Dépouillements

“Risk of Autism Spectrum Disorder in Descendants of Women With Gestational Diabetes and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis” / Francisca BRAVO-MUÑOZ in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.1916-1934 Titre : “Risk of Autism Spectrum Disorder in Descendants of Women With Gestational Diabetes and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis” Type de document : texte imprimé Auteurs : Francisca BRAVO-MUÑOZ, Auteur ; Isidora BUSTOS, Auteur ; Diana MUÑOZ-FIERRO, Auteur ; Sofía SAN-MARTÍN, Auteur ; Catalina TABILO, Auteur ; Macarena VÉLIZ, Auteur ; Taide ZAROR, Auteur ; Paulina ORMAZABAL, Auteur ; Nele BRUSSELAERS, Auteur ; Romina FORNES, Auteur Article en page(s) : p.1916-1934 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  gestational diabetes  neurodevelopmental disorders  polycystic ovary syndrome Index. décimale : PER Périodiques Résumé : ABSTRACT Some reports show that children exposed to hyperandrogenemia or hyperglycemic states in utero are more prone to be diagnosed with autism spectrum disorder (ASD). This systematic review and meta-analysis aim to assess the association between Polycystic Ovary Syndrome (PCOS) or gestational diabetes (GD) and ASD. A systematic review (1980?2023) in Web of Science, PubMed and Scopus, using specific search terms ?gestational diabetes?, ?polycystic ovary syndrome,? ?neurodevelopmental disorder? and ?autism spectrum disorder? was performed. Generic inverse-variance method was used to pool the adjusted or crude effect measures with a random-effects model. Results were presented as relative risk (RR) with 95% confidence interval (CI). Only studies from the northern hemisphere were found. All the articles evaluated the association between either GD (n?=?16) or PCOS (8) and ASD separately. The overall analysis revealed that there is an increased risk of ASD in the offspring of women diagnosed with GD [RR?=?1.23 (95% CI 1.13?1.34), n?=?14] and in women diagnosed with PCOS [RR?=?1.35 (95% CI 1.17?1.56), n?=?6]. In a sensitivity analysis, the risk of ASD was particularly higher in mothers with GD and obesity. Although both GD and PCOS have been associated with ASD in offspring, studies in other geographical regions are needed. Future research should investigate how varying androgen levels in PCOS and the timing of GD diagnosis might influence the observed associations. Additional studies are needed to confirm these associations, address potential confounding variables, and explore whether these maternal conditions contribute directly or indirectly to autism risk. En ligne : https://doi.org/10.1002/aur.70110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] “Risk of Autism Spectrum Disorder in Descendants of Women With Gestational Diabetes and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis” [texte imprimé] / Francisca BRAVO-MUÑOZ, Auteur ; Isidora BUSTOS, Auteur ; Diana MUÑOZ-FIERRO, Auteur ; Sofía SAN-MARTÍN, Auteur ; Catalina TABILO, Auteur ; Macarena VÉLIZ, Auteur ; Taide ZAROR, Auteur ; Paulina ORMAZABAL, Auteur ; Nele BRUSSELAERS, Auteur ; Romina FORNES, Auteur . - p.1916-1934. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.1916-1934 Mots-clés : autism spectrum disorder  gestational diabetes  neurodevelopmental disorders  polycystic ovary syndrome Index. décimale : PER Périodiques Résumé : ABSTRACT Some reports show that children exposed to hyperandrogenemia or hyperglycemic states in utero are more prone to be diagnosed with autism spectrum disorder (ASD). This systematic review and meta-analysis aim to assess the association between Polycystic Ovary Syndrome (PCOS) or gestational diabetes (GD) and ASD. A systematic review (1980?2023) in Web of Science, PubMed and Scopus, using specific search terms ?gestational diabetes?, ?polycystic ovary syndrome,? ?neurodevelopmental disorder? and ?autism spectrum disorder? was performed. Generic inverse-variance method was used to pool the adjusted or crude effect measures with a random-effects model. Results were presented as relative risk (RR) with 95% confidence interval (CI). Only studies from the northern hemisphere were found. All the articles evaluated the association between either GD (n?=?16) or PCOS (8) and ASD separately. The overall analysis revealed that there is an increased risk of ASD in the offspring of women diagnosed with GD [RR?=?1.23 (95% CI 1.13?1.34), n?=?14] and in women diagnosed with PCOS [RR?=?1.35 (95% CI 1.17?1.56), n?=?6]. In a sensitivity analysis, the risk of ASD was particularly higher in mothers with GD and obesity. Although both GD and PCOS have been associated with ASD in offspring, studies in other geographical regions are needed. Future research should investigate how varying androgen levels in PCOS and the timing of GD diagnosis might influence the observed associations. Additional studies are needed to confirm these associations, address potential confounding variables, and explore whether these maternal conditions contribute directly or indirectly to autism risk. En ligne : https://doi.org/10.1002/aur.70110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome / Vic LIN in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.1935-1964 Titre : A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome Type de document : texte imprimé Auteurs : Vic LIN, Auteur ; Samantha M. MATTA, Auteur ; Julia E. DALLMAN, Auteur ; Suzanne HOSIE, Auteur ; Manon MOREAU, Auteur ; Ashley E. FRANKS, Auteur ; Thomas BOURGERON, Auteur ; Elisa L. HILL-YARDIN, Auteur Article en page(s) : p.1935-1964 Langues : Anglais (eng) Mots-clés : autism  behavior  brain  gut  mouse  Phelan McDermid  SHANK3 Index. décimale : PER Périodiques Résumé : ABSTRACT Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking. Here, we clarify behavioral traits (social, vocalization, repetitive and anxiety-like behavior), developmental trajectories, and motor activity in addition to changes in brain structure and function in 10 widely available Shank3 transgenic mouse models. Although behavioral deficits in Shank3B?/? and Shank3?C/?C mice were most extensively reported, each model reviewed here displayed autism-relevant behavioral traits. Most studies focused on assessing social, anxiety-like, and repetitive behavior, whereas few studies examined changes in vocalization, developmental milestones, motor function, or aggressive behavior. We did not identify any studies of gut function in the ten selected Shank3 models. Alterations in the gastrointestinal microbiome of Shank3-deficient mice are associated with changes in bacterial abundance and composition, which may impact social behavior and gastrointestinal function. Studying preclinical models can provide critical insights into molecular pathways contributing to PMS. Further research is needed to determine how various genetic variations in Shank3 impact the brain, behavior, and potentially the gastrointestinal system. En ligne : https://doi.org/10.1002/aur.70112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome [texte imprimé] / Vic LIN, Auteur ; Samantha M. MATTA, Auteur ; Julia E. DALLMAN, Auteur ; Suzanne HOSIE, Auteur ; Manon MOREAU, Auteur ; Ashley E. FRANKS, Auteur ; Thomas BOURGERON, Auteur ; Elisa L. HILL-YARDIN, Auteur . - p.1935-1964. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.1935-1964 Mots-clés : autism  behavior  brain  gut  mouse  Phelan McDermid  SHANK3 Index. décimale : PER Périodiques Résumé : ABSTRACT Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking. Here, we clarify behavioral traits (social, vocalization, repetitive and anxiety-like behavior), developmental trajectories, and motor activity in addition to changes in brain structure and function in 10 widely available Shank3 transgenic mouse models. Although behavioral deficits in Shank3B?