ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development / S. E. LEVY in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2348-2357 Titre : ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : S. E. LEVY, Auteur ; L. A. RESCORLA, Auteur ; J. L. CHITTAMS, Auteur ; T. J. KRAL, Auteur ; E. J. MOODY, Auteur ; J. PANDEY, Auteur ; J. A. PINTO-MARTIN, Auteur ; A. T. POMYKACZ, Auteur ; A. RAMIREZ, Auteur ; N. REYES, Auteur ; C. R. ROSENBERG, Auteur ; Laura A. SCHIEVE, Auteur ; A. THOMPSON, Auteur ; Larry J. YOUNG, Auteur ; J. ZHANG, Auteur ; Lisa D. WIGGINS, Auteur Article en page(s) : p.2348-2357 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Child Behavior Checklist (CBCL)  Developmental delay (DD) Index. décimale : PER Périodiques Résumé : We analyzed CBCL/1(1/2)-5 Pervasive Developmental Problems (DSM-PDP) scores in 3- to 5-year-olds from the Study to Explore Early Development (SEED), a multi-site case control study, with the objective to discriminate children with ASD (N = 656) from children with Developmental Delay (DD) (N = 646), children with Developmental Delay (DD) plus ASD features (DD-AF) (N = 284), and population controls (POP) (N = 827). ASD diagnosis was confirmed with the ADOS and ADI-R. With a cut-point of T >/= 65, sensitivity was 80% for ASD, with specificity varying across groups: POP (0.93), DD-noAF (0.85), and DD-AF (0.50). One-way ANOVA yielded a large group effect (eta(2) = 0.50). Our results support the CBCL/1(1/2)-5's as a time-efficient ASD screener for identifying preschoolers needing further evaluation. En ligne : https://dx.doi.org/10.1007/s10803-019-03895-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development [Texte imprimé et/ou numérique] / S. E. LEVY, Auteur ; L. A. RESCORLA, Auteur ; J. L. CHITTAMS, Auteur ; T. J. KRAL, Auteur ; E. J. MOODY, Auteur ; J. PANDEY, Auteur ; J. A. PINTO-MARTIN, Auteur ; A. T. POMYKACZ, Auteur ; A. RAMIREZ, Auteur ; N. REYES, Auteur ; C. R. ROSENBERG, Auteur ; Laura A. SCHIEVE, Auteur ; A. THOMPSON, Auteur ; Larry J. YOUNG, Auteur ; J. ZHANG, Auteur ; Lisa D. WIGGINS, Auteur . - p.2348-2357. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2348-2357 Mots-clés : Autism spectrum disorder (ASD)  Child Behavior Checklist (CBCL)  Developmental delay (DD) Index. décimale : PER Périodiques Résumé : We analyzed CBCL/1(1/2)-5 Pervasive Developmental Problems (DSM-PDP) scores in 3- to 5-year-olds from the Study to Explore Early Development (SEED), a multi-site case control study, with the objective to discriminate children with ASD (N = 656) from children with Developmental Delay (DD) (N = 646), children with Developmental Delay (DD) plus ASD features (DD-AF) (N = 284), and population controls (POP) (N = 827). ASD diagnosis was confirmed with the ADOS and ADI-R. With a cut-point of T >/= 65, sensitivity was 80% for ASD, with specificity varying across groups: POP (0.93), DD-noAF (0.85), and DD-AF (0.50). One-way ANOVA yielded a large group effect (eta(2) = 0.50). Our results support the CBCL/1(1/2)-5's as a time-efficient ASD screener for identifying preschoolers needing further evaluation. En ligne : https://dx.doi.org/10.1007/s10803-019-03895-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Early life influences on child weight outcomes in the Study to Explore Early Development / T. V. KRAL in Autism, 23-4 (May 2019)  

Public ISBD [article]  inAutism > 23-4 (May 2019) . - p.954-962 Titre : Early life influences on child weight outcomes in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : T. V. KRAL, Auteur ; J. CHITTAMS, Auteur ; C. B. BRADLEY, Auteur ; Julie L. DANIELS, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; S. L. JOHNSON, Auteur ; J. PANDEY, Auteur ; J. A. PINTO-MARTIN, Auteur ; N. RAHAI, Auteur ; A. RAMIREZ, Auteur ; Laura A. SCHIEVE, Auteur ; A. THOMPSON, Auteur ; G. WINDHAM, Auteur ; W. YORK, Auteur ; Larry J. YOUNG, Auteur ; S. E. LEVY, Auteur Article en page(s) : p.954-962 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  gestational weight gain  maternal obesity  medical comorbidity  obesity Index. décimale : PER Périodiques Résumé : We examined associations between child body mass index at 2-5 years and maternal pre-pregnancy body mass index, gestational weight gain, and rapid weight gain during infancy in children with autism spectrum disorder, developmental delays, or population controls. The Study to Explore Early Development is a multi-site case-control study of children, aged 2-5 years, classified as autism spectrum disorder ( n = 668), developmental delays ( n = 914), or population controls ( n = 884). Maternal gestational weight gain was compared to the Institute of Medicine recommendations. Rapid weight gain was a change in weight-for-age z-scores from birth to 6 months > 0.67 standard deviations. After adjusting for case status, mothers with pre-pregnancy overweight/obesity were 2.38 times (95% confidence interval: 1.96-2.90) more likely, and mothers who exceeded gestational weight gain recommendations