Brief Report: Difficulty in Understanding Social Acting (But Not False Beliefs) Mediates the Link Between Autistic Traits and Ingroup Relationships / Daniel Y.J. YANG in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2199-2206 Titre : Brief Report: Difficulty in Understanding Social Acting (But Not False Beliefs) Mediates the Link Between Autistic Traits and Ingroup Relationships Type de document : texte imprimé Auteurs : Daniel Y.J. YANG, Auteur ; Renée BAILLARGEON, Auteur Article en page(s) : p.2199-2206 Langues : Anglais (eng) Mots-clés : Social acting  False beliefs  Social relationships  Autism  Asperger syndrome Index. décimale : PER Périodiques Résumé : Why do individuals with more autistic traits experience social difficulties? Here we examined the hypothesis that these difficulties stem in part from a challenge in understanding social acting, the prosocial pretense that adults routinely produce to maintain positive relationships with their ingroup. In Study 1, we developed a self-administered test of social-acting understanding: participants read stories in which a character engaged in social acting and rated the appropriateness of the character’s response. Adults who scored 26 or higher on the Autism Spectrum Quotient (AQ) questionnaire gave significantly lower ratings than comparison participants (AQ 26). Study 2 found that difficulty in understanding social acting, but not false beliefs, mediated the link between autistic traits and perceived ingroup relationships. En ligne : http://dx.doi.org/10.1007/s10803-013-1757-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Brief Report: Difficulty in Understanding Social Acting (But Not False Beliefs) Mediates the Link Between Autistic Traits and Ingroup Relationships [texte imprimé] / Daniel Y.J. YANG, Auteur ; Renée BAILLARGEON, Auteur . - p.2199-2206. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2199-2206 Mots-clés : Social acting  False beliefs  Social relationships  Autism  Asperger syndrome Index. décimale : PER Périodiques Résumé : Why do individuals with more autistic traits experience social difficulties? Here we examined the hypothesis that these difficulties stem in part from a challenge in understanding social acting, the prosocial pretense that adults routinely produce to maintain positive relationships with their ingroup. In Study 1, we developed a self-administered test of social-acting understanding: participants read stories in which a character engaged in social acting and rated the appropriateness of the character’s response. Adults who scored 26 or higher on the Autism Spectrum Quotient (AQ) questionnaire gave significantly lower ratings than comparison participants (AQ 26). Study 2 found that difficulty in understanding social acting, but not false beliefs, mediated the link between autistic traits and perceived ingroup relationships. En ligne : http://dx.doi.org/10.1007/s10803-013-1757-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment / Pamela VENTOLA in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2813-2820 Titre : Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment Type de document : texte imprimé Auteurs : Pamela VENTOLA, Auteur ; Daniel YANG, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Courtney A. PAISLEY, Auteur ; Megan L. BRACONNIER, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.2813-2820 Langues : Anglais (eng) Mots-clés : Restricted and repetitive behaviors  Pivotal Response Treatment (PRT)  Behavior therapy  Repetitive Behavior Scale-Revised (RBS-R) Index. décimale : PER Périodiques Résumé : Children with ASD show high frequency of restricted and repetitive behaviors (RRBs); however, higher-order RRBs, such as restricted interests, have remained largely resistant to treatment. This study evaluated change in severity of RRBs following a 16-weeks open trial of Pivotal Response Treatment (PRT). Participants included 15 children with ASD ages 4–7 years. RRBs, as measured by the repetitive behavioral scales-revised (RBS-R) and aberrant behaviors checklist, decreased significantly after treatment. These reductions remained significant after controlling for change in social communication skills. PRT shows promise in reducing RRBs; although PRT explicitly addresses pivotal social communication skills, there is a secondary and less direct effect on RRBs. En ligne : http://dx.doi.org/10.1007/s10803-016-2813-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment [texte imprimé] / Pamela VENTOLA, Auteur ; Daniel YANG, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Courtney A. PAISLEY, Auteur ; Megan L. BRACONNIER, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.2813-2820. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2813-2820 Mots-clés : Restricted and repetitive behaviors  Pivotal Response Treatment (PRT)  Behavior therapy  Repetitive Behavior Scale-Revised (RBS-R) Index. décimale : PER Périodiques Résumé : Children with ASD show high frequency of restricted and repetitive behaviors (RRBs); however, higher-order RRBs, such as restricted interests, have remained largely resistant to treatment. This study evaluated change in severity of RRBs following a 16-weeks open trial of Pivotal Response Treatment (PRT). Participants included 15 children with ASD ages 4–7 years. RRBs, as measured by the repetitive behavioral scales-revised (RBS-R) and aberrant behaviors checklist, decreased significantly after treatment. These reductions remained significant after controlling for change in social communication skills. PRT shows promise in reducing RRBs; although PRT explicitly addresses pivotal social communication skills, there is a secondary and less direct effect on RRBs. En ligne : http://dx.doi.org/10.1007/s10803-016-2813-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification / Daniel Y.J. YANG in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 11p. Titre : Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification Type de document : texte imprimé Auteurs : Daniel Y.J. YANG, Auteur ; Danielle BEAM, Auteur ; Kevin A. PELPHREY, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Roger J. JOU, Auteur Article en page(s) : 11p. Langues : Anglais (eng) Mots-clés : Age Factors  Cerebral Cortex/pathology  Child  Child Development Disorders, Pervasive/pathology  Child, Preschool  Gray Matter/pathology  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Neuroimaging  Organ Size  White Matter/pathology  Autism spectrum disorder  Brain development  Brain structure  Neuroanatomy  Surface-based morphometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) have been characterized by altered cerebral cortical structures; however, the field has yet to identify consistent markers and prior studies have included mostly adolescents and adults. While there are multiple cortical morphological measures, including cortical thickness, surface area, cortical volume, and cortical gyrification, few single studies have examined all these measures. The current study analyzed all of the four measures and focused on pre-adolescent children with ASD. METHODS: We employed the FreeSurfer pipeline to examine surface-based morphometry in 60 high-functioning boys with ASD (mean age = 8.35 years, range = 4-12 years) and 41 gender-, age-, and IQ-matched typically developing (TD) peers (mean age = 8.83 years), while testing for age-by-diagnosis interaction and between-group differences. RESULTS: During childhood and in specific regions, ASD participants exhibited a lack of normative age-related cortical thinning and volumetric reduction and an abnormal age-related increase in gyrification. Regarding surface area, ASD and TD exhibited statistically comparable age-related development during childhood. Across childhood, ASD relative to TD participants tended to have higher mean levels of gyrification in specific regions. Within ASD, those with higher Social Responsiveness Scale total raw scores tended to have greater age-related increase in gyrification in specific regions during childhood. CONCLUSIONS: ASD is characterized by cortical neuroanatomical abnormalities that are age-, measure-, statistical model-, and region-dependent. The current study is the first to examine the development of all four cortical measures in one of the largest pre-adolescent samples. Strikingly, Neurosynth-based quantitative reverse inference of the surviving clusters suggests that many of the regions identified above are related to social perception, language, self-referential, and action observation networks-those frequently found to be functionally altered in individuals with ASD. The comprehensive, multilevel analyses across a wide range of cortical measures help fill a knowledge gap and present a complex but rich picture of neuroanatomical developmental differences in children with ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0076-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification [texte imprimé] / Daniel Y.J. YANG, Auteur ; Danielle BEAM, Auteur ; Kevin A. PELPHREY, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Roger J. JOU, Auteur . - 11p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 11p. Mots-clés : Age Factors  Cerebral Cortex/pathology  Child  Child Development Disorders, Pervasive/pathology  Child, Preschool  Gray Matter/pathology  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Neuroimaging  Organ Size  White Matter/pathology  Autism spectrum disorder  Brain development  Brain structure  Neuroanatomy  Surface-based morphometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) have been characterized by altered cerebral cortical structures; however, the field has yet to identify consistent markers and prior studies