Dépouillements

Understanding Barriers to Assessment and Diagnosis of Autism in Adulthood: Where Are We Now and How Do We Move Forward? / Aspasia Stacey RABBA in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2362-2367 Titre : Understanding Barriers to Assessment and Diagnosis of Autism in Adulthood: Where Are We Now and How Do We Move Forward? Type de document : texte imprimé Auteurs : Aspasia Stacey RABBA, Auteur ; Linnea LAMPINEN, Auteur ; Phoebe MELDRUM, Auteur ; Patrick DWYER, Auteur ; Mikle SOUTH, Auteur ; Lauren TAYLOR, Auteur ; Mirko ULJAREVIĆ, Auteur ; Vanessa H. BAL, Auteur Article en page(s) : p.2362-2367 Langues : Anglais (eng) Résumé : ABSTRACT Assessment and diagnosis of autism in adulthood is a growing area of interest for both clinical and research practice. In this commentary, we present a thematic analysis following the first International Society for Autism Research Special Interest Group (SIG) focused on assessment and diagnosis of autism in adulthood. An increasing recognition of missed or misdiagnosed autistic adults is highlighted throughout the commentary. Recommendations for reducing barriers in diagnostic processes are reviewed, including improving existing adult autism measures and developing new ones, especially self-report/interview tools capturing what cannot be externally observed; providing more information about the process ahead of time and better post-diagnostic support; better assessment of psychosocial and mental health histories; training to promote clinicians' understanding of adult autism; and the importance of considering culture. Professional and government bodies should support the development of neuroaffirming, client-centered practice guidelines that actively include input and co-design from autistic adults. En ligne : https://doi.org/10.1002/aur.70136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Understanding Barriers to Assessment and Diagnosis of Autism in Adulthood: Where Are We Now and How Do We Move Forward? [texte imprimé] / Aspasia Stacey RABBA, Auteur ; Linnea LAMPINEN, Auteur ; Phoebe MELDRUM, Auteur ; Patrick DWYER, Auteur ; Mikle SOUTH, Auteur ; Lauren TAYLOR, Auteur ; Mirko ULJAREVIĆ, Auteur ; Vanessa H. BAL, Auteur . - p.2362-2367. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2362-2367 Résumé : ABSTRACT Assessment and diagnosis of autism in adulthood is a growing area of interest for both clinical and research practice. In this commentary, we present a thematic analysis following the first International Society for Autism Research Special Interest Group (SIG) focused on assessment and diagnosis of autism in adulthood. An increasing recognition of missed or misdiagnosed autistic adults is highlighted throughout the commentary. Recommendations for reducing barriers in diagnostic processes are reviewed, including improving existing adult autism measures and developing new ones, especially self-report/interview tools capturing what cannot be externally observed; providing more information about the process ahead of time and better post-diagnostic support; better assessment of psychosocial and mental health histories; training to promote clinicians' understanding of adult autism; and the importance of considering culture. Professional and government bodies should support the development of neuroaffirming, client-centered practice guidelines that actively include input and co-design from autistic adults. En ligne : https://doi.org/10.1002/aur.70136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Comparative Analysis of Cannabidiol and Risperidone on Behavioral and Neurochemical Outcomes, and Neurodevelopment Markers in a Zebrafish Model of Embryonic Exposure to Sodium Valproate / Karla C.M. COSTA in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2368-2381 Titre : Comparative Analysis of Cannabidiol and Risperidone on Behavioral and Neurochemical Outcomes, and Neurodevelopment Markers in a Zebrafish Model of Embryonic Exposure to Sodium Valproate Type de document : texte imprimé Auteurs : Karla C.M. COSTA, Auteur ; Tamires A.V. BRIGANTE, Auteur ; Pedro H. C. LIRIO, Auteur ; Gabriel G. FERNANDES, Auteur ; Franciele F. SCARANTE, Auteur ; Davi S. SCOMPARIN, Auteur ; Rafael R. FERREIRA, Auteur ; Maria A. VICENTE, Auteur ; Flavia R. ABE, Auteur ; Francisco S. GUIMARÃES, Auteur ; Jaime E. C. HALLAK, Auteur ; Jose A. CRIPPA, Auteur ; Danielle P. DE OLIVEIRA, Auteur ; Alline C. CAMPOS, Auteur Article en page(s) : p.2368-2381 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cannabidiol  endocannabinoids  lipid peroxidation  risperidone  zebrafish Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication deficits, repetitive behaviors, and sensory abnormalities. Sodium valproate (VPA) exposure during embryonic development is a well-established preclinical model for ASD, leading to increased oxidative stress in the developing brain, including lipid peroxidation, which affects cell proliferation and organization. This study aimed to investigate the potential therapeutic effects of cannabidiol (CBD) and risperidone (RISP) in reversing ASD-like behaviors and associated neurobiological alterations induced by embryonic VPA exposure in a zebrafish model. Zebrafish embryos were exposed to 125??M VPA for 2?days post-fertilization (dpf). At 3?4?dpf, embryos were treated with 0.06??M CBD or 1??M RISP. Behavioral assays were conducted to assess hyperlocomotion and aggressive behavior. At 7?dpf, lipid peroxidation levels were measured, and expression of glial fibrillary acidic protein (GFAP) and calcium/calmodulin (CaM) were analyzed to evaluate neurobiological changes. VPA exposure resulted in increased hyperlocomotion and aggression. CBD treatment effectively reversed these behaviors, while RISP showed limited efficacy. Additionally, CBD reduced lipid peroxidation and restored anandamide levels, whereas RISP did not exhibit these effects. CBD also normalized GFAP and CaM expression, indicating restoration of glial function and excitatory/inhibitory balance. CBD demonstrated a better efficacy and safety profile compared to RISP in reversing ASD-like behaviors and associated neurobiological alterations in the zebrafish model. These findings suggest that CBD may offer a safer and more effective therapeutic alternative for managing ASD-related symptoms. En ligne : https://doi.org/10.1002/aur.70151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Comparative Analysis of Cannabidiol and Risperidone on Behavioral and Neurochemical Outcomes, and Neurodevelopment Markers in a Zebrafish Model of Embryonic Exposure to Sodium Valproate [texte imprimé] / Karla C.M. COSTA, Auteur ; Tamires A.V. BRIGANTE, Auteur ; Pedro H. C. LIRIO, Auteur ; Gabriel G. FERNANDES, Auteur ; Franciele F. SCARANTE, Auteur ; Davi S. SCOMPARIN, Auteur ; Rafael R. FERREIRA, Auteur ; Maria A. VICENTE, Auteur ; Flavia R. ABE, Auteur ; Francisco S. GUIMARÃES, Auteur ; Jaime E. C. HALLAK, Auteur ; Jose A. CRIPPA, Auteur ; Danielle P. DE OLIVEIRA, Auteur ; Alline C. CAMPOS, Auteur . - p.2368-2381. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2368-2381 Mots-clés : autism spectrum disorder  cannabidiol  endocannabinoids  lipid peroxidation  risperidone  zebrafish Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication deficits, repetitive behaviors, and sensory abnormalities. Sodium valproate (VPA) exposure during embryonic development is a well-established preclinical model for ASD, leading to increased oxidative stress in the developing brain, including lipid peroxidation, which affects cell proliferation and organization. This study aimed to investigate the potential therapeutic effects of cannabidiol (CBD) and risperidone (RISP) in reversing ASD-like behaviors and associated neurobiological alterations induced by embryonic VPA exposure in a zebrafish model. Zebrafish embryos were exposed to 125??M VPA for 2?days post-fertilization (dpf). At 3?4?dpf, embryos were treated with 0.06??M CBD or 1??M RISP. Behavioral assays were conducted to assess hyperlocomotion and aggressive behavior. At 7?dpf, lipid peroxidation levels were measured, and expression of glial fibrillary acidic protein (GFAP) and calcium/calmodulin (CaM) were analyzed to evaluate neurobiological changes. VPA exposure resulted in increased hyperlocomotion and aggression. CBD treatment effectively reversed these behaviors, while RISP showed limited efficacy. Additionally, CBD reduced lipid peroxidation and restored anandamide levels, whereas RISP did not exhibit these effects. CBD also normalized GFAP and CaM expression, indicating restoration of glial function and excitatory/inhibitory balance. CBD demonstrated a better efficacy and safety profile compared to RISP in reversing ASD-like behaviors and associated neurobiological alterations in the zebrafish model. These findings suggest that CBD may offer a safer and more effective therapeutic alternative for managing ASD-related symptoms. En ligne : https://doi.org/10.1002/aur.70151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function / Sara CACCIATO-SALCEDO in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2382-2408 Titre : Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function Type de document : texte imprimé Auteurs : Sara CACCIATO-SALCEDO, Auteur ; Ana B. LAO-RODRÍGUEZ, Auteur ; Manuel S. MALMIERCA, Auteur Article en page(s) : p.2382-2408 Langues : Anglais (eng) Mots-clés : ABR  auditory  auditory phenotypes  autism  Grin2b gene  sex  valproic acid Résumé : ABSTRACT Autism is an early-onset neurodevelopmental disorder characterized by restricted, repetitive behaviors and atypical patterns of social communication and interaction. A considerable proportion of autistic individuals experience divergent auditory perception, which can interfere with their ability to navigate everyday sound environments. Auditory brainstem responses are electrophysiological potentials elicited by auditory stimuli that evaluate neural activity along the auditory nerve and brainstem. Importantly, the auditory brainstem response varies by sex, with females typically showing higher amplitudes and shorter latencies than males. This sex-specific neurophysiological profile is especially relevant in autism research, where the male-to-female diagnosis ratio is approximately 3:1. Thus, exploring the neurobiological mechanisms underlying sex-specific variations in autistic traits is essential. Furthermore, autism sensory profiles may vary based on the independent and mutual effects of environmental and genetic factors. To deepen this understanding, we examined auditory brainstem responses in two rat models of autism: the GRIN2B rare mutation model and the prenatal valproic acid induction model, alongside control animals. We assessed peak amplitudes and latencies (Waves I through V), inter-peak intervals (I?III, I?V, and III?V), and amplitude ratios (III:I, V:I, and V:III). Female rats generally exhibited greater amplitudes and longer latencies across waveforms. Regarding rat models, control animals consistently showed larger amplitudes and shorter latencies compared to autism-like models. Exploratory analyses further suggested pairwise interactions between sex and rat model, indicating modulation of auditory phenotypes linked to autism. Thus, our findings reveal key insights into the effects of sex and rat model, as well as their interactions. En ligne : https://doi.org/10.1002/aur.70125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function [texte imprimé] / Sara CACCIATO-SALCEDO, Auteur ; Ana B. LAO-RODRÍGUEZ, Auteur ; Manuel S. MALMIERCA, Auteur . - p.2382-2408. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2382-2408 Mots-clés : ABR  auditory  auditory phenotypes  autism  Grin2b gene  sex  valproic acid Résumé : ABSTRACT Autism is an early-onset neurodevelopmental disorder characterized by restricted, repetitive behaviors and atypical patterns of social communication and interaction. A considerable proportion of autistic individuals experience divergent auditory perception, which can interfere with their ability to navigate everyday sound environments. Auditory brainstem responses are electrophysiological potentials elicited by auditory stimuli that evaluate neural activity along the auditory nerve and brainstem. Importantly, the auditory brainstem response varies by sex, with females typically showing higher amplitudes and shorter latencies than males. This sex-specific neurophysiological profile is especially relevant in autism research, where the male-to-female diagnosis ratio is approximately 3:1. Thus, exploring the neurobiological mechanisms underlying sex-specific variations in autistic traits is essential. Furthermore, autism sensory profiles may vary based on the independent and mutual effects of environmental and genetic factors. To deepen this understanding, we examined auditory brainstem responses in two rat models of autism: the GRIN2B rare mutation model and the prenatal valproic acid induction model, alongside control animals. We assessed peak amplitudes and latencies (Waves I through V), inter-peak intervals (I?III, I?V, and III?V), and amplitude ratios (III:I, V:I, and V:III). Female rats generally exhibited greater amplitudes and longer latencies across waveforms. Regarding rat models, control animals consistently showed larger amplitudes and shorter latencies compared to autism-like models. Exploratory analyses further suggested pairwise interactions between sex and rat model, indicating modulation of auditory phenotypes linked to autism. Thus, our findings reveal key insights into the effects of sex and rat model, as well as their interactions. En ligne : https://doi.org/10.1002/aur.70125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Patterns and Stability of Repetitive and Restricted Behaviors in Chinese Children With Autism: A 1–3 Year Follow-Up Study / Yanting HOU in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2409-2418 Titre : Patterns and Stability of Repetitive and Restricted Behaviors in Chinese Children With Autism: A 1–3 Year Follow-Up Study Type de document : texte imprimé Auteurs : Yanting HOU, Auteur ; Wenwen HUANG, Auteur ; Lijing LIN, Auteur ; Xiaosong LI, Auteur ; Si DAI, Auteur ; Yidong SHEN, Auteur ; Jianjun OU, Auteur Article en page(s) : p.2409-2418 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  longitudinal design  repetitive and restricted behaviors  sex-related differences Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by significant clinical heterogeneity. Sex-based differences are observed in the core symptoms of ASD. This study investigated the patterns and stability of restricted and repetitive behaviors (RRBs) among Chinese children with ASD. For cross-sectional comparisons, researchers recruited 1760 male and 350 female participants whose ages ranged from 4 to 17?years. The Social Responsiveness Scale-2 (SRS-2) was used to measure the core symptoms of ASD. Compared with males, females exhibited lower severity and incidence rates of RRB both overall and at the symptom level. Furthermore, multigroup confirmatory factor analyses demonstrated that sex-related differences did not significantly affect the conceptualization of RRBs. An online follow-up study involving a subset of participants (166 males and 41 females) revealed that RRB symptoms remained stable between the two visits for males; however, only specific symptoms were highly consistent over time for females. This study revealed potential sex-related differences in RRBs among Chinese individuals with ASD and revealed sex-dependent variations in symptom-level presentation patterns and stability. These findings may contribute to a better understanding of the mechanisms underlying sex-related differences and aid in the development of sex-specific diagnostic criteria. En ligne : https://doi.org/10.1002/aur.70130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Patterns and Stability of Repetitive and Restricted Behaviors in Chinese Children With Autism: A 1–3 Year Follow-Up Study [texte imprimé] / Yanting HOU, Auteur ; Wenwen HUANG, Auteur ; Lijing LIN, Auteur ; Xiaosong LI, Auteur ; Si DAI, Auteur ; Yidong SHEN, Auteur ; Jianjun OU, Auteur . - p.2409-2418. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2409-2418 Mots-clés : autism spectrum disorder  longitudinal design  repetitive and restricted behaviors  sex-related differences Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by significant clinical heterogeneity. Sex-based differences are observed in the core symptoms of ASD. This study investigated the patterns and stability of restricted and repetitive behaviors (RRBs) among Chinese children with ASD. For cross-sectional comparisons, researchers recruited 1760 male and 350 female participants whose ages ranged from 4 to 17?years. The Social Responsiveness Scale-2 (SRS-2) was used to measure the core symptoms of ASD. Compared with males, females exhibited lower severity and incidence rates of RRB both overall and at the symptom level. Furthermore, multigroup confirmatory factor analyses demonstrated that sex-related differences did not significantly affect the conceptualization of RRBs. An online follow-up study involving a subset of participants (166 males and 41 females) revealed that RRB symptoms remained stable between the two visits for males; however, only specific symptoms were highly consistent over time for females. This study revealed potential sex-related differences in RRBs among Chinese individuals with ASD and revealed sex-dependent variations in symptom-level presentation patterns and stability. These findings may contribute to a better understanding of the mechanisms underlying sex-related differences and aid in the development of sex-specific diagnostic criteria. En ligne : https://doi.org/10.1002/aur.70130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Proximity of Maternal Time of Immigration to Child's Birth Is Associated With Autism Spectrum Disorder With Early Learning Delay Among Immigrant Populations in the United States: Findings From the Study to Explore Early Development / Kaylynn AIONA in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2419-2430 Titre : Proximity of Maternal Time of Immigration to Child's Birth Is Associated With Autism Spectrum Disorder With Early Learning Delay Among Immigrant Populations in the United States: Findings From the Study to Explore Early Development Type de document : texte imprimé Auteurs : Kaylynn AIONA, Auteur ; Tessa CRUME, Auteur ; Nuri REYES, Auteur ; Sarah J. SCHMIEGE, Auteur ; Janine YOUNG, Auteur ; Brady HOLST, Auteur ; Maureen S. DURKIN, Auteur ; Melissa MAGALLANES, Auteur ; Carolyn DIGUISEPPI, Auteur Article en page(s) : p.2419-2430 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early learning delay  health disparities  immigrant  intellectual disability  migrant Résumé : ABSTRACT Our objective was to examine the relationship between the timing of parental US immigration and autism spectrum disorder (ASD) without early learning delay (ELD), ASD with ELD, and ELD alone among US-born children. We analyzed data from a multi-site case?control study that recruited children aged 2?5?years with ASD or non-ASD developmental disorders and same-age population controls. Parental demographics were collected from caregivers at study enrollment. Mullen Scales of Early Learning ≤?70 was used to define ELD. Among children with a non-US-born parent (N?=?1048), we used multinomial logistic regression to examine time from parental immigration to the child's birth in relation to ASD alone, ASD with ELD (ASD?+?ELD), and ELD alone compared to population controls. Having a non-US-born mother (regardless of the father's birthplace) versus a non-US-born father only was evaluated as a potential effect modifier. Among those with a non-US-born mother, closer proximity of maternal time of immigration to the child's birth is associated with increased odds for ASD?+?ELD and ELD alone. There was no significant association between years since US arrival and ASD alone. Among those with a non-US-born father only, we did not observe a significant relationship between time since paternal US arrival and ASD/ELD categories. Our study suggests that time-varying exposures among immigrant mothers may be of importance for the development of ASD?+?ELD and ELD alone in the offspring. These results may inform research into the etiology of ASD and ELD and ways to support immigrant women of childbearing age. En ligne : https://doi.org/10.1002/aur.70133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Proximity of Maternal Time of Immigration to Child's Birth Is Associated With Autism Spectrum Disorder With Early Learning Delay Among Immigrant Populations in the United States: Findings From the Study to Explore Early Development [texte imprimé] / Kaylynn AIONA, Auteur ; Tessa CRUME, Auteur ; Nuri REYES, Auteur ; Sarah J. SCHMIEGE, Auteur ; Janine YOUNG, Auteur ; Brady HOLST, Auteur ; Maureen S. DURKIN, Auteur ; Melissa MAGALLANES, Auteur ; Carolyn DIGUISEPPI, Auteur . - p.2419-2430. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2419-2430 Mots-clés : autism spectrum disorder  early learning delay  health disparities  immigrant  intellectual disability  migrant Résumé : ABSTRACT Our objective was to examine the relationship between the timing of parental US immigration and autism spectrum disorder (ASD) without early learning delay (ELD), ASD with ELD, and ELD alone among US-born children. We analyzed data from a multi-site case?control study that recruited children aged 2?5?years with ASD or non-ASD developmental disorders and same-age population controls. Parental demographics were collected from caregivers at study enrollment. Mullen Scales of Early Learning ≤?70 was used to define ELD. Among children with a non-US-born parent (N?=?1048), we used multinomial logistic regression to examine time from parental immigration to the child's birth in relation to ASD alone, ASD with ELD (ASD?+?ELD), and ELD alone compared to population controls. Having a non-US-born mother (regardless of the father's birthplace) versus a non-US-born father only was evaluated as a potential effect modifier. Among those with a non-US-born mother, closer proximity of maternal time of immigration to the child's birth is associated with increased odds for ASD?+?ELD and ELD alone. There was no significant association between years since US arrival and ASD alone. Among those with a non-US-born father only, we did not observe a significant relationship between time since paternal US arrival and ASD/ELD categories. Our study suggests that time-varying exposures among immigrant mothers may be of importance for the development of ASD?+?ELD and ELD alone in the offspring. These results may inform research into the etiology of ASD and ELD and ways to support immigrant women of childbearing age. En ligne : https://doi.org/10.1002/aur.70133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms / Laurie-Anne SAPEY-TRIOMPHE in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2431-2450 Titre : Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms Type de document : texte imprimé Auteurs : Laurie-Anne SAPEY-TRIOMPHE, Auteur ; Romain BOUET, Auteur ; Jérémie MATTOUT, Auteur ; Sandrine SONIE, Auteur ; Christina SCHMITZ, Auteur ; Françoise LECAIGNARD, Auteur Article en page(s) : p.2431-2450 Langues : Anglais (eng) Mots-clés : adaptation  auditory  Autism Spectrum Disorders  EEG  mismatch negativity (MMN)  perceptual learning  predictive coding Résumé : ABSTRACT Mismatch negativity (MMN) has been frequently used to assess auditory processing and change detection in autism spectrum disorder (ASD), but findings have been fairly inconsistent. To address this issue, we conducted a systematic review and meta-analysis of MMN amplitude (76 effect sizes) and latency (62 effect sizes) in ASD to identify factors contributing to this heterogeneity and to interpret findings within the predictive coding framework. While residual heterogeneity remained, significant effects of the interaction between age group and design type (unifeature vs. multifeature, i.e., one or several types of deviants) and deviant type were found for MMN amplitude. In multifeature designs, autistic children and adolescents exhibited reduced MMN amplitudes compared to neurotypical peers (g?=?0.25, p?=?0.01), whereas autistic adults showed increased MMN amplitudes (g?