were 1.48 times (95% confidence interval: 1.17-1.87) more likely, to have an overweight/obese child than other mothers ( P < 0.001). Children with autism spectrum disorder showed the highest frequency of rapid weight gain (44%) and were 3.47 times (95% confidence interval: 1.85-6.51) more likely to be overweight/obese as children with autism spectrum disorder without rapid weight gain ( P < 0.001). Helping mothers achieve a healthy pre-pregnancy body mass index and gestational weight gain represent important targets for all children. Healthy infant growth patterns carry special importance for children at increased risk for an autism spectrum disorder diagnosis. En ligne : http://dx.doi.org/10.1177/1362361318791545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Early life influences on child weight outcomes in the Study to Explore Early Development [Texte imprimé et/ou numérique] / T. V. KRAL, Auteur ; J. CHITTAMS, Auteur ; C. B. BRADLEY, Auteur ; Julie L. DANIELS, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; S. L. JOHNSON, Auteur ; J. PANDEY, Auteur ; J. A. PINTO-MARTIN, Auteur ; N. RAHAI, Auteur ; A. RAMIREZ, Auteur ; Laura A. SCHIEVE, Auteur ; A. THOMPSON, Auteur ; G. WINDHAM, Auteur ; W. YORK, Auteur ; Larry J. YOUNG, Auteur ; S. E. LEVY, Auteur . - p.954-962. Langues : Anglais (eng) in Autism > 23-4 (May 2019) . - p.954-962 Mots-clés : autism spectrum disorder  gestational weight gain  maternal obesity  medical comorbidity  obesity Index. décimale : PER Périodiques Résumé : We examined associations between child body mass index at 2-5 years and maternal pre-pregnancy body mass index, gestational weight gain, and rapid weight gain during infancy in children with autism spectrum disorder, developmental delays, or population controls. The Study to Explore Early Development is a multi-site case-control study of children, aged 2-5 years, classified as autism spectrum disorder ( n = 668), developmental delays ( n = 914), or population controls ( n = 884). Maternal gestational weight gain was compared to the Institute of Medicine recommendations. Rapid weight gain was a change in weight-for-age z-scores from birth to 6 months > 0.67 standard deviations. After adjusting for case status, mothers with pre-pregnancy overweight/obesity were 2.38 times (95% confidence interval: 1.96-2.90) more likely, and mothers who exceeded gestational weight gain recommendations were 1.48 times (95% confidence interval: 1.17-1.87) more likely, to have an overweight/obese child than other mothers ( P < 0.001). Children with autism spectrum disorder showed the highest frequency of rapid weight gain (44%) and were 3.47 times (95% confidence interval: 1.85-6.51) more likely to be overweight/obese as children with autism spectrum disorder without rapid weight gain ( P < 0.001). Helping mothers achieve a healthy pre-pregnancy body mass index and gestational weight gain represent important targets for all children. Healthy infant growth patterns carry special importance for children at increased risk for an autism spectrum disorder diagnosis. En ligne : http://dx.doi.org/10.1177/1362361318791545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Examining Trajectories of Daily Living Skills over the Preschool Years for Children with Autism Spectrum Disorder / B. DI REZZE in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4390-4399 Titre : Examining Trajectories of Daily Living Skills over the Preschool Years for Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : B. DI REZZE, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; J. VOLDEN, Auteur ; S. GEORGIADES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur ; T. VAILLANCOURT, Auteur ; Teresa BENNETT, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur ; W. J. UNGAR, Auteur ; C. WADDELL, Auteur Article en page(s) : p.4390-4399 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Daily living skills  Preschool  Vineland Adaptive Behavior Scales Index. décimale : PER Périodiques Résumé : Preschool children with autism spectrum disorder (ASD) experience slower development of daily living skills (DLS) that are essential for independent functioning compared to typically developing children. Few studies have examined the trajectories of DLS in preschoolers with ASD and the existing literature has reported conflicting results. This study examined DLS trajectories and potential covariates for preschoolers with ASD from a multi-site longitudinal study following children from diagnosis to the end of grade 1. Multi-level modeling was conducted with DLS domain scores from the Vineland Adaptive Behavior Scales-2. The results demonstrated a positive trajectory of increasing scores over time, associations of age of diagnosis, developmental level, stereotypy, and language skills with the mean score at T4 or age 6 years, whereas rate of change was only associated with ASD symptom severity, such that an improvement in DLS trajectory was associated with lower and improving ASD symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-019-04150-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Examining Trajectories of Daily Living Skills over the Preschool Years for Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / B. DI REZZE, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; J. VOLDEN, Auteur ; S. GEORGIADES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur ; T. VAILLANCOURT, Auteur ; Teresa BENNETT, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur ; W. J. UNGAR, Auteur ; C. WADDELL, Auteur . - p.4390-4399. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4390-4399 Mots-clés : Autism spectrum disorder  Daily living skills  Preschool  Vineland Adaptive Behavior Scales Index. décimale : PER Périodiques Résumé : Preschool children with autism spectrum disorder (ASD) experience slower development of daily living skills (DLS) that are essential for independent functioning compared to typically developing children. Few studies have examined the trajectories of DLS in preschoolers with ASD and the existing literature has reported conflicting results. This study examined DLS trajectories and potential covariates for preschoolers with ASD from a multi-site longitudinal study following children from diagnosis to the end of grade 1. Multi-level modeling was conducted with DLS domain scores from the Vineland Adaptive Behavior Scales-2. The results demonstrated a positive trajectory of increasing scores over time, associations of age of diagnosis, developmental level, stereotypy, and language skills with the mean score at T4 or age 6 years, whereas rate of change was only associated with ASD symptom severity, such that an improvement in DLS trajectory was associated with lower and improving ASD symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-019-04150-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees / M. WOODBURY-SMITH in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 20 p. Titre : A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees Type de document : Texte imprimé et/ou numérique Auteurs : M. WOODBURY-SMITH, Auteur ; Andrew D. PATERSON, Auteur ; I. O'CONNOR, Auteur ; M. ZARREI, Auteur ; R. K. C. YUEN, Auteur ; J. L. HOWE, Auteur ; A. THOMPSON, Auteur ; M. PARLIER, Auteur ; B. FERNANDEZ, Auteur ; J. PIVEN, Auteur ; Stephen SCHERER, Auteur ; V. VIELAND, Auteur ; P. SZATMARI, Auteur Année de publication : 2018 Article en page(s) : 20 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Extended pedigrees  Family genetics  Genome-wide linkage  Posterior probability of linkage (PPL) Index. décimale : PER Périodiques Résumé : BACKGROUND: Although several genetic variants for autism spectrum disorder (ASD) have now been identified, these largely occur sporadically or are de novo. Much less progress has been made in identifying inherited variants, even though the disorder itself is familial in the majority of cases. The objective of this study was to identify chromosomal regions that harbor inherited variants increasing the risk for ASD using an approach that examined both ASD and the broad autism phenotype (BAP) among a unique sample of extended pedigrees. METHODS: ASD and BAP were assessed using standardized tools in 28 pedigrees from Canada and the USA, each with at least three ASD-diagnosed individuals from two nuclear families. Genome-wide linkage analysis was performed using the posterior probability of linkage (PPL) statistic, a quasi-Bayesian method that provides strength of evidence for or against linkage in an essentially model-free manner, with outcomes on the probability scale. RESULTS: The results confirm appreciable interfamilial heterogeneity as well as a high level of intrafamilial heterogeneity. Both ASD and combined ASD/BAP specific loci are apparent. CONCLUSIONS: Inclusion of subclinical phenotypes such as BAP should be more widely employed in genetic studies of ASD as a way of identifying inherited genetic variants for the disorder. Moreover, the results underscore the need for approaches to identifying genetic risk factors in extended pedigrees that are robust to high levels of inter/intrafamilial locus and allelic heterogeneity. En ligne : http://dx.doi.org/10.1186/s11689-018-9238-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees [Texte imprimé et/ou numérique] / M. WOODBURY-SMITH, Auteur ; Andrew D. PATERSON, Auteur ; I. O'CONNOR, Auteur ; M. ZARREI, Auteur ; R. K. C. YUEN, Auteur ; J. L. HOWE, Auteur ; A. THOMPSON, Auteur ; M. PARLIER, Auteur ; B. FERNANDEZ, Auteur ; J. PIVEN, Auteur ; Stephen SCHERER, Auteur ; V. VIELAND, Auteur ; P. SZATMARI, Auteur . - 2018 . - 20 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 20 p. Mots-clés : Autism spectrum disorder (ASD)  Extended pedigrees  Family genetics  Genome-wide linkage  Posterior probability of linkage (PPL) Index. décimale : PER Périodiques Résumé : BACKGROUND: Although several genetic variants for autism spectrum disorder (ASD) have now been identified, these largely occur sporadically or are