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9-12 - December 2016 [Texte imprimé et/ou numérique] . - 2016. Langues : Anglais (eng)
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Code-barres | Cote | Support | Localisation | Section | Disponibilité |
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PER0001533 | PER ARE | Périodique | Centre d'Information et de Documentation du CRA Rhône-Alpes | PER - Périodiques | Exclu du prêt |
Dépouillements


[article]
inAutism Research > 9-12 (December 2016) . - p.1233-1236
Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1233-1236 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Issue Information [Texte imprimé et/ou numérique] . - p.1233-1236.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1233-1236
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Commentary – Autism Spectrum Disorder: Spectrum or Cluster? / John R. PRUETT in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1237-1240
Titre : Commentary – Autism Spectrum Disorder: Spectrum or Cluster? Type de document : Texte imprimé et/ou numérique Auteurs : John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur Article en page(s) : p.1237-1240 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Commentary – Autism Spectrum Disorder: Spectrum or Cluster? [Texte imprimé et/ou numérique] / John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur . - p.1237-1240.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1237-1240
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder / ?eref ?IMSEK in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1241-1247
Titre : Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : ?eref ?IMSEK, Auteur ; ?hsan ÇETIN, Auteur ; Abdullah ÇIM, Auteur ; Sava? KAYA, Auteur Article en page(s) : p.1241-1247 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder inflammation selectin tissue plasminogen activator sPECAM-1 Index. décimale : PER Périodiques Résumé : Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P?=?0.025) and E-selectin (P?=?0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r?=??0.349, P?=?0.04; r?=??0.411, P?=?0.01; r?=??0.412, P?=?0.01; r?=??0.417, P?=?0.01, and r?=??0.531, P? En ligne : http://dx.doi.org/10.1002/aur.1638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder [Texte imprimé et/ou numérique] / ?eref ?IMSEK, Auteur ; ?hsan ÇETIN, Auteur ; Abdullah ÇIM, Auteur ; Sava? KAYA, Auteur . - p.1241-1247.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1241-1247
Mots-clés : Autism spectrum disorder inflammation selectin tissue plasminogen activator sPECAM-1 Index. décimale : PER Périodiques Résumé : Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P?=?0.025) and E-selectin (P?=?0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r?=??0.349, P?=?0.04; r?=??0.411, P?=?0.01; r?=??0.412, P?=?0.01; r?=??0.417, P?=?0.01, and r?=??0.531, P? En ligne : http://dx.doi.org/10.1002/aur.1638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons / Amy E. CLIPPERTON-ALLEN in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1248-1262
Titre : Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons Type de document : Texte imprimé et/ou numérique Auteurs : Amy E. CLIPPERTON-ALLEN, Auteur ; Youjun CHEN, Auteur ; Damon T. PAGE, Auteur Article en page(s) : p.1248-1262 Langues : Anglais (eng) Mots-clés : phosphatase and tensin homolog autism spectrum disorder oxytocin social behavior anxiety-like behavior hypertrophy Index. décimale : PER Périodiques Résumé : Germline heterozygous mutations in Pten (phosphatase and tensin homolog) are associated with macrocephaly and autism spectrum disorders (ASD). Pten germline heterozygous (Pten+/?) mice approximate these mutations, and both sexes show widespread brain overgrowth and impaired social behavior. Strikingly similar behavior phenotypes have been reported in oxytocin (Oxt) and/or oxytocin receptor (OxtR) knockout mice. Thus, we hypothesized that the behavioral phenotypes of germline Pten+/? mice may be caused by reduced Pten function in Oxt-expressing cells. To investigate this, we tested mice in which Pten was conditionally deleted using oxytocin-Cre (Oxt-Cre+; PtenloxP/+, Oxt-Cre+; PtenloxP/loxP) on a battery including assays of social, repetitive, depression-like, and anxiety-like behaviors. Minimal behavioral abnormalities were found; decreased anxiety-like behavior in the open field test in Oxt-Cre+; PtenloxP/loxP males was the only result that phenocopied germline Pten+/? mice. However, Oxt cell size was dramatically increased in Oxt-Cre+; PtenloxP/loxP mice in adulthood. Thus, conditional deletion of Pten using Oxt-Cre has a profound effect on Oxt cell structure, but not on ASD-relevant behavior. We interpret these results as inconsistent with our starting hypothesis that reduced Pten function in Oxt-expressing cells causes the behavioral deficits observed in germline Pten+/? mice. En ligne : http://dx.doi.org/10.1002/aur.1641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons [Texte imprimé et/ou numérique] / Amy E. CLIPPERTON-ALLEN, Auteur ; Youjun CHEN, Auteur ; Damon T. PAGE, Auteur . - p.1248-1262.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1248-1262