=??0.26, p?=?0.02). In addition, autistic individuals had significantly smaller MMN amplitudes than neurotypical individuals in paradigms using phoneme deviants (g?=?0.41, p? En ligne : https://doi.org/10.1002/aur.70131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms [texte imprimé] / Laurie-Anne SAPEY-TRIOMPHE, Auteur ; Romain BOUET, Auteur ; Jérémie MATTOUT, Auteur ; Sandrine SONIE, Auteur ; Christina SCHMITZ, Auteur ; Françoise LECAIGNARD, Auteur . - p.2431-2450. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2431-2450 Mots-clés : adaptation  auditory  Autism Spectrum Disorders  EEG  mismatch negativity (MMN)  perceptual learning  predictive coding Résumé : ABSTRACT Mismatch negativity (MMN) has been frequently used to assess auditory processing and change detection in autism spectrum disorder (ASD), but findings have been fairly inconsistent. To address this issue, we conducted a systematic review and meta-analysis of MMN amplitude (76 effect sizes) and latency (62 effect sizes) in ASD to identify factors contributing to this heterogeneity and to interpret findings within the predictive coding framework. While residual heterogeneity remained, significant effects of the interaction between age group and design type (unifeature vs. multifeature, i.e., one or several types of deviants) and deviant type were found for MMN amplitude. In multifeature designs, autistic children and adolescents exhibited reduced MMN amplitudes compared to neurotypical peers (g?=?0.25, p?=?0.01), whereas autistic adults showed increased MMN amplitudes (g?=??0.26, p?=?0.02). In addition, autistic individuals had significantly smaller MMN amplitudes than neurotypical individuals in paradigms using phoneme deviants (g?=?0.41, p? En ligne : https://doi.org/10.1002/aur.70131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder / Toshiki IWABUCHI in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2451-2462 Titre : Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Toshiki IWABUCHI, Auteur ; Takaharu HIRAI, Auteur ; Naoko UMEDA, Auteur ; Hideto YOGO, Auteur ; Yuuta NISHIMIYA, Auteur ; Yuuki NISHIGAKI, Auteur ; Masaru WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur ; Hideo MATSUZAKI, Auteur Article en page(s) : p.2451-2462 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  glutathione  magnetic resonance spectroscopy  myelin map  resting-state functional connectivity Résumé : ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking. Using proton magnetic resonance spectroscopy, T1-weighted/T2-weighted ratio-derived myelin maps, resting-state functional magnetic resonance imaging (MRI), and cognitive tasks, we examined whether brain GSH levels are lower in individuals with ASD than in those with typical development (TD) and explored ASD-specific association patterns between brain GSH levels, myelination, functional connectivity, and behavioral characteristics. Data from 30 adults with ASD and 27 adults with TD were analyzed. Contrary to our hypothesis, GSH levels in the left temporoparietal junction (TPJ) were higher in the ASD group than in the TD group. Using individual myelin maps, we found a significant group difference in the correlation between left middle frontal gyrus (MFG) myelination and left TPJ GSH levels. Multivariate pattern analysis of resting-state functional MRI revealed that whole-brain functional connectivity patterns from the left MFG differed between the groups in their association with left MFG myelination. Finally, we found a significant group difference in the correlation between emotion recognition ability and the functional connectivity of the left MFG with the bilateral occipitoparietal junction. In conclusion, our findings demonstrate an ASD-specific pattern of associations between left TPJ GSH levels, left MFG myelination, whole-brain functional connectivity patterns of the left MFG, and cognitive phenotype, which suggests compensatory neural mechanisms in ASD. En ligne : https://doi.org/10.1002/aur.70134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder [texte imprimé] / Toshiki IWABUCHI, Auteur ; Takaharu HIRAI, Auteur ; Naoko UMEDA, Auteur ; Hideto YOGO, Auteur ; Yuuta NISHIMIYA, Auteur ; Yuuki NISHIGAKI, Auteur ; Masaru WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur ; Hideo MATSUZAKI, Auteur . - p.2451-2462. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2451-2462 Mots-clés : autism spectrum disorder  glutathione  magnetic resonance spectroscopy  myelin map  resting-state functional connectivity Résumé : ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking. Using proton magnetic resonance spectroscopy, T1-weighted/T2-weighted ratio-derived myelin maps, resting-state functional magnetic resonance imaging (MRI), and cognitive tasks, we examined whether brain GSH levels are lower in individuals with ASD than in those with typical development (TD) and explored ASD-specific association patterns between brain GSH levels, myelination, functional connectivity, and behavioral characteristics. Data from 30 adults with ASD and 27 adults with TD were analyzed. Contrary to our hypothesis, GSH levels in the left temporoparietal junction (TPJ) were higher in the ASD group than in the TD group. Using individual myelin maps, we found a significant group difference in the correlation between left middle frontal gyrus (MFG) myelination and left TPJ GSH levels. Multivariate pattern analysis of resting-state functional MRI revealed that whole-brain functional connectivity patterns from the left MFG differed between the groups in their association with left MFG myelination. Finally, we found a significant group difference in the correlation between emotion recognition ability and the functional connectivity of the left MFG with the bilateral occipitoparietal junction. In conclusion, our findings demonstrate an ASD-specific pattern of associations between left TPJ GSH levels, left MFG myelination, whole-brain functional connectivity patterns of the left MFG, and cognitive phenotype, which suggests compensatory neural mechanisms in ASD. En ligne : https://doi.org/10.1002/aur.70134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Multilevel Resting-State Dysfunctional Connectivity in People With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis / Xinyun LIN in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2463-2477 Titre : Multilevel Resting-State Dysfunctional Connectivity in People With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Xinyun LIN, Auteur ; Simin DENG, Auteur ; Xiuhong LI, Auteur Article en page(s) : p.2463-2477 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional connectivity  meta-analysis  resting-state functional MRI  seed-based d mapping Résumé : ABSTRACT Autism spectrum disorder (ASD) has been linked to dysfunctional communication among brain regions and functional networks, as reflected by abnormal resting-state functional connectivity (rsFC). However, the consistent findings thus far have been elusive. To examine whether individuals with ASD show rsFC differently than healthy individuals at multiple seed levels, we performed a systematic analysis and meta-analysis at all prior seeds, functional network seeds, and single seed levels. This study was registered in the PROSPERO (registration number CRD42024559418). Publications were identified in PubMed, Embase, and PsycINFO from database inception until December 20, 2023. Publications were included that provided seed-based whole-brain rsFC contrasts between a sample with ASD and controls at rest. Seed and peak effect coordinates and intergroup effects were extracted for analysis. Random-effects meta-analysis was performed using the Seed-based d Mapping software. This study included 26 studies from 709 people with ASD and 705 controls. The frontal regions, right medial cingulate gyrus (MCG) (g?=??0.51; 95% CI, ?0.69 to ?0.33) of the ventral attention network (VAN), and medial left superior frontal gyrus (g?