Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD / Kate STEPHENS in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2663-2672 Titre : Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD Type de document : texte imprimé Auteurs : Kate STEPHENS, Auteur ; Tim J. SILK, Auteur ; Vicki ANDERSON, Auteur ; Philip L. HAZELL, Auteur ; Peter G. ENTICOTT, Auteur ; Emma SCIBERRAS, Auteur Article en page(s) : p.2663-2672 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/psychology  Child  Comorbidity  Emotions/physiology  Humans  Limbic System/physiopathology  Male  Nerve Net  Surveys and Questionnaires  White Matter  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Brain imaging Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) combined with autism spectrum disorder (ASD) symptoms (ADHD + ASD) have poorer social and emotional functioning than those with ADHD alone. However, no studies have specifically examined the associations between ASD symptoms, measures of social and emotional functioning and limbic system white matter microstructure. Tractography on the cingulum, uncinate fasciculus and fornix were performed for 151 children with (N = 78) and without (N = 73) ADHD. Participants in the ADHD group who scored 11 or above on the Social Communication Questionnaire were classified as the ADHD + ASD group (N = 16). Significant differences in mean cingulum FA were present between the control group and the ADHD (all) group, however, no significant differences were seen between the ADHD and ADHD + ASD groups. Despite this, significant associations were seen between mean FA of the left cingulum and emotional problems for the ADHD + ASD group. Results give greater insights into the specific biological basis of emotional problems in the ADHD + ASD group, indicating that the cingulum may play a role. En ligne : http://dx.doi.org/10.1007/s10803-020-04738-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD [texte imprimé] / Kate STEPHENS, Auteur ; Tim J. SILK, Auteur ; Vicki ANDERSON, Auteur ; Philip L. HAZELL, Auteur ; Peter G. ENTICOTT, Auteur ; Emma SCIBERRAS, Auteur . - p.2663-2672. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2663-2672 Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/psychology  Child  Comorbidity  Emotions/physiology  Humans  Limbic System/physiopathology  Male  Nerve Net  Surveys and Questionnaires  White Matter  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Brain imaging Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) combined with autism spectrum disorder (ASD) symptoms (ADHD + ASD) have poorer social and emotional functioning than those with ADHD alone. However, no studies have specifically examined the associations between ASD symptoms, measures of social and emotional functioning and limbic system white matter microstructure. Tractography on the cingulum, uncinate fasciculus and fornix were performed for 151 children with (N = 78) and without (N = 73) ADHD. Participants in the ADHD group who scored 11 or above on the Social Communication Questionnaire were classified as the ADHD + ASD group (N = 16). Significant differences in mean cingulum FA were present between the control group and the ADHD (all) group, however, no significant differences were seen between the ADHD and ADHD + ASD groups. Despite this, significant associations were seen between mean FA of the left cingulum and emotional problems for the ADHD + ASD group. Results give greater insights into the specific biological basis of emotional problems in the ADHD + ASD group, indicating that the cingulum may play a role. En ligne : http://dx.doi.org/10.1007/s10803-020-04738-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Categorical and dimensional approaches to the developmental relationship between ADHD and irritability / Rania JOHNS-MEAD in Journal of Child Psychology and Psychiatry, 64-10 (October 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1422-1431 Titre : Categorical and dimensional approaches to the developmental relationship between ADHD and irritability Type de document : texte imprimé Auteurs : Rania JOHNS-MEAD, Auteur ; Nandita VIJAYAKUMAR, Auteur ; Melissa MULRANEY, Auteur ; Glenn MELVIN, Auteur ; George YOUSSEF, Auteur ; Emma SCIBERRAS, Auteur ; Vicki ANDERSON, Auteur ; Jan M. NICHOLSON, Auteur ; Daryl EFRON, Auteur ; Philip HAZEL, Auteur ; Tim J. SILK, Auteur Article en page(s) : p.1422-1431 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and irritability commonly co-occur, and follow similar developmental trajectories from childhood to adolescence. Understanding of the developmental relationship between these co-occurrences is limited. This study provides a longitudinal assessment of how ADHD