Mots-clés : phosphatase and tensin homolog autism spectrum disorder oxytocin social behavior anxiety-like behavior hypertrophy Index. décimale : PER Périodiques Résumé : Germline heterozygous mutations in Pten (phosphatase and tensin homolog) are associated with macrocephaly and autism spectrum disorders (ASD). Pten germline heterozygous (Pten+/?) mice approximate these mutations, and both sexes show widespread brain overgrowth and impaired social behavior. Strikingly similar behavior phenotypes have been reported in oxytocin (Oxt) and/or oxytocin receptor (OxtR) knockout mice. Thus, we hypothesized that the behavioral phenotypes of germline Pten+/? mice may be caused by reduced Pten function in Oxt-expressing cells. To investigate this, we tested mice in which Pten was conditionally deleted using oxytocin-Cre (Oxt-Cre+; PtenloxP/+, Oxt-Cre+; PtenloxP/loxP) on a battery including assays of social, repetitive, depression-like, and anxiety-like behaviors. Minimal behavioral abnormalities were found; decreased anxiety-like behavior in the open field test in Oxt-Cre+; PtenloxP/loxP males was the only result that phenocopied germline Pten+/? mice. However, Oxt cell size was dramatically increased in Oxt-Cre+; PtenloxP/loxP mice in adulthood. Thus, conditional deletion of Pten using Oxt-Cre has a profound effect on Oxt cell structure, but not on ASD-relevant behavior. We interpret these results as inconsistent with our starting hypothesis that reduced Pten function in Oxt-expressing cells causes the behavioral deficits observed in germline Pten+/? mice. En ligne : http://dx.doi.org/10.1002/aur.1641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths / Pin-Jane CHEN in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1263-1273
Titre : Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths Type de document : Texte imprimé et/ou numérique Auteurs : Pin-Jane CHEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Shu-Hui LEE, Auteur ; Tai-Li CHOU, Auteur Article en page(s) : p.1263-1273 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD) fMRI semantic processing age-dependent Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age?=?13.3 years, standard deviation?=?2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age?=?13.3 years, standard deviation?=?2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings suggest that TD boys may engage more in higher-level processing of retrieving or selecting semantic features while boys with ASD may rely more on lower-level visual processing during semantic judgments. The findings imply different functional organizations of the semantic system between the two groups. En ligne : http://dx.doi.org/10.1002/aur.1616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths [Texte imprimé et/ou numérique] / Pin-Jane CHEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Shu-Hui LEE, Auteur ; Tai-Li CHOU, Auteur . - p.1263-1273.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1263-1273
Mots-clés : autism spectrum disorders (ASD) fMRI semantic processing age-dependent Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age?=?13.3 years, standard deviation?=?2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age?=?13.3 years, standard deviation?=?2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings suggest that TD boys may engage more in higher-level processing of retrieving or selecting semantic features while boys with ASD may rely more on lower-level visual processing during semantic judgments. The findings imply different functional organizations of the semantic system between the two groups. En ligne : http://dx.doi.org/10.1002/aur.1616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Executive function predicts the development of play skills for verbal preschoolers with autism spectrum disorders / Susan FAJA in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1274-1284
Titre : Executive function predicts the development of play skills for verbal preschoolers with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Susan FAJA, Auteur ; Geraldine DAWSON, Auteur ; Katherine SULLIVAN, Auteur ; Andrew N. MELTZOFF, Auteur ; Annette ESTES, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.1274-1284 Langues : Anglais (eng) Mots-clés : autism executive function inhibition spatial working memory play language Index. décimale : PER Périodiques Résumé : Executive function and play skills develop in early childhood and are linked to cognitive and language ability. The present study examined these abilities longitudinally in two groups with autism spectrum disorder—a group with higher initial language (n?=?30) and a group with lower initial language ability (n?=?36). Among the lower language group, concurrent nonverbal cognitive ability contributed most to individual differences in executive function and play skills. For the higher language group, executive function during preschool significantly predicted play ability at age 6 over and above intelligence, but early play did not predict later executive function. These results suggested that factors related to the development of play and executive function differ for subgroups of children with different language abilities and that early executive function skills may be critical in order for verbal children with autism to develop play. En ligne : http://dx.doi.org/10.1002/aur.1608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Executive function predicts the development of play skills for verbal preschoolers with autism spectrum disorders [Texte imprimé et/ou numérique] / Susan FAJA, Auteur ; Geraldine DAWSON, Auteur ; Katherine SULLIVAN, Auteur ; Andrew N. MELTZOFF, Auteur ; Annette ESTES, Auteur ; Raphael BERNIER, Auteur . - p.1274-1284.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1274-1284