=??0.42; 95% CI, ?0.60 to ?0.24) of the DMN were the most robust peak clusters at all prior seeds, functional network seeds, and medial prefrontal cortex seed level respectively. The findings not only support DMN dysfunction in people with ASD but also provide the first evidence of meta-analysis to suggest VAN dysfunction in individuals with ASD. En ligne : https://doi.org/10.1002/aur.70128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Multilevel Resting-State Dysfunctional Connectivity in People With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis [texte imprimé] / Xinyun LIN, Auteur ; Simin DENG, Auteur ; Xiuhong LI, Auteur . - p.2463-2477. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2463-2477 Mots-clés : autism spectrum disorder  functional connectivity  meta-analysis  resting-state functional MRI  seed-based d mapping Résumé : ABSTRACT Autism spectrum disorder (ASD) has been linked to dysfunctional communication among brain regions and functional networks, as reflected by abnormal resting-state functional connectivity (rsFC). However, the consistent findings thus far have been elusive. To examine whether individuals with ASD show rsFC differently than healthy individuals at multiple seed levels, we performed a systematic analysis and meta-analysis at all prior seeds, functional network seeds, and single seed levels. This study was registered in the PROSPERO (registration number CRD42024559418). Publications were identified in PubMed, Embase, and PsycINFO from database inception until December 20, 2023. Publications were included that provided seed-based whole-brain rsFC contrasts between a sample with ASD and controls at rest. Seed and peak effect coordinates and intergroup effects were extracted for analysis. Random-effects meta-analysis was performed using the Seed-based d Mapping software. This study included 26 studies from 709 people with ASD and 705 controls. The frontal regions, right medial cingulate gyrus (MCG) (g?=??0.51; 95% CI, ?0.69 to ?0.33) of the ventral attention network (VAN), and medial left superior frontal gyrus (g?=??0.42; 95% CI, ?0.60 to ?0.24) of the DMN were the most robust peak clusters at all prior seeds, functional network seeds, and medial prefrontal cortex seed level respectively. The findings not only support DMN dysfunction in people with ASD but also provide the first evidence of meta-analysis to suggest VAN dysfunction in individuals with ASD. En ligne : https://doi.org/10.1002/aur.70128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders / Isaac Ho Wai WONG in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2478-2489 Titre : The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders Type de document : texte imprimé Auteurs : Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur Article en page(s) : p.2478-2489 Langues : Anglais (eng) Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders [texte imprimé] / Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur . - p.2478-2489. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2478-2489 Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

A Cross-Sectional Study on Narrative Microstructure in Tamil-Speaking Autistic and Non-Autistic Children / Madhumitha SARAVANAPERUMAL in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2490-2498 Titre : A Cross-Sectional Study on Narrative Microstructure in Tamil-Speaking Autistic and Non-Autistic Children Type de document : texte imprimé Auteurs : Madhumitha SARAVANAPERUMAL, Auteur ; Krupa VENKATRAMAN, Auteur ; Aswathy MURALEEDHARAN, Auteur Article en page(s) : p.2490-2498 Langues : Anglais (eng) Mots-clés : lexical diversity  microstructure  story generation  story retelling  syntactic complexity  weak central coherence Résumé : ABSTRACT Narrative skills involve retelling or generating stories, reflecting cognitive and communication development. This use of language is decontextualized and requires a fluent interplay of various components. Autistic children often demonstrate atypical language development and restricted communication tailored to specific needs. This cross-sectional study examines narrative microstructure in language-level-matched Tamil-speaking autistic children and those without autism, aged 3?5?years. Six microstructure parameters were analyzed through story-retelling and story-generation tasks to assess narrative abilities. The research included 38 Tamil-speaking children, divided based on autism diagnosis and matched for language level using standardized tests. The assessment focused on a retelling task and sequencing cards for story retelling (SR) and story generation (SG). The six microstructure variables evaluated were: total number of words (TNW), total number of utterances (TNU), mean length of utterances in words (MLU-W), mean length of utterances in morphemes (MLU-M), number of different words (NDW), and type-token ratio (TTR). The results indicated that autistic children consistently scored lower across all parameters, exhibiting difficulties with fluency and using shorter, simpler sentences. This study highlights the significance of narrative assessment in enhancing our understanding and support of language development in autistic children. En ligne : https://doi.org/10.1002/aur.70106 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] A Cross-Sectional Study on Narrative Microstructure in Tamil-Speaking Autistic and Non-Autistic Children [texte imprimé] / Madhumitha SARAVANAPERUMAL, Auteur ; Krupa VENKATRAMAN, Auteur ; Aswathy MURALEEDHARAN, Auteur . - p.2490-2498. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2490-2498 Mots-clés : lexical diversity  microstructure  story generation  story retelling  syntactic complexity  weak central coherence Résumé : ABSTRACT Narrative skills involve retelling or generating stories, reflecting cognitive and communication development. This use of language is decontextualized and requires a fluent interplay of various components. Autistic children often demonstrate atypical language development and restricted communication tailored to specific needs. This cross-sectional study examines narrative microstructure in language-level-matched Tamil-speaking autistic children and those without autism, aged 3?5?years. Six microstructure parameters were analyzed through story-retelling and story-generation tasks to assess narrative abilities. The research included 38 Tamil-speaking children, divided based on autism diagnosis and matched for language level using standardized tests. The assessment focused on a retelling task and sequencing cards for story retelling (SR) and story generation (SG). The six microstructure variables evaluated were: total number of words (TNW), total number of utterances (TNU), mean length of utterances in words (MLU-W), mean length of utterances in morphemes (MLU-M), number of different words (NDW), and type-token ratio (TTR). The results indicated that autistic children consistently scored lower across all parameters, exhibiting difficulties with fluency and using shorter, simpler sentences. This study highlights the significance of narrative assessment in enhancing our understanding and support of language development in autistic children. En ligne : https://doi.org/10.1002/aur.70106 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Meaningful Determinants of Early Response: Predicting and Characterizing Behavioral Changes for Minimally Verbal Autistic Children / Jonathan PANGANIBAN in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2499-2507 Titre : Meaningful Determinants of Early Response: Predicting and Characterizing Behavioral Changes for Minimally Verbal Autistic Children Type de document : texte imprimé Auteurs : Jonathan PANGANIBAN, Auteur ; Wendy SHIH, Auteur ; Lynne LEVATO, Auteur ; Stephanie SHIRE, Auteur ; Connie KASARI, Auteur ; The A.I.M. – A.S.D. Team,, Auteur Article en page(s) : p.2499-2507 Langues : Anglais (eng) Résumé : ABSTRACT Autism encompasses a wide range of developmental abilities. Notably, nearly 30% of children fail to achieve phrase speech by kindergarten, even when provided with years of early interventions or participation in rigorously conducted clinical trials. Our understanding of why these challenges persist is limited by an underrepresentation of minimally verbal (MV) children in autism research. Consequently, our understanding of benefits from early intervention is limited. There is promising evidence that minimally verbal autistic children may benefit from an adaptive approach that can address their dynamic needs. Adaptive interventions give service providers the ability to adjust strategies and approaches to match the needs of an individual. A critical component of an adaptive intervention approach is the ability to assess response to the intervention in order to make a decision on the best course of action. Previous work in identifying response to intervention has identified key predictors such as IQ, age, and expressive language ability. However, it may be helpful to examine core developmental skills as important variables driving decisions in adaptive intervention approaches. The current study aims to explore how core developmental skills of MV autistic children are related to early response in the first phase of an adaptive intervention. Our secondary aim examines the skills that are changing among MV children identified as fast responders. This is a secondary data analysis of 194 MV autistic children (M?