/? and Shank3?C/?C mice were most extensively reported, each model reviewed here displayed autism-relevant behavioral traits. Most studies focused on assessing social, anxiety-like, and repetitive behavior, whereas few studies examined changes in vocalization, developmental milestones, motor function, or aggressive behavior. We did not identify any studies of gut function in the ten selected Shank3 models. Alterations in the gastrointestinal microbiome of Shank3-deficient mice are associated with changes in bacterial abundance and composition, which may impact social behavior and gastrointestinal function. Studying preclinical models can provide critical insights into molecular pathways contributing to PMS. Further research is needed to determine how various genetic variations in Shank3 impact the brain, behavior, and potentially the gastrointestinal system. En ligne : https://doi.org/10.1002/aur.70112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Associations Between Brain Network Connectivity and Cognitive Measures in Autism Spectrum Disorder: A Post Hoc Analysis of a Parent Study “Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder” / Chun Liang HSU in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.1965-1977 Titre : Associations Between Brain Network Connectivity and Cognitive Measures in Autism Spectrum Disorder: A Post Hoc Analysis of a Parent Study “Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder” Type de document : texte imprimé Auteurs : Chun Liang HSU, Auteur ; Eva MATT, Auteur ; Tommy Kwan Hin FONG, Auteur ; Joyce Yuen Ting LAM, Auteur ; Bolton CHAU, Auteur ; Calvin Pak Wing CHENG, Auteur ; Roland BEISTEINER, Auteur ; Teris CHEUNG, Auteur Article en page(s) : p.1965-1977 Langues : Anglais (eng) Mots-clés : adolescents  autism spectrum disorder  functional connectivity  neuromodulation  transcranial pulse stimulation Index. décimale : PER Périodiques Résumé : ABSTRACT This study presents a post hoc analysis of our parent study ?Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder? study which was a double-blind, sham-controlled, randomized controlled trial. In this study, we examined associations between changes in brain network connectivity and cognitive performance in young adolescents (12?17?years) with autism spectrum disorder (ASD) following the administration of transcranial pulse stimulation (TPS) which is considered non-invasive, evidenced-based brain stimulation for neurodegenerative disorders and neuropsychiatric disorders. Our findings indicate that increased connectivity in specific brain networks is associated with improvements in cognitive measures, suggesting that connectivity changes may underpin cognitive changes observed after six TPS intervention. These results highlight potential neural mechanisms underlying cognitive improvements in ASD, although causality cannot be inferred from these associations. Trial Registration: ClinicalTrials.gov identifier: NCT05408793 En ligne : https://doi.org/10.1002/aur.70093 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Associations Between Brain Network Connectivity and Cognitive Measures in Autism Spectrum Disorder: A Post Hoc Analysis of a Parent Study “Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder” [texte imprimé] / Chun Liang HSU, Auteur ; Eva MATT, Auteur ; Tommy Kwan Hin FONG, Auteur ; Joyce Yuen Ting LAM, Auteur ; Bolton CHAU, Auteur ; Calvin Pak Wing CHENG, Auteur ; Roland BEISTEINER, Auteur ; Teris CHEUNG, Auteur . - p.1965-1977. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.1965-1977 Mots-clés : adolescents  autism spectrum disorder  functional connectivity  neuromodulation  transcranial pulse stimulation Index. décimale : PER Périodiques Résumé : ABSTRACT This study presents a post hoc analysis of our parent study ?Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder? study which was a double-blind, sham-controlled, randomized controlled trial. In this study, we examined associations between changes in brain network connectivity and cognitive performance in young adolescents (12?17?years) with autism spectrum disorder (ASD) following the administration of transcranial pulse stimulation (TPS) which is considered non-invasive, evidenced-based brain stimulation for neurodegenerative disorders and neuropsychiatric disorders. Our findings indicate that increased connectivity in specific brain networks is associated with improvements in cognitive measures, suggesting that connectivity changes may underpin cognitive changes observed after six TPS intervention. These results highlight potential neural mechanisms underlying cognitive improvements in ASD, although causality cannot be inferred from these associations. Trial Registration: ClinicalTrials.gov identifier: NCT05408793 En ligne : https://doi.org/10.1002/aur.70093 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

A New Paradigm for Autism Spectrum Disorder Discrimination in Children Utilizing EEG Data Collected During Cartoon Viewing With a Focus on Atypical Semantic Processing / Lin DENG in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.1978-1990 Titre : A New Paradigm for Autism Spectrum Disorder Discrimination in Children Utilizing EEG Data Collected During Cartoon Viewing With a Focus on Atypical Semantic Processing Type de document : texte imprimé Auteurs : Lin DENG, Auteur ; Meng-Jie LU, Auteur ; Le-tong YANG, Auteur ; Yue ZHANG, Auteur ; Hang-yu TAN, Auteur ; Miao CAO, Auteur ; Fei Li, Auteur Article en page(s) : p.1978-1990 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cartoons as topic  early diagnosis  electroencephalography  semantics Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication skills, with semantic processing difficulties being a hallmark feature that significantly impacts social communication. While traditional neuroimaging studies have provided insights into language processing in ASD, ecological validity remains a challenge, particularly when assessing young children. This study introduces a novel approach to evaluate atypical semantic processing in children with ASD (aged 4?10?years) through electroencephalography (EEG) data collection during cartoon viewing, offering a more natural assessment environment. We developed an innovative methodology combining pretrained language models with regression techniques in a machine learning framework. The analysis incorporated the Six-dimensional Semantic Database system and EEG topographical mapping to investigate semantic processing preferences and neural mechanisms across various word dimensions. Our semantic processing model demonstrated robust performance with high sensitivity (91.3%) and moderate specificity (61.0%); findings successfully replicated in validation analysis. These results reveal distinct patterns in how children with ASD process semantic information, particularly in their integration and response to emotional semantic dimensions. These findings help us understand the language processing patterns in ASD and provide potential applications for auxiliary diagnosis in more natural settings, meeting important needs in clinical practice. En ligne : https://doi.org/10.1002/aur.70105 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A New Paradigm for Autism Spectrum Disorder Discrimination in Children Utilizing EEG Data Collected During Cartoon Viewing With a Focus on Atypical Semantic Processing [texte imprimé] / Lin DENG, Auteur ; Meng-Jie LU, Auteur ; Le-tong YANG, Auteur ; Yue ZHANG, Auteur ; Hang-yu TAN, Auteur ; Miao CAO, Auteur ; Fei Li, Auteur . - p.1978-1990. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.1978-1990 Mots-clés : autism spectrum disorder  cartoons as topic  early diagnosis  electroencephalography  semantics Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication skills, with semantic processing difficulties being a hallmark feature that significantly impacts social communication. While traditional neuroimaging studies have provided insights into language processing in ASD, ecological validity remains a challenge, particularly when assessing young children. This study introduces a novel approach to evaluate atypical semantic processing in children with ASD (aged 4?10?years) through electroencephalography (EEG) data collection during cartoon viewing, offering a more natural assessment environment. We developed an innovative methodology combining pretrained language models with regression techniques in a machine learning framework. The analysis incorporated the Six-dimensional Semantic Database system and EEG topographical mapping to investigate semantic processing preferences and neural mechanisms across various word dimensions. Our semantic processing model demonstrated robust performance with high sensitivity (91.3%) and moderate specificity (61.0%); findings successfully replicated in validation analysis. These results reveal distinct patterns in how children with ASD process semantic information, particularly in their integration and response to emotional semantic dimensions. These findings help us understand the language processing patterns in ASD and provide potential applications for auxiliary diagnosis in more natural settings, meeting important needs in clinical practice. En ligne : https://doi.org/10.1002/aur.70105 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Transdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions / Emily SPACKMAN in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.1991-1998 Titre : Transdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions Type de document : texte imprimé Auteurs : Emily SPACKMAN, Auteur ; Lacey CHETCUTI, Auteur ; Emma K. BAKER, Auteur ; Emily F. FERGUSON, Auteur ; Benjamin E. YERYS, Auteur ; John D. HERRINGTON, Auteur ; Thomas W. FRAZIER, Auteur ; Susan R. LEEKAM, Auteur ; Antonio Y. HARDAN, Auteur ; John W. HARRINGTON, Auteur ; Mirko ULJAREVIC, Auteur Article en page(s) : p.1991-1998 Langues : Anglais (eng) Mots-clés : anxiety  autism  compulsions  insistence on sameness  transdiagnostic Index. décimale : PER Périodiques Résumé : ABSTRACT Although insistence on sameness (IS) and compulsions occur across a wide range of neurodevelopmental (NDD) and neuropsychiatric (NPD) conditions, they are typically only examined within the confines of specific singular disorders. Indeed, while anxiety has been consistently linked to IS in autism and compulsions in obsessive-compulsive disorder (OCD), no empirical study has examined these associations in a sample spanning a range of NDD and NPD. Therefore, this study utilized a large sample of children and adolescents spanning several NDD and NPD to examine whether anxiety shows different patterns of association with IS or compulsions within and across diagnostic groups. The transdiagnostic sample encompassed youth (mean age?=?10.36 [3.40]; N?=?1852) diagnosed with autism (N?=?387), attention-deficit hyperactivity disorder (ADHD; N?=?931), internalizing disorders (N?=?208), OCD/Tic disorder (N?=?59) and oppositional defiant/conduct disorder (ODD/CD; N?=?267). IS and compulsions were assessed using the Repetitive Behavior Scale-Revised, and anxiety using the Screen for Child Anxiety Related Disorders. Within-group comparisons revealed that, in the autism, ADHD, and OCD/Tic groups, anxiety showed a slightly stronger association with IS than compulsions although effect sizes indicated small to no effect (q? En ligne : https://doi.org/10.1002/aur.70096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Transdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions [texte imprimé] / Emily SPACKMAN, Auteur ; Lacey CHETCUTI, Auteur ; Emma K. BAKER, Auteur ; Emily F. FERGUSON, Auteur ; Benjamin E. YERYS, Auteur ; John D. HERRINGTON, Auteur ; Thomas W. FRAZIER, Auteur ; Susan R. LEEKAM, Auteur ; Antonio Y. HARDAN, Auteur ; John W. HARRINGTON, Auteur ; Mirko ULJAREVIC, Auteur . - p.1991-1998. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.1991-1998 Mots-clés : anxiety  autism  compulsions  insistence on sameness  transdiagnostic Index. décimale : PER Périodiques Résumé : ABSTRACT Although insistence on sameness (IS) and compulsions occur across a wide range of neurodevelopmental (NDD) and neuropsychiatric (NPD) conditions, they are typically only examined within the confines of specific singular disorders. Indeed, while anxiety has been consistently linked to IS in autism and compulsions in obsessive-compulsive disorder (OCD), no empirical study has examined these associations in a sample spanning a range of NDD and NPD. Therefore, this study utilized a large sample of children and adolescents spanning several NDD and NPD to examine whether anxiety shows different patterns of association with IS or compulsions within and across diagnostic groups. The transdiagnostic sample encompassed youth (mean age?=?10.36 [3.40]; N?=?1852) diagnosed with autism (N?=?387), attention-deficit hyperactivity disorder (ADHD; N?=?931), internalizing disorders (N?=?208), OCD/Tic disorder (N?=?59) and oppositional defiant/conduct disorder (ODD/CD; N?=?267). IS and compulsions were assessed using the Repetitive Behavior Scale-Revised, and anxiety using the Screen for Child Anxiety Related Disorders. Within-group comparisons revealed that, in the autism, ADHD, and OCD/Tic groups, anxiety showed a slightly stronger association with IS than compulsions although effect sizes indicated small to no effect (q? En ligne : https://doi.org/10.1002/aur.70096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Characterizing the Relationship Among the Social Competence Elements in Autistic Adolescents / Alexandra P. KEY in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.1999-2010 Titre : Characterizing the Relationship Among the Social Competence Elements in Autistic Adolescents Type de document : texte imprimé Auteurs : Alexandra P. KEY, Auteur ; Trey MCGONIGLE, Auteur ; Jinyuan LIU, Auteur ; Rachael MUSCATELLO, Auteur ; Philip GABLE, Auteur ; Susan WHITE, Auteur ; Matthew LERNER, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.1999-2010 Langues : Anglais (eng) Mots-clés : autism  behavior  brain  cognition  social competence  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder have significant difficulties in social competence. This study provided empirical evaluation of the theoretical model by Kennedy and Adolphs (2012) positing that social competence relies on an interconnected network of four components: social brain, cognition, behavior, and functioning. Data from 243 youth (69 female, 174 male), age 10?17?years, were used to test the hypothesized mediation effect of social cognition (Theory of Mind) from social brain (event-related potential markers of face perception and memory) to social behavior (Contextual Assessment of Social Skills) and functioning (Child Behavior Checklist). An additional analysis evaluated whether the structure of the social competence model varied based on the biological sex of the autistic participants. The findings support the conceptual model of social competence where the social brain's contributions to social behavior and functioning are mediated by social cognition, with an additional direct path between the brain and behavior. The relationship among the four components of social competence is not significantly different for autistic males and females. Social competence is best represented as a network of direct and indirect connections among the neural, cognitive, and behavioral components. Thus, focusing on any single element is not sufficient for effective design of novel assessment and treatment approaches in autism. The findings also highlight the importance of self-initiated active engagement with social cues as a contributor to successful social behavior and functioning in autism. En ligne : https://doi.org/10.1002/aur.70095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Characterizing the Relationship Among the Social Competence Elements in Autistic Adolescents [texte imprimé] / Alexandra P. KEY, Auteur ; Trey MCGONIGLE, Auteur ; Jinyuan LIU, Auteur ; Rachael MUSCATELLO, Auteur ; Philip GABLE, Auteur ; Susan WHITE, Auteur ; Matthew LERNER, Auteur ; Blythe A. CORBETT, Auteur . - p.1999-2010. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.1999-2010 Mots-clés : autism  behavior  brain  cognition  social competence  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder have significant difficulties in social competence. This study provided empirical evaluation of the theoretical model by Kennedy and Adolphs (2012) positing that social competence relies on an interconnected network of four components: social brain, cognition, behavior, and functioning. Data from 243 youth (69 female, 174 male), age 10?17?years, were used to test the hypothesized mediation effect of social cognition (Theory of Mind) from social brain (event-related potential markers of face perception and memory) to social behavior (Contextual Assessment of Social Skills) and functioning (Child Behavior Checklist). An additional analysis evaluated whether the structure of the social competence model varied based on the biological sex of the autistic participants. The findings support the conceptual model of social competence where the social brain's contributions to social behavior and functioning are mediated by social cognition, with an additional direct path between the brain and behavior. The relationship among the four components of social competence is not significantly different for autistic males and females. Social competence is best represented as a network of direct and indirect connections among the neural, cognitive, and behavioral components. Thus, focusing on any single element is not sufficient for effective design of novel assessment and treatment approaches in autism. The findings also highlight the importance of self-initiated active engagement with social cues as a contributor to successful social behavior and functioning in autism. En ligne : https://doi.org/10.1002/aur.70095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Auditory and Semantic Processing of Speech-in-Noise in Autism: A Behavioral and EEG Study / Jiayin LI in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2011-2030 Titre : Auditory and Semantic Processing of Speech-in-Noise in Autism: A Behavioral and EEG Study Type de document : texte imprimé Auteurs : Jiayin LI, Auteur ; Maleeha SUJAWAL, Auteur ; Zivile BERNOTAITE, Auteur ; Ian CUNNINGS, Auteur ; Fang LIU, Auteur Article en page(s) : p.2011-2030 Langues : Anglais (eng) Mots-clés : autism  N400  neural tracking  speech-in-noise  temporal response functions Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals often struggle to recognize speech in noisy environments, but the neural mechanisms behind these challenges remain unclear. Effective speech-in-noise (SiN) processing relies on auditory processing, which tracks target sounds amidst noise, and semantic processing, which further integrates relevant acoustic information to derive meaning. This study examined these two processes in autism. Thirty-one autistic and 31 non-autistic adults completed a sentence judgment task under three conditions: quiet, babble noise, and competing speech. Auditory processing was measured using EEG-derived temporal response functions (TRFs), which tracked how the brain follows speech sounds, while semantic processing was assessed via behavioral accuracy and the N400 component, a neural marker of semantic processing. Autistic participants showed reduced TRF responses and delayed N400 onset, indicating less efficient auditory processing and slower semantic processing, despite similar N400 amplitude and behavioral performance. Moreover, non-autistic participants demonstrated a trade-off between auditory and semantic processing resources. In the competing speech condition, they showed enhanced semantic integration but reduced neural tracking of auditory information when managing linguistic competition introduced by intelligible speech noise. In contrast, the autistic group showed no modulation of neural responses, suggesting reduced flexibility in adjusting auditory and semantic demands. These findings highlight distinct neural processing patterns in autistic individuals during SiN tasks, providing new insights into how atypical auditory and semantic processing shape SiN perception in autism. En ligne : https://doi.org/10.1002/aur.70097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Auditory and Semantic Processing of Speech-in-Noise in Autism: A Behavioral and EEG Study [texte imprimé] / Jiayin LI, Auteur ; Maleeha SUJAWAL, Auteur ; Zivile BERNOTAITE, Auteur ; Ian CUNNINGS, Auteur ; Fang LIU, Auteur . - p.2011-2030. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2011-2030 Mots-clés : autism  N400  neural tracking  speech-in-noise  temporal response functions Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals often struggle to recognize speech in noisy environments, but the neural mechanisms behind these challenges remain unclear. Effective speech-in-noise (SiN) processing relies on auditory processing, which tracks target sounds amidst noise, and semantic processing, which further integrates relevant acoustic information to derive meaning. This study examined these two processes in autism. Thirty-one autistic and 31 non-autistic adults completed a sentence judgment task under three conditions: quiet, babble noise, and competing speech. Auditory processing was measured using EEG-derived temporal response functions (TRFs), which tracked how the brain follows speech sounds, while semantic processing was assessed via behavioral accuracy and the N400 component, a neural marker of semantic processing. Autistic participants showed reduced TRF responses and delayed N400 onset, indicating less efficient auditory processing and slower semantic processing, despite similar N400 amplitude and behavioral performance. Moreover, non-autistic participants demonstrated a trade-off between auditory and semantic processing resources. In the competing speech condition, they showed enhanced semantic integration but reduced neural tracking of auditory information when managing linguistic competition introduced by intelligible speech noise. In contrast, the autistic group showed no modulation of neural responses, suggesting reduced flexibility in adjusting auditory and semantic demands. These findings highlight distinct neural processing patterns in autistic individuals during SiN tasks, providing new insights into how atypical auditory and semantic processing shape SiN perception in autism. En ligne : https://doi.org/10.1002/aur.70097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Enhancing Handwriting Performance in Autistic Children: A Randomized Crossover Study on the Effectiveness of a Spatial-Structured Handwriting Intervention Program / Jia LE PONG in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2031-2040 Titre : Enhancing Handwriting Performance in Autistic Children: A Randomized Crossover Study on the Effectiveness of a Spatial-Structured Handwriting Intervention Program Type de document : texte imprimé Auteurs : Jia LE PONG, Auteur ; Tsu-Hsin HOWE, Auteur ; Hao-Ling CHEN, Auteur ; Zhi-Chi WENG, Auteur ; Tien-Ni WANG, Auteur Article en page(s) : p.2031-2040 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  logographic handwriting  weak central coherence Index. décimale : PER Périodiques Résumé : ABSTRACT Handwriting is an essential skill for school-aged children. Research indicates that autistic children often demonstrate poor handwriting fundamentals, which significantly affect their handwriting performance. These children also often exhibit weak central coherence (WCC), a cognitive visual processing characteristic that impairs their ability to integrate details into a cohesive whole in writing tasks. This challenge is particularly pronounced in logographic handwriting, where spatial relationships between radicals are essential for legibility, adding another layer of complexity. The modified geometric-based handwriting intervention program was designed to improve fundamental skills while addressing the spatial demands of logographic characters and the impact of WCC for autistic children. Twenty-two first- and second-grade autistic students were recruited and received a 12-h one-on-one handwriting intervention. Assessments of handwriting performance (legibility and speed), fundamental skills (visual perception, fine motor coordination, and visual-motor integration), and acceptability (motivation and satisfaction) were collected for data analysis. Results showed significant improvements in handwriting legibility, visual perception, and fine motor coordination, with high acceptance ratings from both participants and caregivers. This study provides evidence that the program effectively enhances handwriting legibility and foundational skills while maintaining high motivation levels in autistic children. En ligne : https://doi.org/10.1002/aur.70102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Enhancing Handwriting Performance in Autistic Children: A Randomized Crossover Study on the Effectiveness of a Spatial-Structured Handwriting Intervention Program [texte imprimé] / Jia LE PONG, Auteur ; Tsu-Hsin HOWE, Auteur ; Hao-Ling CHEN, Auteur ; Zhi-Chi WENG, Auteur ; Tien-Ni WANG, Auteur . - p.2031-2040. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2031-2040 Mots-clés : autism spectrum disorder  logographic handwriting  weak central coherence Index. décimale : PER Périodiques Résumé : ABSTRACT Handwriting is an essential skill for school-aged children. Research indicates that autistic children often demonstrate poor handwriting fundamentals, which significantly affect their handwriting performance. These children also often exhibit weak central coherence (WCC), a cognitive visual processing characteristic that impairs their ability to integrate details into a cohesive whole in writing tasks. This challenge is particularly pronounced in logographic handwriting, where spatial relationships between radicals are essential for legibility, adding another layer of complexity. The modified geometric-based handwriting intervention program was designed to improve fundamental skills while addressing the spatial demands of logographic characters and the impact of WCC for autistic children. Twenty-two first- and second-grade autistic students were recruited and received a 12-h one-on-one handwriting intervention. Assessments of handwriting performance (legibility and speed), fundamental skills (visual perception, fine motor coordination, and visual-motor integration), and acceptability (motivation and satisfaction) were collected for data analysis. Results showed significant improvements in handwriting legibility, visual perception, and fine motor coordination, with high acceptance ratings from both participants and caregivers. This study provides evidence that the program effectively enhances handwriting legibility and foundational skills while maintaining high motivation levels in autistic children. En ligne : https://doi.org/10.1002/aur.70102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Dis/Associations Between Language and In-the-Moment Mental Rotation Effort in Autism / Caroline LARSON in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2041-2053 Titre : Dis/Associations Between Language and In-the-Moment Mental Rotation Effort in Autism Type de document : texte imprimé Auteurs : Caroline LARSON, Auteur ; Laura M. MORETT, Auteur ; Sophie BARTH, Auteur ; Stephanie DURRLEMAN, Auteur ; Mila VULCHANOVA, Auteur Article en page(s) : p.2041-2053 Langues : Anglais (eng) Mots-clés : autism  language  mental rotation  pupillometry Index. décimale : PER Périodiques Résumé : ABSTRACT In-the-moment dissociations between language and visuospatial systems in autism spectrum disorder (ASD) may explain notable heterogeneity observed in both language and visuospatial skills. The current study used pupillometry, a physiological measure of in-the-moment cognitive effort, during a mental rotation task to examine associations between structural language and visuospatial cognition. Participants were 25 children and young adults with ASD and 25 age- and IQ-matched neurotypical (NT) peers. The mental rotation task involved four conditions: two- and three-dimensional figures, and two- and three-dimensional objects. We measured structural language using the grammar subscale from the Test of Language Development: Intermediate. Growth-curve mixed-effects model results indicated no overall group differences in average pupil dilation or the time course of cognitive effort. Group differences were evident in the association between grammar skills and latency of cognitive effort for stimuli in the objects, 3D, and, more narrowly, 3D objects conditions. Autistic individuals with relatively better grammar skills deployed cognitive effort less efficiently, whereas, NT individuals with relatively better grammar skills deployed cognitive effort more efficiently. These findings suggest that language and visuospatial systems are more dissociated in autistic individuals than in NT peers. This work underscores the importance of examining the time course of how language and cognition interact in ASD. En ligne : https://doi.org/10.1002/aur.70101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Dis/Associations Between Language and In-the-Moment Mental Rotation Effort in Autism [texte imprimé] / Caroline LARSON, Auteur ; Laura M. MORETT, Auteur ; Sophie BARTH, Auteur ; Stephanie DURRLEMAN, Auteur ; Mila VULCHANOVA, Auteur . - p.2041-2053. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2041-2053 Mots-clés : autism  language  mental rotation  pupillometry Index. décimale : PER Périodiques Résumé : ABSTRACT In-the-moment dissociations between language and visuospatial systems in autism spectrum disorder (ASD) may explain notable heterogeneity observed in both language and visuospatial skills. The current study used pupillometry, a physiological measure of in-the-moment cognitive effort, during a mental rotation task to examine associations between structural language and visuospatial cognition. Participants were 25 children and young adults with ASD and 25 age- and IQ-matched neurotypical (NT) peers. The mental rotation task involved four conditions: two- and three-dimensional figures, and two- and three-dimensional objects. We measured structural language using the grammar subscale from the Test of Language Development: Intermediate. Growth-curve mixed-effects model results indicated no overall group differences in average pupil dilation or the time course of cognitive effort. Group differences were evident in the association between grammar skills and latency of cognitive effort for stimuli in the objects, 3D, and, more narrowly, 3D objects conditions. Autistic individuals with relatively better grammar skills deployed cognitive effort less efficiently, whereas, NT individuals with relatively better grammar skills deployed cognitive effort more efficiently. These findings suggest that language and visuospatial systems are more dissociated in autistic individuals than in NT peers. This work underscores the importance of examining the time course of how language and cognition interact in ASD. En ligne : https://doi.org/10.1002/aur.70101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Screen to Screen Versus Face to Face: Evaluating Telehealth Autism Diagnostic Assessments for Young Children in a Diverse Clinical Setting / Rebecca SUTHERLAND in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2054-2062 Titre : Screen to Screen Versus Face to Face: Evaluating Telehealth Autism Diagnostic Assessments for Young Children in a Diverse Clinical Setting Type de document : texte imprimé Auteurs : Rebecca SUTHERLAND, Auteur ; Marie Antoinette HODGE, Auteur ; Kelsie BOULTON, Auteur ; Sarah BARACZ, Auteur ; Gillian BROOKS, Auteur ; Beverley BENNETT, Auteur ; Natalie ONG, Auteur ; Angela PAPANICOLAOU, Auteur ; Gail TOMSIC, Auteur ; Marcia WILLIAMSZ, Auteur ; Adam GUASTELLA, Auteur ; Natalie SILOVE, Auteur Article en page(s) : p.2054-2062 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Access to autism diagnostic assessments continues to be problematic for many families and children. While telehealth assessments have been shown to be feasible and reliable in research settings, less is known about the agreement between telehealth autism assessments compared with in-person evaluations in clinical settings with linguistic, cultural, and social diversity. Twenty-one minimally verbal children (between 23.9 and 51.7?months, mean?