Mots-clés : autism executive function inhibition spatial working memory play language Index. décimale : PER Périodiques Résumé : Executive function and play skills develop in early childhood and are linked to cognitive and language ability. The present study examined these abilities longitudinally in two groups with autism spectrum disorder—a group with higher initial language (n?=?30) and a group with lower initial language ability (n?=?36). Among the lower language group, concurrent nonverbal cognitive ability contributed most to individual differences in executive function and play skills. For the higher language group, executive function during preschool significantly predicted play ability at age 6 over and above intelligence, but early play did not predict later executive function. These results suggested that factors related to the development of play and executive function differ for subgroups of children with different language abilities and that early executive function skills may be critical in order for verbal children with autism to develop play. En ligne : http://dx.doi.org/10.1002/aur.1608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Reduced goal-directed action control in autism spectrum disorder / Gail A. ALVARES in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1285-1293
Titre : Reduced goal-directed action control in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gail A. ALVARES, Auteur ; Bernard W. BALLEINE, Auteur ; Lisa WHITTLE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.1285-1293 Langues : Anglais (eng) Mots-clés : goal-directed behavior habits behavioral neuroscience action control outcome devaluation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental conditions associated with persistent, stereotyped or repetitive actions, and patterns of interest that are maintained in spite of possible negative outcomes. The aim of the present study was to investigate whether impairments in the ability to execute flexible goal-directed actions may be an underlying feature in ASD contributing to these symptoms. Young adults diagnosed with ASD were recruited along with controls and adults with social anxiety disorder (SAD). Participants were trained to make keyboard actions for food outcomes and then subsequently allowed to consume one outcome till satiety. As expected, this outcome devaluation procedure reduced subsequent responding for actions predicting the devalued outcome, while maintaining responding on the other still-valued action, in controls. However, both ASD and SAD participants were unable to demonstrate flexible goal-directed actions, and were insensitive to the change in outcome value on subsequent action control. This behavioral deficit was not due to impairments in appropriate contingency awareness, as all groups rated the devalued food outcome as less pleasant after devaluation. A lack of control over actions may underlie persistent and habitual actions in anxiety-inducing contexts typical in both ASD and SAD, such as avoidance and safety behaviors. Using a translational behavioral paradigm, this study demonstrated that individuals with ASD are unable to use changes in the environment to flexibly update their behavior in the same context. This reduced behavioral control may underlie persistence of intrusive actions and restricted inflexible cognition, representing a specific area for targeted behavioral interventions. En ligne : http://dx.doi.org/10.1002/aur.1613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Reduced goal-directed action control in autism spectrum disorder [Texte imprimé et/ou numérique] / Gail A. ALVARES, Auteur ; Bernard W. BALLEINE, Auteur ; Lisa WHITTLE, Auteur ; Adam J. GUASTELLA, Auteur . - p.1285-1293.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1285-1293
Mots-clés : goal-directed behavior habits behavioral neuroscience action control outcome devaluation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental conditions associated with persistent, stereotyped or repetitive actions, and patterns of interest that are maintained in spite of possible negative outcomes. The aim of the present study was to investigate whether impairments in the ability to execute flexible goal-directed actions may be an underlying feature in ASD contributing to these symptoms. Young adults diagnosed with ASD were recruited along with controls and adults with social anxiety disorder (SAD). Participants were trained to make keyboard actions for food outcomes and then subsequently allowed to consume one outcome till satiety. As expected, this outcome devaluation procedure reduced subsequent responding for actions predicting the devalued outcome, while maintaining responding on the other still-valued action, in controls. However, both ASD and SAD participants were unable to demonstrate flexible goal-directed actions, and were insensitive to the change in outcome value on subsequent action control. This behavioral deficit was not due to impairments in appropriate contingency awareness, as all groups rated the devalued food outcome as less pleasant after devaluation. A lack of control over actions may underlie persistent and habitual actions in anxiety-inducing contexts typical in both ASD and SAD, such as avoidance and safety behaviors. Using a translational behavioral paradigm, this study demonstrated that individuals with ASD are unable to use changes in the environment to flexibly update their behavior in the same context. This reduced behavioral control may underlie persistence of intrusive actions and restricted inflexible cognition, representing a specific area for targeted behavioral interventions. En ligne : http://dx.doi.org/10.1002/aur.1613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Aging and autism spectrum disorder: Evidence from the broad autism phenotype / Gregory L. WALLACE in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1294-1303