=?72.42?months old, SD?=?15.14?months) that were recruited to receive an adaptive intervention. The children were assessed for their development in social communication, play, expressive language, and cognition prior to receiving the adaptive intervention, and again after 6?weeks of intervention. At the 6-week mark, children were also assessed for their response to the intervention using a Clinical Global Impression Scale (CGI), which identified children as fast or slow responders to the intervention. Logistic regressions examined the association between core developmental skills and early response to initial intervention while controlling for site differences, age, and gender. Child-initiated joint attention (Z?=?2.15, p?=?0.031) predicted fast response to intervention. Higher play mastery level and more play diversity at baseline also significantly predicted fast response (Z?=?2.20, p?=?0.03; Z?=?2.01, p?=?0.04). Examination of developmental skills that changed during the initial intervention phase showed requesting skills and responding to joint attention as important determinants. Children with improved requesting skills (Z?=?2.69, p?=?0.007) and response to joint attention (Z?=?2.69, p?=?0.007) had increased odds of being identified as fast responders to the intervention. Identifying important core developmental skills among MV autistic children can play a critical role in the decision-making process of adaptive interventions. Especially helpful for MV children is the ability to identify meaningful skills and changes related to early intervention. Our analyses identified the importance of core developmental skills like joint attention and play as meaningful predictors of fast responders. Furthermore, the skills that made the most change among these fast responders were requesting skills and response to joint attention. En ligne : https://doi.org/10.1002/aur.70123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Meaningful Determinants of Early Response: Predicting and Characterizing Behavioral Changes for Minimally Verbal Autistic Children [texte imprimé] / Jonathan PANGANIBAN, Auteur ; Wendy SHIH, Auteur ; Lynne LEVATO, Auteur ; Stephanie SHIRE, Auteur ; Connie KASARI, Auteur ; The A.I.M. – A.S.D. Team,, Auteur . - p.2499-2507. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2499-2507 Résumé : ABSTRACT Autism encompasses a wide range of developmental abilities. Notably, nearly 30% of children fail to achieve phrase speech by kindergarten, even when provided with years of early interventions or participation in rigorously conducted clinical trials. Our understanding of why these challenges persist is limited by an underrepresentation of minimally verbal (MV) children in autism research. Consequently, our understanding of benefits from early intervention is limited. There is promising evidence that minimally verbal autistic children may benefit from an adaptive approach that can address their dynamic needs. Adaptive interventions give service providers the ability to adjust strategies and approaches to match the needs of an individual. A critical component of an adaptive intervention approach is the ability to assess response to the intervention in order to make a decision on the best course of action. Previous work in identifying response to intervention has identified key predictors such as IQ, age, and expressive language ability. However, it may be helpful to examine core developmental skills as important variables driving decisions in adaptive intervention approaches. The current study aims to explore how core developmental skills of MV autistic children are related to early response in the first phase of an adaptive intervention. Our secondary aim examines the skills that are changing among MV children identified as fast responders. This is a secondary data analysis of 194 MV autistic children (M?=?72.42?months old, SD?=?15.14?months) that were recruited to receive an adaptive intervention. The children were assessed for their development in social communication, play, expressive language, and cognition prior to receiving the adaptive intervention, and again after 6?weeks of intervention. At the 6-week mark, children were also assessed for their response to the intervention using a Clinical Global Impression Scale (CGI), which identified children as fast or slow responders to the intervention. Logistic regressions examined the association between core developmental skills and early response to initial intervention while controlling for site differences, age, and gender. Child-initiated joint attention (Z?=?2.15, p?=?0.031) predicted fast response to intervention. Higher play mastery level and more play diversity at baseline also significantly predicted fast response (Z?=?2.20, p?=?0.03; Z?=?2.01, p?=?0.04). Examination of developmental skills that changed during the initial intervention phase showed requesting skills and responding to joint attention as important determinants. Children with improved requesting skills (Z?=?2.69, p?=?0.007) and response to joint attention (Z?=?2.69, p?=?0.007) had increased odds of being identified as fast responders to the intervention. Identifying important core developmental skills among MV autistic children can play a critical role in the decision-making process of adaptive interventions. Especially helpful for MV children is the ability to identify meaningful skills and changes related to early intervention. Our analyses identified the importance of core developmental skills like joint attention and play as meaningful predictors of fast responders. Furthermore, the skills that made the most change among these fast responders were requesting skills and response to joint attention. En ligne : https://doi.org/10.1002/aur.70123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Parental Insightfulness and Its Association With Social Competence in Autistic and Non-Autistic Children / Liron OLIVER-ARONSON in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2508-2520 Titre : Parental Insightfulness and Its Association With Social Competence in Autistic and Non-Autistic Children Type de document : texte imprimé Auteurs : Liron OLIVER-ARONSON, Auteur ; Lital KOHN, Auteur ; Tali GEV, Auteur ; Ofer GOLAN, Auteur Article en page(s) : p.2508-2520 Langues : Anglais (eng) Mots-clés : autism  parental insightfulness  reflective functioning  social competence  social skills Résumé : ABSTRACT Parental insightfulness (PI), the parent's capacity to reflect upon their own and their child's mental and emotional states, has been associated with various aspects of children's socio-emotional development. This study examined PI regarding child-peer interactions and its association with social competence in autistic and non-autistic (NA) children, aged 4?7?years. We hypothesized that parents of autistic and NA children would demonstrate different patterns of PI and that PI would moderate the association