=?36.5?months, SD?=?8?months) participated in a telehealth autism assessment (the TELE-ASD-PEDS; TAP) with a parent, and then in an in-person, multidisciplinary team assessment. Telehealth clinicians were blinded to history and questionnaire information; in-person clinicians were blinded to the telehealth results. Assessment results in each setting, along with diagnostic impression (telehealth) and diagnostic outcome (in-person), were compared. Assessment scores across the settings showed very good agreement and were strongly correlated (r?=?0.75, p? En ligne : https://doi.org/10.1002/aur.70113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Screen to Screen Versus Face to Face: Evaluating Telehealth Autism Diagnostic Assessments for Young Children in a Diverse Clinical Setting [texte imprimé] / Rebecca SUTHERLAND, Auteur ; Marie Antoinette HODGE, Auteur ; Kelsie BOULTON, Auteur ; Sarah BARACZ, Auteur ; Gillian BROOKS, Auteur ; Beverley BENNETT, Auteur ; Natalie ONG, Auteur ; Angela PAPANICOLAOU, Auteur ; Gail TOMSIC, Auteur ; Marcia WILLIAMSZ, Auteur ; Adam GUASTELLA, Auteur ; Natalie SILOVE, Auteur . - p.2054-2062. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2054-2062 Index. décimale : PER Périodiques Résumé : ABSTRACT Access to autism diagnostic assessments continues to be problematic for many families and children. While telehealth assessments have been shown to be feasible and reliable in research settings, less is known about the agreement between telehealth autism assessments compared with in-person evaluations in clinical settings with linguistic, cultural, and social diversity. Twenty-one minimally verbal children (between 23.9 and 51.7?months, mean?=?36.5?months, SD?=?8?months) participated in a telehealth autism assessment (the TELE-ASD-PEDS; TAP) with a parent, and then in an in-person, multidisciplinary team assessment. Telehealth clinicians were blinded to history and questionnaire information; in-person clinicians were blinded to the telehealth results. Assessment results in each setting, along with diagnostic impression (telehealth) and diagnostic outcome (in-person), were compared. Assessment scores across the settings showed very good agreement and were strongly correlated (r?=?0.75, p? En ligne : https://doi.org/10.1002/aur.70113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics / Emily C. SKALETSKI in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2063-2075 Titre : Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics Type de document : texte imprimé Auteurs : Emily C. SKALETSKI, Auteur ; Rebekah M. RODRIGUEZ, Auteur ; Sharon G. GARTLAND, Auteur ; Karla K. AUSDERAU, Auteur ; Lauren BISHOP, Auteur ; James J. LI, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : p.2063-2075 Langues : Anglais (eng) Mots-clés : attention-deficit hyperactivity disorder  autism  children  quality of life  sensory  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Quality of life (QoL) is important for everyone and has been identified as a priority for autistic people. However, studies typically focus on caregiver-proxy-reported QoL and its related individual characteristics, even though self- and caregiver-proxy-reported QoL may differ in autistic children. In 74 autistic children (5.04?10.99?years old, intelligence quotient [IQ] 47?141), we sought to determine the level of agreement between self- and caregiver-proxy-reported QoL and determine if self- and caregiver-proxy-reported QoL are differently related to personal characteristics such as age, IQ, autism features, attention-deficit/hyperactivity disorder (ADHD) features, sleep difficulties, and sensory features. Findings suggested poor inter-rater agreement (ICC?=?0.16) between self- and caregiver-proxy-reported QoL. Across both self- and caregiver-proxy reports, sensory features and sleep difficulties related to QoL, but age and IQ did not. We also found an interaction effect of reporter on the relation between QoL and both autism and ADHD features, with these associations driven by caregiver-proxy-reported QoL. These findings emphasize the importance of measuring both self- and caregiver-proxy-reported QoL to provide complementary perspectives. Moreover, these results underscore the importance of understanding a child's sensory features and sleep difficulties, as these two areas were similarly related to both self- and caregiver-proxy-reported QoL. En ligne : https://doi.org/10.1002/aur.70108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics [texte imprimé] / Emily C. SKALETSKI, Auteur ; Rebekah M. RODRIGUEZ, Auteur ; Sharon G. GARTLAND, Auteur ; Karla K. AUSDERAU, Auteur ; Lauren BISHOP, Auteur ; James J. LI, Auteur ; Brittany G. TRAVERS, Auteur . - p.2063-2075. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2063-2075 Mots-clés : attention-deficit hyperactivity disorder  autism  children  quality of life  sensory  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Quality of life (QoL) is important for everyone and has been identified as a priority for autistic people. However, studies typically focus on caregiver-proxy-reported QoL and its related individual characteristics, even though self- and caregiver-proxy-reported QoL may differ in autistic children. In 74 autistic children (5.04?10.99?years old, intelligence quotient [IQ] 47?141), we sought to determine the level of agreement between self- and caregiver-proxy-reported QoL and determine if self- and caregiver-proxy-reported QoL are differently related to personal characteristics such as age, IQ, autism features, attention-deficit/hyperactivity disorder (ADHD) features, sleep difficulties, and sensory features. Findings suggested poor inter-rater agreement (ICC?=?0.16) between self- and caregiver-proxy-reported QoL. Across both self- and caregiver-proxy reports, sensory features and sleep difficulties related to QoL, but age and IQ did not. We also found an interaction effect of reporter on the relation between QoL and both autism and ADHD features, with these associations driven by caregiver-proxy-reported QoL. These findings emphasize the importance of measuring both self- and caregiver-proxy-reported QoL to provide complementary perspectives. Moreover, these results underscore the importance of understanding a child's sensory features and sleep difficulties, as these two areas were similarly related to both self- and caregiver-proxy-reported QoL. En ligne : https://doi.org/10.1002/aur.70108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence / Catrina A. CALUB in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2076-2087 Titre : Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence Type de document : texte imprimé Auteurs : Catrina A. CALUB, Auteur ; Ana-Maria IOSIF, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Julie B. SCHWEITZER, Auteur Article en page(s) : p.2076-2087 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  emotion regulation  females  irritability  sex differences Index. décimale : PER Périodiques Résumé : ABSTRACT This study examines changes in irritability from early childhood to adolescence and differences by diagnostic group, sex, and early childhood nonverbal and verbal abilities. Participants included 243 autistic (AUT) and 194 typically developing (TD) children, with 20% of participants being female, 47% identifying as non-White, and 26% identifying as Hispanic. Data were drawn from the CHARGE (Childhood Autism Risks from Genetics and the Environment) Study, which evaluated children at ages 2?5?years and followed up during pre- (ages 8?12) or late (ages 15?19) adolescence through the