Titre : Aging and autism spectrum disorder: Evidence from the broad autism phenotype Type de document : Texte imprimé et/ou numérique Auteurs : Gregory L. WALLACE, Auteur ; Jessica BUDGETT, Auteur ; Rebecca A. CHARLTON, Auteur Article en page(s) : p.1294-1303 Langues : Anglais (eng) Mots-clés : broad autism phenotype autism aging older adulthood executive function anxiety depression social support Index. décimale : PER Périodiques Résumé : This study investigated for the first time the broad autism phenotype (BAP) in the context of older adulthood and its associations with real-world executive function, social support, and both depression and anxiety symptomatology. Based on self-ratings of autistic traits, 66 older adults (60+ years old, range?=?61–88) were split into BAP (n?=?20) and control (n?=?46) groups. Individuals in the BAP group, even after controlling for age, education level, sex, and health problems, exhibited more real-world executive function problems in multiple domains, reported lower levels of social support, and self-rated increased depression and anxiety symptomatology compared to the control group. Regression analysis revealed that level of social support was the strongest predictor of BAP traits across both groups, although real-world executive function problems and depression symptomatology were also significant predictors. Moreover, when predicting anxiety and depression symptomatology, BAP traits were the strongest predictors above and beyond the effects of demographic factors, real-world executive function problems, and social support levels. These findings suggest that the BAP in older adulthood imparts additional risks to areas of functioning that are known to be crucial to aging-related outcomes in the context of typical development. These results might in turn inform aging in autism spectrum disorder, which has been largely unexplored to date. En ligne : http://dx.doi.org/10.1002/aur.1620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Aging and autism spectrum disorder: Evidence from the broad autism phenotype [Texte imprimé et/ou numérique] / Gregory L. WALLACE, Auteur ; Jessica BUDGETT, Auteur ; Rebecca A. CHARLTON, Auteur . - p.1294-1303.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1294-1303
Mots-clés : broad autism phenotype autism aging older adulthood executive function anxiety depression social support Index. décimale : PER Périodiques Résumé : This study investigated for the first time the broad autism phenotype (BAP) in the context of older adulthood and its associations with real-world executive function, social support, and both depression and anxiety symptomatology. Based on self-ratings of autistic traits, 66 older adults (60+ years old, range?=?61–88) were split into BAP (n?=?20) and control (n?=?46) groups. Individuals in the BAP group, even after controlling for age, education level, sex, and health problems, exhibited more real-world executive function problems in multiple domains, reported lower levels of social support, and self-rated increased depression and anxiety symptomatology compared to the control group. Regression analysis revealed that level of social support was the strongest predictor of BAP traits across both groups, although real-world executive function problems and depression symptomatology were also significant predictors. Moreover, when predicting anxiety and depression symptomatology, BAP traits were the strongest predictors above and beyond the effects of demographic factors, real-world executive function problems, and social support levels. These findings suggest that the BAP in older adulthood imparts additional risks to areas of functioning that are known to be crucial to aging-related outcomes in the context of typical development. These results might in turn inform aging in autism spectrum disorder, which has been largely unexplored to date. En ligne : http://dx.doi.org/10.1002/aur.1620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Relations between language and cognition in native-signing children with autism spectrum disorder / Aaron SHIELD in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1304-1315
Titre : Relations between language and cognition in native-signing children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Aaron SHIELD, Auteur ; Jennie PYERS, Auteur ; Amber MARTIN, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.1304-1315 Langues : Anglais (eng) Mots-clés : theory of mind social cognition developmental psychology cognitive neuroscience Index. décimale : PER Périodiques Résumé : Two populations have been found to exhibit delays in theory of mind (ToM): deaf children of hearing parents and children with autism spectrum disorder (ASD). Deaf children exposed to sign from birth by their deaf parents, however, show no such delay, suggesting that early language exposure is key to ToM development. Sign languages also present frequent opportunities with visual perspective-taking (VPT), leading to the question of whether sign exposure could benefit children with ASD. We present the first study of children with ASD exposed to sign from birth by their deaf parents. Seventeen native-signing children with a confirmed ASD diagnosis and a chronological- and mental age-matched control group of 18 typically developing (TD) native-signing deaf children were tested on American Sign Language (ASL) comprehension, two minimally verbal social cognition tasks (ToM and VPT), and one spatial cognition task (mental rotation). The TD children outperformed the children with ASD on ASL comprehension (p? En ligne : http://dx.doi.org/10.1002/aur.1621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Relations between language and cognition in native-signing children with autism spectrum disorder [Texte imprimé et/ou numérique] / Aaron SHIELD, Auteur ; Jennie PYERS, Auteur ; Amber MARTIN, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.1304-1315.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1304-1315