between autism diagnosis and social competence. Participants included 68 autistic children and their parents and 46 NA children and their parents. Parents watched videos of their child playing with a peer and completed the Insightfulness Assessment (IA) interview. They also reported on their child's social competence and their own parental reflective functioning. Results revealed that compared to NA children's parents, parents of autistic children showed similar levels of positive insightfulness about their child but had greater difficulties maintaining focus on their child's mental states, showed less acceptance, and more concern about the child. PI moderated the negative association between autism diagnosis and children's social competence so that in higher PI levels, the association was weaker than in lower PI levels. This study's findings suggest higher PI may mitigate social challenges for autistic children. Hence, PI and its nuances may be an intervention target for autistic children's parents with the aim of improving children's social outcomes. En ligne : https://doi.org/10.1002/aur.70127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Parental Insightfulness and Its Association With Social Competence in Autistic and Non-Autistic Children [texte imprimé] / Liron OLIVER-ARONSON, Auteur ; Lital KOHN, Auteur ; Tali GEV, Auteur ; Ofer GOLAN, Auteur . - p.2508-2520. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2508-2520 Mots-clés : autism  parental insightfulness  reflective functioning  social competence  social skills Résumé : ABSTRACT Parental insightfulness (PI), the parent's capacity to reflect upon their own and their child's mental and emotional states, has been associated with various aspects of children's socio-emotional development. This study examined PI regarding child-peer interactions and its association with social competence in autistic and non-autistic (NA) children, aged 4?7?years. We hypothesized that parents of autistic and NA children would demonstrate different patterns of PI and that PI would moderate the association between autism diagnosis and social competence. Participants included 68 autistic children and their parents and 46 NA children and their parents. Parents watched videos of their child playing with a peer and completed the Insightfulness Assessment (IA) interview. They also reported on their child's social competence and their own parental reflective functioning. Results revealed that compared to NA children's parents, parents of autistic children showed similar levels of positive insightfulness about their child but had greater difficulties maintaining focus on their child's mental states, showed less acceptance, and more concern about the child. PI moderated the negative association between autism diagnosis and children's social competence so that in higher PI levels, the association was weaker than in lower PI levels. This study's findings suggest higher PI may mitigate social challenges for autistic children. Hence, PI and its nuances may be an intervention target for autistic children's parents with the aim of improving children's social outcomes. En ligne : https://doi.org/10.1002/aur.70127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

The Influence of Refractive Errors on Facial Expression Processing in Children With Autism Spectrum Disorder: An Eye-Tracking Study / Lingyue KONG in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2521-2537 Titre : The Influence of Refractive Errors on Facial Expression Processing in Children With Autism Spectrum Disorder: An Eye-Tracking Study Type de document : texte imprimé Auteurs : Lingyue KONG, Auteur ; Mingmei LIU, Auteur ; Aohua LI, Auteur ; Xiaoguang PAN, Auteur ; Yan ZHAO, Auteur ; Haotian TAN, Auteur ; Honglin LI, Auteur ; Jia SHI, Auteur ; Liyu REN, Auteur ; Junjun WANG, Auteur ; Zhujun ZHANG, Auteur ; Yatu GUO, Auteur ; Wei ZHANG, Auteur ; Chongying WANG, Auteur Article en page(s) : p.2521-2537 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  children  eye tracking  facial expression  refractive errors Résumé : ABSTRACT Facial expression processing is important for social understanding; among children with autism spectrum disorder (ASD), refractive errors may reduce visual input, further hindering their ability to recognize and interpret faces. This study aimed to investigate the gaze patterns of children with ASD when viewing facial emotion expression pictures under refractive errors and compare these patterns with those of typically developing (TD) children. A total of 76 participants diagnosed with ASD and 73 TD children matched by age were included. All children underwent a comprehensive ophthalmic examination and successfully completed the eye-tracking tasks. Astigmatism accounted for >?90% of refractive errors, though all types were included to reflect real-world visual challenges. The results showed that children with refractive errors showed slower responses to the visual stimuli than children with typical refractive status. Children with ASD and refractive errors exhibited slower responses to the mouth area compared to the nose and eyes and experienced difficulty in rapidly distinguishing between the nose and eyes. Additionally, they were unable to differentiate visual patterns between the nose and mouth regions during fixation tasks. In contrast, children with ASD with typical refractive status showed visual sensitivity and tendencies for areas of interest (AOIs) comparable to those of TD children, with response times fastest for the nose, followed by the eyes, and slowest for the mouth. In conclusion, refractive errors, particularly astigmatism, may substantially contribute to difficulties in accurately responding to facial social cues and directing visual attention to socially relevant areas in children with ASD. En ligne : https://doi.org/10.1002/aur.70129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] The Influence of Refractive Errors on Facial Expression Processing in Children With Autism Spectrum Disorder: An Eye-Tracking Study [texte imprimé] / Lingyue KONG, Auteur ; Mingmei LIU, Auteur ; Aohua LI, Auteur ; Xiaoguang PAN, Auteur ; Yan ZHAO, Auteur ; Haotian TAN, Auteur ; Honglin LI, Auteur ; Jia SHI, Auteur ; Liyu REN, Auteur ; Junjun WANG, Auteur ; Zhujun ZHANG, Auteur ; Yatu GUO, Auteur ; Wei ZHANG, Auteur ; Chongying WANG, Auteur . - p.2521-2537. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2521-2537 Mots-clés : autism spectrum disorder  children  eye tracking  facial expression  refractive errors Résumé : ABSTRACT Facial expression processing is important for social understanding; among children with autism spectrum disorder (ASD), refractive errors may reduce visual input, further hindering their ability to recognize and interpret faces. This study aimed to investigate the gaze patterns of children with ASD when viewing facial emotion expression pictures under refractive errors and compare these patterns with those of typically developing (TD) children. A total of 76 participants diagnosed with ASD and 73 TD children matched by age were included. All children underwent a comprehensive ophthalmic examination and successfully completed the eye-tracking tasks. Astigmatism accounted for >?90% of refractive errors, though all types were included to reflect real-world visual challenges. The results showed that children with refractive errors showed slower responses to the visual stimuli than children with typical refractive status. Children with ASD and refractive errors exhibited slower responses to the mouth area compared to the nose and eyes and experienced difficulty in rapidly distinguishing between the nose and eyes. Additionally, they were unable to differentiate visual patterns between the nose and mouth regions during fixation tasks. In contrast, children with ASD with typical refractive status showed visual sensitivity and tendencies for areas of interest (AOIs) comparable to those of TD children, with response times fastest for the nose, followed by the eyes, and slowest for the mouth. In conclusion, refractive errors, particularly astigmatism, may