ReCHARGE Study. Irritability was higher in the AUT group than in the TD group across all time points; participants overall experienced a decrease in irritability over time. A three-way interaction among sex, diagnosis, and time emerged in late adolescence but not in pre-adolescence, and this effect remained significant even after adjusting for early cognitive abilities. Specifically, TD males and females, and AUT males, showed reductions in irritability, while AUT females exhibited persistently high irritability. In pre-adolescence, higher early verbal and nonverbal cognitive abilities were linked to greater reductions in irritability regardless of diagnosis, whereas in late adolescence, only nonverbal ability predicted irritability change, with this effect specific to autistic youth. Higher levels of adolescent psychopathology were associated with less improvement in irritability, regardless of diagnostic group. Collectively, these findings reveal that while irritability generally decreases over time, its trajectory varies by diagnostic group, sex, and early cognitive ability?highlighting the importance of early identification and interventions, particularly in autistic females, targeting irritability to support positive long-term outcomes. En ligne : https://doi.org/10.1002/aur.70100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence [texte imprimé] / Catrina A. CALUB, Auteur ; Ana-Maria IOSIF, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Julie B. SCHWEITZER, Auteur . - p.2076-2087. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2076-2087 Mots-clés : autism spectrum disorder  emotion regulation  females  irritability  sex differences Index. décimale : PER Périodiques Résumé : ABSTRACT This study examines changes in irritability from early childhood to adolescence and differences by diagnostic group, sex, and early childhood nonverbal and verbal abilities. Participants included 243 autistic (AUT) and 194 typically developing (TD) children, with 20% of participants being female, 47% identifying as non-White, and 26% identifying as Hispanic. Data were drawn from the CHARGE (Childhood Autism Risks from Genetics and the Environment) Study, which evaluated children at ages 2?5?years and followed up during pre- (ages 8?12) or late (ages 15?19) adolescence through the ReCHARGE Study. Irritability was higher in the AUT group than in the TD group across all time points; participants overall experienced a decrease in irritability over time. A three-way interaction among sex, diagnosis, and time emerged in late adolescence but not in pre-adolescence, and this effect remained significant even after adjusting for early cognitive abilities. Specifically, TD males and females, and AUT males, showed reductions in irritability, while AUT females exhibited persistently high irritability. In pre-adolescence, higher early verbal and nonverbal cognitive abilities were linked to greater reductions in irritability regardless of diagnosis, whereas in late adolescence, only nonverbal ability predicted irritability change, with this effect specific to autistic youth. Higher levels of adolescent psychopathology were associated with less improvement in irritability, regardless of diagnostic group. Collectively, these findings reveal that while irritability generally decreases over time, its trajectory varies by diagnostic group, sex, and early cognitive ability?highlighting the importance of early identification and interventions, particularly in autistic females, targeting irritability to support positive long-term outcomes. En ligne : https://doi.org/10.1002/aur.70100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Incidence of Physical Health Conditions in Autistic Children Within 5 Years After Their Autism Diagnosis / Yu-Chieh CHUANG in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2088-2103 Titre : Incidence of Physical Health Conditions in Autistic Children Within 5 Years After Their Autism Diagnosis Type de document : texte imprimé Auteurs : Yu-Chieh CHUANG, Auteur ; Yu-Jui HUANG, Auteur ; Meng-Chuan LAI, Auteur ; Sheng-Siang SU, Auteur ; Chian-Jue KUO, Auteur Article en page(s) : p.2088-2103 Langues : Anglais (eng) Mots-clés : autism  comorbidity  incidence  incidence rate ratio  physical illness  prevalence Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to investigate the incidence of physical illnesses of autistic young children compared with children in the general population. This population-based study included children (aged ≤?5?years) with newly diagnosed autism (autism group), followed up for 5?years after their autism diagnoses. Data were collected from Taiwan's National Health Insurance Research Database in the period of 2000?2019. Autistic children (n?=?45,680) were matched (1:20; by age and sex [assigned at birth]) with a comparison group from the general population (n?=?913,600). We calculated incidence rate ratios (IRRs) for physical illnesses diagnosed within 5?years after autism diagnoses. Data were analyzed using Poisson regression models adjusted for person-time and stratified by sex and the presence/absence of intellectual disabilities. The prevalence of almost all illnesses across major organ systems after 1?year of autism diagnosis was higher in the autism group than in the comparison group. The autism group exhibited significantly elevated incidence of cardiovascular disorders, cerebrovascular disorders, and endocrine diseases within 1?year after autism diagnosis (IRR 2.30?71.42). Although the incidence rates of these illnesses decreased over the 5-year follow-up period in the autism group, they remained higher than those in the comparison group, with most IRRs exceeding 2 in the fifth year after autism diagnosis. The IRRs were significant in both autistic male and female children and those with and without intellectual disabilities, although those with intellectual disabilities displayed descriptively larger IRRs. Autistic young children have heightened risks of being diagnosed with physical illnesses soon after their autism diagnoses. Future research should understand the etiological associations between autism and physical illnesses to offer tailored care from early in life. En ligne : https://doi.org/10.1002/aur.70109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Incidence of Physical Health Conditions in Autistic Children Within 5 Years After Their Autism Diagnosis [texte imprimé] / Yu-Chieh CHUANG, Auteur ; Yu-Jui HUANG, Auteur ; Meng-Chuan LAI, Auteur ; Sheng-Siang SU, Auteur ; Chian-Jue KUO, Auteur . - p.2088-2103. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2088-2103 Mots-clés : autism  comorbidity  incidence  incidence rate ratio  physical illness  prevalence Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to investigate the incidence of physical illnesses of autistic young children compared with children in the general population. This population-based study included children (aged ≤?5?years) with newly diagnosed autism (autism group), followed up for 5?years after their autism diagnoses. Data were collected from Taiwan's National Health Insurance Research Database in the period of 2000?2019. Autistic children (n?=?45,680) were matched (1:20; by age and sex [assigned at birth]) with a comparison group from the general population (n?