. All enrolled families  provided written consent for participation. Consent for publication: Not  applicable. Competing interests: CLA reports receiving consulting fees from the  University of Iowa for providing expertise on epigenetics outside of this work.  All other authors declare that they have no conflict of interest. The findings  and conclusions in this report are those of the authors and do not necessarily  represent the official position of the Centers for Disease Control and  Prevention. Index. décimale : PER Périodiques Résumé : BACKGROUND: Quantitative measures of autism spectrum disorder (ASD)-related traits can provide insight into trait presentation across the population. Previous studies have identified epigenomic variation associated with ASD diagnosis, but few have evaluated quantitative traits. We sought to identify DNA methylation patterns in child blood associated with Social Responsiveness Scale score, Second Edition (SRS). METHODS: We conducted an epigenome-wide association study of SRS in child blood at approximately age 5 in the Study to Explore Early Development, a case-control study of ASD in the United States. We measured DNA methylation using the Illumina 450K array with 857 samples in our analysis after quality control. We performed regression of the M-value to identify single sites or differentially methylated regions (DMRs) associated with SRS scores, adjusting for sources of biological and technical variation. We examined methylation quantitative trait loci and conducted gene-ontology-term pathway analyses for regions of interest. RESULTS: We identified a region about 3.5 kb upstream of ZFP57 on chromosome 6 as differentially methylated (family-wise error rate [fwer] < 0.1) by continuous SRS T-score in the full sample (N = 857; fwer = 0.074) and among ASD cases only (N = 390; fwer = 0.021). ZFP57 encodes a transcription factor involved in imprinting regulation and maintenance, and this DMR has been previously associated with ASD in brain and buccal samples. CONCLUSIONS: Blood DNA methylation near ZFP57 was associated (fwer < 0.1) with SRS in the full population sample and appears to be largely driven by trait heterogeneity within the autism case group. Our results indicate DNA methylation associations with ASD quantitative traits are observable in a population and provide insights into specific biologic changes related to autism trait heterogeneity. En ligne : https://dx.doi.org/10.1186/s11689-025-09637-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits [texte imprimé] / Ellen M. HOWERTON, Auteur ; Valerie MORRILL, Auteur ; Rose SCHROTT, Auteur ; Jason DANIELS, Auteur ; Ashley Y. SONG, Auteur ; Kelly BENKE, Auteur ; Heather VOLK, Auteur ; Homayoon FARZADEGAN, Auteur ; Aimee ANIDO ALEXANDER, Auteur ; Amanda L. TAPIA, Auteur ; Gabriel S. DICHTER, Auteur ; Lisa A. CROEN, Auteur ; Lisa WIGGINS, Auteur ; Genevieve WOJCIK, Auteur ; M. Daniele FALLIN, Auteur ; Christine LADD-ACOSTA, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  DNA Methylation/genetics  Male  Female  Case-Control Studies  Genome-Wide Association Study  Autism Spectrum Disorder/genetics  Child, Preschool  DNA-Binding Proteins/genetics  Transcription Factors/genetics  Epigenome  Quantitative Trait Loci  Repressor Proteins  Autism  DNA methylation  Quantitative trait  Social Responsiveness Scale  by the institutional review boards (IRBs) at each SEED site. SEED 1 recruitment  was approved by the IRB of each recruitment site: IRB-C, CDC Human Research  Protection Office  Kaiser Foundation Research Institute (KFRI) Kaiser Permanente  Northern California IRB, Colorado Multiple IRB, Emory University IRB, Georgia  Department of Public Health IRB, Maryland Department of Health and Mental Hygiene  IRB, Johns Hopkins Bloomberg School of Public Health IRB, University of North  Carolina IRB and Office of Human Research Ethics, IRB of The Children’s Hospital  of Philadelphia, and IRB of the University of Pennsylvania. All enrolled families  provided written consent for participation. Consent for publication: Not  applicable. Competing interests: CLA reports receiving consulting fees from the  University of Iowa for providing expertise on epigenetics outside of this work.  All other authors declare that they have no conflict of interest. The findings  and conclusions in this report are those of the authors and do not necessarily  represent the official position of the Centers for Disease Control and  Prevention. Index. décimale : PER Périodiques Résumé : BACKGROUND: Quantitative measures of autism spectrum disorder (ASD)-related traits can provide insight into trait presentation across the population. Previous studies have identified epigenomic variation associated with ASD diagnosis, but few have evaluated quantitative traits. We sought to identify DNA methylation patterns in child blood associated with Social Responsiveness Scale score, Second Edition (SRS). METHODS: We conducted an epigenome-wide association study of SRS in child blood at approximately age 5 in the Study to Explore Early Development, a case-control study of ASD in the United States. We measured DNA methylation using the Illumina 450K array with 857 samples in our analysis after quality control. We performed regression of the M-value to identify single sites or differentially methylated regions (DMRs) associated with SRS scores, adjusting for sources of biological and technical variation. We examined