Mots-clés : theory of mind social cognition developmental psychology cognitive neuroscience Index. décimale : PER Périodiques Résumé : Two populations have been found to exhibit delays in theory of mind (ToM): deaf children of hearing parents and children with autism spectrum disorder (ASD). Deaf children exposed to sign from birth by their deaf parents, however, show no such delay, suggesting that early language exposure is key to ToM development. Sign languages also present frequent opportunities with visual perspective-taking (VPT), leading to the question of whether sign exposure could benefit children with ASD. We present the first study of children with ASD exposed to sign from birth by their deaf parents. Seventeen native-signing children with a confirmed ASD diagnosis and a chronological- and mental age-matched control group of 18 typically developing (TD) native-signing deaf children were tested on American Sign Language (ASL) comprehension, two minimally verbal social cognition tasks (ToM and VPT), and one spatial cognition task (mental rotation). The TD children outperformed the children with ASD on ASL comprehension (p? En ligne : http://dx.doi.org/10.1002/aur.1621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Sensory subtypes and associated outcomes in children with autism spectrum disorders / Karla K. AUSDERAU in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1316-1327
Titre : Sensory subtypes and associated outcomes in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Karla K. AUSDERAU, Auteur ; John SIDERIS, Auteur ; Lauren M. LITTLE, Auteur ; Melissa FURLONG, Auteur ; John C. BULLUCK, Auteur ; Grace T. BARANEK, Auteur Article en page(s) : p.1316-1327 Langues : Anglais (eng) Mots-clés : children sensory subtypes stress adaptive outcomes Index. décimale : PER Périodiques Résumé : Sensory features are prevalent and heterogeneous across children with ASD and these features have been associated with child outcomes. Identification of clinically defined sensory subtypes may enhance our understanding of unique phenotypes that have implications for etiology, prognosis, and intervention. This longitudinal study used a national online survey aimed to identify associations of previously validated sensory subtypes to specific child and family characteristics and functional outcomes [vineland adaptive behavior scale-II (VABS) and parenting stress index short form (PSI)]. The sensory experiences questionnaire-3.0 was collected from caregivers with children with ASD, ages 2–12, at two time points (Time 1, n?=?1307, Time 2, n?=?884), 1 year apart. Functional outcomes assessments were collected at the second time point. A latent profile transition analysis (LPTA) was used to test associations, and results indicated that the attenuated-preoccupied subtype presented with the significantly lowest levels of VABS adaptive behavior composite scores compared to the other three sensory subtypes. Both the VABS maladaptive behavior index and the total PSI score were significantly highest in the extreme-mixed subtype. These results underscore the clinical utility of this subtyping approach for differentiating characteristics and functional outcomes associated with clinically defined sensory phenotypes. These findings may have implications for better understanding etiology, prognosis, and more precise targets for interventions designed to ameliorate sensory difficulties, and ultimately mitigate negative developmental consequences and parenting stress. En ligne : http://dx.doi.org/10.1002/aur.1626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Sensory subtypes and associated outcomes in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Karla K. AUSDERAU, Auteur ; John SIDERIS, Auteur ; Lauren M. LITTLE, Auteur ; Melissa FURLONG, Auteur ; John C. BULLUCK, Auteur ; Grace T. BARANEK, Auteur . - p.1316-1327.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1316-1327
Mots-clés : children sensory subtypes stress adaptive outcomes Index. décimale : PER Périodiques Résumé : Sensory features are prevalent and heterogeneous across children with ASD and these features have been associated with child outcomes. Identification of clinically defined sensory subtypes may enhance our understanding of unique phenotypes that have implications for etiology, prognosis, and intervention. This longitudinal study used a national online survey aimed to identify associations of previously validated sensory subtypes to specific child and family characteristics and functional outcomes [vineland adaptive behavior scale-II (VABS) and parenting stress index short form (PSI)]. The sensory experiences questionnaire-3.0 was collected from caregivers with children with ASD, ages 2–12, at two time points (Time 1, n?=?1307, Time 2, n?