de novo. Much less progress has been made in identifying inherited variants, even though the disorder itself is familial in the majority of cases. The objective of this study was to identify chromosomal regions that harbor inherited variants increasing the risk for ASD using an approach that examined both ASD and the broad autism phenotype (BAP) among a unique sample of extended pedigrees. METHODS: ASD and BAP were assessed using standardized tools in 28 pedigrees from Canada and the USA, each with at least three ASD-diagnosed individuals from two nuclear families. Genome-wide linkage analysis was performed using the posterior probability of linkage (PPL) statistic, a quasi-Bayesian method that provides strength of evidence for or against linkage in an essentially model-free manner, with outcomes on the probability scale. RESULTS: The results confirm appreciable interfamilial heterogeneity as well as a high level of intrafamilial heterogeneity. Both ASD and combined ASD/BAP specific loci are apparent. CONCLUSIONS: Inclusion of subclinical phenotypes such as BAP should be more widely employed in genetic studies of ASD as a way of identifying inherited genetic variants for the disorder. Moreover, the results underscore the need for approaches to identifying genetic risk factors in extended pedigrees that are robust to high levels of inter/intrafamilial locus and allelic heterogeneity. En ligne : http://dx.doi.org/10.1186/s11689-018-9238-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles / Teresa BENNETT in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2797-2808 Titre : Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; K. GEORGIADES, Auteur ; S. HANNA, Auteur ; M. JANUS, Auteur ; S. GEORGIADES, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; E. FOMBONNE, Auteur ; I. M. SMITH, Auteur ; P. MIRENDA, Auteur ; J. VOLDEN, Auteur ; C. WADDELL, Auteur ; W. ROBERTS, Auteur ; T. VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur Article en page(s) : p.2797-2808 Langues : Anglais (eng) Mots-clés : Social competence  Language impairment  DSM-5  Autism spectrum disorders  Longitudinal epidemiology Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and structural language impairment (LI) may be at risk of more adverse social-developmental outcomes. We examined trajectories of early social competence (using the Vineland-II) in 330 children aged 2–4 years recently diagnosed with ASD, and compared 3 subgroups classified by: language impairment (ASD/LI); intellectual disability (ASD/ID) and ASD without LI or ID (ASD/alone). Children with ASD/LI were significantly more socially impaired at baseline than the ASD/alone subgroup, and less impaired than those with ASD/ID. Growth in social competence was significantly slower for the ASD/ID group. Many preschool-aged children with ASD/LI at time of diagnosis resembled “late talkers” who appeared to catch up linguistically. Children with ASD/ID were more severely impaired and continued to lag further behind. En ligne : http://dx.doi.org/10.1007/s10803-014-2138-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; K. GEORGIADES, Auteur ; S. HANNA, Auteur ; M. JANUS, Auteur ; S. GEORGIADES, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; E. FOMBONNE, Auteur ; I. M. SMITH, Auteur ; P. MIRENDA, Auteur ; J. VOLDEN, Auteur ; C. WADDELL, Auteur ; W. ROBERTS, Auteur ; T. VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur . - p.2797-2808. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2797-2808 Mots-clés : Social competence  Language impairment  DSM-5  Autism spectrum disorders  Longitudinal epidemiology Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and structural language impairment (LI) may be at risk of more adverse social-developmental outcomes. We examined trajectories of early social competence (using the Vineland-II) in 330 children aged 2–4 years recently diagnosed with ASD, and compared 3 subgroups classified by: language impairment (ASD/LI); intellectual disability (ASD/ID) and ASD without LI or ID (ASD/alone). Children with ASD/LI were significantly more socially impaired at baseline than the ASD/alone subgroup, and less impaired than those with ASD/ID. Growth in social competence was significantly slower for the ASD/ID group. Many preschool-aged children with ASD/LI at time of diagnosis resembled “late talkers” who appeared to catch up linguistically. Children with ASD/ID were more severely impaired and continued to lag further behind. En ligne : http://dx.doi.org/10.1007/s10803-014-2138-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

A molecular genetic study of autism and related phenotypes in extended pedigrees / J. PIVEN in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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Mutations in RAB39B in individuals with intellectual disability, autism spectrum disorder, and macrocephaly / M. WOODBURY-SMITH in Molecular Autism, 8 (2017)  

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