Characterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample / Aneta D. KRAKOWSKI in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1534-1543 Titre : Characterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample Type de document : Texte imprimé et/ou numérique Auteurs : Aneta D. KRAKOWSKI, Auteur ; Katherine Tombeau COST, Auteur ; Peter SZATMARI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Eric DUKU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Elizabeth KELLEY, Auteur ; Rob NICOLSON, Auteur ; Eleanor PULLENAYEGUM, Auteur ; Carolina BARNETT-TAPIA, Auteur Article en page(s) : p.1534-1543 Langues : Anglais (eng) Mots-clés : Humans  Attention Deficit Disorder with Hyperactivity/diagnosis/genetics  Autism Spectrum Disorder/diagnosis  Parents  Phenotype  Surveys and Questionnaires  Adhd  Asd  factor analysis  measurement invariance  measurement structure Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) have considerable overlap, supporting the need for a dimensional framework that examines neurodevelopmental domains which cross traditional diagnostic boundaries. In the following study, we use factor analysis to deconstruct the ASD-ADHD phenotype into its underlying phenotypic domains and test for measurement invariance across adaptive functioning, age, gender and ASD/ADHD clinical diagnoses. METHODS: Participants included children and youth (aged 3-20 years) with a clinical diagnosis of ASD (n=727) or ADHD (n=770) for a total of 1,497 participants. Parents of these children completed the Social Communication Questionnaire (SCQ), a measure of autism symptoms, and the Strengths and Weaknesses of ADHD and Normal Behaviour (SWAN) questionnaire, a measure of ADHD symptoms. An exploratory factor analysis (EFA) was performed on combined SCQ and SWAN items. This was followed by a confirmatory factor analysis (CFA) and tests of measurement invariance. RESULTS: EFA revealed a four-factor solution (inattention, hyperactivity/impulsivity, social-communication, and restricted, repetitive, behaviours and interests (RRBI)) and a CFA confirmed good model fit. This solution also showed good model fit across subgroups of interest. CONCLUSIONS: Our study shows that a combined ASD-ADHD phenotype is characterized by two latent ASD domains (social communication and RRBIs) and two latent ADHD domains (inattention and hyperactivity/impulsivity). We established measurement invariance of the derived measurement model across adaptive functioning, age, gender and ASD/ADHD diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.13609 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Characterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample [Texte imprimé et/ou numérique] / Aneta D. KRAKOWSKI, Auteur ; Katherine Tombeau COST, Auteur ; Peter SZATMARI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Eric DUKU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Elizabeth KELLEY, Auteur ; Rob NICOLSON, Auteur ; Eleanor PULLENAYEGUM, Auteur ; Carolina BARNETT-TAPIA, Auteur . - p.1534-1543. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1534-1543 Mots-clés : Humans  Attention Deficit Disorder with Hyperactivity/diagnosis/genetics  Autism Spectrum Disorder/diagnosis  Parents  Phenotype  Surveys and Questionnaires  Adhd  Asd  factor analysis  measurement invariance  measurement structure Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) have considerable overlap, supporting the need for a dimensional framework that examines neurodevelopmental domains which cross traditional diagnostic boundaries. In the following study, we use factor analysis to deconstruct the ASD-ADHD phenotype into its underlying phenotypic domains and test for measurement invariance across adaptive functioning, age, gender and ASD/ADHD clinical diagnoses. METHODS: Participants included children and youth (aged 3-20 years) with a clinical diagnosis of ASD (n=727) or ADHD (n=770) for a total of 1,497 participants. Parents of these children completed the Social Communication Questionnaire (SCQ), a measure of autism symptoms, and the Strengths and Weaknesses of ADHD and Normal Behaviour (SWAN) questionnaire, a measure of ADHD symptoms. An exploratory factor analysis (EFA) was performed on combined SCQ and SWAN items. This was followed by a confirmatory factor analysis (CFA) and tests of measurement invariance. RESULTS: EFA revealed a four-factor solution (inattention, hyperactivity/impulsivity, social-communication, and restricted, repetitive, behaviours and interests (RRBI)) and a CFA confirmed good model fit. This solution also showed good model fit across subgroups of interest. CONCLUSIONS: Our study shows that a combined ASD-ADHD phenotype is characterized by two latent ASD domains (social communication and RRBIs) and two latent ADHD domains (inattention and hyperactivity/impulsivity). We established measurement invariance of the derived measurement model across adaptive functioning, age, gender and ASD/ADHD diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.13609 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities / Liana KAUFMAN  

Public ISBD in Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment / Stephen I. DEUTSCH   Titre : Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Liana KAUFMAN, Auteur ; Abdul NOOR, Auteur ; Muhammad AYUB, Auteur ; John B. VINCENT, Auteur Année de publication : 2011 Importance : p.126-158 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 in Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment / Stephen I. DEUTSCH   Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities [Texte imprimé et/ou numérique] / Liana KAUFMAN, Auteur ; Abdul NOOR, Auteur ; Muhammad AYUB, Auteur ; John B. VINCENT, Auteur . - 2011 . - p.126-158. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