=?884), 1 year apart. Functional outcomes assessments were collected at the second time point. A latent profile transition analysis (LPTA) was used to test associations, and results indicated that the attenuated-preoccupied subtype presented with the significantly lowest levels of VABS adaptive behavior composite scores compared to the other three sensory subtypes. Both the VABS maladaptive behavior index and the total PSI score were significantly highest in the extreme-mixed subtype. These results underscore the clinical utility of this subtyping approach for differentiating characteristics and functional outcomes associated with clinically defined sensory phenotypes. These findings may have implications for better understanding etiology, prognosis, and more precise targets for interventions designed to ameliorate sensory difficulties, and ultimately mitigate negative developmental consequences and parenting stress. En ligne : http://dx.doi.org/10.1002/aur.1626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Exploring ‘The autisms’ at a cognitive level / Cathriona CANTIO in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1328-1339
Titre : Exploring ‘The autisms’ at a cognitive level Type de document : Texte imprimé et/ou numérique Auteurs : Cathriona CANTIO, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Gitte FALCHER MADSEN, Auteur ; Niels BILENBERG, Auteur ; Sarah J. WHITE, Auteur Article en page(s) : p.1328-1339 Langues : Anglais (eng) Mots-clés : autism spectrum disorders cognition theory of mind executive function local bias fractionation symptomatology Behavior Index. décimale : PER Périodiques Résumé : The autism spectrum is characterized by genetic and behavioral heterogeneity. However, it is still unknown whether there is a universal pattern of cognitive impairment in autism spectrum disorder (ASD) and whether multiple cognitive impairments are needed to explain the full range of behavioral symptoms. This study aimed to determine whether three widely acknowledged cognitive abnormalities (Theory of Mind (ToM) impairment, Executive Function (EF) impairment, and the presence of a Local Processing Bias (LB)) are universal and fractionable in autism, and whether the relationship between cognition and behavior is dependent on the method of behavioral assessment. Thirty-one high-functioning children with ASD and thirty-seven children with neurotypical development (NTD), comparable in age, gender and Intelligence Quotient (IQ), completed several tasks tapping into ToM, EF, and LB, and autistic symptomatology was assessed through parental and teacher questionnaires, parental interview and direct observation. We found that ToM and EF deficits differentiated the groups and some ToM and EF tasks were related to each other. ToM and EF were together able to correctly classify more than three-quarters of the children into cases and controls, despite relating to none of the specific behavioral measures. Only a small subgroup of individuals displayed a LB, which was unrelated to ToM and EF, and did not aid diagnostic classification, most likely contributing to non-diagnostic symptoms in a subgroup. Despite the characteristic heterogeneity of the autism spectrum, it remains a possibility therefore that a single cognitive cause may underlie the range of diagnostic symptoms in all individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.1630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Exploring ‘The autisms’ at a cognitive level [Texte imprimé et/ou numérique] / Cathriona CANTIO, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Gitte FALCHER MADSEN, Auteur ; Niels BILENBERG, Auteur ; Sarah J. WHITE, Auteur . - p.1328-1339.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1328-1339
Mots-clés : autism spectrum disorders cognition theory of mind executive function local bias fractionation symptomatology Behavior Index. décimale : PER Périodiques Résumé : The autism spectrum is characterized by genetic and behavioral heterogeneity. However, it is still unknown whether there is a universal pattern of cognitive impairment in autism spectrum disorder (ASD) and whether multiple cognitive impairments are needed to explain the full range of behavioral symptoms. This study aimed to determine whether three widely acknowledged cognitive abnormalities (Theory of Mind (ToM) impairment, Executive Function (EF) impairment, and the presence of a Local Processing Bias (LB)) are universal and fractionable in autism, and whether the relationship between cognition and behavior is dependent on the method of behavioral assessment. Thirty-one high-functioning children with ASD and thirty-seven children with neurotypical development (NTD), comparable in age, gender and Intelligence Quotient (IQ), completed several tasks tapping into ToM, EF, and LB, and autistic symptomatology was assessed through parental and teacher questionnaires, parental interview and direct observation. We found that ToM and EF deficits differentiated the groups and some ToM and EF tasks were related to each other. ToM and EF were together able to correctly classify more than three-quarters of the children into cases and controls, despite relating to none of the specific behavioral measures. Only a small subgroup of individuals displayed a LB, which was unrelated to ToM and EF, and did not aid diagnostic classification, most likely contributing to non-diagnostic symptoms in a subgroup. Despite the characteristic heterogeneity of the autism spectrum, it remains a possibility therefore that a single cognitive cause may underlie the range of diagnostic symptoms in all individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.1630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Discourse comprehension in autism spectrum disorder: Effects of working memory load and common ground / Jillian M. SCHUH in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1340-1352