substantially contribute to difficulties in accurately responding to facial social cues and directing visual attention to socially relevant areas in children with ASD. En ligne : https://doi.org/10.1002/aur.70129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey / Shu-Li SHEN in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2538-2547 Titre : The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey Type de document : texte imprimé Auteurs : Shu-Li SHEN, Auteur ; Ning PAN, Auteur ; Jun-Shan LIN, Auteur ; Ying-Qian CHEN, Auteur ; Li-Zi LIN, Auteur ; Li CAI, Auteur ; Zhao-Yan LIU, Auteur ; Qiang FENG, Auteur ; Jin JING, Auteur ; Xin WANG, Auteur Article en page(s) : p.2538-2547 Langues : Anglais (eng) Mots-clés : adolescents  China  health conditions  neurodevelopmental disorders  prevalence Résumé : ABSTRACT Neurodevelopmental disorders (NDDs) remain poorly understood in adolescents, particularly in middle-income countries like China. To assess NDDs prevalence and their associations with health conditions among Chinese general junior high school students, data from the China Education Panel Survey (CEPS, 2013?2015) were used. A total of 8324 junior high school students were included. Validated questionnaires and tests assessed NDDs (autism spectrum disorder [ASD], language disorder [LD], and attention-deficit/hyperactivity disorder [ADHD]) and health conditions (physical health through overweight/obesity and myopia; mental health through anxiety symptoms and depression symptoms; cognitive functioning through academic performance and cognitive ability; adherence to social norms). Of 8324 participants, 299 (4.59%) had NDDs. Students with NDDs showed higher rates of anxiety symptoms and poor cognitive ability compared to those without NDDs. Specific NDD associations included anxiety symptoms with LD and ADHD, depression symptoms with ASD and ADHD, and poor cognitive ability with ASD and LD. Sex-specific disparities were observed in the associations: the link between NDDs and depression symptoms was evident solely in boys, whereas the association between NDDs and academic performance was significant only in girls. Increased surveillance of NDDs prevalence nationwide and improved support services through better integration of families, schools, and society are needed. En ligne : https://doi.org/10.1002/aur.70111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey [texte imprimé] / Shu-Li SHEN, Auteur ; Ning PAN, Auteur ; Jun-Shan LIN, Auteur ; Ying-Qian CHEN, Auteur ; Li-Zi LIN, Auteur ; Li CAI, Auteur ; Zhao-Yan LIU, Auteur ; Qiang FENG, Auteur ; Jin JING, Auteur ; Xin WANG, Auteur . - p.2538-2547. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2538-2547 Mots-clés : adolescents  China  health conditions  neurodevelopmental disorders  prevalence Résumé : ABSTRACT Neurodevelopmental disorders (NDDs) remain poorly understood in adolescents, particularly in middle-income countries like China. To assess NDDs prevalence and their associations with health conditions among Chinese general junior high school students, data from the China Education Panel Survey (CEPS, 2013?2015) were used. A total of 8324 junior high school students were included. Validated questionnaires and tests assessed NDDs (autism spectrum disorder [ASD], language disorder [LD], and attention-deficit/hyperactivity disorder [ADHD]) and health conditions (physical health through overweight/obesity and myopia; mental health through anxiety symptoms and depression symptoms; cognitive functioning through academic performance and cognitive ability; adherence to social norms). Of 8324 participants, 299 (4.59%) had NDDs. Students with NDDs showed higher rates of anxiety symptoms and poor cognitive ability compared to those without NDDs. Specific NDD associations included anxiety symptoms with LD and ADHD, depression symptoms with ASD and ADHD, and poor cognitive ability with ASD and LD. Sex-specific disparities were observed in the associations: the link between NDDs and depression symptoms was evident solely in boys, whereas the association between NDDs and academic performance was significant only in girls. Increased surveillance of NDDs prevalence nationwide and improved support services through better integration of families, schools, and society are needed. En ligne : https://doi.org/10.1002/aur.70111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis / Christy D. YOON in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2548-2565 Titre : Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis Type de document : texte imprimé Auteurs : Christy D. YOON, Auteur ; Yan XIA, Auteur ; Adriana Kaori TEROL, Auteur ; Hedda MEADAN, Auteur ; Frederick SHIC, Auteur Article en page(s) : p.2548-2565 Langues : Anglais (eng) Mots-clés : autism  eye tracking  intervention  meta-analysis  treatment Résumé : ABSTRACT There is a growing body of evidence suggesting a concurrent association between attentional indices measured via eye tracking and autism symptoms. This meta-analysis examined the utility of eye tracking within longitudinal frameworks for autism interventions, including treatment monitoring and prediction of treatment response. We conducted a multivariate random-effects meta-analysis with a multilevel structure on 25 studies (828 autistic participants; M age?=?3?28?years) to estimate: (a) changes in eye-tracking outcomes from pre- to post-treatment (k?=?179); and (b) the correlation between baseline eye-tracking profiles and changes in developmental outcomes following treatment (k?=?39). Our analysis revealed a moderate and significant summary effect size for changes in eye-tracking outcomes from pre- to post-treatment (Hedge's g?=?0.32, p?=?0.010). Additionally, a moderate but non-significant summary effect size was revealed for the correlation between baseline eye-tracking outcomes and changes in developmental outcomes following treatment (Fisher's z?=?0.20, p?=?0.115), with moderation effects observed based on developmental domain and sex. These findings highlight the potential of eye tracking as a tool for monitoring treatment-induced changes in autistic individuals, while its predictive utility remains less supported. Limitations and implications are discussed. En ligne : https://doi.org/10.1002/aur.70141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis [texte imprimé] / Christy D. YOON, Auteur ; Yan XIA, Auteur ; Adriana Kaori TEROL, Auteur ; Hedda MEADAN, Auteur ; Frederick SHIC, Auteur . - p.2548-2565. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2548-2565 Mots-clés : autism  eye tracking  intervention  meta-analysis  treatment Résumé : ABSTRACT There is a growing body of evidence suggesting a concurrent association between attentional indices measured via eye tracking and autism symptoms. This meta-analysis examined the utility of eye tracking within longitudinal frameworks for autism interventions, including treatment monitoring and prediction of treatment response. We conducted a multivariate random-effects meta-analysis with a multilevel structure on 25 studies (828 autistic participants; M age?=?3?28?years) to estimate: (a) changes in eye-tracking outcomes from pre- to post-treatment (k?=?179); and (b) the correlation between baseline eye-tracking profiles and changes in developmental outcomes following treatment (k?=?39). Our analysis revealed a moderate and significant summary effect size for changes in eye-tracking outcomes from pre- to post-treatment (Hedge's g?=?0.32, p?=?0.010). Additionally, a moderate but non-significant summary effect size was revealed for the correlation between baseline eye-tracking outcomes and changes in developmental outcomes following treatment (Fisher's z?=?0.20, p?=?0.115), with moderation effects observed based on developmental domain and sex. These findings highlight the potential of eye tracking as a tool for monitoring treatment-induced changes in autistic individuals, while its predictive utility remains less supported. Limitations and implications are discussed. En ligne : https://doi.org/10.1002/aur.70141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578