diagnostic status and symptom patterns predict change in irritability. Methods A community sample of 337 participants (45.2% ADHD), recruited for the Childhood Attention Project, completed the Affective Reactivity Index (ARI) to measure irritability at baseline (mean age 10.5 years) and follow-up after 18-months. Latent change score models were used to assess how (a) baseline ADHD vs. control group status, (b) baseline symptom domain (inattention, hyperactivity-impulsivity) and (c) longitudinal change in ADHD symptom severity predicted change in irritability. Results Irritability was significantly higher among the ADHD group than controls; however, change in irritability over time did not differ between groups. When assessed across the entire cohort, change in irritability was predicted by higher symptom count in the hyperactive-impulsive domain, but not the inattentive domain. Greater declines in ADHD symptoms over time significantly predicted greater declines in irritability. Baseline ADHD symptom severity was found to significantly predict change in irritability; however, baseline irritability did not significantly predict change in ADHD symptoms. Conclusions ADHD symptoms-particularly hyperactive-impulsive symptoms-predict the degree and trajectory of irritability during childhood and adolescence, even when symptoms are below diagnostic thresholds. The use of longitudinal, dimensional and symptom domain-specific measures provides additional insight into this relationship. En ligne : https://doi.org/10.1111/jcpp.13818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Categorical and dimensional approaches to the developmental relationship between ADHD and irritability [texte imprimé] / Rania JOHNS-MEAD, Auteur ; Nandita VIJAYAKUMAR, Auteur ; Melissa MULRANEY, Auteur ; Glenn MELVIN, Auteur ; George YOUSSEF, Auteur ; Emma SCIBERRAS, Auteur ; Vicki ANDERSON, Auteur ; Jan M. NICHOLSON, Auteur ; Daryl EFRON, Auteur ; Philip HAZEL, Auteur ; Tim J. SILK, Auteur . - p.1422-1431. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1422-1431 Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and irritability commonly co-occur, and follow similar developmental trajectories from childhood to adolescence. Understanding of the developmental relationship between these co-occurrences is limited. This study provides a longitudinal assessment of how ADHD diagnostic status and symptom patterns predict change in irritability. Methods A community sample of 337 participants (45.2% ADHD), recruited for the Childhood Attention Project, completed the Affective Reactivity Index (ARI) to measure irritability at baseline (mean age 10.5 years) and follow-up after 18-months. Latent change score models were used to assess how (a) baseline ADHD vs. control group status, (b) baseline symptom domain (inattention, hyperactivity-impulsivity) and (c) longitudinal change in ADHD symptom severity predicted change in irritability. Results Irritability was significantly higher among the ADHD group than controls; however, change in irritability over time did not differ between groups. When assessed across the entire cohort, change in irritability was predicted by higher symptom count in the hyperactive-impulsive domain, but not the inattentive domain. Greater declines in ADHD symptoms over time significantly predicted greater declines in irritability. Baseline ADHD symptom severity was found to significantly predict change in irritability; however, baseline irritability did not significantly predict change in ADHD symptoms. Conclusions ADHD symptoms-particularly hyperactive-impulsive symptoms-predict the degree and trajectory of irritability during childhood and adolescence, even when symptoms are below diagnostic thresholds. The use of longitudinal, dimensional and symptom domain-specific measures provides additional insight into this relationship. En ligne : https://doi.org/10.1111/jcpp.13818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Delineating the autistic phenotype in children with neurofibromatosis type 1 / Anita K. CHISHOLM in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 3p. Titre : Delineating the autistic phenotype in children with neurofibromatosis type 1 Type de document : texte imprimé Auteurs : Anita K. CHISHOLM, Auteur ; Kristina M. HAEBICH, Auteur ; Natalie A. PRIDE, Auteur ; Karin S. WALSH, Auteur ; Francesca LAMI, Auteur ; Alexandra URE, Auteur ; Tiba MALOOF, Auteur ; Amanda BRIGNELL, Auteur ; Melissa ROUEL, Auteur ; Yael GRANADER, Auteur ; Alice MAIER, Auteur ; Belinda BARTON, Auteur ; Hayley DARKE, Auteur ; Gabriel DABSCHECK, Auteur ; Vicki ANDERSON, Auteur ; Katrina WILLIAMS, Auteur ; Kathryn N. NORTH, Auteur ; Jonathan M. PAYNE, Auteur