have included mostly adolescents and adults. While there are multiple cortical morphological measures, including cortical thickness, surface area, cortical volume, and cortical gyrification, few single studies have examined all these measures. The current study analyzed all of the four measures and focused on pre-adolescent children with ASD. METHODS: We employed the FreeSurfer pipeline to examine surface-based morphometry in 60 high-functioning boys with ASD (mean age = 8.35 years, range = 4-12 years) and 41 gender-, age-, and IQ-matched typically developing (TD) peers (mean age = 8.83 years), while testing for age-by-diagnosis interaction and between-group differences. RESULTS: During childhood and in specific regions, ASD participants exhibited a lack of normative age-related cortical thinning and volumetric reduction and an abnormal age-related increase in gyrification. Regarding surface area, ASD and TD exhibited statistically comparable age-related development during childhood. Across childhood, ASD relative to TD participants tended to have higher mean levels of gyrification in specific regions. Within ASD, those with higher Social Responsiveness Scale total raw scores tended to have greater age-related increase in gyrification in specific regions during childhood. CONCLUSIONS: ASD is characterized by cortical neuroanatomical abnormalities that are age-, measure-, statistical model-, and region-dependent. The current study is the first to examine the development of all four cortical measures in one of the largest pre-adolescent samples. Strikingly, Neurosynth-based quantitative reverse inference of the surviving clusters suggests that many of the regions identified above are related to social perception, language, self-referential, and action observation networks-those frequently found to be functionally altered in individuals with ASD. The comprehensive, multilevel analyses across a wide range of cortical measures help fill a knowledge gap and present a complex but rich picture of neuroanatomical developmental differences in children with ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0076-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder / Daniel Y.J. YANG in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.1 Titre : Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder Type de document : texte imprimé Auteurs : Daniel Y.J. YANG, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Jiedi LEI, Auteur ; Eran DAYAN, Auteur ; Kevin A. PELPHREY, Auteur ; Pamela VENTOLA, Auteur Article en page(s) : p.1 Langues : Anglais (eng) Mots-clés : Adhd  Anxiety disorders  Autism spectrum disorder  Comorbidity  Default mode network  Disruptive behavior  Neuroimaging  Oppositional defiant disorder  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Disruptive behavior in autism spectrum disorder (ASD) is an important clinical problem, but its neural basis remains poorly understood. The current research aims to better understand the neural underpinnings of disruptive behavior in ASD, while addressing whether the neural basis is shared with or separable from that of core ASD symptoms. METHODS: Participants consisted of 48 male children and adolescents: 31 ASD (7 had high disruptive behavior) and 17 typically developing (TD) controls, well-matched on sex, age, and IQ. For ASD participants, autism symptom severity, disruptive behavior, anxiety symptoms, and ADHD symptoms were measured. All participants were scanned while viewing biological motion (BIO) and scrambled motion (SCR). Two fMRI contrasts were analyzed: social perception (BIO > SCR) and Default Mode Network (DMN) deactivation (fixation > BIO). Age and IQ were included as covariates of no interest in all analyses. RESULTS: First, the between-group analyses on BIO > SCR showed that ASD is characterized by hypoactivation in the social perception circuitry, and ASD with high or low disruptive behavior exhibited similar patterns of hypoactivation. Second, the between-group analyses on fixation > BIO showed that ASD with high disruptive behavior exhibited more restricted and less DMN deactivation, when compared to ASD with low disruptive behavior or TD. Third, the within-ASD analyses showed that (a) autism symptom severity (but not disruptive behavior) was uniquely associated with less activation in the social perception regions including the posterior superior temporal sulcus and inferior frontal gyrus; (b) disruptive behavior (but not autism symptom severity) was uniquely associated with less DMN deactivation in the medial prefrontal cortex (MPFC) and lateral parietal cortex; and (c) anxiety symptoms mediated the link between disruptive behavior and less DMN deactivation in both anterior cingulate cortex (ACC) and MPFC, while ADHD symptoms mediated the link primarily in ACC. CONCLUSIONS: In boys with ASD, disruptive behavior has a neural basis in reduced DMN deactivation, which is distinct and separable from that of core ASD symptoms, with the latter characterized by hypoactivation in the social perception circuitry. These differential neurobiological markers may potentially serve as neural targets or predictors for interventions when treating disruptive behavior vs. core symptoms in ASD. En ligne : http://dx.doi.org/10.1186/s11689-017-9183-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder [texte imprimé] / Daniel Y.J. YANG, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Jiedi LEI, Auteur ; Eran DAYAN, Auteur ; Kevin A. PELPHREY, Auteur ; Pamela VENTOLA, Auteur . - p.1. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.1 Mots-clés : Adhd  Anxiety disorders  Autism spectrum disorder  Comorbidity  Default mode network  Disruptive behavior  Neuroimaging  Oppositional defiant disorder  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Disruptive behavior in autism spectrum disorder (ASD) is an important clinical problem, but its neural basis remains poorly understood. The current research aims to better understand the neural underpinnings of disruptive behavior in ASD, while addressing whether the neural basis is shared with or separable from that of core ASD symptoms. METHODS: Participants consisted of 48 male children and adolescents: 31 ASD (7 had high disruptive behavior) and 17 typically developing (TD) controls, well-matched on sex, age, and IQ. For ASD participants, autism symptom severity, disruptive behavior, anxiety symptoms, and ADHD symptoms were measured. All participants were scanned while viewing biological motion (BIO) and scrambled motion (SCR). Two fMRI contrasts were analyzed: social perception (BIO > SCR) and Default Mode Network (DMN) deactivation (fixation > BIO). Age and IQ were included as covariates of no interest in all analyses. RESULTS: First, the between-group analyses on BIO > SCR showed that ASD is characterized by hypoactivation in the social perception circuitry, and ASD with high or low disruptive behavior exhibited similar patterns of hypoactivation. Second, the between-group analyses on fixation > BIO showed that ASD with high disruptive behavior exhibited more restricted and less DMN deactivation, when compared to ASD with low disruptive behavior or TD. Third, the within-ASD analyses showed that (a) autism symptom severity (but not disruptive behavior) was uniquely associated with less activation in the social perception regions including the posterior superior temporal sulcus and inferior frontal gyrus; (b) disruptive behavior (but not autism symptom severity) was uniquely associated with less DMN deactivation in the medial prefrontal cortex (MPFC) and lateral parietal cortex; and (c) anxiety symptoms mediated the link between disruptive behavior and less DMN deactivation in both anterior cingulate cortex (ACC) and MPFC, while ADHD symptoms mediated the link primarily in ACC. CONCLUSIONS: In boys with ASD, disruptive behavior has a neural basis in reduced DMN deactivation, which is distinct and separable from that of core ASD symptoms, with the latter characterized by hypoactivation in the social perception circuitry. These differential neurobiological markers may potentially serve as neural targets or predictors for interventions when treating disruptive behavior vs. core symptoms in ASD. En ligne : http://dx.doi.org/10.1186/s11689-017-9183-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

Neural mechanisms of behavioral change in young adults with high‐functioning autism receiving virtual reality social cognition training: A pilot study / Daniel Y.J. YANG in Autism Research, 11-5 (May 2018)  

Public ISBD [article]  inAutism Research > 11-5 (May 2018) . - p.713-725 Titre : Neural mechanisms of behavioral change in young adults with high‐functioning autism receiving virtual reality social cognition training: A pilot study Type de document : texte imprimé Auteurs : Daniel Y.J. YANG, Auteur ; Tandra T. ALLEN, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Kevin A. PELPHREY, Auteur ; Fred R. VOLKMAR, Auteur ; Sandra B. CHAPMAN, Auteur Article en page(s) : p.713-725 Langues : Anglais (eng) Mots-clés : neuroplasticity  adults with autism  emotion recognition  theory of mind  clinical trials  computerized treatment  virtual reality Index. décimale : PER Périodiques Résumé : Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses this void by investigating neural and behavioral changes in a Phase I trial in young adults with high?functioning ASD who received an evidence?based behavioral intervention, Virtual Reality?Social Cognition Training over 5 weeks for a total of 10 hr. The participants were tested pre? and post?training with a validated biological/social versus scrambled/nonsocial motion neuroimaging task, previously shown to