methylation quantitative trait loci and conducted gene-ontology-term pathway analyses for regions of interest. RESULTS: We identified a region about 3.5 kb upstream of ZFP57 on chromosome 6 as differentially methylated (family-wise error rate [fwer] < 0.1) by continuous SRS T-score in the full sample (N = 857; fwer = 0.074) and among ASD cases only (N = 390; fwer = 0.021). ZFP57 encodes a transcription factor involved in imprinting regulation and maintenance, and this DMR has been previously associated with ASD in brain and buccal samples. CONCLUSIONS: Blood DNA methylation near ZFP57 was associated (fwer < 0.1) with SRS in the full population sample and appears to be largely driven by trait heterogeneity within the autism case group. Our results indicate DNA methylation associations with ASD quantitative traits are observable in a population and provide insights into specific biologic changes related to autism trait heterogeneity. En ligne : https://dx.doi.org/10.1186/s11689-025-09637-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development / Susan E. LEVY in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2348-2357 Titre : ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development Type de document : texte imprimé Auteurs : Susan E. LEVY, Auteur ; Leslie A. RESCORLA, Auteur ; Jesse L. CHITTAMS, Auteur ; Tanja J. KRAL, Auteur ; Eric J. MOODY, Auteur ; Juhi PANDEY, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Alison POMYKACZ, Auteur ; AnnJosette RAMIREZ, Auteur ; Nuri M. REYES, Auteur ; C. Robinson ROSENBERG, Auteur ; Laura A. SCHIEVE, Auteur ; Aleda THOMPSON, Auteur ; Larry J. YOUNG, Auteur ; Jishui ZHANG, Auteur ; Lisa D. WIGGINS, Auteur Article en page(s) : p.2348-2357 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Child Behavior Checklist (CBCL)  Developmental delay (DD) Index. décimale : PER Périodiques Résumé : We analyzed CBCL/1(1/2)-5 Pervasive Developmental Problems (DSM-PDP) scores in 3- to 5-year-olds from the Study to Explore Early Development (SEED), a multi-site case control study, with the objective to discriminate children with ASD (N = 656) from children with Developmental Delay (DD) (N = 646), children with Developmental Delay (DD) plus ASD features (DD-AF) (N = 284), and population controls (POP) (N = 827). ASD diagnosis was confirmed with the ADOS and ADI-R. With a cut-point of T >/= 65, sensitivity was 80% for ASD, with specificity varying across groups: POP (0.93), DD-noAF (0.85), and DD-AF (0.50). One-way ANOVA yielded a large group effect (eta(2) = 0.50). Our results support the CBCL/1(1/2)-5's as a time-efficient ASD screener for identifying preschoolers needing further evaluation. En ligne : https://dx.doi.org/10.1007/s10803-019-03895-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development [texte imprimé] / Susan E. LEVY, Auteur ; Leslie A. RESCORLA, Auteur ; Jesse L. CHITTAMS, Auteur ; Tanja J. KRAL, Auteur ; Eric J. MOODY, Auteur ; Juhi PANDEY, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Alison POMYKACZ, Auteur ; AnnJosette RAMIREZ, Auteur ; Nuri M. REYES, Auteur ; C. Robinson ROSENBERG, Auteur ; Laura A. SCHIEVE, Auteur ; Aleda THOMPSON, Auteur ; Larry J. YOUNG, Auteur ; Jishui ZHANG, Auteur ; Lisa D. WIGGINS, Auteur . - p.2348-2357. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2348-2357 Mots-clés : Autism spectrum disorder (ASD)  Child Behavior Checklist (CBCL)  Developmental delay (DD) Index. décimale : PER Périodiques Résumé : We analyzed CBCL/1(1/2)-5 Pervasive Developmental Problems (DSM-PDP) scores in 3- to 5-year-olds from the Study to Explore Early Development (SEED), a multi-site case control study, with the objective to discriminate children with ASD (N = 656) from children with Developmental Delay (DD) (N = 646), children with Developmental Delay (DD) plus ASD features (DD-AF) (N = 284), and population controls (POP) (N = 827). ASD diagnosis was confirmed with the ADOS and ADI-R. With a cut-point of T >/= 65, sensitivity was 80% for ASD, with specificity varying across groups: POP (0.93), DD-noAF (0.85), and DD-AF (0.50). One-way ANOVA yielded a large group effect (eta(2) = 0.50). Our results support the CBCL/1(1/2)-5's as a time-efficient ASD screener for identifying preschoolers needing further evaluation. En ligne : https://dx.doi.org/10.1007/s10803-019-03895-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development / Eric RUBENSTEIN in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.436-448 Titre : Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development Type de document : texte imprimé Auteurs : Eric RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Catherine BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Eric J. MOODY, Auteur ; Juhi PANDEY, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Annie G. HOWARD, Auteur ; Andrew F. OLSHAN, Auteur ; Brian W. PENCE, Auteur ; Jena DANIELS, Auteur Article en page(s) : p.436-448 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development [texte imprimé] / Eric RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Catherine BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Eric J. MOODY, Auteur ; Juhi PANDEY, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Annie G. HOWARD, Auteur ; Andrew F. OLSHAN, Auteur ; Brian W. PENCE, Auteur ; Jena DANIELS, Auteur . - p.436-448. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.436-448 Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