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Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children / Evdokia ANAGNOSTOU ; Jason P. LERCH ; Margot J. TAYLOR ; Doug P. VANDERLAAN ; Peter SZATMARI ; Jennifer CROSBIE ; Robert NICOLSON ; Stelios GEORGIADIS ; Elizabeth KELLEY ; Muhammad AYUB ; Jessica BRIAN ; Meng-Chuan LAI ; Mark R. PALMERT in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1223-1236 Titre : Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children Type de document : Texte imprimé et/ou numérique Auteurs : Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur ; Margot J. TAYLOR, Auteur ; Doug P. VANDERLAAN, Auteur ; Peter SZATMARI, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADIS, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica BRIAN, Auteur ; Meng-Chuan LAI, Auteur ; Mark R. PALMERT, Auteur Article en page(s) : p.1223-1236 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Gender clinic and single-item questionnaire-based data report increased co-occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under-studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children. Methods Data from 291 children (Autism N = 104, ADHD N = 104, Autism?+?ADHD N = 17, neurotypical N = 66) aged 4-12?years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi-dimensionally using a well-validated parent-report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex-assigned-at-birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates. Results Neither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC-derived scores. Instead, higher early-childhood dimensional autistic social-communication traits correlated with higher current overall gender incongruence (as defined by GIQC-14 score). This correlation was potentially moderated by sex-assigned-at-birth: greater early-childhood autistic social-communication traits were associated with higher current overall gender incongruence in assigned-males-at-birth, but not assigned-females-at-birth. For fine-grained gender diversity domains, greater autistic restricted-repetitive behavior traits were associated with greater diversity in gender identity across sexes-assigned-at-birth; greater autistic social-communication traits were associated with lower stereotypical male expression across sexes-assigned-at-birth. Conclusions Dimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early-childhood autistic social-communication traits and overall current gender diversity was most evident in assigned-males-at-birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender-diverse populations. En ligne : https://doi.org/10.1111/jcpp.13965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children [Texte imprimé et/ou numérique] / Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur ; Margot J. TAYLOR, Auteur ; Doug P. VANDERLAAN, Auteur ; Peter SZATMARI, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADIS, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica BRIAN, Auteur ; Meng-Chuan LAI, Auteur ; Mark R. PALMERT, Auteur . - p.1223-1236. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1223-1236 Index. décimale : PER Périodiques Résumé : Background Gender clinic and single-item questionnaire-based data report increased co-occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under-studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children. Methods Data from 291 children (Autism N = 104, ADHD N = 104, Autism?+?ADHD N = 17, neurotypical N = 66) aged 4-12?years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi-dimensionally using a well-validated parent-report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex-assigned-at-birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates. Results Neither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC-derived scores. Instead, higher early-childhood dimensional autistic social-communication traits correlated with higher current overall gender incongruence (as defined by GIQC-14 score). This correlation was potentially moderated by sex-assigned-at-birth: greater early-childhood autistic social-communication traits were associated with higher current overall gender incongruence in assigned-males-at-birth, but not assigned-females-at-birth. For fine-grained gender diversity domains, greater autistic restricted-repetitive behavior traits were associated with greater diversity in gender identity across sexes-assigned-at-birth; greater autistic social-communication traits were associated with lower stereotypical male expression across sexes-assigned-at-birth. Conclusions Dimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early-childhood autistic social-communication traits and overall current gender diversity was most evident in assigned-males-at-birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender-diverse populations. En ligne : https://doi.org/10.1111/jcpp.13965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD / Calvin P. SJAARDA in Research in Autism Spectrum Disorders, 60 (April 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35 Titre : Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur Article en page(s) : p.25-35 Langues : Anglais (eng) Mots-clés : ASD  Autism  Electroencephalogram  DAT1  Dopamine  Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 [article] Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD [Texte imprimé et/ou numérique] / Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur . - p.25-35. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35 Mots-clés : ASD  Autism  Electroencephalogram  DAT1  Dopamine  Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387

Investigating language skills as a mediator between IQ and anxiety in autistic youth / Ethan RINALDO in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101846 Titre : Investigating language skills as a mediator between IQ and anxiety in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur Article en page(s) : 101846 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  IQ  Language  Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Investigating language skills as a mediator between IQ and anxiety in autistic youth [Texte imprimé et/ou numérique] / Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur . - 101846. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101846 Mots-clés : Autism  Autism spectrum disorder  IQ  Language  Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study / Danielle A. BARIBEAU in Autism Research, 16-8 (August 2023)  

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Transdiagnostic Patterns of Sensory Processing in Autism and ADHD / Anahid POURTOUSI ; Connie YANG ; Zining DING ; Bobby STOJANOSKI ; Evdokia ANAGNOSTOU ; Robert NICOLSON ; Elizabeth KELLEY ; Stelios GEORGIADES ; Jennifer CROSBIE ; Russell SCHACHAR ; Muhammad AYUB ; Ryan A. STEVENSON in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

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