activate regions within the social brain networks. Three significant brain behavior changes were identified. First, the right posterior superior temporal sulcus, a hub for socio?cognitive processing, showed increased brain activation to social versus nonsocial stimuli in individuals with greater gains on a theory?of?mind measure. Second, the left inferior frontal gyrus, a region for socio?emotional processing, tracked individual gains in emotion recognition with decreased activation to social versus nonsocial stimuli. Finally, the left superior parietal lobule, a region for visual attention, showed significantly decreased activation to nonsocial versus social stimuli across all participants, where heightened attention to nonsocial contingencies has been considered a disabling aspect of ASD. This study provides, albeit preliminary, some of the first evidence of the harnessable neuroplasticity in adults with ASD through an age?appropriate intervention in brain regions tightly linked to social abilities. This pilot trial motivates future efforts to develop and test social interventions to improve behaviors and supporting brain networks in adults with ASD. Autism Res 2018, 11: 713 725. ? 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay Summary This study addresses how the behavioral changes after treatment for ASD reflect underlying brain changes. Before and after receiving VR?SCT, young adults with high?functioning ASD passively viewed biological motion stimuli in a MRI scanner, tapping changes in the social brain network. The results reveal neuroplasticity in this age population, extending the window of opportunity for interventions to impact social competency in adults with ASD. En ligne : https://doi.org/10.1002/aur.1941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Neural mechanisms of behavioral change in young adults with high‐functioning autism receiving virtual reality social cognition training: A pilot study [texte imprimé] / Daniel Y.J. YANG, Auteur ; Tandra T. ALLEN, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Kevin A. PELPHREY, Auteur ; Fred R. VOLKMAR, Auteur ; Sandra B. CHAPMAN, Auteur . - p.713-725. Langues : Anglais (eng) in Autism Research > 11-5 (May 2018) . - p.713-725 Mots-clés : neuroplasticity  adults with autism  emotion recognition  theory of mind  clinical trials  computerized treatment  virtual reality Index. décimale : PER Périodiques Résumé : Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses this void by investigating neural and behavioral changes in a Phase I trial in young adults with high?functioning ASD who received an evidence?based behavioral intervention, Virtual Reality?Social Cognition Training over 5 weeks for a total of 10 hr. The participants were tested pre? and post?training with a validated biological/social versus scrambled/nonsocial motion neuroimaging task, previously shown to activate regions within the social brain networks. Three significant brain behavior changes were identified. First, the right posterior superior temporal sulcus, a hub for socio?cognitive processing, showed increased brain activation to social versus nonsocial stimuli in individuals with greater gains on a theory?of?mind measure. Second, the left inferior frontal gyrus, a region for socio?emotional processing, tracked individual gains in emotion recognition with decreased activation to social versus nonsocial stimuli. Finally, the left superior parietal lobule, a region for visual attention, showed significantly decreased activation to nonsocial versus social stimuli across all participants, where heightened attention to nonsocial contingencies has been considered a disabling aspect of ASD. This study provides, albeit preliminary, some of the first evidence of the harnessable neuroplasticity in adults with ASD through an age?appropriate intervention in brain regions tightly linked to social abilities. This pilot trial motivates future efforts to develop and test social interventions to improve behaviors and supporting brain networks in adults with ASD. Autism Res 2018, 11: 713 725. ? 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay Summary This study addresses how the behavioral changes after treatment for ASD reflect underlying brain changes. Before and after receiving VR?SCT, young adults with high?functioning ASD passively viewed biological motion stimuli in a MRI scanner, tapping changes in the social brain network. The results reveal neuroplasticity in this age population, extending the window of opportunity for interventions to impact social competency in adults with ASD. En ligne : https://doi.org/10.1002/aur.1941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Neurogenetic analysis of childhood disintegrative disorder / Abha R. GUPTA in Molecular Autism, 8 (2017)  

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