Titre : Discourse comprehension in autism spectrum disorder: Effects of working memory load and common ground Type de document : Texte imprimé et/ou numérique Auteurs : Jillian M. SCHUH, Auteur ; Inge-Marie EIGSTI, Auteur ; Daniel MIRMAN, Auteur Article en page(s) : p.1340-1352 Langues : Anglais (eng) Mots-clés : autism spectrum disorder referential communication discourse common ground working memory theory of mind eyetracking Index. décimale : PER Périodiques Résumé : Pragmatic language impairments are nearly universal in autism spectrum disorders (ASD). Discourse requires that we monitor information that is shared or mutually known, called “common ground.” While many studies have examined the role of Theory of Mind (ToM) in such impairments, few have examined working memory (WM). Common ground impairments in ASD could reflect limitations in both WM and ToM. This study explored common ground use in youth ages 8–17 years with high-functioning ASD (n?=?13) and typical development (n?=?22); groups did not differ on age, gender, IQ, or standardized language. We tracked participants' eye movements while they performed a discourse task in which some information was known only to the participant (e.g., was privileged; a manipulation of ToM). In addition, the amount of privileged information varied (a manipulation of WM). All participants were slower to fixate the target when considering privileged information, and this effect was greatest during high WM load trials. Further, the ASD group was more likely to fixate competing (non-target) shapes. Predictors of fixation patterns included ASD symptomatology, language ability, ToM, and WM. Groups did not differ in ToM. Individuals with better WM fixated the target more rapidly, suggesting an association between WM capacity and efficient discourse. In addition to ToM knowledge, WM capacity constrains common ground representation and impacts pragmatic skills in ASD. Social impairments in ASD are thus associated with WM capacity, such that deficits in domain-general, nonsocial processes such as WM exert an influence during complex social interactions. En ligne : http://dx.doi.org/10.1002/aur.1632 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Discourse comprehension in autism spectrum disorder: Effects of working memory load and common ground [Texte imprimé et/ou numérique] / Jillian M. SCHUH, Auteur ; Inge-Marie EIGSTI, Auteur ; Daniel MIRMAN, Auteur . - p.1340-1352.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1340-1352
Mots-clés : autism spectrum disorder referential communication discourse common ground working memory theory of mind eyetracking Index. décimale : PER Périodiques Résumé : Pragmatic language impairments are nearly universal in autism spectrum disorders (ASD). Discourse requires that we monitor information that is shared or mutually known, called “common ground.” While many studies have examined the role of Theory of Mind (ToM) in such impairments, few have examined working memory (WM). Common ground impairments in ASD could reflect limitations in both WM and ToM. This study explored common ground use in youth ages 8–17 years with high-functioning ASD (n?=?13) and typical development (n?=?22); groups did not differ on age, gender, IQ, or standardized language. We tracked participants' eye movements while they performed a discourse task in which some information was known only to the participant (e.g., was privileged; a manipulation of ToM). In addition, the amount of privileged information varied (a manipulation of WM). All participants were slower to fixate the target when considering privileged information, and this effect was greatest during high WM load trials. Further, the ASD group was more likely to fixate competing (non-target) shapes. Predictors of fixation patterns included ASD symptomatology, language ability, ToM, and WM. Groups did not differ in ToM. Individuals with better WM fixated the target more rapidly, suggesting an association between WM capacity and efficient discourse. In addition to ToM knowledge, WM capacity constrains common ground representation and impacts pragmatic skills in ASD. Social impairments in ASD are thus associated with WM capacity, such that deficits in domain-general, nonsocial processes such as WM exert an influence during complex social interactions. En ligne : http://dx.doi.org/10.1002/aur.1632 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study / James FINDON in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1353-1363