Article en page(s) : 3p. Langues : Anglais (eng) Mots-clés : Autism  Autism Diagnostic Interview-Revised (ADI-R)  Autism Diagnostic Observation Schedule-Second Edition (ADOS-2)  Autistic behaviours  Neurofibromatosis type 1 Index. décimale : PER Périodiques Résumé : BACKGROUND: Existing research has demonstrated elevated autistic behaviours in children with neurofibromatosis type 1 (NF1), but the autistic phenotype and its relationship to other neurodevelopmental manifestations of NF1 remains unclear. To address this gap, we performed detailed characterisation of autistic behaviours in children with NF1 and investigated their association with other common NF1 child characteristics. METHODS: Participants were drawn from a larger cross-sectional study examining autism in children with NF1. The population analysed in this study scored above threshold on the Social Responsiveness Scale-Second Edition (T-score ≥ 60; 51% larger cohort) and completed the Autism Diagnostic Interview-Revised (ADI-R) and/or the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). All participants underwent evaluation of their intellectual function, and behavioural data were collected via parent questionnaires. RESULTS: The study cohort comprised 68 children (3-15 years). Sixty-three per cent met the ADOS-2 'autism spectrum' cut-off, and 34% exceeded the more stringent threshold for 'autistic disorder' on the ADI-R. Social communication symptoms were common and wide-ranging, while restricted and repetitive behaviours (RRBs) were most commonly characterised by 'insistence on sameness' (IS) behaviours such as circumscribed interests and difficulties with minor changes. Autistic behaviours were weakly correlated with hyperactive/impulsive attention deficit hyperactivity disorder (ADHD) symptoms but not with inattentive ADHD or other behavioural characteristics. Language and verbal IQ were weakly related to social communication behaviours but not to RRBs. LIMITATIONS: Lack of genetic validation of NF1, no clinical diagnosis of autism, and a retrospective assessment of autistic behaviours in early childhood. CONCLUSIONS: Findings provide strong support for elevated autistic behaviours in children with NF1. While these behaviours were relatively independent of other NF1 comorbidities, the importance of taking broader child characteristics into consideration when interpreting data from autism-specific measures in this population is highlighted. Social communication deficits appear similar to those observed in idiopathic autism and are coupled with a unique RRB profile comprising prominent IS behaviours. This autistic phenotype and its relationship to common NF1 comorbidities such as anxiety and executive dysfunction will be important to examine in future research. Current findings have important implications for the early identification of autism in NF1 and clinical management. En ligne : http://dx.doi.org/10.1186/s13229-021-00481-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Delineating the autistic phenotype in children with neurofibromatosis type 1 [texte imprimé] / Anita K. CHISHOLM, Auteur ; Kristina M. HAEBICH, Auteur ; Natalie A. PRIDE, Auteur ; Karin S. WALSH, Auteur ; Francesca LAMI, Auteur ; Alexandra URE, Auteur ; Tiba MALOOF, Auteur ; Amanda BRIGNELL, Auteur ; Melissa ROUEL, Auteur ; Yael GRANADER, Auteur ; Alice MAIER, Auteur ; Belinda BARTON, Auteur ; Hayley DARKE, Auteur ; Gabriel DABSCHECK, Auteur ; Vicki ANDERSON, Auteur ; Katrina WILLIAMS, Auteur ; Kathryn N. NORTH, Auteur ; Jonathan M. PAYNE, Auteur . - 3p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 3p. Mots-clés : Autism  Autism Diagnostic Interview-Revised (ADI-R)  Autism Diagnostic Observation Schedule-Second Edition (ADOS-2)  Autistic behaviours  Neurofibromatosis type 1 Index. décimale : PER Périodiques Résumé : BACKGROUND: Existing research has demonstrated elevated autistic behaviours in children with neurofibromatosis type 1 (NF1), but the autistic phenotype and its relationship to other neurodevelopmental manifestations of NF1 remains unclear. To address this gap, we performed detailed characterisation of autistic behaviours in children with NF1 and investigated their association with other common NF1 child characteristics. METHODS: Participants were drawn from a larger cross-sectional study examining autism in children with NF1. The population analysed in this study scored above threshold on the Social Responsiveness Scale-Second Edition (T-score ≥ 60; 51% larger cohort) and completed the Autism Diagnostic Interview-Revised (ADI-R) and/or the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). All participants underwent evaluation of their intellectual function, and behavioural