Associations of maternal peripregnancy cannabis use with behavioral and developmental outcomes in children with and without symptoms of autism spectrum disorder: Study to Explore Early Development / Carolyn G. DIGUISEPPI ; Tessa CRUME ; Brady HOLST ; Kaylynn AIONA ; Julia VAN DYKE ; Lisa A. CROEN ; Julie L. DANIELS ; Sandra FRIEDMAN ; Katherine R. SABOURIN ; Laura A. SCHIEVE ; Lisa WIGGINS ; Gayle C. WINDHAM ; Cordelia ROBINSON ROSENBERG in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.202-216 Titre : Associations of maternal peripregnancy cannabis use with behavioral and developmental outcomes in children with and without symptoms of autism spectrum disorder: Study to Explore Early Development : Autism Research Type de document : texte imprimé Auteurs : Carolyn G. DIGUISEPPI, Auteur ; Tessa CRUME, Auteur ; Brady HOLST, Auteur ; Kaylynn AIONA, Auteur ; Julia VAN DYKE, Auteur ; Lisa A. CROEN, Auteur ; Julie L. DANIELS, Auteur ; Sandra FRIEDMAN, Auteur ; Katherine R. SABOURIN, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa WIGGINS, Auteur ; Gayle C. WINDHAM, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur Article en page(s) : p.202-216 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cannabis  child behavior  child preschool  developmental disabilities  pregnancy  prenatal risk factors  sleep wake disorders Index. décimale : PER Périodiques Résumé : Abstract Some studies report increased prevalence of autism spectrum disorder (ASD) and associated symptoms with prenatal cannabis exposure. We examined whether associations of maternal cannabis use from 3 months preconception through delivery (?peripregnancy?) with behavior and development in the offspring varied with the presence of ASD symptoms. Children ages 30 68 months with ASD symptoms (i.e., met study criteria for ASD or had ASD symptoms on standardized assessments or community ASD diagnosis, N 2734) and without ASD symptoms (other developmental delay/disorders or general population sample, N 3454) were evaluated with the Child Behavior Checklist and Mullen Scales of Early Learning. We examined cannabis use during three time periods: peripregnancy, pregnancy, and only preconception. Peripregnancy cannabis exposure was reported for 6.0% of children with and 4.6% of children without ASD symptoms. Preconception-only cannabis use (versus no use) was associated with more aggressive behavior, emotional reactivity, and sleep problems in children with ASD symptoms, but not in children without ASD symptoms. Cannabis use during pregnancy was associated with increased attention and sleep problems in children with ASD symptoms; these associations did not differ significantly by ASD symptoms. Peripregnancy cannabis use was not associated with child developmental abilities regardless of ASD symptoms. In summary, associations of peripregnancy cannabis use with some behavioral outcomes differed in children with and without ASD symptoms. With rising cannabis use among pregnant women, future studies that examine a range of developmental risks associated with timing and patterns of cannabis use prior to conception as well as during pregnancy could inform clinical guidance. En ligne : https://doi.org/10.1002/aur.3284 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Associations of maternal peripregnancy cannabis use with behavioral and developmental outcomes in children with and without symptoms of autism spectrum disorder: Study to Explore Early Development : Autism Research [texte imprimé] / Carolyn G. DIGUISEPPI, Auteur ; Tessa CRUME, Auteur ; Brady HOLST, Auteur ; Kaylynn AIONA, Auteur ; Julia VAN DYKE, Auteur ; Lisa A. CROEN, Auteur ; Julie L. DANIELS, Auteur ; Sandra FRIEDMAN, Auteur ; Katherine R. SABOURIN, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa WIGGINS, Auteur ; Gayle C. WINDHAM, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur . - p.202-216. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.202-216 Mots-clés : autism spectrum disorder  cannabis  child behavior  child preschool  developmental disabilities  pregnancy  prenatal risk factors  sleep wake disorders Index. décimale : PER Périodiques Résumé : Abstract Some studies report increased prevalence of autism spectrum disorder (ASD) and associated symptoms with prenatal cannabis exposure. We examined whether associations of maternal cannabis use from 3 months preconception through delivery (?peripregnancy?) with behavior and development in the offspring varied with the presence of ASD symptoms. Children ages 30 68 months with ASD symptoms (i.e., met study criteria for ASD or had ASD symptoms on standardized assessments or community ASD diagnosis, N 2734) and without ASD symptoms (other developmental delay/disorders or general population sample, N 3454) were evaluated with the Child Behavior Checklist and Mullen Scales of Early Learning. We examined cannabis use during three time periods: peripregnancy, pregnancy, and only preconception. Peripregnancy cannabis exposure was reported for 6.0% of children with and 