=?913,600). We calculated incidence rate ratios (IRRs) for physical illnesses diagnosed within 5?years after autism diagnoses. Data were analyzed using Poisson regression models adjusted for person-time and stratified by sex and the presence/absence of intellectual disabilities. The prevalence of almost all illnesses across major organ systems after 1?year of autism diagnosis was higher in the autism group than in the comparison group. The autism group exhibited significantly elevated incidence of cardiovascular disorders, cerebrovascular disorders, and endocrine diseases within 1?year after autism diagnosis (IRR 2.30?71.42). Although the incidence rates of these illnesses decreased over the 5-year follow-up period in the autism group, they remained higher than those in the comparison group, with most IRRs exceeding 2 in the fifth year after autism diagnosis. The IRRs were significant in both autistic male and female children and those with and without intellectual disabilities, although those with intellectual disabilities displayed descriptively larger IRRs. Autistic young children have heightened risks of being diagnosed with physical illnesses soon after their autism diagnoses. Future research should understand the etiological associations between autism and physical illnesses to offer tailored care from early in life. En ligne : https://doi.org/10.1002/aur.70109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Meta-Analysis of Soft Skills Interventions for Transition-Age Autistic Individuals / Heerak CHOI in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2104-2119 Titre : Meta-Analysis of Soft Skills Interventions for Transition-Age Autistic Individuals Type de document : texte imprimé Auteurs : Heerak CHOI, Auteur ; Hyun-Ju JU, Auteur ; Connie SUNG, Auteur Article en page(s) : p.2104-2119 Langues : Anglais (eng) Mots-clés : autistic individuals  employment-related social skills  meta-analysis  moderation  soft skills Index. décimale : PER Périodiques Résumé : ABSTRACT There has been growing interest in developing and evaluating soft skills interventions for transition-age autistic individuals. While many interventions demonstrated effectiveness in improving social competence, there is limited evidence on the pooled effectiveness of these interventions. In response to the research gap, this study aimed to investigate the effectiveness of soft skills interventions in enhancing social competence among transition-age autistic individuals. A total of 18 articles consisting of eight randomized controlled trials and 10 pre- and post-intervention studies were identified after a systematic review, and the effectiveness of these interventions was examined using the meta package on R 4.4.1. The analysis revealed overall positive effects of soft skills interventions in social adjustment (g?=?0.53, p? En ligne : https://doi.org/10.1002/aur.70085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Meta-Analysis of Soft Skills Interventions for Transition-Age Autistic Individuals [texte imprimé] / Heerak CHOI, Auteur ; Hyun-Ju JU, Auteur ; Connie SUNG, Auteur . - p.2104-2119. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2104-2119 Mots-clés : autistic individuals  employment-related social skills  meta-analysis  moderation  soft skills Index. décimale : PER Périodiques Résumé : ABSTRACT There has been growing interest in developing and evaluating soft skills interventions for transition-age autistic individuals. While many interventions demonstrated effectiveness in improving social competence, there is limited evidence on the pooled effectiveness of these interventions. In response to the research gap, this study aimed to investigate the effectiveness of soft skills interventions in enhancing social competence among transition-age autistic individuals. A total of 18 articles consisting of eight randomized controlled trials and 10 pre- and post-intervention studies were identified after a systematic review, and the effectiveness of these interventions was examined using the meta package on R 4.4.1. The analysis revealed overall positive effects of soft skills interventions in social adjustment (g?=?0.53, p? En ligne : https://doi.org/10.1002/aur.70085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children / Roseann C. SCHAAF in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2120-2134 Titre : A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children Type de document : texte imprimé Auteurs : Roseann C. SCHAAF, Auteur ; Elizabeth M. RIDGWAY, Auteur ; Emily A. JONES, Auteur ; Rachel L. DUMONT, Auteur ; John FOXE, Auteur ; Tim CONLY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Zoe MAILLOUX, Auteur ; Joanne M. HUNT, Auteur ; Leon KIRSCHNER, Auteur ; Ben E. LEIBY, Auteur ; Sophie MOLHOLM, Auteur Article en page(s) : p.2120-2134 Langues : Anglais (eng) Mots-clés : applied behavior analysis  autism  autistic  autistic children  Ayres Sensory Integration  occupational therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic children demonstrate sensory integration differences that impact their participation in daily living activities and tasks. Occupational Therapy using Ayres Sensory Integration (OT-ASI) is an evidence-based intervention for autistic children that addresses the sensory integrative factors impacting daily living skills and participation in a variety of tasks and activities. Applied Behavior Analysis (ABA) is the recommended evidence-based practice for autism to improve a range of developmental domains. This study compared Occupational Therapy using Ayres Sensory Integration, Applied Behavior Analysis, and no treatment on daily living skills and individualized goals for autistic children who also show sensory differences. A parallel arm comparative effectiveness trial design with participants randomized equally to OT-ASI, ABA, or no treatment. Intervention consisted of 30 one-hour sessions. Significant gains in individualized goals, measured by Goal Attainment Scaling, were found in both treatment arms over the no treatment group. Both the OT-ASI and the ABA groups improved in daily living skills measured on the Pediatric Evaluation of Disabilities Inventory; although the improvements over the no treatment group were not significant. Both OT-ASI and ABA improved individualized goals and daily living skills at comparable levels. These findings are discussed in light of their implications for intervention. Trial Registration: NCT02536365 En ligne : https://doi.org/10.1002/aur.70099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children [texte imprimé] / Roseann C. SCHAAF, Auteur ; Elizabeth M. RIDGWAY, Auteur ; Emily A. JONES, Auteur ; Rachel L. DUMONT, Auteur ; John FOXE, Auteur ; Tim CONLY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Zoe MAILLOUX, Auteur ; Joanne M. HUNT, Auteur ; Leon KIRSCHNER, Auteur ; Ben E. LEIBY, Auteur ; Sophie MOLHOLM, Auteur . - p.2120-2134. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2120-2134 Mots-clés : applied behavior analysis  autism  autistic  autistic children  Ayres Sensory Integration  occupational therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic children demonstrate sensory integration differences that impact their participation in daily living activities and tasks. Occupational Therapy using Ayres Sensory Integration (OT-ASI) is an evidence-based intervention for autistic children that addresses the sensory integrative factors impacting daily living skills and participation in a variety of tasks and activities. Applied Behavior Analysis (ABA) is the recommended evidence-based practice for autism to improve a range of developmental domains. This study compared Occupational Therapy using Ayres Sensory Integration, Applied Behavior Analysis, and no treatment on daily living skills and individualized goals for autistic children who also show sensory differences. A parallel arm comparative effectiveness trial design with participants randomized equally to OT-ASI, ABA, or no treatment. Intervention consisted of 30 one-hour sessions. Significant gains in individualized goals, measured by Goal Attainment Scaling, were found in both treatment arms over the no treatment group. Both the OT-ASI and the ABA groups improved in daily living skills measured on the Pediatric Evaluation of Disabilities Inventory; although the improvements over the no treatment group were not significant. Both OT-ASI and ABA improved individualized goals and daily living skills at comparable levels. These findings are discussed in light of their implications for intervention. Trial Registration: NCT02536365 En ligne : https://doi.org/10.1002/aur.70099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569