data were collected via parent questionnaires. RESULTS: The study cohort comprised 68 children (3-15 years). Sixty-three per cent met the ADOS-2 'autism spectrum' cut-off, and 34% exceeded the more stringent threshold for 'autistic disorder' on the ADI-R. Social communication symptoms were common and wide-ranging, while restricted and repetitive behaviours (RRBs) were most commonly characterised by 'insistence on sameness' (IS) behaviours such as circumscribed interests and difficulties with minor changes. Autistic behaviours were weakly correlated with hyperactive/impulsive attention deficit hyperactivity disorder (ADHD) symptoms but not with inattentive ADHD or other behavioural characteristics. Language and verbal IQ were weakly related to social communication behaviours but not to RRBs. LIMITATIONS: Lack of genetic validation of NF1, no clinical diagnosis of autism, and a retrospective assessment of autistic behaviours in early childhood. CONCLUSIONS: Findings provide strong support for elevated autistic behaviours in children with NF1. While these behaviours were relatively independent of other NF1 comorbidities, the importance of taking broader child characteristics into consideration when interpreting data from autism-specific measures in this population is highlighted. Social communication deficits appear similar to those observed in idiopathic autism and are coupled with a unique RRB profile comprising prominent IS behaviours. This autistic phenotype and its relationship to common NF1 comorbidities such as anxiety and executive dysfunction will be important to examine in future research. Current findings have important implications for the early identification of autism in NF1 and clinical management. En ligne : http://dx.doi.org/10.1186/s13229-021-00481-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury / Nicholas P. RYAN in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1150-1161 Titre : Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury Type de document : texte imprimé Auteurs : Nicholas P. RYAN, Auteur ; Cathy CATROPPA, Auteur ; Nathan HUGHES, Auteur ; Felicity L. PAINTER, Auteur ; Stephen HEARPS, Auteur ; Miriam H. BEAUCHAMP, Auteur ; Vicki ANDERSON, Auteur Article en page(s) : p.1150-1161 Langues : Anglais (eng) Mots-clés : Brain/diagnostic imaging  Brain Injuries, Traumatic/diagnostic imaging  Child  Executive Function  Humans  Longitudinal Studies  Prospective Studies  Anti-social behavior  aggression  childhood traumatic brain injury  longitudinal design  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite increasing evidence of a link between early life brain injury and anti-social behavior, very few studies have assessed factors that explain this association in children with traumatic brain injury (TBI). One hypothesis suggests that childhood TBI elevates risk for anti-social behavior via disruption to anatomically distributed neural networks implicated in executive functioning (EF). In this longitudinal prospective study, we employed high-resolution structural neuroimaging to (a) evaluate the impact of childhood TBI on regional morphometry of the central executive network (CEN) and (b) evaluate the prediction that lower EF mediates the prospective relationship between structural differences within the CEN and postinjury anti-social behaviors. METHODS: This study involved 155 children, including 112 consecutively recruited, hospital-confirmed cases of mild-severe TBI and 43 typically developing control (TDC) children. T1-weighted brain magnetic resonance imaging (MRI) sequences were acquired sub-acutely in a subset of 137 children [TBI: n = 103; TDC: n = 34]. All participants were evaluated using direct assessment of EF 6 months postinjury, and parents provided ratings of anti-social behavior 12 months postinjury. RESULTS: Severe TBI was associated with postinjury volumetric differences within the CEN and its putative hub regions. When compared with TD controls, the TBI group had significantly worse EF, which was associated with more frequent anti-social behaviors and abnormal CEN morphometry. Mediation analysis indicated that reduced EF mediated the prospective association between postinjury volumetric differences within the CEN and more frequent anti-social behavior. CONCLUSIONS: Our longitudinal prospective findings suggest that detection of neurostructural abnormalities within the CEN may aid in the early identification of children at elevated risk for postinjury executive dysfunction, which may in turn contribute to chronic anti-social behaviors after early life brain injury. Findings underscore the potential value of early surveillance and preventive measures for children presenting with neurostructural and/or neurocognitive risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury [texte imprimé] / Nicholas P. RYAN, Auteur ; Cathy CATROPPA, Auteur ; Nathan HUGHES, Auteur ; Felicity L. PAINTER, Auteur ; Stephen HEARPS, Auteur ; Miriam H. BEAUCHAMP, Auteur ; Vicki ANDERSON, Auteur . - p.1150-1161. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1150-1161 Mots-clés : Brain/diagnostic imaging  Brain Injuries, Traumatic/diagnostic imaging  Child  Executive Function  Humans  Longitudinal Studies  Prospective Studies  Anti-social behavior  aggression  childhood traumatic brain injury  longitudinal design  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite increasing evidence of a link between early life brain injury and anti-social behavior, very few studies have assessed factors that explain this association in children with traumatic brain injury (TBI). One hypothesis suggests that childhood TBI elevates risk for anti-social behavior via disruption to anatomically distributed neural networks implicated in executive functioning (EF). In this longitudinal prospective study, we employed high-resolution structural neuroimaging to (a) evaluate the impact of childhood TBI on regional morphometry of the central executive network (CEN) and (b) evaluate the prediction that lower EF mediates the prospective relationship between structural differences within the CEN and postinjury anti-social behaviors. METHODS: This study involved 155 children, including 112 consecutively recruited, hospital-confirmed cases of mild-severe TBI and 43 typically developing control (TDC) children. T1-weighted brain magnetic resonance imaging (MRI) sequences were acquired sub-acutely in a subset of 137 children [TBI: n = 103; TDC: n = 34]. All participants were evaluated using direct assessment of EF 6 months postinjury, and parents provided ratings of anti-social behavior 12 months postinjury. RESULTS: Severe TBI was associated with postinjury volumetric differences within the CEN and its putative hub regions. When compared with TD controls, the TBI group had significantly worse EF, which was associated with more frequent anti-social behaviors and abnormal CEN morphometry. Mediation analysis indicated that reduced EF mediated the prospective association between postinjury volumetric differences within the CEN and more frequent anti-social behavior. CONCLUSIONS: Our longitudinal prospective findings suggest that detection of neurostructural abnormalities within the CEN may aid in the early identification of children at elevated risk for postinjury executive dysfunction, which may in turn contribute to chronic anti-social behaviors after early life brain injury. Findings underscore the potential value of early surveillance and preventive measures for children presenting with neurostructural and/or neurocognitive risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Interruptions du développement normal chez les enfants victimes de lésions aux lobes frontaux / Vicki ANDERSON

Public ISBD contenu dans Neuropsychologie / Pierre NOLIN Titre : Interruptions du développement normal chez les enfants victimes de lésions aux lobes frontaux Type de document : texte imprimé Auteurs : Vicki ANDERSON, Auteur ; Rani JACOBS, Auteur Année de publication : 2004 Importance : p.85-106 Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=760 contenu dans Neuropsychologie / Pierre NOLIN Interruptions du développement normal chez les enfants victimes de lésions aux lobes frontaux [texte imprimé] / Vicki ANDERSON, Auteur ; Rani JACOBS, Auteur . - 2004 . - p.85-106. Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=760

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Pourquoi les fonctions exécutives sont-elles vulnérables chez les enfants cérébrolésés ? / Vicki ANDERSON

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Relationship Between Executive Functioning and Symptoms of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in 6–8 Year Old Children / Rachel Jane NEELY in Journal of Autism and Developmental Disorders, 46-10 (October 2016)  

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Research Review: Language problems in children with Attention-Deficit Hyperactivity Disorder – a systematic meta-analytic review / Hannah KORREL in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

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Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1 / Anita K. CHISHOLM in Journal of Autism and Developmental Disorders, 53-7 (July 2023)  

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TEA-Ch. Test d'Evaluation de l'Attention chez l'Enfant / Tom MANLY

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