4.6% of children without ASD symptoms. Preconception-only cannabis use (versus no use) was associated with more aggressive behavior, emotional reactivity, and sleep problems in children with ASD symptoms, but not in children without ASD symptoms. Cannabis use during pregnancy was associated with increased attention and sleep problems in children with ASD symptoms; these associations did not differ significantly by ASD symptoms. Peripregnancy cannabis use was not associated with child developmental abilities regardless of ASD symptoms. In summary, associations of peripregnancy cannabis use with some behavioral outcomes differed in children with and without ASD symptoms. With rising cannabis use among pregnant women, future studies that examine a range of developmental risks associated with timing and patterns of cannabis use prior to conception as well as during pregnancy could inform clinical guidance. En ligne : https://doi.org/10.1002/aur.3284 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED) / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3183-3194 Titre : Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED) Type de document : texte imprimé Auteurs : Lisa D. WIGGINS, Auteur ; Susan E. LEVY, Auteur ; Julie L. DANIELS, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa BLASKEY, Auteur ; Ellen GIARELLI, Auteur ; Li-Ching LEE, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Ann REYNOLDS, Auteur ; Catherine E. RICE, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Patrick THOMPSON, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Lisa YOUNG, Auteur ; Diana SCHENDEL, Auteur Article en page(s) : p.3183-3194 Langues : Anglais (eng) Mots-clés : Autism  Etiology  Symptoms  Phenotype  Study to Explore Early Development Index. décimale : PER Périodiques Résumé : This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses. En ligne : http://dx.doi.org/10.1007/s10803-015-2476-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED) [texte imprimé] / Lisa D. WIGGINS, Auteur ; Susan E. LEVY, Auteur ; Julie L. DANIELS, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa BLASKEY, Auteur ; Ellen GIARELLI, Auteur ; Li-Ching LEE, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Ann REYNOLDS, Auteur ; Catherine E. RICE, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Patrick THOMPSON, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Lisa YOUNG, Auteur ; Diana SCHENDEL, Auteur . - p.3183-3194. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3183-3194 Mots-clés : Autism  Etiology  Symptoms  Phenotype  Study to Explore Early Development Index. décimale : PER Périodiques Résumé : This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses. En ligne : http://dx.doi.org/10.1007/s10803-015-2476-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Brief Report: Excluding the ADI-R Behavioral Domain Improves Diagnostic Agreement in Toddlers / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 38-5 (May 2008)  

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Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children / Eric RUBENSTEIN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

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Brief Report: Prevalence of Self-injurious Behaviors among Children with Autism Spectrum Disorder—A Population-Based Study / Gnakub N. SOKE in Journal of Autism and Developmental Disorders, 46-11 (November 2016)  

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Brief Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 39-7 (July 2009)  

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Brief Report: The ADOS Calibrated Severity Score Best Measures Autism Diagnostic Symptom Severity in Pre-School Children / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

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Community-based service use in preschool children with autism spectrum disorder and associations with insurance status / Eric RUBENSTEIN in Research in Autism Spectrum Disorders, 66 (October 2019)  

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Comparison of a broad-based screen versus disorder-specific screen in detecting young children with an autism spectrum disorder / Lisa D. WIGGINS in Autism, 18-2 (February 2014)  

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Correction to: Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children / Eric RUBENSTEIN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

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Correction to: Defining in Detail and Evaluating Reliability of DSM-5 Criteria for Autism Spectrum Disorder (ASD) Among Children / Catherine E. RICE in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

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Defining in Detail and Evaluating Reliability of DSM-5 Criteria for Autism Spectrum Disorder (ASD) Among Children / Catherine E. RICE in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

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