Titre : Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : James FINDON, Auteur ; Tim CADMAN, Auteur ; Catherine S. STEWART, Auteur ; Emma WOODHOUSE, Auteur ; Hanna EKLUND, Auteur ; Hannah HAYWARD, Auteur ; Daniel DE LE HARPE GOLDEN, Auteur ; Eddie CHAPLIN, Auteur ; Karen GLASER, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Patrick BOLTON, Auteur ; Fiona S. MCEWEN, Auteur Article en page(s) : p.1353-1363 Langues : Anglais (eng) Mots-clés : autism spectrum disorder co-occurring disorder co-morbid disorder hyperactivity attention deficit hyperactivity disorder anxiety depression obsessive–compulsive disorder Index. décimale : PER Périodiques Résumé : Adolescents and adults with autism spectrum disorder (ASD) are at elevated risk of co-occurring mental health problems. These are often undiagnosed, can cause significant impairment, and place a very high burden on family and carers. Detecting co-occurring disorders is extremely important. However, there is no validated screening tool for this purpose. The aim of this pilot study is to test the utility of the strengths and difficulties questionnaire (SDQ) to screen for co-occurring emotional disorders and hyperactivity in adolescents and adults with ASD. The SDQ was completed by 126 parents and 98 individuals with ASD (in 79 cases both parent and self-report were available from the same families). Inter-rater reliability, test-retest stability, internal consistency, and construct validity were examined. SDQ subscales were also compared to clinically utilized measures of emotional disorders and hyperactivity to establish the ability to predict risk of disorder. Inter-rater reliability (r?=?0.42), test-retest stability (r?=?0.64), internal consistency (??=?0.52–0.81) and construct validity (r?=?0.42–0.57) for the SDQ subscales were comparable to general population samples. Parent- and self-report SDQ subscales were significantly associated with measures of anxiety, depression and hyperactivity (62–74% correctly classified). Parent-report performed significantly better than self-report; adults with ASD under-reported difficulties. The SDQ shows promise as a simple and efficient way to screen for emotional disorders and hyperactivity in adolescents and adults with ASD that could help reduce the impact of these disorders on individuals and their families. However, further more systematic attempts at validation are warranted. En ligne : http://dx.doi.org/10.1002/aur.1625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study [Texte imprimé et/ou numérique] / James FINDON, Auteur ; Tim CADMAN, Auteur ; Catherine S. STEWART, Auteur ; Emma WOODHOUSE, Auteur ; Hanna EKLUND, Auteur ; Hannah HAYWARD, Auteur ; Daniel DE LE HARPE GOLDEN, Auteur ; Eddie CHAPLIN, Auteur ; Karen GLASER, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Patrick BOLTON, Auteur ; Fiona S. MCEWEN, Auteur . - p.1353-1363.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1353-1363
Mots-clés : autism spectrum disorder co-occurring disorder co-morbid disorder hyperactivity attention deficit hyperactivity disorder anxiety depression obsessive–compulsive disorder Index. décimale : PER Périodiques Résumé : Adolescents and adults with autism spectrum disorder (ASD) are at elevated risk of co-occurring mental health problems. These are often undiagnosed, can cause significant impairment, and place a very high burden on family and carers. Detecting co-occurring disorders is extremely important. However, there is no validated screening tool for this purpose. The aim of this pilot study is to test the utility of the strengths and difficulties questionnaire (SDQ) to screen for co-occurring emotional disorders and hyperactivity in adolescents and adults with ASD. The SDQ was completed by 126 parents and 98 individuals with ASD (in 79 cases both parent and self-report were available from the same families). Inter-rater reliability, test-retest stability, internal consistency, and construct validity were examined. SDQ subscales were also compared to clinically utilized measures of emotional disorders and hyperactivity to establish the ability to predict risk of disorder. Inter-rater reliability (r?=?0.42), test-retest stability (r?=?0.64), internal consistency (??=?0.52–0.81) and construct validity (r?=?0.42–0.57) for the SDQ subscales were comparable to general population samples. Parent- and self-report SDQ subscales were significantly associated with measures of anxiety, depression and hyperactivity (62–74% correctly classified). Parent-report performed significantly better than self-report; adults with ASD under-reported difficulties. The SDQ shows promise as a simple and efficient way to screen for emotional disorders and hyperactivity in adolescents and adults with ASD that could help reduce the impact of these disorders on individuals and their families. However, further more systematic attempts at validation are warranted. En ligne : http://dx.doi.org/10.1002/aur.1625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
[article]
inAutism Research > 9-12 (December 2016) . - p.1364-1368
Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1364-1368 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1736 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.1364-1368.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1364-1368
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1736 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 International society for autism research news www.autism-insar.org in Autism Research, 9-12 (December 2016)
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[article]
inAutism Research > 9-12 (December 2016) . - p.1369-1369
Titre : International society for autism research news www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1369-1369 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1737 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] International society for autism research news www.autism-insar.org [Texte imprimé et/ou numérique] . - p.1369-1369.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1369-1369
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1737 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298